Blockade of Na/H exchanger stimulates glioma tumor immunogenicity and enhances combinatorial TMZ and anti-PD-1 therapy

Hypoxia-Inducible Factor-1α Activity as a Switch for Glioblastoma Responsiveness to Temozolomide

(2018) Alessia Lo Dico et al.   Frontiers in Oncology

A phase II trial of autologous dendritic cell vaccination and radiochemotherapy following fluorescence-guided surgery in newly diagnosed glioblastoma patients

(2017) Susana Inogés et al.   Journal of Translational Medicine

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

(2017) Michael Weller et al.   LANCET ONCOLOGY

Immunotherapies for malignant glioma

(2017) Vassiliki A. Boussiotis et al.   ONCOGENE

Roles of pH and the Na + /H + exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?

(2017) Christian Stock et al.   SEMINARS IN CANCER BIOLOGY

Role of AHR and HIF-1α in Glioblastoma Metabolism

(2017) Galina Gabriely et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2

(2016) Ruth Hendus-Altenburger et al.   BMC BIOLOGY

Immunotherapy approaches in the treatment of malignant brain tumors

(2016) Anastasie M. Dunn-Pirio et al.   CANCER

CGCG clinical practice guidelines for the management of adult diffuse gliomas

(2016) Tao Jiang et al.   CANCER LETTERS

Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma

(2016) Alina Filatova et al.   CANCER RESEARCH

Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+exchanger isoform 1

(2016) Wen Zhu et al.   CARCINOGENESIS

The Basis of Oncoimmunology

(2016) A. Karolina Palucka et al.   CELL

Downregulation of HIF-1a sensitizes U251 glioma cells to the temozolomide (TMZ) treatment

(2016) Jun-Hai Tang et al.   EXPERIMENTAL CELL RESEARCH

Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency

(2016) Eric Bouffet et al.   JOURNAL OF CLINICAL ONCOLOGY

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ion Transporters in Brain Tumors

(2015) Damin Cong et al.   CURRENT MEDICINAL CHEMISTRY

Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide

(2015) Khaled Messaoudi et al.   DRUG DISCOVERY TODAY

Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

(2015) Stefano Ugel et al.   JOURNAL OF CLINICAL INVESTIGATION

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice

(2015) Stefano Garofalo et al.   Nature Communications

A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy

(2015) Rosa Angela Cardone et al.   NEOPLASIA

Immunotherapy for cancer in the central nervous system: Current and future directions

(2015) David C. Binder et al.   OncoImmunology

CD44 targets Na+/H+ exchanger 1 to mediate MDA-MB-231 cells’ metastasis via the regulation of ERK1/2

(2014) G Chang et al.   BRITISH JOURNAL OF CANCER

Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells

(2014) Akemi Kosaka et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Natural Killer Cells Eradicate Galectin-1-Deficient Glioma in the Absence of Adaptive Immunity

(2014) G. J. Baker et al.   CANCER RESEARCH

Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+extrusion, cell migration and survival

(2014) Damin Cong et al.   CARCINOGENESIS

Membrane androgen receptor sensitive Na+/H+exchanger activity in prostate cancer cells

(2014) Soumya Chatterjee et al.   FEBS LETTERS

P17.40 * GLIOMA ASSOCIATED MICROGLIAL MMP9 EXPRESSION IS UP REGULATED BY TLR2 SIGNALLING AND SENSITIVE TO MINOCYCLINE

(2014) F. Hu et al.   NEURO-ONCOLOGY

Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccination for Recurrent Glioblastoma: A Phase II, Single Arm Trial

(2014) O. Bloch et al.   NEURO-ONCOLOGY

Proton-sensitive cation channels and ion exchangers in ischemic brain injury: New therapeutic targets for stroke?

(2014) Tiandong Leng et al.   PROGRESS IN NEUROBIOLOGY

Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-Independent Vascularization, and Resistance to Antiangiogenic Therapy

(2014) Gregory J. Baker et al.   NEOPLASIA

Glioblastoma cancer stem cells: Role of the microenvironment and therapeutic targeting

(2012) Luca Persano et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of Na+-K+-2Cl–Cotransporter isoform 1 Accelerates Temozolomidemediated Apoptosis in Glioblastoma Cancer Cells

(2012) Jehad Algharabil et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1

(2012) Chii-Wen Chou et al.   NEURO-ONCOLOGY

BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression

(2012) L Persano et al.   Cell Death & Disease

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Myeloid-Derived Suppressor Cells: General Characteristics and Relevance to Clinical Management of Pancreatic Cancer

(2011) P. Goedegebuure et al.   CURRENT CANCER DRUG TARGETS

An optimized protocol for the acute isolation of human microglia from autopsy brain samples

(2011) Marta Olah et al.   GLIA

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Annexin A2 Promotes Glioma Cell Invasion and Tumor Progression

(2011) H. Zhai et al.   JOURNAL OF NEUROSCIENCE

Adjuvant Immunotherapy with Whole-Cell Lysate Dendritic Cells Vaccine for Glioblastoma Multiforme: A Phase II Clinical Trial

(2011) Der-Yang Cho et al.   World Neurosurgery

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression

(2008) Jennifer S. Fang et al.   SEMINARS IN CANCER BIOLOGY