The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells

Small Molecule Inhibitors of Wnt/β-Catenin/Lef-1 Signaling Induces Apoptosis in Chronic Lymphocytic Leukemia Cells In Vitro and In Vivo

(2015) Rajesh Kumar Gandhirajan et al.   NEOPLASIA

Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis

(2013) J Beaudouin et al.   CELL DEATH AND DIFFERENTIATION

SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase-8 signaling pathway

(2013) Yachao Yao et al.   FEBS Journal

Sodium selenite alters microtubule assembly and induces apoptosis in vitro and in vivo

(2013) Kejian Shi et al.   Journal of Hematology & Oncology

Comparative proteomics analysis of sodium selenite-induced apoptosis in human prostate cancer cells

(2013) Ping Chen et al.   Metallomics

PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells

(2013) H Luo et al.   Cell Death & Disease

Cell-Context Dependent TCF/LEF Expression and Function: Alternative Tales of Repression, De-Repression and Activation Potentials

(2012) Catherine D. Mao et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

(2012) John A. Flygare et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selenium and human health

(2012) Margaret P Rayman   LANCET

Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner

(2012) L Wagner et al.   ONCOGENE

Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species

(2012) Shin-Hyung Park et al.   TOXICOLOGY LETTERS

ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells

(2012) S Cristofanon et al.   Cell Death & Disease

Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis

(2011) Hui Luo et al.   CANCER LETTERS

De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF

(2011) A-L Mahul-Mellier et al.   CELL DEATH AND DIFFERENTIATION

Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1

(2011) P Liu et al.   LEUKEMIA

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

(2011) S Löder et al.   LEUKEMIA

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

Inhibitor of apoptosis protein family as diagnostic markers and therapeutic targets of colorectal cancer

(2011) Koh Miura et al.   SURGERY TODAY

BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane

(2010) Z T Schug et al.   CELL DEATH AND DIFFERENTIATION

Ubiquitin chain cleavage: CYLD at work

(2010) Ramin Massoumi   TRENDS IN BIOCHEMICAL SCIENCES

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells

(2009) Fang Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ubiquitin-specific Peptidase 21 Inhibits Tumor Necrosis Factor α-induced Nuclear Factor κB Activation via Binding to and Deubiquitinating Receptor-interacting Protein 1

(2009) Gufeng Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiproliferative and cytotoxic effects of sodium selenite in human colon cancer cells

(2009) Věra Králová et al.   TOXICOLOGY IN VITRO

Inhibitor of apoptosis proteins and apoptosis

(2008) Yunbo Wei et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

(2008) M. Vogler et al.   BLOOD

Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies

(2008) Kim Newton et al.   CELL

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL