Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome

Tumour selective targeting of cell cycle kinases for cancer treatment

(2013) Marieke Aarts et al.   CURRENT OPINION IN PHARMACOLOGY

PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts

(2013) A Bluwstein et al.   Cell Death & Disease

Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members

(2012) Denise Tischner et al.   APOPTOSIS

Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage

(2012) F J Bock et al.   CELL DEATH AND DIFFERENTIATION

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling

(2012) Kiyohiro Ando et al.   MOLECULAR CELL

P53-induced protein with a death domain (PIDD): master of puppets?

(2012) F J Bock et al.   ONCOGENE

Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21WAF1/CIP1

(2011) D Sohn et al.   CELL DEATH AND DIFFERENTIATION

Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs

(2011) Luis I. Toledo et al.   Molecular Oncology

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitosis as an anti-cancer target

(2011) A Janssen et al.   ONCOGENE

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

(2010) H. Christian Reinhardt et al.   MOLECULAR CELL

Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents

(2010) S Zenvirt et al.   ONCOGENE

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

(2010) Cynthia X. Ma et al.   TRENDS IN MOLECULAR MEDICINE

DNA damage- and stress-induced apoptosis occurs independently of PIDD

(2009) Ira R. Kim et al.   APOPTOSIS

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

Protein kinase C isoforms: Multi-functional regulators of cell life and death

(2009) Mary et al.   Frontiers in Bioscience-Landmark

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY

Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation

(2009) K R Greenow et al.   ONCOGENE

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

(2008) Samuel Sidi et al.   CELL

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development

(2008) Verena Labi et al.   JOURNAL OF EXPERIMENTAL MEDICINE