P53-induced protein with a death domain (PIDD): master of puppets?

PIDD4, a novel PIDD isoform without the LRR domain, can independently induce cell apoptosis in cytoplasm

(2011) Lin Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21WAF1/CIP1

(2011) D Sohn et al.   CELL DEATH AND DIFFERENTIATION

PIDD orchestrates translesion DNA synthesis in response to UV irradiation

(2011) E Logette et al.   CELL DEATH AND DIFFERENTIATION

LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway

(2011) H Hasegawa et al.   LEUKEMIA

A Cytosolic ATM/NEMO/RIP1 Complex Recruits TAK1 To Mediate the NF- B and p38 Mitogen-Activated Protein Kinase (MAPK)/MAPK-Activated Protein 2 Responses to DNA Damage

(2011) Y. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

NF-κB Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress

(2011) Moon Hee Lee et al.   MOLECULAR CELL

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90

(2010) A Tinel et al.   CELL DEATH AND DIFFERENTIATION

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

(2010) Shigeki Miyamoto   CELL RESEARCH

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

(2010) T. G. Oliver et al.   GENES & DEVELOPMENT

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

(2010) Zhao-Hui Wu et al.   MOLECULAR CELL

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

DNA damage- and stress-induced apoptosis occurs independently of PIDD

(2009) Ira R. Kim et al.   APOPTOSIS

cIAP1, cIAP2, and XIAP Act Cooperatively via Nonredundant Pathways to Regulate Genotoxic Stress-Induced Nuclear Factor- B Activation

(2009) H.-S. Jin et al.   CANCER RESEARCH

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY

A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase Activation

(2009) Michael Stilmann et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis

(2009) M Olsson et al.   ONCOGENE

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

(2008) Samuel Sidi et al.   CELL

The enigma of caspase-2: the laymen's view

(2008) G Krumschnabel et al.   CELL DEATH AND DIFFERENTIATION

ATM mediates constitutive NF-κB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

(2008) J Grosjean-Raillard et al.   ONCOGENE

Caspase-2 is required for cell death induced by cytoskeletal disruption

(2008) L H Ho et al.   ONCOGENE

Caspases in apoptosis and beyond

(2008) J Li et al.   ONCOGENE

The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats

(2008) K. Niizuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA