Dysregulation of core components of SCF complex in poly-glutamine disorders

Dysfunction of the Ubiquitin Ligase Ube3a May Be Associated with Synaptic Pathophysiology in a Mouse Model of Huntington Disease

(2012) Megha Maheshwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modifiers and mechanisms of multi-system polyglutamine neurodegenerative disorders: lessons from fly models

(2011) Moushami Mallik et al.   JOURNAL OF GENETICS

Targeting Skp1, an Ubiquitin E3 Ligase Component Found Decreased in Sporadic Parkinson’s Disease

(2011) Silvia A. Mandel et al.   Neurodegenerative Diseases

Genetic reduction of the E3 ubiquitin ligase element, SKP1A and environmental manipulation to emulate cardinal features of Parkinson's disease

(2011) Silvia A. Mandel et al.   PARKINSONISM & RELATED DISORDERS

Mutant huntingtin-impaired degradation of β-catenin causes neurotoxicity in Huntington's disease

(2010) Juliette D Godin et al.   EMBO JOURNAL

A Genomewide RNA Interference Screen for Modifiers of Aggregates Formation by Mutant Huntingtin in Drosophila

(2010) S. Zhang et al.   GENETICS

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Silencing/Overexpressing Selected Genes as a Model of Sporadic Parkinson’s Disease

(2010) Tali Fishman-Jacob et al.   Neurodegenerative Diseases

The ubiquitin proteasome system in neuropathology

(2009) Norman L. Lehman   ACTA NEUROPATHOLOGICA

Control of cell growth by the SCF and APC/C ubiquitin ligases

(2009) Jeffrey R Skaar et al.   CURRENT OPINION IN CELL BIOLOGY

The Developmentally Active and Stress-Inducible Noncoding hsr  Gene Is a Novel Regulator of Apoptosis in Drosophila

(2009) M. Mallik et al.   GENETICS

A Sporadic Parkinson Disease Model via Silencing of the Ubiquitin-Proteasome/E3 Ligase Component SKP1A

(2009) Tali Fishman-Jacob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins

(2009) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNAi Screening in Drosophila Cells Identifies New Modifiers of Mutant Huntingtin Aggregation

(2009) Joanna Doumanis et al.   PLoS One

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

(2009) R. Mehta et al.   SCIENCE

E6-AP Promotes Misfolded Polyglutamine Proteins for Proteasomal Degradation and Suppresses Polyglutamine Protein Aggregation and Toxicity

(2008) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Transcription Factor 1-activating Compounds Suppress Polyglutamine-induced Neurodegeneration through Induction of Multiple Molecular Chaperones

(2008) Nobuhiro Fujikake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling

(2008) H.-C. S. Yen et al.   SCIENCE