Article
Medicine, Research & Experimental
Elisabetta Valentini, Simona D'Aguanno, Marta Di Martile, Camilla Montesano, Virginia Ferraresi, Alexandros Patsilinakos, Manuela Sabatino, Lorenzo Antonini, Martina Chiacchiarini, Sergio Valente, Antonello Mai, Gianni Colotti, Rino Ragno, Daniela Trisciuoglio, Donatella Del Bufalo
Summary: Bcl-2 family anti-apoptotic proteins play a significant role in cancer, and finding new molecules targeting these proteins has therapeutic potential. Through virtual screening and experimental validation, IS20 and IS21 were identified as compounds that can inhibit the activity of Bcl-2 family proteins and have anti-proliferative and pro-apoptotic effects on various tumors.
Article
Plant Sciences
Jiazhe Liu, Yongzhi Liu, Hongchang Li, Chuangchao Wei, Anwei Mao, Weiyan Liu, Gaofeng Pan
Summary: The study found that Polyphyllin D (PD) can induce autophagy in breast cancer cells through activation of the JNK1/Bcl-2 pathway, and increase PD-induced cell apoptosis by inhibiting autophagy, thus achieving anti-tumor effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Alakananda Basu
Summary: The interplay between apoptosis and senescence is crucial in cancer development, and targeting the Bcl-2 family proteins could be a promising strategy for cancer therapy. Therapy-induced senescence (TIS), induced by chemotherapeutic agents, has been controversial in its effect on therapeutic outcome. Clearance of senescent cells and overcoming their pro-survival mechanisms are important challenges in cancer treatment. This review article discusses recent literature on the role of the Bcl-2 family proteins in apoptosis and senescence, and the progress and limitations in targeting them for cancer therapy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Akanksha Pandey, Surendra Kumar Trigun
Summary: Modulation of autophagy is a promising strategy in cancer therapy. This study examines the relationship between autophagy and apoptosis markers, as well as nuclear factor erythroid 2-related factor 2 (Nrf2) and reactive oxygen species (ROS), in colorectal cancer cells. Fisetin, an anticancer agent, was found to suppress autophagy and induce apoptosis in SW-480 cells. The effects of autophagy inhibitors and inducers further supported the correlation between fisetin-mediated autophagy suppression and apoptotic induction.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang, Yibo Mei, Jinlai Zhou, Minghai Ma, Jianbin Ma, Yue Chong, Xinyang Wang, Peng Guo, Dalin He, Jin Zeng
Summary: The study found that the novel 450-nm laser-mediated DVDMS-based photodynamic therapy (PDT) can inhibit and induce apoptosis in gastric cancer cells by producing excessive reactive oxygen species (ROS). Additionally, PDT also promoted apoptosis in gastric cancer cells through the autophagy pathway. Furthermore, the study identified the involvement of the ROS/PI3K/Akt/mTOR pathway in the regulation of PDT-induced autophagy.
Review
Biochemistry & Molecular Biology
Daniel Barriuso, Lucia Alvarez-Frutos, Lucia Gonzalez-Gutierrez, Omar Motino, Guido Kroemer, Roberto Palacios-Ramirez, Laura Senovilla
Summary: The Bcl-2 family of proteins, known for regulating apoptosis, is also involved in cellular senescence. These proteins play a role in determining the entry into senescence and the expression levels are modulated during senescence, promoting cell survival. Manipulation of Bax and Bcl-2 expression affects the appearance and survival of tetraploid cells. Understanding the role of Bcl-2 family proteins in senescence can lead to new therapeutic strategies for targeting cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lisenn Lalier, Francois Vallette, Stephen Manon
Summary: This review examines the role of mitochondrial import machineries in the localization of Bcl-2 family members and how these machineries regulate the function of pro- and anti-apoptotic proteins in resting and apoptotic cells.
Article
Food Science & Technology
Hsin-Ling Yang, Sheng-Teng Huang, Zi-He Lyu, Asif Ali Bhat, Chithravel Vadivalagan, Yu-Lyu Yeh, You-Cheng Hseu
Summary: Coenzyme Q0 (CoQ0) from Antrodia camphorata exhibits therapeutic benefits in cancer treatment by activating apoptotic and autophagic cell death pathways.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Oncology
Shanna Qian, Zhong Wei, Wanting Yang, Jinling Huang, Yinfeng Yang, Jinghui Wang
Summary: Apoptosis, a crucial biological process, plays a central role in cancer development and traditional cytotoxic therapies. The study of BCL-2 family proteins in regulating apoptosis and the development of anticancer drugs targeting BCL-2 anti-apoptotic proteins has gained increasing attention, showing great potential in cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Julie Bas, Trang Nguyen, Germain Gillet
Summary: Bcl-2 family proteins, known for their role in regulating apoptosis, also have non-canonical functions in the CNS. Bcl-xL, a close homolog of Bcl-2, plays a crucial role in neuronal development, promoting ATP generation in mitochondria and contributing to synaptic transmission without causing cell death. Understanding the roles of cell death machinery in neurons may have important clinical implications for degenerative diseases and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chathura D. Suraweera, Suresh Banjara, Mark G. Hinds, Marc Kvansakul
Summary: The B-cell lymphoma-2 (Bcl-2) family of genes regulates intrinsic apoptosis by coordinating the integrity of the mitochondrial outer membrane. Bcl-2 genes are present in early metazoans and have different variations among species. The structure of Bcl-2 proteins is highly conserved over evolutionary time, and some Bcl-2 proteins may have non-apoptotic functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hector Flores-Romero, Lisa Hohorst, Malina John, Marie-Christine Albert, Louise E. King, Laura Beckmann, Tamas Szabo, Vanessa Hertlein, Xu Luo, Andreas Villunger, Lukas P. Frenzel, Hamid Kashkar, Ana J. Garcia-Saez
Summary: This study reveals a previously unrecognized activity of tBID in mediating mitochondrial permeabilization independently of BAX and BAK, which has physiological relevance in immune response and cancer therapy. This novel function of tBID is dependent on a specific helix structure and can be blocked by anti-apoptotic proteins, providing potential implications for therapeutic intervention in bacterial infections and cancer treatment.
Article
Pharmacology & Pharmacy
Jiali Yuan, Luke Mo, Yiqun Mo, Yuanbao Zhang, Yue Zhang, Qunwei Zhang
Summary: This study evaluated the toxic effects and mechanisms of fine airborne particulate matter (PM2.5) on human glioblastoma LN-229 cells. The results showed that PM2.5 exposure reduced cell viability and increased autophagy, apoptosis, and ROS production. Further experiments revealed that PM2.5-induced autophagy and apoptosis were mainly caused by ROS generation, particularly by mitochondria, and JNK activation.
Article
Chemistry, Multidisciplinary
Xue-qi Liu, Ling Jiang, Yuan-yuan Li, Yue-bo Huang, Xue-ru Hu, Wei Zhu, Xian Wang, Yong-gui Wu, Xiao-ming Meng, Xiang-ming Qi
Summary: Wogonin has been shown to alleviate glomerulopathy and podocyte injury in diabetic kidney disease (DKD) by regulating the Bcl-2-mediated crosstalk between autophagy and apoptosis. The study also demonstrated the inhibitory effects of wogonin on cellular damage and apoptosis induced by high glucose, as well as its promotion of autophagy in podocytes.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Yao Wang, Qian Chen, Fangzhou Jiao, Chunxia Shi, Maohua Pei, Luwen Wang, Zuojiong Gong
Summary: This study demonstrated that HDAC2 plays a regulatory role in pyroptosis levels during acute liver failure by affecting the ULK1-NLRP3-pyroptosis pathway. Inhibition of HDAC2 may reduce pyroptosis by modulating the K68 lysine site of ULK1. The findings suggest a potential therapeutic target for ALF treatment.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Luciana Dini, Elisa Panzarini, Stefania Mariano, Daniele Passeri, Melania Reggente, Marco Rossi, Cristian Vergallo
CURRENT DRUG TARGETS
(2015)
Article
Toxicology
Elisa Panzarini, Stefania Mariano, Cristian Vergallo, Elisabetta Carata, Gian Maria Fimia, Francesco Mura, Marco Rossi, Viviana Vergaro, Giuseppe Ciccarella, Marco Corazzari, Luciana Dini
TOXICOLOGY IN VITRO
(2017)
Review
Biochemistry & Molecular Biology
Elisa Panzarini, Stefania Mariano, Elisabetta Carata, Francesco Mura, Marco Rossi, Luciana Dini
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Integrative & Complementary Medicine
Elisa Panzarini, Majdi Dwikat, Stefania Mariano, Cristian Vergallo, Luciana Dini
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2014)
Review
Medicine, Research & Experimental
Elisa Panzarini, Luciana Dini
MOLECULAR PHARMACEUTICS
(2014)
Article
Multidisciplinary Sciences
Cristian Vergallo, Claudia Piccoli, Alberto Romano, Elisa Panzarini, Antonio Serra, Daniela Manno, Luciana Dini
Article
Multidisciplinary Sciences
Cristian Vergallo, Luciana Dini, Zsuzsanna Szamosvoelgyi, Bernardetta Anna Tenuzzo, Elisabetta Carata, Elisa Panzarini, Janos F. Laszlo
Article
Multidisciplinary Sciences
Elisa Panzarini, Valentina Inguscio, Gian Maria Fimia, Luciana Dini
Article
Biochemistry & Molecular Biology
Cristian Vergallo, Elisa Panzarini, Bernardetta Anna Tenuzzo, Stefania Mariano, Ada Maria Tata, Luciana Dini
Article
Chemistry, Multidisciplinary
Stefania Mariano, Elisa Panzarini, Maria D. Inverno, Nick Voulvoulis, Luciana Dini
Review
Chemistry, Multidisciplinary
Elisa Panzarini, Stefania Mariano, Stefano Tacconi, Elisabetta Carata, Ada Maria Tata, Luciana Dini
Summary: Nutraceuticals serve as beneficial supplements to modern medicine, with curcumin being an attractive herbal compound due to its multipurpose properties. However, its instability and susceptibility to degradation pose limits to its clinical development, particularly in the context of brain pathologies involving the blood brain barrier. Various studies have focused on developing nanoconstructs to enhance the stability and bioavailability of curcumin, showing promising therapeutical potential in treating neurological disorders.
Article
Health Care Sciences & Services
Elisa Panzarini, Stefano Leporatti, Bernardetta Anna Tenuzzo, Alessandra Quarta, Nemany A. N. Hanafy, Gianluigi Giannelli, Camilla Moliterni, Diana Vardanyan, Carolina Sbarigia, Marco Fidaleo, Stefano Tacconi, Luciana Dini
Summary: Encapsulation of TGF- beta 1 receptor inhibitor GLY in nanomicelles has shown improved pharmacological activity in the treatment of hepatic fibrosis, surpassing free GLY in efficacy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Simona Di Giulio, Elisabetta Carata, Stefania Mariano, Elisa Panzarini
Summary: Plant-derived extracellular vesicles (EVs) have significant therapeutic potential for their anticancer, anti-inflammatory, and antioxidant properties. They can transport bioactive molecules effectively and have low toxicity, making them versatile in nanomedicine and drug delivery systems. Additionally, their physicochemical stability in gastric and intestinal fluids make them ideal as carriers in oral formulations for nutritional purposes.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Elisa Panzarini, Stefano Tacconi, Elisabetta Carata, Stefania Mariano, Ada Maria Tata, Luciana Dini
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Physics, Multidisciplinary
E. Panzarini, B. Tenuzzo, C. Vergallo, L. Dini
NUOVO CIMENTO C-COLLOQUIA AND COMMUNICATIONS IN PHYSICS
(2013)