Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

MdmX regulates transformation and chromosomal stability in p53-deficient cells

(2011) Zdenka Matijasevic et al.   CELL CYCLE

p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways

(2010) Y. Buganim et al.   CANCER RESEARCH

Mutations in the tetramerization domain of p53: More than just keeping monomers apart

(2010) Ido Goldstein et al.   CELL CYCLE

Characterization of a new cancer-associated mutant of p53 with a missense mutation (K351N) in the tetramerization domain

(2010) Michela Muscolini et al.   CELL CYCLE

Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function

(2010) Aymone Gurtner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis

(2009) Vera V. Grinkevich et al.   CANCER CELL

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

HIPK2 Regulation by MDM2 Determines Tumor Cell Response to the p53-Reactivating Drugs Nutlin-3 and RITA

(2009) C. Rinaldo et al.   CANCER RESEARCH

Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53

(2009) S. Haupt et al.   CANCER RESEARCH

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

A Regulatory Loop Composed of RAP80-HDM2-p53 Provides RAP80-enhanced p53 Degradation by HDM2 in Response to DNA Damage

(2009) Jun Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis

(2009) V Marcel et al.   JOURNAL OF MEDICAL GENETICS

Identification of New p53 Acetylation Sites in COS-1 Cells

(2009) Anita Joubel et al.   MOLECULAR & CELLULAR PROTEOMICS

Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

(2009) Salah Mahmoudi et al.   MOLECULAR CELL

p53 mutations as fingerprints for aristolochic acid – an environmental carcinogen in endemic (Balkan) nephropathy

(2009) Neda Slade et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

(2009) Kaori Fujita et al.   NATURE CELL BIOLOGY

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis

(2009) Giulia Fontemaggi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recent advances in p53 research: an interdisciplinary perspective

(2008) M Olivier et al.   CANCER GENE THERAPY

Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence

(2008) K. Kumamoto et al.   CANCER RESEARCH

Peptide Aptamers Targeting Mutant p53 Induce Apoptosis in Tumor Cells

(2008) E. Guida et al.   CANCER RESEARCH

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

(2008) Myung-Kwan Han et al.   Cell Stem Cell

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

(2008) T. Terzian et al.   GENES & DEVELOPMENT

TP53mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours

(2008) Tatiana Nedelko et al.   INTERNATIONAL JOURNAL OF CANCER

Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype

(2008) Helene R. McMurray et al.   NATURE

Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells

(2008) T Maimets et al.   ONCOGENE

Cancer cells suppress p53 in adjacent fibroblasts

(2008) J Bar et al.   ONCOGENE

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

(2008) F. M. Boeckler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

(2008) Jennifer J. Jordan et al.   PLoS Genetics