Article
Multidisciplinary Sciences
Alice H. Reis, Sergei Y. Sokol
Summary: In Xenopus anteroposterior axis specification, Rspo2 acts as a Wnt antagonist by inhibiting TCF3/TCF7L1 phosphorylation, therefore suppressing target gene activation. This mechanism suggests that Rspo2 is a context-specific regulator of TCF3 phosphorylation and Wnt signaling.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Hiroshi Kishimoto, Masayoshi Iwasaki, Kensaku Wada, Keita Horitani, Osamu Tsukamoto, Kenta Kamikubo, Seitaro Nomura, Shinji Matsumoto, Takeshi Harada, Daisuke Motooka, Daisuke Okuzaki, Seiji Takashima, Issei Komuro, Akira Kikuchi, Ichiro Shiojima
Summary: The study shows that cardiomyocyte-specific Wnt5a knockout mice exhibit improved systolic function and reduced expression of mechanosensitive genes when subjected to pressure overload. Further experiments reveal that Wnt5a knockdown leads to downregulation of TEAD1 and YAP, which are important factors in cardiomyocyte mechanotransduction. Therefore, the Wnt5a-YAP signaling axis plays a crucial role in the progression of heart failure.
Review
Cell Biology
Benjamin Steventon, Lara Busby, Alfonso Martinez Arias
Summary: The emergence of a conserved body plan in vertebrate embryos through gastrulation involves gene regulatory networks and multicellular interactions. Stem cell models of early embryogenesis from different species show similar structures in culture, with the main difference being the boundary conditions of multicellular ensembles. The mechanical and geometric boundary conditions of different embryos before gastrulation reveal a morphogenetic ground state in stem-cell-based models of embryo development.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Anja Tursch, Natascha Bartsch, Moritz Mercker, Jana Schlueter, Mark Lommel, Anna Marciniak-Czochra, Suat Oezbek, Thomas W. Holstein
Summary: In Hydra regeneration, the interaction between MAPKs and Wnt signaling determines the fate of regenerating tissue by integrating different injury response patterns. This mechanism plays a crucial role in Hydra's regeneration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Developmental Biology
Nicolle A. Bonar, David Gittin, Christian P. Petersen
Summary: A factor called src-1 is found to play a crucial role in planarian tissue identity determination, promoting body regionalization by restricting head and trunk identities. It acts in parallel with Wnt/FGFRL signaling pathways.
Article
Oncology
Fei Yue, Weiyu Jiang, Amy T. Ku, Adelaide I. J. Young, Weijie Zhang, Eric P. Souto, Yankun Gao, Zihan Yu, Yi Wang, Chad J. Creighton, Chandandeep Nagi, Tao Wang, Susan G. Hilsenbeck, Xin-Hua Feng, Shixia Huang, Cristian Coarfa, Xiang H-F Zhang, Qingyun Liu, Xia Lin, Yi Li
Summary: The mechanism by which LGR4 promotes cancer metastasis is independent of the Wnt signaling pathway and involves interaction with EGFR to block its degradation, leading to increased migration and invasion of cancer cells.
Article
Oncology
Gui-Feng Su, Ze-Xiu Huang, Deng-Liang Huang, Peng-Xiao Chen, Yao Wang, Yi-Fei Wang
Summary: Cepharanthine was found to inhibit cellular proliferation and invasion, and promote apoptosis in liver cancer cells. Mechanistic investigations revealed that cepharanthine suppressed the Hedgehog/Gli1 signaling pathway and inhibited Wnt/beta-catenin signaling, suggesting cepharanthine as a potential therapy for refractory liver cancer and other Wnt/Hedgehog-driven cancers.
Article
Cell Biology
Abdulkhaliq Alsaadi, Mara Artibani, Zhiyuan Hu, Nina Wietek, Matteo Morotti, Laura Santana Gonzalez, Moiad Alazzam, Jason Jiang, Beena Abdul, Hooman Soleymani Majd, Levi L. Blazer, Jarret Adams, Francesca Silvestri, Sachdev S. Sidhu, Joan S. Brugge, Ahmed Ashour Ahmed
Summary: The study addresses the limited knowledge about fallopian tube (FT) stem cells and lack of in vitro models for their renewal and differentiation. It identifies the importance of WNT/β-catenin signaling for FT stem cell renewal and the critical role of an endogenous hormone-regulated WNT7A-FZD5 signaling axis in this process.
Article
Cell Biology
Eirini-Maria Giatagana, Aikaterini Berdiaki, Margrethe Gaardlos, Aristidis M. Tsatsakis, Sergey A. Samsonov, Dragana Nikitovic
Summary: Biglycan exhibits protective effects against doxorubicin in MG63 osteosarcoma cells through activating the Wnt signaling pathway and inhibiting autophagy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Mei Hua Chen, Li Sheng Fu, Fan Zhang, Ying Yang, Xing Zhong Wu
Summary: The study revealed that m6A-modified lncAY functions through m6A reader protein YTHDF2 to upregulate BMI1 expression in HCC cells, showing a positive correlation between the two. BMI1 was found to be upregulated in HCC tissues and higher BMI1 expression in patients was associated with poor clinical prognosis, indicating a novel regulatory signaling pathway involved in liver cancer progression.
Article
Cell Biology
Tie Liu, Jie Hu, Bo Han, Shishan Tan, Wenqing Jia, Yu Xin
Summary: The study revealed that RMRP is highly expressed in glioma, and its knockdown can inhibit cell proliferation, promote apoptosis, reduce resistance to TMZ, and hinder the growth of glioma xenograft tumors. RMRP down-regulates ZNRF3 in glioma cells, while forming a positive feedback loop with Wnt/β-catenin signaling to regulate TMZ resistance in glioma.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Mengting Wu, Qiongzi Qiu, Qing Zhou, Jia Li, Juze Yang, Chengcai Zheng, Aoran Luo, Xufan Li, Honghe Zhang, Xiaodong Cheng, Weiguo Lu, Pengyuan Liu, Bingjian Lu, Yan Lu
Summary: This study identifies circFBXO7, a novel circRNA, as a tumor suppressor in ovarian cancer. The circFBXO7/miR-96-5p/MTSS1 axis is found to be an important regulator in the Wnt/beta-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Zhaobo Cheng, Renjie Yu, Li Li, Junhao Mu, Yijia Gong, Fan Wu, Yujia Liu, Xiangyi Zhou, Xiaohua Zeng, Yongzhong Wu, Ran Sun, Tingxiu Xiang
Summary: In our research, we identified ZNF334 as a novel tumor suppressor of triple-negative breast cancer (TNBC). ZNF334 expression was usually reduced in breast cancer tissues and TNBC cell lines, likely due to promoter hypermethylation. Ectopic expression of ZNF334 suppressed the growth and metastatic capacity of TNBC cell lines, induced cell cycle arrest at S phase and apoptosis. Additionally, re-expression of ZNF334 restored the Epithelial-Mesenchymal Transition (EMT) process and inhibited stemness by up-regulating SFRP1.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
So-Yeon Park, Ji-Young Kim, Gyu-Beom Jang, Jang-Hyun Choi, Jee-Heun Kim, Choong-Jae Lee, Sunjae Lee, Jeong-Heum Baek, Kwan-Kyu Park, Jin-Man Kim, Hee Jin Chang, Nam-Chul Cho, Jeong-Seok Nam
Summary: This study identified an increased expression of CD45 in CRC (EpCAM+) epithelial cells after CRT treatment. High CD45 expression promoted CRC cell survival upon 5-fluorouracil or radiation treatment, while CD45 depletion sensitized CRC cells to CRT. CD45 was found to be preferentially expressed in cancer stem-like cells (CSCs) and played a crucial role in CSC functions such as cancer initiation, repopulation, and metastasis.
Article
Developmental Biology
Bo Wang, Xiaozhi Rong, Yumei Zhou, Yunzhang Liu, Jiqin Sun, Beibei Zhao, Bei Deng, Lei Lu, Ling Lu, Yun Li, Jianfeng Zhou
Summary: This study reveals that EIF4A3 acts as a Wnt inhibitor by interfering with the formation of beta-catenin/Tcf transcription activation complex, playing a crucial role in regulating embryonic development in zebrafish.
Article
Multidisciplinary Sciences
Carles Gaston-Massuet, Mark J. McCabe, Valeria Scagliotti, Rodrigo M. Young, Gabriela Carreno, Louise C. Gregory, Sujatha A. Jayakody, Sara Pozzi, Angelica Gualtieri, Basudha Basu, Markela Koniordou, Chun-I Wu, Rodrigo E. Bancalari, Elisa Rahikkala, Riitta Veijola, Tuija Lopponen, Federica Graziola, James Turton, Massimo Signore, Seyedeh Neda Mousavy Gharavy, Nicoletta Charolidi, Sergei Y. Sokol, Cynthia Lilian Andoniadou, Stephen W. Wilson, Bradley J. Merrill, Mehul T. Dattani, Juan Pedro Martinez-Barbera
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biology
Chih-Wen Chu, Sergei Y. Sokol
Article
Developmental Biology
Olga Ossipova, Ryan Kerney, Jean-Pierre Saint-Jeannet, Sergei Y. Sokol
Article
Cell Biology
Chih-Wen Chu, Bo Xiang, Olga Ossipova, Andriani Ioannou, Sergei Y. Sokol
JOURNAL OF CELL SCIENCE
(2018)
Article
Biology
Ilya Chuykin, Olga Ossipova, Sergei Y. Sokol
Article
Multidisciplinary Sciences
Keiji Itoh, Alice H. Reis, Andrew Hayhurst, Sergei Y. Sokol
Article
Developmental Biology
Alice H. Reis, Sergei Y. Sokol
Article
Developmental Biology
Olga Ossipova, Keiji Itoh, Aurelian Radu, Jerome Ezan, Sergei Y. Sokol
Review
Urology & Nephrology
Elena Torban, Sergei Y. Sokol
Summary: Planar cell polarity (PCP) is crucial for the coordinated orientation of cells in the tissue plane and is involved in various morphogenetic processes, particularly in kidney development. Mutations in PCP genes can lead to malformations in organs, including the kidney, emphasizing the importance of PCP pathway in normal development and disease.
NATURE REVIEWS NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
Keiji Itoh, Olga Ossipova, Sergei Y. Sokol
Summary: Pnhd binds and inactivates Admp to promote notochord development by reducing Smad1 phosphorylation. Additionally, Pnhd cooperates with Chordin and a truncated BMP4 receptor in inducing notochord markers in ectoderm cells, leading to notochord defects in Pnhd-depleted embryos.
Article
Multidisciplinary Sciences
Alice H. Reis, Sergei Y. Sokol
Summary: In Xenopus anteroposterior axis specification, Rspo2 acts as a Wnt antagonist by inhibiting TCF3/TCF7L1 phosphorylation, therefore suppressing target gene activation. This mechanism suggests that Rspo2 is a context-specific regulator of TCF3 phosphorylation and Wnt signaling.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Pamela Mancini, Olga Ossipova, Sergei Y. Sokol
Summary: The research findings indicate that PCP in the neural plate is progressively acquired and requires a signal from the posterior region of the embryo. PCP is triggered by a planar cue from the dorsal blastopore lip in the neural plate, independent of the orientation of the graft and distinct from neural inducers.
Article
Cell Biology
Ilya Chuykin, Keiji Itoh, Kyeongmi Kim, Sergei Y. Sokol
Summary: This study demonstrates that the association of Vangl2 and Pk3 is inhibited by Fz3 through phosphorylation of Vangl2, affecting the establishment and orientation of PCP in the tissue. These findings provide new insights into the regulation of Vangl2-Pk3 complex formation by Frizzled receptor in the neural plate.
JOURNAL OF CELL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Alice H. Reis, Bo Xiang, Olga Ossipova, Keiji Itoh, Sergei Y. Sokol
Summary: The interaction between Wtip and SSX2IP proteins is essential for cell junction remodeling and morphogenetic processes during neurulation. Targeted proximity biotinylation (TPB) can be a useful method for identifying protein-protein interactions in cells.
Article
Developmental Biology
Miho Matsuda, Chih-Wen Chu, Sergei Y. Sokol
Summary: This study demonstrates that Lim domain only protein 7 (Lmo7) promotes apical constriction in the Xenopus superficial ectoderm, while its depletion leads to an increase in apical domain size. Lmo7 functions as a scaffold that regulates actomyosin contractility and apical domain size by modulating the localization of non-muscle myosin II (NMII) at apical junctions.
