Article
Cell Biology
Yin Peng, Xiaojing Zhang, Huijuan Lin, Shiqi Deng, Ying Qin, Jieqiong He, Fan Hu, Xiaohui Zhu, Xianling Feng, Jian Wang, Yanjie Wei, Xinmin Fan, Huan Lin, Hassan Ashktorab, Duane Smoot, Yansi Lv, Song Li, Stephen J. Meltzer, Zhe Jin
Summary: Mounting evidence suggests that miRNA-150 upregulation in gastric cancer promotes cell proliferation, migration, and EMT by targeting the tumor suppressor SUFU and activating Hedgehog and Wnt signaling. Inhibition of miRNA-150 shows promise in reducing tumor volume by suppressing Wnt and Hh signaling pathways.
Article
Multidisciplinary Sciences
German Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Summary: RNF43/ZNRF3 alterations contribute to liver disease and liver cancer by affecting differentiation and lipid metabolism of hepatocytes. The loss of these genes leads to steatohepatitis and an increase in unsaturated lipids. Deletion of Rnf43/Znrf3 results in defective hepatocyte regeneration and liver cancer, causing an imbalance between differentiation and proliferation. Interestingly, ZNRF3 mutant liver cancer patients have a poorer prognosis and exhibit altered hepatic lipid metabolism and steatohepatitis/NASH signatures.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Waleed Hassan Almalki, Hafiz A. Makeen, Mohammed Albratty, Abdulkarim M. Meraya, Rupak Nagraik, Avinash Sharma, Deepak Kumar, Dinesh Kumar Chellappan, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Summary: Breast cancer is a challenging cancer to treat, but nutraceuticals can be a beneficial supplementary therapy in reducing disease severity, limiting malignant cell growth, and modifying cancer-related mechanisms.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Ahmed G. Abd Elhameed, Manar G. Helal, Eman Said, Hatem A. Salem
Summary: The study demonstrated that saxagliptin can delay experimentally-induced hepatocellular carcinoma progression by improving liver function biomarkers and acting through the suppression of specific signaling pathways, enhancing tumor apoptosis, and suppressing proliferation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biology
Victor Martinez-Heredia, Danielle Blackwell, Sujith Sebastian, Timothy Pearson, Gi Fay Mok, Laura Mincarelli, Charlotte Utting, Leighton Folkes, Ernst Poeschl, Iain Macaulay, Ulrike Mayer, Andrea Munsterberg
Summary: Skeletal muscle stem cells play a crucial role in tissue homeostasis and repair. This study demonstrates that primary cilia and the Talpid3 gene are essential for self-renewal of muscle stem cells and proper muscle regeneration.
COMMUNICATIONS BIOLOGY
(2023)
Article
Genetics & Heredity
Min Wang, Haiyan Tao, Ping Huang
Summary: The study revealed that LARGE1 is upregulated in liver cancer cells and its knockdown significantly inhibits cell proliferation, migration, and invasion. It also affects cell cycle and tumor growth while regulating the Wnt/beta-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Xichao Xu, Yi Zhang, Xing Wang, Shun Li, Liling Tang
Summary: In liver cancer, higher liver tissue stiffness enhances malignant cell phenotypes and promotes G1/S transition. NEAT1 is identified as a matrix stiffness-responsive lncRNA regulating proliferation and EMT. The activation of the WNT/beta-catenin pathway by NEAT1 in response to increasing matrix stiffness drives EMT and proliferation in liver cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Cell Biology
Florian Hermans, Lara Hemeryck, Ivo Lambrichts, Annelies Bronckaers, Hugo Vankelecom
Summary: Tooth development relies on interactions between dental epithelium and mesenchyme, regulated by molecular pathways including Wnt, BMP, FGF, and Shh. These signaling modules intertwine during tooth development, outlining specific cell populations' development pathways.Recent studies have uncovered crucial Wnt-Shh interactions during odontogenesis, showing conservation in developing ectodermal appendages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Niraj Kumar Jha, Wei-Chih Chen, Sanjay Kumar, Rajni Dubey, Lung-Wen Tsai, Rohan Kar, Saurabh Kumar Jha, Piyush Kumar Gupta, Ankur Sharma, Rohit Gundamaraju, Kumud Pant, Shalini Mani, Sandeep Kumar Singh, Ricardo B. Maccioni, Tirtharaj Datta, Sachin Kumar Singh, Gaurav Gupta, Parteek Prasher, Kamal Dua, Abhijit Dey, Charu Sharma, Yasir Hayat Mughal, Janne Ruokolainen, Kavindra Kumar Kesari, Shreesh Ojha
Summary: Developmental signalling pathways play a central role in neuronal development and any aberration in these pathways can contribute towards neurological disorders. Extensive research has been conducted in the past decade on these pathways, revealing their potential as therapeutic targets for diseases.
Article
Biochemistry & Molecular Biology
Maria Abancens, Brian J. Harvey, Jean McBryan
Summary: Women have lower incidence and mortality rates for colorectal cancer compared to men. Estrogen may protect against colorectal cancer progression through GPER-mediated modulation of the Wnt/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Lingling Zhang, Ran Ren, Xue Yang, Yiman Ge, Xiajun Zhang, Hongping Yuan
Summary: This study found that EGR1 promotes the malignant behaviors of LC cells through mediating the miRNA-675/SESN3/Wnt/β-catenin axis, while knockdown of EGR1 weakens proliferation and invasiveness of LC cells.
Article
Cell Biology
Rihao Qu, Khusali Gupta, Danni Dong, Yiqun Jiang, Boris Landa, Charles Saez, Gwendolyn Strickland, Jonathan Levinsohn, Pei-lun Weng, M. Mark Taketo, Yuval Kluger, Peggy Myung
Summary: This study designed a computational approach to resolve signals and cell behaviors in organogenesis, revealing the role of Wnt/β-catenin and SHH signaling gradients in cell proliferation and spatial patterning.
DEVELOPMENTAL CELL
(2022)
Article
Cell Biology
Vikash Singh, Vonn Walter, Irina Elcheva, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Summary: In this study, the role of IGF2BP1 in the post-transcriptional regulation of Wnt/beta-catenin-induced genes in colorectal cancer (CRC) cells was investigated using iCLIP and RNA sequencing techniques. The study revealed that CRC cells exhibit a stronger dependency on IGF2BP1 expression for Wnt/beta-catenin-regulated genes compared to normal cells. iCLIP analysis showed significant changes in IGF2BP1-binding sites and enrichment of 6-mer motifs associated with IGF2BP1 binding in response to Wnt/beta-catenin signaling. Additionally, a signature of IGF2BP1-regulated genes significantly associated with colon cancer-free survival in humans was identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Arundhathi Dev, Meenakshi Vachher, Chandra Prakash Prasad
Summary: beta-catenin is a crucial protein involved in various cellular processes, including cellular homeostasis, embryonic development, and cancer. It functions as a signaling molecule and also plays a role in cell adhesion. Aberrant expression of beta-catenin promotes the transcription of oncogenes and contributes to tumorigenesis. Understanding the regulation of beta-catenin is important for understanding the mechanisms of cancer progression.