Review
Cell Biology
Willy Antoni Abreu de Oliveira, Youssef El Laithy, Alejandra Bruna, Daniela Annibali, Frederic Lluis
Summary: This review explores the role of the Wnt signaling pathway in mammary gland development and cancer, focusing on the interplay between its molecular network defects and breast cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Developmental Biology
Yanshu Wang, Arjun Venkatesh, Jiajia Xu, Mingxin Xu, John Williams, Philip M. Smallwood, Aaron James, Jeremy Nathans
Summary: In vascular endothelial cells of the central nervous system, signaling involving ligands WNT7A and WNT7B and co-activator proteins GPR124 and RECK is crucial for limb development. Reductions in the function of these ligands and/or co-activators result in decreased and abnormal limb bone growth, as well as other limb phenotypes. These findings demonstrate that the WNT7A/WNT7B-FRIZZLED-LRP5/LRP6-GPR124-RECK signaling system functions as a unified unit in limb development.
Review
Neurosciences
Amir Rattner, Yanshu Wang, Jeremy Nathans
Summary: This review discusses the mechanisms by which signals from neurons and glia control the vascular development in the central nervous system (CNS). The vascular endothelial growth factor (VEGF) and beta-catenin (canonical Wnt) signaling are highlighted as the two best-understood systems that regulate CNS vascular development. The review emphasizes foundational discoveries, interactions between different signaling systems, the integration of genetic and cell biological studies, advances that are of clinical relevance, and provides questions for future research.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Article
Biology
Hidenobu Miyazawa, Marteinn T. Snaebjornsson, Nicole Prior, Eleni Kafkia, Henrik M. Hammaren, Nobuko Tsuchida-Straeten, Kiran R. Patil, Martin Beck, Alexander Aulehla, Joshua M. Brickman
Summary: This study investigated how glycolytic flux affects embryonic development and found that fructose 1,6-bisphosphate (FBP) can serve as a sentinel metabolite to reflect glycolytic flux. Supplementation of FBP impaired mesoderm segmentation in mouse embryos, potentially by altering the subcellular localization of proteins. The study highlights the importance of glycolytic flux in cellular programs during embryonic development.
Article
Biochemistry & Molecular Biology
Kento Takaya, Ayano Sunohara, Noriko Aramaki-Hattori, Shigeki Sakai, Keisuke Okabe, Hideko Kanazawa, Toru Asou, Kazuo Kishi
Summary: This study analyzed the expression and localization of Wnt proteins in a mouse fetal-wound-healing model and found their association with scar formation. The results indicated that Wnt signaling may be involved in wound healing and scar formation. Regulation of Wnt signaling could be a possible mechanism to control scar formation.
Article
Multidisciplinary Sciences
Morgane Le Rolle, Filippo Massa, Pam Siggers, Laurent Turchi, Agnes Loubat, Bon-Kyoung Koo, Hans Clevers, Andy Greenfield, Andreas Schedl, Marie-Christine Chaboissier, Anne-Amandine Chassot
Summary: This study shows that germ cell-intrinsic beta-catenin activity in mouse embryonic ovaries is essential for maintaining pluripotency and its repression is crucial for differentiation and meiosis entry. The interaction of beta-catenin with the pluripotent-associated factor POU5F1 in the nucleus is associated with germ cell pluripotency, and its exit from the nucleus correlates with germ cell differentiation. These findings highlight the role of beta-catenin as a central gatekeeper in ovarian differentiation and gametogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Shefali Mehta, Swapnil Hingole, Varun Chaudhary
Summary: Wnt proteins are lipid-modified secreted proteins that activate multiple signaling pathways, regulating crucial processes during development. Despite being hydrophobic, they can travel several cell distances in the extracellular space. Research has identified factors and mechanisms regulating their expression, secretion, and extracellular travel, recognizing the importance of Wnt protein gradients in maintaining tissue homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rui Wang, Hao Xie, Lin Yang, Ping Wang, Meng-Meng Chen, Hong-Yan Wu, Yan-Lin Liao, Ming-Ying Wang, Qiang Wang, Xiao-Xia Gong, Qian Cheng, Lin Cheng, Fei-Yan Xie, Cai-Li Bi, Ming Fang
Summary: The study shows that nkd plays an important role in wing pattern formation in fruit flies, with both gain and loss of nkd resulting in disrupted Wg target gene expression and abnormal adult wing morphologies. A thirty amino acid fragment in Nkd is critical for canonical Wg signaling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Cell Biology
Edward V. Prochownik, Huabo Wang
Summary: Despite being extensively studied, the role of MYC in normal development remains uncertain due to the limited lifespan of Myc-/- mice. Recent research delaying Myc inactivation has allowed for the study of its complete loss and its impact on aging. Surprisingly, MycKO mice lived longer than wild-type mice but displayed accelerated aging phenotypes, potentially due to a reduced incidence of cancer. Myc loss accelerated the accumulation of Aging Hallmarks in both mice and humans, suggesting that the strong association between aging and cancer can be genetically separated and is maintained by a single gene.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Keonwoo Choi, Sang-Hee Park, Seo-Yeon Park, Sungjoo Kim Yoon
Summary: The hairpoor mouse exhibits disrupted hair cycle and loss of quiescent state of HFSC, leading to completely disarrayed hair cycle of HFs. These findings provide insights into the mechanism underlying the development of alopecia with age in MUHH patients.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Endocrinology & Metabolism
Jung Hoon Cho, Jing W. Hughes
Summary: Primary cilia in pancreatic islet cells play a crucial role in regulating islet function, and their dysregulation is associated with diabetes. Studies using genetic deletion have shown that primary cilia are involved in the regulation of islet hormone secretion, and disruption of cilia function can lead to endocrine and exocrine defects relevant to human disease. Future research directions include investigating the role of cilia in different groups of islet cells, GPCR signaling, and the crosstalk between endocrine and exocrine signaling.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Xinyan Li, Yuanyuan Han, Guimiao Li, Yingze Zhang, Juan Wang, Chen Feng
Summary: This review summarizes the role of Wnt signaling pathways in joint development and cartilage maintenance, with a focus on aberrant mechanical loading and inflammation as major contributors to osteoarthritis progression. Additionally, emerging Wnt-related modulators and treatments targeting Wnt signaling are discussed, providing valuable insights for diagnosing and treating osteoarthritis and other degenerative joint diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Physiology
Natalia Bottasso-Arias, Lauren Leesman, Kaulini Burra, John Snowball, Ronak Shah, Megha Mohanakrishnan, Yan Xu, Debora Sinner
Summary: Tracheobronchomalacia and complete tracheal rings are congenital malformations of the trachea, and the etiology is poorly understood. The study found that Wnt and BMP signaling pathways cooperatively regulate the development of tracheal cartilage and muscle. Deletion of Bmp4 disrupted muscle formation and abnormal Wnt signaling impaired cartilage formation. The study further revealed the mechanism of interaction between Wnt and BMP signaling during tracheal development.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bianca Dietrich, Sandra Haider, Gudrun Meinhardt, Juergen Pollheimer, Martin Knoefler
Summary: This article discusses two important signaling pathways, WNT and NOTCH, in the development of human placenta and trophoblasts. The WNT pathway is necessary for the expansion of trophoblast progenitors and stem cells, while NOTCH1 is required for the proliferation and survival of extravillous trophoblast precursors.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biology
Hila Barzilai-Tutsch, Valerie Morin, Gauthier Toulouse, Oleksandr Chernyavskiy, Stephen Firth, Christophe Marcelle, Olivier Serralbo
Summary: The Wnt/beta-catenin signaling pathway plays crucial roles in development and pathology. Multiple tools, including transgenic quail lines, have been developed to monitor Wnt activity and characterize TCF/beta-catenin transcriptional dynamics during embryogenesis.
Article
Developmental Biology
Tanvi Sinha, Lizhu Lin, Ding Li, Jennifer Davis, Sylvia Evans, Anthony Wynshaw-Boris, Jianbo Wang
DEVELOPMENTAL BIOLOGY
(2015)
Article
Oncology
Rajani Rajbhandari, Braden C. McFarland, Ashish Patel, Magda Gerigk, G. Kenneth Gray, Samuel C. Fehling, Markus Bredel, Nicolas F. Berbari, Hyunsoo Kim, Margaret P. Marks, Gordon P. Meares, Tanvi Sinha, Jeffrey Chuang, Etty N. Benveniste, Susan E. Nozell
Article
Developmental Biology
Ralston M. Barnes, Ian S. Harris, Eric J. Jaehnig, Kimberly Sauls, Tanvi Sinha, Anabel Rojas, William Schachterle, David J. McCulley, Russell A. Norris, Brian L. Black
Article
Developmental Biology
Ding Li, Tanvi Sinha, Riero Ajima, Hwa-Seon Seo, Terry P. Yamaguchi, Jianbo Wang
DEVELOPMENTAL BIOLOGY
(2016)
Article
Developmental Biology
Tanvi Sinha, Bing Wang, Sylvia Evans, Anthony Wynshaw-Boris, Jianbo Wang
DEVELOPMENTAL BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Bing Wang, Tanvi Sinha, Kai Jiao, Rosa Serra, Jianbo Wang
HUMAN MOLECULAR GENETICS
(2011)
Article
Biochemistry & Molecular Biology
Tanvi Sinha, Ding Li, Magali Theveniau-Ruissy, Mary R. Hutson, Robert G. Kelly, Jianbo Wang
HUMAN MOLECULAR GENETICS
(2015)
Article
Cardiac & Cardiovascular Systems
Vincent W. W. van Eif, Stephanie I. Protze, Fernanda M. Bosada, Xuefei Yuan, Tanvi Sinha, Karel van Duijvenboden, Auriane C. Ernault, Rajiv A. Mohan, Vincent Wakker, Corrie de Gier-de Vries, Ingeborg B. Hooijkaas, Michael D. Wilson, Arie O. Verkerk, Jeroen Bakkers, Bastiaan J. Boukens, Brian L. Black, Ian C. Scott, Vincent M. Christoffels
CIRCULATION RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Giselle Galang, Ravi Mandla, Hongmei Ruan, Catherine Jung, Tanvi Sinha, Nicole R. Stone, Roland S. Wu, Brandon J. Mannion, Prasanna K. R. Allu, Kevin Chang, Ashwin Rammohan, Marie B. Shi, Len A. Pennacchio, Brian L. Black, Vasanth Vedantham
CIRCULATION RESEARCH
(2020)
Article
Cell Biology
Tanvi Sinha, Kelly Lammerts van Bueren, Diane E. Dickel, Ivana Zlatanova, Reuben Thomas, Carlos O. Lizama, Shan-Mei Xu, Ann C. Zovein, Kohta Ikegami, Ivan P. Moskowitz, Katherine S. Pollard, Len A. Pennacchio, Brian L. Black
Summary: This study investigates the initiation of gene-regulatory networks (GRNs) for endothelial and erythropoietic development by analyzing a hypomorphic Etv2 mutant. The researchers find that Etv2 has different threshold requirements for initiating the downstream GRNs for each lineage, directly regulating the endothelial GRN and indirectly activating Tal1 for erythropoietic development.
Article
Developmental Biology
Courtney M. Anderson, Jianxin Hu, Reuben Thomas, T. Blair Gainous, Barbara Celona, Tanvi Sinha, Diane E. Dickel, Analeah B. Heidt, Shan-Mei Xu, Benoit G. Bruneau, Katherine S. Pollard, Len A. Pennacchio, Brian L. Black
Meeting Abstract
Oncology
Rajani Rajbhandari, Tanvi Sinha, Gordon Meares, Etty N. Benveniste, Susan Nozell
