Article
Gastroenterology & Hepatology
Hana Cipcic Paljetak, Anja Baresic, Marina Panek, Mihaela Peric, Mario Matijasic, Ivana Lojkic, Ana Barisic, Darija Vranesic Bender, Dina Ljubas Kelecic, Marko Brinar, Mirjana Kalauz, Marija Milicevic, Dora Grgic, Niksa Turk, Irena Karas, Silvija Cukovic-Cavka, Zeljko Krznaric, Donatella Verbanac
Summary: This study compares the differences in gut microbiota between newly diagnosed, treatment-naive adult inflammatory bowel disease (IBD) patients (CD and UC) with irritable bowel syndrome (IBS) patients and healthy individuals. The results show that changes in gut microbiota are detectable at the onset of disease and may play a significant role in the development of IBD.
Article
Gastroenterology & Hepatology
Jasmijn Z. Jagt, Eduard A. Struys, Ibrahim Ayada, Abdellatif Bakkali, Erwin E. W. Jansen, Jurgen Claesen, Johan E. van Limbergen, Marc A. Benninga, Nanne K. H. de Boer, Tim G. J. de Meij
Summary: Fecal amino acid analysis can differentiate newly diagnosed children with IBD from a non-IBD control group with an accuracy of 82%, providing insights into the pathophysiology of IBD. Increased levels of certain amino acids may be the most differentiating features.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Paula Anderco, Sabrina Birsan
Summary: Inflammatory bowel diseases (IBD) are complex diseases characterized by chronic inflammation in the gastrointestinal tract. Fecal microbiota transplantation (FMT) has shown increasing effectiveness and safety in treating recurrent Clostridium difficile infection (CDI) and co-infection of SARS-CoV-2 and CDI. By modifying the gut microbiota, FMT offers an alternative approach to indirectly influence the host's immune system in a safe way, improving clinical symptoms and endoscopic findings in IBD patients. Further validation is needed to establish a clinical protocol for FMT in IBD.
Article
Engineering, Environmental
Zehua Yan, Yafei Liu, Ting Zhang, Faming Zhang, Hongqiang Ren, Yan Zhang
Summary: The study found that the concentration of fecal microplastics in patients with inflammatory bowel disease was significantly higher than in healthy individuals, with poly(ethylene terephthalate) and polyamide being the main components in the feces. A positive correlation between fecal microplastics concentration and the severity of IBD was also observed. Plastic packaging of drinking water and food, as well as dust exposure, were identified as important sources of human exposure to microplastics.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Laila Aldars-Garcia, Ruben Gil-Redondo, Nieves Embade, Sabino Riestra, Montserrat Rivero, Ana Gutierrez, Iago Rodriguez-Lago, Luis Fernandez-Salazar, Daniel Ceballos, Jose Manuel Benitez, Mariam Aguas, Iria Baston-Rey, Fernando Bermejo, Maria Jose Casanova, Rufo Lorente, Yolanda Ber, Daniel Ginard, Maria Esteve, Ruth de Francisco, Maria Jose Garcia, Ruben Frances, Ainhoa Rodriguez Pescador, Benito Velayos, Elena Guerra del Rio, Sandra Marin Pedrosa, Alejandro Minguez Sabater, Manuel Barreiro-de Acosta, Alicia Algaba, Cristina Verdejo Gil, Olga Rivas, Vanesa Royo, Montserrat Aceituno, Ana Garre, Montserrat Baldan-Martin, Cristina Ramirez, Ancor Sanz-Garcia, Juan J. Lozano, Julia Sidorova, Oscar Millet, David Bernardo, Javier P. Gisbert, Maria Chaparro
Summary: This study investigates the metabolic differences in different subgroups of newly diagnosed treatment-naive IBD patients. The results indicate alterations in energy and amino acid metabolism in IBD patients, with an increased demand for ketone bodies. The differences in metabolites are more pronounced in Crohn's disease patients compared to ulcerative colitis patients, and in serum compared to urine. Cluster analysis identifies three distinct patient profiles with significant differences in clinical, anthropometric, and metabolomic variables.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Nutrition & Dietetics
Anna Pietrzak, Marcin Banasiuk, Mariusz Szczepanik, Agnieszka Borys-Iwanicka, Tomasz Pytrus, Jaroslaw Walkowiak, Aleksandra Banaszkiewicz
Summary: This study evaluated the effectiveness of oral sodium butyrate as an add-on to standard therapy in children and adolescents with newly diagnosed IBD. The results showed that a 12-week supplementation with sodium butyrate did not show efficacy in these patients.
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Joon Seop Lee, Hyun Seok Lee, Byung Ik Jang, Eun Soo Kim, Sung Kook Kim, Kyeong Ok Kim, Yoo Jin Lee, Hyun Jik Lee, Eun Young Kim, Yun Jin Lung, Chang Heon Yang
Summary: The study found that approximately one-third of newly diagnosed IBD Asian patients had low BMD. Clinical factors associated with low BMD included a high level of alkaline phosphatase in UC patients and being underweight in CD patients.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Medicine, Research & Experimental
Qichen Shen, Bingbai Xu, Caihong Wang, Yingping Xiao, Yuanxiang Jin
Summary: Inflammatory bowel disease (IBD) is a chronic intestinal inflammation with no cure. Disruption of the microbial ecosystem in the intestine is considered a key factor in IBD. Bacterial membrane vesicles (MVs) play important roles in regulating intestinal microecology and have potential therapeutic applications in IBD patients.
Article
Medicine, General & Internal
Edyta Szymanska, Aldona Wierzbicka, Maciej Dadalski, Jaroslaw Kierkus
Summary: Increased intestinal permeability is associated with inflammatory bowel diseases, and fecal ZRP levels may serve as a noninvasive biomarker of disease activity. The study found a slight correlation between ZRP levels and disease activity in CD patients, but not in UC patients. Furthermore, fecal ZRP strongly correlated with FCP levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sudpreeda Chainitikun, Sadia Saleem, Bora Lim, Vicente Valero, Naoto T. Ueno
Summary: The review focuses on the development of systemic treatment of IBC from the past to the present, including chemotherapy and targeted therapies. The effects on pathologic complete response (pCR), survival outcomes, predictive markers, and adverse events of these therapies are discussed, along with current standard treatment stratified by molecular subtypes. The future trend of systemic therapy, including immunotherapy and ongoing IBC clinical trials, is also addressed.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Endocrinology & Metabolism
Gareth J. Dunseath, Stephen D. Luzio, Rajesh Peter, David R. Owens
Summary: The study found that as fasting glucose levels increased, postprandial glucose peaks also increased progressively, while beta-cell secretory capacity decreased. In patients with IGT, there was a significant decrease in early insulin response to intravenous glucose, accompanied by a dramatic drop in insulin sensitivity.
ACTA DIABETOLOGICA
(2022)
Review
Gastroenterology & Hepatology
Benedicte Caron, Subrata Ghosh, Silvio Danese, Laurent Peyrin-Biroulet
Summary: Fecal urgency is a common and distressing symptom experienced by patients with inflammatory bowel disease, but there is a lack of standardized definition, pathophysiology, and therapeutic management. Medications such as loperamide, tricyclic antidepressants, and biofeedback therapy may be necessary when nonpharmacologic measures fail. However, medical management of fecal urgency is challenging due to limited data from randomized clinical trials.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Georgios K. Vasileiadis, Anna-Carin Lundell, Yuan Zhang, Kerstin Andersson, Inger Gjertsson, Anna Rudin, Cristina Maglio
Summary: The study found a positive association between total adiponectin and pro-inflammatory chemokines, as well as markers of inflammation in patients with untreated newly diagnosed RA. However, high-molecular weight adiponectin was only associated with specific chemokines. Leptin and resistin showed no association with plasma chemokines, markers of inflammation, or disease activity scores.
Article
Gastroenterology & Hepatology
Grace Cushman, Mary Gray Stolz, Sharon Shih, Zoe Listernick, Clair Talmadge, Benjamin D. Gold, Bonney Reed
Summary: This study found that demographic, disease-related, and psychosocial factors are associated with body image dissatisfaction (BID) in youth newly diagnosed with inflammatory bowel disease (IBD). Older child age, greater patient-reported disease symptoms, and worse depression symptoms were most strongly associated with overall body dissatisfaction. These findings highlight the importance of screening and interventions for BID in patients with IBD.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Biotechnology & Applied Microbiology
Ekaterina Avershina, Knut Rudi
ANNALS OF MICROBIOLOGY
(2016)
Article
Genetics & Heredity
Eirik Nataas Hanssen, Ekaterina Avershina, Knut Rudi, Peter Gill, Lars Snipen
FORENSIC SCIENCE INTERNATIONAL-GENETICS
(2017)
Letter
Allergy
Ekaterina Avershina, Raul Cabrera Rubio, Krister Lundgard, Gaspar Perez Martinez, Maria Carmen Collado, Ola Storro, Torbjorn Oien, Christian Kvikne Dotterud, Roar Johnsen, Knut Rudi
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Article
Microbiology
Kasper Schei, Ekaterina Avershina, Torbjorn Oien, Knut Rudi, Turid Follestad, Saideh Salamati, Ronnaug Astri Odegard
Article
Agriculture, Dairy & Animal Science
Melanie Rae Simpson, Ekaterina Avershina, Ola Storro, Roar Johnsen, Knut Rudi, Torbjorn Oien
JOURNAL OF DAIRY SCIENCE
(2018)
Article
Biochemical Research Methods
Anuradha Ravi, Ekaterina Avershina, Inga Leena Angell, Jane Ludvigsen, Prasanth Manohar, Sumathi Padmanaban, Ramesh Nachimuthu, Lars Snipen, Knut Rudi
JOURNAL OF MICROBIOLOGICAL METHODS
(2018)
Article
Genetics & Heredity
Ekaterina Avershina, Inga Leena Angell, Melanie Simpson, Ola Storro, Torbjorn Oien, Roar Johnsen, Knut Rudi
Article
Multidisciplinary Sciences
Ekaterina Avershina, Silje Slangsvold, Melanie Rae Simpson, Ola Storro, Roar Johnsen, Torbjorn Oien, Knut Rudi
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Ekaterina Avershina, Marte Gro Larsen, Marina Aspholm, Toril Lindback, Ola Storro, Torbjorn Oien, Roar Johnsen, Knut Rudi
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Arne M. Taxt, Ekaterina Avershina, Stephan A. Frye, Umaer Naseer, Rafi Ahmad
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Abdolrahman Khezri, Ekaterina Avershina, Rafi Ahmad
Summary: This study analyzed strains from Norwegian patients and found the IncFIB plasmid to be the most prevalent in both E. coli and K. pneumoniae isolates, along with identifying certain plasmid-mediated antibiotic resistance genes. Hybrid assembly was used to more confidently locate plasmids and predict antibiotic resistance genes.
Review
Infectious Diseases
Ekaterina Avershina, Abdolrahman Khezri, Rafi Ahmad
Summary: Antimicrobial resistance (AMR) causes millions of deaths annually and its rapid spread requires changes in healthcare routines. The lack of rapid diagnostic tools for pathogen identification and AMR detection is a major issue. DNA sequencing technologies offer potential for rapid diagnostics, but currently require advanced bioinformatics knowledge and are not suitable for routine use.
Article
Biochemistry & Molecular Biology
Ekaterina Avershina, Priyanka Sharma, Arne M. Taxt, Harpreet Singh, Stephan A. Frye, Kolin Paul, Arti Kapil, Umaer Naseer, Punit Kaur, Rafi Ahmad
Summary: This study utilizes neural networks and sequencing technologies to predict antibiotic susceptibility in Escherichia coli and Klebsiella pneumoniae, reducing the time needed for susceptibility prediction. Through cross-checking and ensemble networks, the accuracy of cross-dataset prediction is improved.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Pediatrics
Kasper Schei, Melanie Rae Simpson, Ekaterina Avershina, Knut Rudi, Torbjorn Oien, Petur Benedikt Juliusson, David Underhill, Saideh Salamati, Ronnaug Astri Odegard
FRONTIERS IN PEDIATRICS
(2020)
Article
Food Science & Technology
Guro Alette Bjerke, Knut Rudi, Ekaterina Avershina, Birgitte Moen, Hans Blom, Lars Axelsson