Review
Immunology
Zhifeng Fang, Lingzhi Li, Hao Zhang, Jianxin Zhao, Wenwei Lu, Wei Chen
Summary: Atopic dermatitis (AD) is increasing in urban areas, and recent advances show that the development of AD is associated with gut microbiota and skin microbiome. Probiotics can improve AD by enhancing the intestinal environment and balancing immune responses, offering an alternative for prevention and treatment. Studies suggest that targeting gut microbiota with probiotics may help alleviate AD by boosting epidermal barrier and regulating immune signaling.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Paula Danielle Santa Maria Albuquerque de Andrade, Jorgete Silva, Vanessa Carregaro, Lais Amorim Sacramento, Luciana Rodrigues Roberti, Davi Casale Aragon, Fabio Carmona, Persio Roxo-Junior
Summary: This study evaluated the clinical efficacy of a mixture of Lactobacillus and Bifidobacterium probiotics in children and adolescents with atopic dermatitis. The results showed that this probiotic mixture significantly reduced skin symptoms and the need for immunosuppressants.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Caterina Anania, Giulia Brindisi, Ivana Martinelli, Edoardo Bonucci, Miriam D'Orsi, Sara Ialongo, Anna Nyffenegger, Tonia Raso, Mattia Spatuzzo, Giovanna De Castro, Anna Maria Zicari, Carlo Carraro, Maria Grazia Piccioni, Francesca Olivero
Summary: Atopic dermatitis is a chronic inflammatory skin disorder with increasing prevalence in children and adults. The potential role of probiotics in preventing atopic dermatitis has generated considerable interest, as they can modulate systemic inflammation and immune responses. However, the molecular mechanisms and efficacy of probiotics in anti-allergic effects are still unclear and controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Renqiang Yu, Yizhe Ma, Zichen Luo, Ce Qi, Anni Xie, Yifan Jiang, Baoli Zhu, Jin Sun
Summary: This study aims to evaluate the efficacy of maternal consumption of L. reuteri FN041 during late pregnancy and lactation in preventing infantile atopic dermatitis (AD). Through a randomized, double-blind, placebo-controlled intervention study and a multicenter cohort study, the most efficient dosage of L. reuteri FN041 for preventing infantile AD will be determined.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria Garcia-Ricobaraza, Jose Antonio Garcia-Santos, Mireia Escudero-Marin, Estefania Dieguez, Tomas Cerdo, Cristina Campoy
Summary: Human milk is considered the most complete food for infants, providing important nutrients and bioactive components for infant health. Interest in human milk as a potential source of probiotics and commensal bacteria has been growing, which may influence infant gut colonization and immune system maturation. Research on microbial communities in human breast milk samples and the impact of HM microbiota dysbiosis on maternal and infant health provides valuable insights into the role of breast milk-related bacteria as a novel probiotic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Yue Liu, Xiaofan Du, Shujie Zhai, Xiaodong Tang, Cuiling Liu, Weihong Li
Summary: This scoping literature review explores the relationship between gut microbiota and atopic dermatitis (AD) in children. Current research indicates that disturbance of intestinal microbiota is closely associated with the occurrence and development of AD, and probiotics may play a role in the prevention and treatment of AD. However, there is still a lack of high-quality research on the efficacy and safety of probiotics in children with AD.
Review
Biochemistry & Molecular Biology
Dora Hrestak, Mario Matijasic, Hana Cipcic Paljetak, Daniela Ledic Drvar, Suzana Ljubojevic Hadzavdic, Mihaela Peric
Summary: This review provides an overview of the involvement of skin microbiota in atopic dermatitis (AD) and its complex interaction with the host immune response mechanisms, as well as novel therapeutic strategies focused on restoring skin microbial homeostasis for treating AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Quesia S. Damaceno, Bruno Gallotti, Isabela M. M. Reis, Yasmim C. P. Totte, Gabriella B. Assis, Henrique C. Figueiredo, Tales F. Silva, Vasco Azevedo, Jacques R. Nicoli, Flaviano S. Martins
Summary: Breast milk contains beneficial bacteria that can positively influence the health of newborns. The study identified 77 bacteria belonging to four genera, including Staphylococcus, Streptococcus, Leuconostoc, and Lacticaseibacillus. Two potential probiotics, Lacticaseibacillus rhamnosus and Leuconostoc mesenteroides, were selected and found to colonize the gastrointestinal tract in germ-free mice and maintain viability after spray-drying.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Gastroenterology & Hepatology
Britta E. Heiss, Amy M. Ehrlich, Maria X. Maldonado-Gomez, Diana H. Taft, Jules A. Larke, Michael L. Goodson, Carolyn M. Slupsky, Daniel J. Tancredi, Helen E. Raybould, David A. Mills
Summary: The interaction between bacterial-milk glycans alone drives enrichment of beneficial Bifidobacterium, impacting gut microbiota composition, activating anti-inflammatory pathways, and providing protection against chemically-induced colitis. This study demonstrates the importance of human milk oligosaccharides in the colonization of Bifidobacterium in the gut, highlighting the mechanisms of health promotion by bifidobacteria in neonates.
Article
Food Science & Technology
Ce Qi, Huayu Tu, Yuning Zhao, Jingbo Zhou, Jie Chen, Haiting Hu, Renqiang Yu, Jin Sun
Summary: This study demonstrates that supplementing maternal mice with the breast milk-derived probiotic Fn041 during late pregnancy and lactation can prevent atopic dermatitis in offspring. The probiotic directly induces anti-AD immune responses by promoting the absorption and metabolism of retinol in Peyer's patches, and indirectly strengthens the mucosal barrier and increases the abundance of specific anti-AD bacteria in the cecum.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sebastien Cadau, Manon Gault, Nicolas Berthelemy, Chiung-Yueh Hsu, Louis Danoux, Nicolas Pelletier, Dominique Goudouneche, Carole Pons, Corinne Leprince, Valerie Andre-Frei, Michel Simon, Sabine Pain
Summary: Atopic dermatitis is a common inflammatory skin disorder characterized by genetic predisposition, disruption of the epidermal barrier, immune reaction, and altered microbiome. In vitro models have been developed to mimic the pathophysiological features of atopic dermatitis, and a study found that a Castanea sativa extract can prevent the AD-like phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Leonie Jane Kiely, Kizkitza Busca, Jonathan A. Lane, Douwe van Sinderen, Rita M. Hickey
Summary: The abundance of certain bacteria in the feces of breast-fed infants is due to their ability to metabolize human milk oligosaccharides (HMOs). HMOs are complex sugars that reach the infant's intestine intact and serve as a fermentable substrate for specific intestinal microbes. These microbes possess the genes and enzymes necessary for HMO degradation. The degraded HMOs can also be utilized by other gut bacteria.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Microbiology
Chi Tung Choy, Pui Ling Kella Siu, Junwei Zhou, Chi Ho Wong, Yuk Wai Lee, Ho Wang Chan, Joseph Chi Ching Tsui, Claudia Jun Yi Lo, Steven King Fan Loo, Stephen Kwok Wing Tsui
Summary: This study focused on pediatric atopic dermatitis (AD) patients in southern China and used targeted 16S rRNA sequencing and bioinformatic analysis to investigate the impact of orally administered probiotics on the gut microbiome. After an 8-week course of probiotics, a significant improvement in the Eczema Area and Severity Index (EASI) was observed, with no adverse effects. The relative abundances of key microbial drivers also increased. The study provides preliminary evidence supporting targeted probiotic supplementation for childhood AD management.
Review
Medicine, Research & Experimental
Camila Stofella Sodre, Mayra Stambovsky Vieira, Juliany Lima Estefan, Cristiane Moraes, Fernanda Sampaio Cavalcante, Katia Regina Netto dos Santos, Dennis de Carvalho Ferreira
Summary: A literature review found that probiotics have the potential to improve symptoms of atopic dermatitis in adult patients, reducing itchiness and severity as measured by SCORAD. However, there is still controversy and divergence regarding the actual benefits of probiotics in this context.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Yu Ri Woo, Minah Cho, Yujin Han, Se Hoon Lee, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
Summary: Recent studies have investigated the role of skin microbiota in atopic dermatitis (AD), and scalp dermatitis is often observed in AD patients. This study aimed to identify the distinct microbiota associated with scalp dermatitis in AD patients. The results showed dysbiosis of scalp microbiota in AD, with specific bacterial and fungal species being more abundant in AD patients compared to healthy controls. These findings highlight the potential for specific microbiota to serve as biomarkers for scalp dermatitis in AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Torbjorn Oien, Astrid Schjelvaag, Ola Storro, Roar Johnsen, Melanie Rae Simpson
Article
Multidisciplinary Sciences
Ekaterina Avershina, Marte Gro Larsen, Marina Aspholm, Toril Lindback, Ola Storro, Torbjorn Oien, Roar Johnsen, Knut Rudi
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Arne M. Taxt, Ekaterina Avershina, Stephan A. Frye, Umaer Naseer, Rafi Ahmad
SCIENTIFIC REPORTS
(2020)
Article
Nutrition & Dietetics
Daniel O'Reilly, Denis Dorodnykh, Nina Avdeenko, Nikita A. Nekliudov, Johan Garssen, Ahmed A. Elolimy, Loukia Petrou, Melanie Rae Simpson, Laxmi Yeruva, Daniel Munblit
Summary: Human breast milk contains bioactive substances that impact children's health, with EVs playing a potentially significant role. However, research on HM EVs faces challenges due to limited knowledge, methodological issues, and a lack of normative values. Future studies should address these gaps and adhere to MISEV guidelines to improve study design.
ADVANCES IN NUTRITION
(2021)
Article
Obstetrics & Gynecology
Louise Ekelund, Inga Gloppen, Torbjorn Oien, Melanie Rae Simpson
Summary: The study found that longer breastfeeding reduced the risk of wheeze and showed a protective trend against allergic rhinoconjunctivitis (ARC) in early childhood. However, there were no conclusive associations between the duration of breastfeeding or age at introduction to complementary foods and the prevention of asthma and eczema.
INTERNATIONAL BREASTFEEDING JOURNAL
(2021)
Article
Microbiology
Abdolrahman Khezri, Ekaterina Avershina, Rafi Ahmad
Summary: This study analyzed strains from Norwegian patients and found the IncFIB plasmid to be the most prevalent in both E. coli and K. pneumoniae isolates, along with identifying certain plasmid-mediated antibiotic resistance genes. Hybrid assembly was used to more confidently locate plasmids and predict antibiotic resistance genes.
Article
Clinical Neurology
Cecilie L. Vestergaard, Oystein Vedaa, Melanie R. Simpson, Patrick Faaland, Daniel Vethe, Kaia Kjorstad, Knut Langsrud, Lee M. Ritterband, Borge Sivertsen, Tore C. Stiles, Jan Scott, Havard Kallestad
Summary: The study found that reductions in intraindividual variability in sleep (IIV) are significant mediators of changes in insomnia severity and psychological distress, especially in relation to sleep onset latency (SOL) and wake after sleep onset. These findings provide important evidence for the therapeutic action of digital cognitive behavioral therapy for insomnia (dCBT-I) and may guide future development of this intervention.
Article
Medicine, General & Internal
Havard Kallestad, Simen Saksvik, Oystein Vedaa, Knut Langsrud, Gunnar Morken, Stian Lydersen, Melanie R. Simpson, Signe Karen Dorheim, Bjorn Holmoy, Sara G. Selvik, Kristen Hagen, Tore Charles Stiles, Allison Harvey, Lee Ritterband, Borge Sivertsen, Jan Scott
Summary: This multicentre RCT aims to examine the additional benefits of digital adaptation of CBT-I compared with online control intervention in individuals referred to secondary mental health clinics. The study will recruit 800 participants from Norwegian psychiatric services and assess outcomes at multiple time points over a 12-month period. Findings will be disseminated through various channels and exploratory analyses will be reported separately.
Review
Immunology
Lina Tingo, Emelie Ahlberg, Lovisa Johansson, Sindre Andre Pedersen, Konika Chawla, Pal Saetrom, Erika Cione, Melanie Rae Simpson
Summary: Breast milk contains a variety of RNA types, including miRNAs, with some miRNAs being widely reported across different fractions. It is currently challenging to determine which factors influence the characteristics of the miRNA profile, but studies suggest that certain miRNAs are highly expressed and stable in breast milk. Future research needs to further explore the biological effects of miRNAs in breast milk and characterize other ncRNAs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Kasper Schei, Melanie Rae Simpson, Torbjorn Oien, Saideh Salamati, Knut Rudi, Ronnaug Astri Odegard
Summary: The study found that children with higher fungal abundance at 2 years old were more likely to develop asthma and allergic rhinoconjunctivitis by the age of 6, while children with eczema appeared to have a more mature bacterial microbiota. Increased gut permeability did not seem to be involved in the association between gut fungal abundance and allergy-related diseases. The findings need to be confirmed in future microbiota studies.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Review
Allergy
Aysylu Gamirova, Anna Berbenyuk, Daria Levina, Dmitrii Peshko, Melanie R. Simpson, Meghan B. Azad, Kirsi M. Jaervinen, Helen A. Brough, Jon Genuneit, Matthew Greenhawt, Valerie Verhasselt, Diego G. Peroni, Michael R. Perkin, John O. Warner, Debra J. Palmer, Robert J. Boyle, Daniel Munblit
Summary: This is the first systematic review that assesses and summarizes evidence on food proteins in human milk and their potential for IgE-mediated allergic reactions. The study found that the levels of food proteins in human milk are low, resulting in a low probability of allergic reactions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Infectious Diseases
Ekaterina Avershina, Abdolrahman Khezri, Rafi Ahmad
Summary: Antimicrobial resistance (AMR) causes millions of deaths annually and its rapid spread requires changes in healthcare routines. The lack of rapid diagnostic tools for pathogen identification and AMR detection is a major issue. DNA sequencing technologies offer potential for rapid diagnostics, but currently require advanced bioinformatics knowledge and are not suitable for routine use.
Article
Biochemistry & Molecular Biology
Ekaterina Avershina, Priyanka Sharma, Arne M. Taxt, Harpreet Singh, Stephan A. Frye, Kolin Paul, Arti Kapil, Umaer Naseer, Punit Kaur, Rafi Ahmad
Summary: This study utilizes neural networks and sequencing technologies to predict antibiotic susceptibility in Escherichia coli and Klebsiella pneumoniae, reducing the time needed for susceptibility prediction. Through cross-checking and ensemble networks, the accuracy of cross-dataset prediction is improved.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Pediatrics
Kasper Schei, Melanie Rae Simpson, Ekaterina Avershina, Knut Rudi, Torbjorn Oien, Petur Benedikt Juliusson, David Underhill, Saideh Salamati, Ronnaug Astri Odegard
FRONTIERS IN PEDIATRICS
(2020)