Article
Biology
D. Pramanik, M. K. Jolly, R. Bhat
Summary: This study used a computational model to investigate the invasion behavior of malignant epithelial tumor cells in different microenvironments, revealing at least four distinct invasive states. These states were found to be specified by different input signatures of proliferation, adhesion, and extracellular matrix remodeling, and specific input perturbations allowed transitions between the clusters, highlighting variations in the robustness between invasive states. This systems-level approach provides quantitative insights into how the diversity in extracellular matrix microenvironments may influence invasion into diverse phenotypic modes during early dissemination of breast cancer, contributing to tumor heterogeneity.
JOURNAL OF THEORETICAL BIOLOGY
(2021)
Article
Cell Biology
Katharina Joechle, Huda Jumaa, Kerstin Thriene, Claus Hellerbrand, Birte Kulemann, Stefan Fichtner-Feigl, Sven A. Lang, Jessica Guenzle
Summary: The study showed that OSI-027, a dual kinase inhibitor targeting mTOR complexes, can significantly impact the migratory and metastatic capacity of cholangiocarcinoma cells by reducing cell mobility and migration, decreasing colony-forming ability, and downregulating MMP2 and MMP9 expression. Additionally, OSI-027 impaired survival and anti-apoptotic signaling as determined by AKT and MAPK blotting, suggesting that dual targeting of mTORC1/2 may be a viable option for anti-neoplastic therapy in CCA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Stephan Niland, Johannes A. Eble
Summary: The tumor microenvironment (TME) is a key focus in cancer research and treatment, involving various components including ECM and modifying enzymes. Cells within the TME interact with the ECM, influencing tumor progression through feedback mechanisms involving cellular receptors, cytokines, and exosomes. Matrix remodeling in the TME, particularly by matrix metalloproteinases (MMPs), plays a crucial role in modifying ECM barriers and releasing soluble ECM fragments that impact cells both within and outside the TME.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Rohit Siddhartha, Minal Garg
Summary: MMPs are a group of enzymes that play a crucial role in degrading proteins in the extracellular matrix and regulating cell signaling. Dysregulation of MMPs can lead to serious pathological conditions such as inflammation, uncontrolled cell growth, and cancer metastasis. Understanding the functions of MMPs has potential implications for cancer diagnosis, prognosis, and therapy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Veerle Kremer, Diewertje Bink, Laura Stanicek, Eva van Ingen, Theresa Gimbel, Sarah Hilderink, Stefan Guenther, Anne Yael Nossent, Reinier A. Boon
Summary: The non-coding RNA gene MEG8 plays an important role in cardiovascular disease by epigenetically regulating gene expression. Silencing of MEG8 impairs endothelial function, but additional silencing of the target gene TFPI2 partially restores angiogenic sprouting capacity.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Chunqiu Wang, Zhen Deng, Longjun Zang, Yufeng Shu, Suifang He, Xin Wu
Summary: This study conducted bibliometric analysis to provide a comprehensive overview of the matrix metalloproteinases-pancreatic cancer-related field, identifying main research aspects, emerging topics, and future directions for study.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Cell Biology
Shohreh Fakhari, Ali Jalili, Bahram Nikkhoo, Bayazid Ghaderi, Mohammad Amin Boshagh, Sako Mirzaie, Mohammad Moradzad
Summary: This study found that the expression of MT2-MMP is significantly increased in multiple myeloma cells and plays an important role in the growth and progression of these cells. These findings suggest that MT2-MMP may be a potential biomarker for diagnosis and therapeutic interventions of multiple myeloma.
CELLULAR SIGNALLING
(2022)
Article
Biology
Faris Saad Alsubaie, Hamid Khataee, Zoltan Neufeld
Summary: Mathematical and computational models are used to analyze the interaction between two types of epithelial cell layers during tissue invasion. The model predicts that differences in mechanical properties of cells can lead to tissue invasion, even if the division and death rates are the same.
Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Article
Chemistry, Analytical
Wenfei Guo, Xiaonan Gao, Renhui Zhan, Zengteng Zhao, Kehua Xu, Bo Tang
Summary: A tricolor fluorescence nanoprobe based on Au-Se nanoplatform was designed to simultaneously image MMP-2, MMP-7, and MMP-9, investigating tumor cells' invasion and migration behaviors under inflammation. The nanoprobe specifically responds to MMP-2/7/9, allowing visualization in biological systems.
Review
Oncology
Nadezhda V. Popova, Manfred Juecker
Summary: The extracellular matrix plays a critical role in cancer development and progression by influencing the behavior of cancer cells. Abnormal extracellular matrix directly promotes cancer cell proliferation, survival, migration, and differentiation, leading to the emergence of an oncogenic microenvironment.
Article
Nanoscience & Nanotechnology
Yutian Su, Xichen Zhang, Liling Lei, Baolei Liu, Shishan Wu, Jian Shen
Summary: The BAGM nanozyme is an intelligent nanotheranostic platform with multiple therapeutic modalities, enhancing treatment efficacy through a cascade catalytic reaction in the tumor microenvironment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Didem Keles, Murat Sipahi, Seniz Inanc-Surer, Mustafa B. A. Djamgoz, Gulgun Oktay
Summary: Tetracaine, a type of long-acting amino ester local anesthetic, can inhibit the invasive characteristics of breast cancer cells by suppressing their migratory, invasive, and adhesive abilities. This effect may be achieved by reducing the expression and activity of MMP-2 and MMP-9, as well as increasing TIMP-2 expression. The anti-invasive effects of tetracaine make it a potential candidate for clinical use in surgery and combination therapies.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Oncology
Ye Gu, Jiejie Yu, Cong Ding, Yifeng Zhou, Jiangfeng Yang, WeiPing Yu, Xiaofeng Zhang, Haitao Huang
Summary: GL-V9 inhibits the invasion and migration of CRC cells by suppressing the PI3K/Akt signaling pathway and MMP-2/9 axis. It may be a potential novel therapeutic agent against CRC metastasis.
Review
Biochemistry & Molecular Biology
Katerina Strouhalova, Ondrej Tolde, Daniel Rosel, Jan Brabek
Summary: MT1-MMP (MMP-14) is a versatile protease involved in regulating extracellular matrix degradation, activation of other proteases, as well as various cellular processes such as migration and viability in both physiological and pathological conditions. The cytoplasmic tail of MT1-MMP, consisting of the final 20 C-terminal amino acids, plays a crucial role in determining its localization, signal transduction capabilities, and interaction with other proteins. This review summarizes the involvement of the cytoplasmic tail in regulating and executing the functions of MT1-MMP, providing insights into cellular adhesion and invasion mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Marco Scianna, Eleonora Bassino, Luca Munaron
COMPUTERS IN BIOLOGY AND MEDICINE
(2015)
Article
Biology
Marco Scianna
COMPUTERS IN BIOLOGY AND MEDICINE
(2015)
Article
Biology
Marco Scianna, Luigi Preziosi
COMPUTERS IN BIOLOGY AND MEDICINE
(2016)
Article
Cell Biology
Marco Scianna, Eleonora Bassino, Luca Munaron
JOURNAL OF CELLULAR PHYSIOLOGY
(2017)
Article
Biology
A. Colombi, M. Scianna, L. Preziosi
JOURNAL OF MATHEMATICAL BIOLOGY
(2017)
Article
Biology
R. Allena, M. Scianna, L. Preziosi
MATHEMATICAL BIOSCIENCES
(2016)
Review
Oncology
Marco Scianna, Luca Munaron
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2016)
Article
Multidisciplinary Sciences
A. Colombi, M. Scianna
ROYAL SOCIETY OPEN SCIENCE
(2017)
Article
Biology
Jose Antonio Carrillo, Annachiara Colombi, Marco Scianna
JOURNAL OF THEORETICAL BIOLOGY
(2018)
Article
Biology
Annachiara Colombi, Marco Scianna, Luigi Preziosi
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Article
Biology
P. Ferrante, L. Preziosi, M. Scianna
Summary: Cells respond to hypoxia by activating three isoforms of HIFs, which have different activation times. HIF overexpression has various effects on cell behavior, including metabolism changes, promotion of angiogenesis, and induction of pro-inflammatory response. This study focuses on the dynamics of HIF1a and HIF2a under hypoxic conditions and investigates the link between hypoxia and inflammation using a mathematical model.
MATHEMATICAL BIOSCIENCES
(2023)
Article
Mathematics, Applied
Marco Scianna, Luigi Preziosi
Summary: Cell migration in highly constrained environments is influenced by the nucleus, and can be quantitatively analyzed using microfluidic devices and the Cellular Potts model. The numerical results show a high agreement with empirical data.
Article
Mathematics
Marco Scianna, Annachiara Colombi
COMMUNICATIONS IN APPLIED AND INDUSTRIAL MATHEMATICS
(2017)
Article
Mechanics
Annachiara Colombi, Marco Scianna, Andrea Tosin
JOURNAL OF COUPLED SYSTEMS AND MULTISCALE DYNAMICS
(2016)
Proceedings Paper
Computer Science, Theory & Methods
Luigi Preziosi, Marco Scianna
WORKSHOP ON MULTISCALE AND HYBRID MODELLING IN CELL AND CELL POPULATION BIOLOGY
(2015)