Article
Biochemistry & Molecular Biology
Qishan Suo, Yang Yue, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang
Summary: The study identified two peptides (SpH-6 and SpH-7) from Spirulina protein hydrolysate with potent ACE inhibitory activity, which could stably inhibit ACE activity and showed blood pressure-lowering effects in vivo.
Article
Nutrition & Dietetics
Jing Wang, Guoliang Wang, Yufeng Zhang, Runguang Zhang, Youlin Zhang
Summary: In this study, two novel ACE inhibitory peptides were isolated and purified from defatted walnut meal hydrolysates. These peptides showed high ACE inhibitory activities, good stability, and exhibited antihypertensive effects in spontaneously hypertensive rats.
Article
Agriculture, Multidisciplinary
Lingyu Zhang, Jianyin Miao, Junbin Guo, Jie Liu, Zhen Xia, Bingbing Chen, Feng Ma, Yong Cao
Summary: The rice bran protein hydrolysate was purified and two novel peptides FDGSPVGY and VFDGVLRPGQ were obtained. These peptides exhibited significant angiotensin I-converting enzyme (ACE) inhibitory activity in vitro and interacted with the ACE receptor protein through hydrogen bonding and hydrophobic interactions. The peptides also showed the potential to promote nitric oxide (NO) release and reduce endothelin-1 (ET-1) content, indicating their anti-hypertension effects.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Jingjing Dong, Shen Wang, Xiaoyao Yin, Min Fang, Zhiyong Gong, Yongning Wu
Summary: This study investigated the antihypertensive effect of rice peptide (RP) and revealed its mechanism of action. The results demonstrated that RP could effectively reduce systolic blood pressure in hypertensive rats, potentially through regulating the renin-angiotensin system and nitric oxide release.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Chemistry, Applied
Sonu Sharma, Ranjan Pradhan, Annamalai Manickavasagan, Apollinaire Tsopmo, Mahendra Thimmanagari, Animesh Dutta
Summary: By enzymatically hydrolyzing proteins in corn distillers solubles, a hydrolysate called AF was found to have both angiotensin-I converting enzyme (ACE) and dipeptidyl peptidase4 (DPP4) inhibition effects, with high yield and protein content. Mass spectrometry analysis revealed the presence of peptides in the AF hydrolysate, which can bind significantly with other functional groups at enzyme active sites. This demonstrates the dual bioactivity of peptides and their potential applications in food, feed, and pharmaceutical industries.
Article
Food Science & Technology
Waqas N. Baba, Bincy Baby, Priti Mudgil, Chee-Yuen Gan, Ranjit Vijayan, Sajid Maqsood
Summary: This study investigated the ACE inhibiting potential of peptic camel whey hydrolysates under different hydrolysis conditions. Through peptide sequencing and in silico analysis, specific peptides with potential ACE and renin inhibitory activities were identified. Enzymatic hydrolysis of camel whey proteins may release peptides with potential anti-hypertensive properties.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junbo Chen, Xiaodong Yu, Wangxiang Huang, Chen Wang, Qiyi He
Summary: The study isolated and purified an ACE inhibitory peptide WGAP from rabbit meat, which showed significant antihypertensive effects in vivo. Molecular docking analysis revealed the underlying mechanisms of WGAP's action against ACE, indicating its potential as a novel hypertension inhibitor.
Article
Food Science & Technology
Ratchadaporn Kaprasob, Jindaporn Khongdetch, Natta Laohakunjit, Orrapun Selamassakul, Nattapon Kaisangsri
Summary: In this study, King Boletus mushroom protein hydrolysate (KBMPH) was prepared and separated into four fractions based on molecular size. KBMPHF4 showed highest surface hydrophobicity and hydrophobic amino acid content. Several novel peptides from KBMPHF4 exhibited antioxidant and ACE inhibitory activities.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Aprilia Fitriani, Retno Indrati, Yustinus Marsono, Supriyadi Supriyadi
Summary: This study evaluated the ACE-I peptide activity in sprouted lamtoro gung flour through GID simulation and identified the peptide responsible for the ACE-I activity. The 180 min GID simulation showed the highest ACE-I activity, and the <1 kDa peptide fraction had the highest inhibitory activity. The peptides obtained also had other biological activities and were predicted to be non-toxic and safe to consume.
Article
Food Science & Technology
Jeanett Chavez-Ontiveros, Cuauhtemoc Reyes-Moreno, Giovanni Isai Ramirez-Torres, Oscar Gerardo Figueroa-Salcido, Jesus Gilberto Aramburo-Galvez, Alvaro Montoya-Rodriguez, Noe Ontiveros, Edith Oliva Cuevas-Rodriguez
Summary: This study evaluated the antihypertensive potential of chickpea protein hydrolysates and found that the hydrolysate obtained after extrusion had a stronger antihypertensive effect. This has implications for the design and production of functional foods for preventing hypertension or adjunct treatment.
Article
Biochemistry & Molecular Biology
Keer Ma, Yujiao Wang, Mingjie Wang, Zhigao Wang, Xuefeng Wang, Xingrong Ju, Rong He
Summary: Moringa oleifera leaf peptides, especially those under 1 kDa, demonstrated significant antihypertensive activity by inhibiting ACE and renin. Two highly active dual inhibitory peptides, LGF and GLFF, were isolated and identified to effectively reduce blood pressure in spontaneously hypertensive rats. The peptides also showed resistance to gastrointestinal digestion, indicating their potential for hypertension treatment in humans.
Article
Food Science & Technology
Junbin Guo, Aichun Lu, Yunnan Sun, Benying Liu, Jinglin Zhang, Lingyu Zhang, Pantian Huang, Anping Yang, Zhenwei Li, Yong Cao, Jianyin Miao
Summary: In this study, polypeptides with antioxidant and ACE-inhibitory activities were isolated from Guangdong glutinous rice wine, and their activities and molecular mechanisms were studied. The results showed that these polypeptides exhibited significant antioxidant activity and effectively protected cells against oxidative damage.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Hongbing Fan, Jianping Wu
Summary: The study investigated the use of spent hen as a starting material for preparing antihypertensive peptides with both ACE inhibitory (ACEi) and ACE2 upregulating (ACE2u) activities. Several potent ACEi and ACE2u peptides were identified, supporting the potential use of spent hens as functional food ingredients and nutraceuticals for hypertension treatment.
Article
Biochemistry & Molecular Biology
Xinchang Gao, Chaoying Zhang, Ning Wang, Jin-Ming Lin, Yali Dang, Yufen Zhao
Summary: This study predicts the potential activity of peptides derived from Zizyphus jujuba proteins and investigates their ACE-inhibitory activity and in vitro digestion stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Applied
Arshdeep Kaur, Bababode Adesegun Kehinde, Poorva Sharma, Deepansh Sharma, Sawinder Kaur
Summary: Bioactive peptides from food sources have shown potential as therapeutic agents for hypertension by inhibiting ACE and reducing blood pressure. Research has focused on the isolation, hydrolysis, and biofunctionality testing of these peptides, providing valuable literature for hypertension treatment.
Article
Engineering, Environmental
Feng Han, Jiaying Liu, Yuxin Wang, Jingguang Li, Bing Lyu, Yunfeng Zhao, Yongning Wu
Summary: The mechanism of blood to milk transfer of PFOS and Cl-PFESAs was studied using 145 paired maternal serum and human milk samples. The transfer efficiency was found to be influenced by the physicochemical properties and primary components of human milk. Results suggest that passive diffusion through the paracellular route may be the main transfer pathway for PFOS and Cl-PFESAs from blood to milk.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Yizhong Shen, Yunlong Wei, Xiang Gao, Chao Nie, Jianlong Wang, Yongning Wu
Summary: Scientists successfully synthesized a novel blue fluorescence nanozyme CeO2@TPE with high peroxidase-like activity. By embedding aggregation-induced emission (AIE) tetraphenylethene (TPE) into hollow CeO2 nanospheres and combining ethanol oxidase (AOX) and o-phenylenediamine (OPD), they developed an enzymatic cascade activation ratiometric fluorescence-colorimetric dual-mode system for detecting methyl mercaptan (CH3SH). This study provides a new insight into designing target-responsive enzymatic cascade activation systems and enables real-time point-to-point detection of environmental health.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Xuezhen Zhao, Bing Lyu, Lei Zhang, Jingguang Li, Yunfeng Zhao, Yongning Wu, Zhixiong Shi
Summary: Based on the 6th China Total Diet Study, both legacy and novel brominated flame retardants (BFRs) were found in animal-derived foods across China. The levels and estimated dietary intakes (EDIs) of most BFRs showed a significant decrease compared to previous studies conducted from 2007 to 2011. Meat consumption was identified as the primary source of dietary BFR intake. However, daily dietary intakes of BFRs were still unable to cause significant health risks to the general population in China.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Infectious Diseases
Danxia Gu, Zelin Yan, Chang Cai, Jiaping Li, Yanyan Zhang, Yuchen Wu, Jiaxing Yang, Yonglu Huang, Rong Zhang, Yongning Wu
Summary: In this study, the efficacy of three different methods for the rapid detection of carbapenemases (KPC, NDM, IMP, OXA-48, and VIM) was evaluated. The NG-test Carba 5, colloidal gold immunoassay (CGI) test, and Xpert Carba-R assay showed reliable performances in carbapenemase detection, with Xpert Carba-R being recommended for the detection of KPC variants.
Article
Chemistry, Analytical
Xu Zhang, Chaochen Sun, Ruiling Li, Yongning Wu, Xin Jin, FengFu Fu
Summary: This study presents a reusable magnetic enzyme-loading nanoplatform with enhanced peroxidase-like activity for developing colorimetric sensors. It demonstrates stable and enhanced peroxidase-like activity, good enzyme-loading capacity, and magnetic separation capability, which enables the fabrication of sensitive and simple colorimetric sensors. It also successfully detects glucose and cholesterol with high recovery and low relative standard deviation.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Feifei Huang, Lei Zhang, Moqin Zhou, Jianwen Li, Qing Liu, Bo Wang, Ke Deng, Pingping Zhou, Yongning Wu
Summary: Polycyclic aromatics hydrocarbons (PAHs) are commonly found in foods and the environment and have carcinogenic and mutagenic potential. A study in China determined the concentrations of 16 PAHs in commonly consumed food items. Edible vegetable oils had the highest concentration of PAHs, while fruits had the lowest. PAH4 was identified as a suitable indicator for PAH contamination, and the overall dietary exposure for PAHs in the Chinese population was estimated to be within safe limits.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Nutrition & Dietetics
Lan Ma, Huijing Shen, Xiaohong Shang, Shuang Zhou, Bing Lyu, Xin Zhao, Jingguang Li, Yunfeng Zhao, Yongning Wu
Summary: The recent total diet study comprehensively evaluated the intake of nutrient elements in the general Chinese population. Plant foods were the main source of both macro-elements and trace elements. The average intake of Na, Ca, Mg, Zn, and Se did not meet the health guidance values, while the intake of K, P, Mn, Fe, Cu, Mo, and Cr fell within a reasonable range. A dietary imbalance was identified in the Na/K ratio and Ca/P ratio. This study highlights the importance of salt reduction and dietary structure optimization for the population.
Article
Nutrition & Dietetics
Hangyu Yu, Rui Wang, Yunfeng Zhao, Yan Song, Haixia Sui, Yongning Wu, Hongjian Miao, Bing Lyu
Summary: The sixth Total Diet Study (TDS) of China conducted a nationwide study to evaluate the health effects of MSG. The study analyzed 168 samples from seven food categories of the typical Chinese daily diet to determine MSG content, consumption patterns, and associated risks. The study found that the highest MSG level in the Chinese population's daily diet was 8.63 g/kg. By combining food consumption and MSG content measurements, the estimated MSG intake for the general population of China was 17.63 mg/kg bw/d, while the apparent consumption alone resulted in an overestimated intake of 40.20 mg/kg bw/d due to the omission of MSG loss during cooking. The study also compared and analyzed MSG content, food category contributions, and ingestion levels across different nations to provide a global perspective. Furthermore, a realistic, logical, and precise risk assessment protocol for daily MSG intake was developed in this article.
Article
Allergy
Hua Feng, Jiangdong Zhou, Yuanan Lu, Qian Zhao, Zifei Yang, Xiujuan Xiong, Nan Luo, Yan Chen, Lianglu Wang, Yongning Wu
Summary: The prevalence of self-reported food allergy among adults in China is approximately 4.0%, with 3.1% in men and 4.8% in women. The most common allergic symptom is skin reaction, reported by 63.9% of participants with self-reported food allergy. Shrimp, mollusks, and mango are the most common allergenic foods, accounting for 39.8%, 20.8%, and 18.7% of cases respectively. Gender, age, and other allergic conditions are associated factors with food allergy in adults.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Engineering, Environmental
Xin Liu, Lei Zhang, Jiaying Liu, Gerili Zaya, Yuxin Wang, Qian Xiang, Jingguang Li, Yongning Wu
Summary: Growing toxicologic evidence suggests that emerging perfluoroalkyl substances (PFASs), like chlorinated polyfluoroalkyl ether sulfonate (Cl-PFESA), may be as toxic or more toxic than perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA). This study examined the effects of these substances on newborn thyroid homeostasis and found that 6:2 Cl-PFESA has a more pronounced impact on newborns' thyroid homeostasis compared to PFOS. The findings suggest the importance of comparing the thyroid disruption caused by emerging and legacy PFASs in human health risk assessment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Yajie Wang, Jing Cao, Guanzhao Wang, Tao Wei, Kexin Hu, Wenqi Yi, Pingyang Zeng, Huifang Li, Yongning Wu, Qinghua He
Summary: Three ZIFs materials were synthesized and applied to the adsorption and detoxification of gossypol in cottonseed oil. The materials exhibited good crystal structure, thermal stability, and high specific surface area. The adsorption processes followed pseudo-second-order kinetics and were better described by the Langmuir model. The ZIFs materials showed high detoxification rates in both spiked and real cottonseed oil samples.
Article
Food Science & Technology
Hui -Ming Chen, Quan Zhou, Li-Jun Huang, Jun Lin, Jia-Fei Liu, Zi-Yong Huang, Rong-Lin Zhang, Jing-Jing Wang, Yong Zhao, Yong-Ning Wu, Xing-Fen Yang, Wei-Liang Wu
Summary: This study aimed to evaluate the effects of curcumin-mediated photodynamic treatment (PDT) on the shelf-life quality of ready-to-eat salmon fillets. The results showed that PDT had outstanding bacterial inhibition and extended the shelf-life of salmon fillets. Additionally, PDT was able to maintain the physicochemical indicators and freshness of the salmon fillets, and improve the sensory scores.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Jinde Liu, Qiao Rong, Chunxiao Zhang, Ali Tariq, Lin Li, Yongning Wu, Feifei Sun, Michal Tomczyk
Summary: It has been reported that Mori Folium (MF) and Eucommiae Cortex (EC) exhibit pharmacological effects in the treatment of immunosuppression. This study aimed to explore the mechanism of action of MF and EC against immunosuppression using network pharmacology, molecular docking, molecular dynamics simulations, and animal experiments. The results obtained from network pharmacology identified important components, hub targets, and signaling pathways involved in the treatment of immunosuppression. Molecular docking and dynamics simulations confirmed the stable binding of certain critical components to hub targets. Animal experiments also demonstrated the significant effect of MF and EC in treating immunosuppression. These findings suggest that MF and EC may have a multi-component, multi-target, and multi-pathway mode of action in treating immunosuppression.
Article
Biochemistry & Molecular Biology
Luyao Zhang, Jialu Liu, Bufan Xu, Di Wu, Yongning Wu, Guoliang Li
Summary: In this study, the effects of exposure to different concentrations of beta-carbolines norharman and harman on the survival rate and behaviors of C. elegans were assessed. The changes in antioxidant system, neurotransmitter levels, and acetylcholinesterase activity were evaluated. RNA-seq analysis identified potential molecular mechanisms underlying the toxic effects of norharman and harman. The results suggest that long-term exposure to low doses of beta-carbolines in food poses a risk of neurotoxicity.
Review
Chemistry, Analytical
Jin Liu, Guoliang Li, Jianghua Liu, Panxue Wang, Di Wu, Xianlong Zhang, Yongning Wu
Summary: PCBs, a class of synthetic organochlorine chemicals, had been widely used in industrial and commercial applications in the last century. However, PCBs have significant impacts on human health and the ecosystem, including neurotoxicity and carcinogenicity. This review mainly focuses on the recent progress in the toxicity and detection techniques of PCBs in the environment and food, covering classification, source, distribution, and toxicity, as well as sample preparation and analytical determination technologies.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
