Bicycle synthesis through peptide macrocyclization using aziridine aldehydes followed by late stage disulfide bond installation

Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction

(2012) Varun Dewan et al.   ACS Chemical Biology

Conformational Modulation of in Vitro Activity of Cyclic RGD Peptides via Aziridine Aldehyde-Driven Macrocyclization Chemistry

(2012) Áron Roxin et al.   BIOCONJUGATE CHEMISTRY

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition

(2011) Michael M. Madden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of protein–protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors

(2011) Luca Rizzi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure of the Stapled p53 Peptide Bound to Mdm2

(2011) Sohee Baek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology

Contemporary strategies for peptide macrocyclization

(2011) Christopher J. White et al.   Nature Chemistry

Macrocyclization of Linear Peptides Enabled by Amphoteric Molecules

(2010) Ryan Hili et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

Inhibition of HIV Budding by a Genetically Selected Cyclic Peptide Targeting the Gag−TSG101 Interaction

(2008) Ali Tavassoli et al.   ACS Chemical Biology

Synthesis and screening of a cyclic peptide library: Discovery of small-molecule ligands against human prolactin receptor

(2008) Tao Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of backbone cyclic phosphorylated peptides: The IκB model

(2008) Nir Qvit et al.   BIOPOLYMERS

Cyclic Peptidyl Inhibitors of Grb2 and Tensin SH2 Domains Identified from Combinatorial Libraries

(2008) Yanyan Zhang et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY