Article
Environmental Sciences
Marco Corvaro, B. Bhaskar Gollapudi, Jyotigna Mehta
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2020)
Article
Medicine, Legal
Stanley T. Parish, Michael Aschner, Warren Casey, Marco Corvaro, Michelle R. Embry, Suzanne Fitzpatrick, Darren Kidd, Nicole C. Kleinstreuer, Beatriz Silva Lima, Raja S. Settivari, Douglas C. Wolf, Daiju Yamazaki, Alan Boobis
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2020)
Article
Toxicology
Miriam N. Jacobs, Annamaria Colacci, Raffaella Corvi, Monica Vaccari, M. Cecilia Aguila, Marco Corvaro, Nathalie Delrue, Daniel Desaulniers, Norman Ertych, Abigail Jacobs, Mirjam Luijten, Federica Madia, Akiyoshi Nishikawa, Kumiko Ogawa, Kiyomi Ohmori, Martin Paparella, Anoop Kumar Sharma, Paule Vasseur
ARCHIVES OF TOXICOLOGY
(2020)
Editorial Material
Biochemical Research Methods
Neil Spooner, Melanie Anderson, Enaksha R. Wickremsinhe
Article
Biochemical Research Methods
Arundhuti Sen, Molly Gilllett, Lucy Weaver, Matthew Barfield, Pawanbir Singh, Florian Lapierre, Neil Spooner
Article
Medicine, Legal
Claire Terry, Zhongyu Yan, Marco Corvaro, Sean C. Gehen
Summary: Under European Regulation (EC) No 1272/2008, chemicals can be classified as carcinogenic based on their ability to induce tumors, increase tumor incidence, malignancy, or shorten the time to tumor occurrence. Selecting the appropriate classification can be challenging, requiring consideration of hazard data and its relevance to humans. The European Chemical Agency's decisions on cancer classification are based on both the weight-of-evidence and strength-of-evidence of the particular activity.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Sheelan Ahmad, Daniel Baker, Darragh Murnane, Neil Spooner, Ute Gerhard
Summary: This study provides evidence for the potential of solid-phase microextraction (SPME) as an alternative platform for the determination of plasma protein binding (PPB).
Review
Toxicology
Fiona Sewell, Marco Corvaro, Amanda Andrus, Jonathan Burke, George Daston, Bryan Delaney, Jeanne Domoradzki, Carole Forlini, Maia Louise Green, Thomas Hofmann, Sven Jackel, Moung Sook Lee, Michael Temerowski, Paul Whalley, Richard Lewis
Summary: Before registering and marketing new pharmaceutical, (agro)chemical or food ingredient products, manufacturers are required by law to generate data to ensure human safety. The selection of dose levels is crucial in designing studies to identify exposure levels that pose relevant hazards. As the science of predictive human exposure develops, there are exciting opportunities for more human-relevant approaches to dose level selection.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Food Science & Technology
Susan M. Barlow, Claire Terry, Sean Gehen, Marco Corvaro
Summary: This paper presents the results of a rat two-generation study on triclopyr acid and provides a review of all available reproductive and developmental toxicity data from rat studies. The study found that developmental toxicity was only observed at the highest dose, which was likely due to maternal toxicity. Triclopyr was not found to be specifically toxic to reproduction or selectively toxic to the embryo, fetus, or neonate in the rat.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Susan M. Barlow, Claire Terry, Sean Gehen, Marco Corvaro
Summary: Developmental toxicity studies have shown that triclopyr acid and its active-ingredient variants are not specifically toxic to rabbit embryos and fetuses, as post-implantation loss only occurred at doses causing maternal toxicity. However, T-BEE may be associated with increased post-implantation loss, but it was only observed in association with maternal toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Agronomy
Douglas C. Wolf, Yadvinder Bhuller, Rhian Cope, Marco Corvaro, Richard A. Currie, John Doe, Adriana Doi, Gina Hilton, Jyotigna Mehta, David Saltmiras, Fiona Sewell, Maria Trainer, Sandrine E. Deglin
Summary: The current agrochemical safety evaluation paradigm is outdated and does not address the challenges posed by population growth, food insecurity, and climate change. To support sustainable agriculture, the Health and Environmental Sciences Institute (HESI) has formed a technical committee consisting of international experts to establish a framework for modernizing the safety evaluation of crop-protection products. This framework aims to incorporate evolving science and meet the changing global and local needs and regulatory decisions.
PEST MANAGEMENT SCIENCE
(2022)
Article
Medicine, Legal
Manoj Aggarwal, Edward Chikwana, Marco Corvaro
Summary: Phototoxicity testing is required for certain agrochemicals according to European regulations, and this study aims to develop a new approach and framework for assessing non-dietary acute human dermal risk for phototoxicity of agrochemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Medicine, Legal
Namali Corea, Marco Corvaro, Felix M. Kluxen, Arthur Grivel, Neil Morgan, Christiane Wiemann, David Basketter
Summary: Exposure to skin sensitizers is common and regulated in many industry sectors. For cosmetics, a risk-based approach has been implemented, focused on preventing the induction of sensitization. This paper explores modifying existing practice to allow Quantitative Risk Assessment (QRA) of pesticides for bystanders and residents.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Toxicology
Judy Strickland, James Truax, Marco Corvaro, Raja Settivari, Joseph Henriquez, Jeremy McFadden, Travis Gulledge, Victor Johnson, Sean Gehen, Dori Germolec, David G. Allen, Nicole Kleinstreuer
Summary: The skin sensitization potential of agrochemical formulations can be evaluated effectively using non-animal test methods, with the KeratinoSens assay showing the best performance in predicting in vivo hazard outcomes. Defined approaches (DAs) that integrate data from multiple non-animal methods are accepted for hazard classification and potency categorization. However, further research and data generation are needed to improve the accuracy and reliability of these methods.
FRONTIERS IN TOXICOLOGY
(2022)
Article
Medicine, Legal
D. Basketter, S. Beken, H. Bender, J. Bridges, S. Casati, M. Corvaro, S. Cuvellier, B. Hubesch, A. Irizar, M. N. Jacobs, P. Kern, F. Lamplmair, I Manou, B. P. Mueller, R. Roggeband, L. H. Rossi
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2020)
