Article
Multidisciplinary Sciences
Cheng Lyu, L. F. Abbott, Gaby Maimon
Summary: The study reveals how the Drosophila central complex performs vector arithmetic by tracking the fly's absolute travelling angle and transforming egocentric to allocentric coordinates. The neural circuit operates by mapping two-dimensional vectors onto sinusoidal patterns across distinct neuronal populations, which could be applicable to other brains and domains beyond navigation.
Article
Cell Biology
Michele Gianatti, Anna Christina Garvert, Nora Lenkey, Nora Cecilie Ebbesen, Eivind Hennestad, Koen Vervaeke
Summary: Neuronal signals encoding the animal's position widely modulate neocortical processing. This study reveals that the retrosplenial cortex (RSC) receives position information from multiple brain regions, with the secondary motor and posterior parietal cortex transmitting the most position information.
Article
Robotics
Fangwen Yu, Yujie Wu, Songchen Ma, Mingkun Xu, Hongyi Li, Huanyu Qu, Chenhang Song, Taoyi Wang, Rong Zhao, Luping Shi
Summary: The research report introduces a brain-inspired general place recognition system called NeuroGPR, which enables robots to recognize places in natural environments by mimicking the neural mechanism of multimodal sensing, encoding, and computing. The system utilizes a multimodal hybrid neural network to encode and integrate cues from different sensors, and a multiscale liquid state machine to process and fuse the information. Experimental results show that NeuroGPR performs well in various environmental conditions.
Article
Computer Science, Artificial Intelligence
Adithya Krishna, Divyansh Mittal, Siri Garudanagiri Virupaksha, Abhishek Ramdas Nair, Rishikesh Narayanan, Chetan Singh Thakur
Summary: The research has successfully implemented algorithmic and hardware structures mimicking the mammalian spatial navigation system, incorporating grid-cell, place-cell, and decoding modules in a multi-layer architecture to achieve navigation and path integration.
Article
Biochemical Research Methods
Andres Flores-Valle, Johannes D. Seelig
Summary: This study introduces a tethered walking assay for place learning in fruit flies, where the flies learn to remember the location of a cool spot in a virtual reality environment created by a rotating and translating arena. This method enables the investigation of circuit dynamics using functional imaging.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Neurosciences
Liwei Sun, Sebastian M. Frank, Russell A. Epstein, Peter U. Tse
Summary: Research using fMRI and MVPA found that the right parahippocampal place area and hippocampus encode the spatial significance of landmark objects in indoor spaces, with the neural representation of these objects systematically transforming according to their locations.
Article
Multidisciplinary Sciences
Gily Ginosar, Ehud D. Karpas, Idan Weitzner, Nachum Ulanovsky
Summary: The perception of 3D space has been extensively studied, but there are conflicting reports on distortions. This study proposes that 3D perception consists of two processes: perception of traveled space and perception of surrounding space. By testing these two aspects on the same subjects, it was found that the perception of traveled space is experience-dependent, while the perception of surrounding space is not affected by experience. This suggests that these two aspects of 3D spatial perception emerge from distinct processes.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Loes Ottink, Marit Hoogendonk, Christian F. Doeller, Thea M. Van der Geest, Richard J. A. Van Wezel
Summary: This study compared cognitive map formation in small-scale models of city-like environments presented in visual or tactile/haptic modalities, finding no distinct advantage of vision over haptic in the simple maps. The results support the idea of modality-independent representations of space.
SCIENTIFIC REPORTS
(2021)
Review
Behavioral Sciences
Genela Morris, Dori Derdikman
Summary: Place cells and grid cells are essential for the hippocampal cognitive map. The traditional forward model suggests that grid cells are generated by a continuous attractor network, with a velocity signal moving entorhinal activity bumps during locomotion, and place cell activity being the sum of entorhinal grid cell modules. Experimental data support the first hypothesis but not the latter two. A modified model (spatial modulation continuous attractor network; SCAN) is proposed, where place cells are generated from spatially selective non-grid cells, and locomotion causes the movement of the hippocampal activity bump and the entorhinal manifolds. This inversion aligns with the shift of hippocampal function from navigation to more abstract processes.
TRENDS IN COGNITIVE SCIENCES
(2023)
Article
Education & Educational Research
Xiaoshan Li, Wenjing Wang
Summary: Spatial ability is a significant predictor of STEM achievement, with students who integrate navigation cues performing better academically. Results showed that use of navigation cues varied between science and mathematics versus engineering and technology, highlighting the importance of spatial cognitive processes in different disciplines within STEM education.
SCIENCE & EDUCATION
(2021)
Article
Computer Science, Artificial Intelligence
Tristan Baumann, Hanspeter A. Mallot
Summary: The firing fields of hippocampal place cells, known as remapping, change when a rat enters a new compartment in a maze. Remapping cannot be explained solely by path integration and local sensory cues, but requires additional context recognition at gateways between compartments. A model is proposed where place and grid cells follow a joint attractor dynamic, depending on each other's activity and resetting during remapping triggered by passage through a gateway.
Editorial Material
Biochemistry & Molecular Biology
Mark H. Plitt, Lisa M. Giocomo
Summary: The recent study using new holographic optogenetic stimulation technology provides direct evidence that hippocampal place cell activity is sufficient to drive memory and navigation-related behaviors.
Article
Neurosciences
Noah L. Pettit, Xintong C. Yuan, Christopher D. Harvey
Summary: The expression of spatial maps in the hippocampus can be modulated by the internal state of an animal, resulting in changes even without changes to the external world.
NATURE NEUROSCIENCE
(2022)
Review
Neurosciences
Laure Rondi-Reig, Anne-Lise Paradis, Mehdi Fallahnezhad
Summary: This review focuses on the functional and anatomical links between the cerebellum and the hippocampus and their role in goal-directed navigation and spatial cognition. The interactions between these two structures are explored at different scales, including macroscopic, mesoscopic, and cellular levels. The different anatomical pathways that may support this multiscale interaction are summarized.
Article
Biology
Akis Stavropoulos, Kaushik J. Lakshminarasimhan, Jean Laurens, Xaq Pitkow, Dora Angelaki
Summary: This study investigated the impact of sensory observation and latent control dynamics on human path integration using a novel motion-cueing algorithm. The results showed that vestibular signals alone are unable to support accurate path integration without sustained acceleration. Furthermore, the study found that performance in all conditions reflected a failure to fully adapt to changes in the underlying control dynamics.
Article
Neurosciences
Julie M. Lefort, Christelle Rochefort, Laure Rondi-Reig
Article
Neurosciences
Gaetan de lavilleon, Marie Masako Lacroix, Laure Rondi-Reig, Karim Benchenane
NATURE NEUROSCIENCE
(2015)
Article
Neurosciences
Nicolas Traut, Anita Beggiato, Thomas Bourgeron, Richard Delorme, Laure Rondi-Reig, Anne-Lise Paradis, Roberto Toro
BIOLOGICAL PSYCHIATRY
(2018)
Article
Neurosciences
Kinga Igloi, Christian F. Doeller, Anne-Lise Paradis, Karim Benchenane, Alain Berthoz, Neil Burgess, Laure Rondi-Reig
Article
Multidisciplinary Sciences
Benedicte M. Babayan, Aurelie Watilliaux, Guillaume Viejo, Anne-Lise Paradis, Benoit Girard, Laure Rondi-Reig
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Marion Tible, Francois Mouton Liger, Julien Schmitt, Albert Giralt, Karim Farid, Sylvie Thomasseau, Sarah Gourmaud, Claire Paquet, Laure Rondi Reig, Eliane Meurs, Jean-Antoine Girault, Jacques Hugon
Article
Multidisciplinary Sciences
Julie Marie Lefort, Jean Vincent, Lucille Tallot, Frederic Jarlier, Chris Innocentius De Zeeuw, Laure Rondi-Reig, Christelle Rochefort
NATURE COMMUNICATIONS
(2019)
Article
Biology
Thomas Charles Watson, Pauline Obiang, Arturo Torres-Herraez, Aurelie Watilliaux, Patrice Coulon, Christelle Rochefort, Laure Rondi-Reig
Article
Geriatrics & Gerontology
Julien Schmitt, Anne-Lise Paradis, Mathieu Boucher, Laurent Andrieu, Pascal Barneoud, Laure Rondi-Reig
Summary: The study suggests that ApoE4 may lead to flexibility deficits in mice at a younger age, but not memory deficits. The flexibility deficit associated with ApoE4 does not worsen with age or predict memory performance.
NEUROBIOLOGY OF AGING
(2021)
Article
Biology
Ines Gonzalez-Calvo, Keerthana Iyer, Melanie Carquin, Anouar Khayachi, Fernando A. Giuliani, Severine M. Sigoillot, Jean Vincent, Martial Seveno, Maxime Veleanu, Sylvana Tahraoui, Melanie Albert, Oana Vigy, Celia Bosso-Lefevre, Yann Nadjar, Andrea Dumoulin, Antoine Triller, Jean-Louis Bessereau, Laure Rondi-Reig, Philippe Isope, Fekrije Selimi
Summary: The study revealed the importance of Susd4 gene in synaptic function and plasticity, with its constitutive loss affecting motor coordination adaptation and learning in mice. Additionally, SUSD4 was found to interact with proteins regulating AMPA receptor turnover, potentially playing a role in neurodevelopmental diseases.
Article
Biology
Karen Arnaud, Vanessa Oliveira Moreira, Jean Vincent, Glenn Dallerac, Chantal Dubreuil, Edmond Dupont, Max Richter, Ulrike C. Mueller, Laure Rondi-Reig, Alain Prochiantz, Ariel A. Di Nardo
Summary: Elevated APP levels in the choroid plexus impact proliferation in neurogenic niches and long-term expression of mutated APP in the choroid plexus leads to reduced hippocampus function and behavioral deficits. Targeting APP in the choroid plexus may provide a means to improve brain function and alleviate disease-related burdens.
LIFE SCIENCE ALLIANCE
(2021)
Article
Multidisciplinary Sciences
Schmitt Julien, Paradis Anne-Lise, Boucher Mathieu, Andrieu Laurent, Barneoud Pascal, Rondi-Reig Laure
Summary: This article discusses the navigation data of 14 month-old mice in the Starmaze task, serving as positive controls for memory deficit in a model of familial Alzheimer's disease. The data illustrate the extraction of various navigation scores and provide a reference for healthy controls, normal aging, and a model of pathological memory deficit.
Article
Neurosciences
Arturo Torres-Herraez, Thomas C. Watson, Laure Rondi-Reig
Summary: During sleep, coordinated neuronal oscillations across different brain regions support various physiological functions. This study investigated the coordination between the cerebellum and hippocampus during sleep in mice. The results showed sleep stage-specific coordination of oscillations between these two structures, as well as the modulation of hippocampal activity by cerebellar oscillations. These findings suggest multiple physiological mechanisms that support offline, bidirectional interaction within distributed cerebello-hippocampal networks.
JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Laure Rondi-Reig
Summary: In a recent study, researchers discovered that targeted activation of a specific part of the cerebellum can significantly inhibit hippocampal seizures in mice, providing potential applications for treating temporal lobe epilepsy.
TRENDS IN NEUROSCIENCES
(2022)
Review
Neurosciences
Laure Rondi-Reig, Anne-Lise Paradis, Mehdi Fallahnezhad
Summary: This review focuses on the functional and anatomical links between the cerebellum and the hippocampus and their role in goal-directed navigation and spatial cognition. The interactions between these two structures are explored at different scales, including macroscopic, mesoscopic, and cellular levels. The different anatomical pathways that may support this multiscale interaction are summarized.