Article
Computer Science, Information Systems
Francisco Jose Lobato-Camacho, Juan Carlos Lopez, Juan Pedro Vargas
Summary: This study demonstrates the potential of virtual reality tools for evaluating and enhancing attention and memory processes. The researchers developed a virtual water maze to assess search strategies in gamers and analyzed how spatial memory strategies evolve with gaming experience.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Neurosciences
Kylie Isenburg, Thomas M. Morin, Maya L. Rosen, David C. Somers, Chantal E. Stern
Summary: Studies have found that certain brain regions are activated during attentional deployment via long-term memories. We conducted an analysis of task-based functional connectivity to study the communication between these brain regions underlying long-term memory guided attention. Our results showed that different subnetworks, such as default mode, cognitive control, and dorsal attention, contribute differently to long-term memory guided attention, and the connectivity at the network level shifts based on attentional demands. We also found specific nodes within these subnetworks that play a crucial role in facilitating long-term memory guided attention.
Article
Geriatrics & Gerontology
Maite Aznarez-Sanado, Luis Eudave, Martin Martinez, Elkin O. Luis, Federico Villagra, Francis R. Loayza, Maria A. Fernandez-Seara, Maria A. Pastor
Summary: This study focused on motor sequence learning in late middle adulthood and found improvements in motor performance during the learning process. Different stages of learning led to changes in brain activity patterns and age-related alterations in functional connectivity.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Jungtak Park, Karolina Janacsek, Dezso Nemeth, Hyeon-Ae Jeon
Summary: This study used functional magnetic resonance imaging to investigate the whole-brain connectivity involved in statistical learning. The results showed that the activation strength in the superior frontal gyrus and other brain areas were related to statistical learning performance. The activations of the superior frontal network were most correlated with statistical learning performances. The functional connectivity between the superior frontal gyrus and brain regions involved in salience, language, and dorsal attention networks decreased during statistical learning.
Article
Psychology, Mathematical
Michael J. Starrett, Andrew S. McAvan, Derek J. Huffman, Jared D. Stokes, Colin T. Kyle, Dana N. Smuda, Branden S. Kolarik, Jason Laczko, Arne D. Ekstrom
Summary: Recent advances in virtual reality technology have greatly benefited research into spatial cognition and navigation behavior, although a common limitation is the requirement for integration with video game development platforms.
BEHAVIOR RESEARCH METHODS
(2021)
Article
Neurosciences
Haley A. Fritch, Dylan S. Spets, Scott D. Slotnick
Summary: The study found that the anterior and posterior hippocampus interact with regions of the attention and default networks during spatial memory encoding and retrieval. This supports the HERNET model of memory, which predicts different functions for the anterior and posterior hippocampus in memory processes.
Article
Neurosciences
Thomas M. Morin, Allen E. Chang, Weida Ma, Joseph T. McGuire, Chantal E. Stern
Summary: Variations in the functional connectivity of large-scale cortical brain networks may explain individual differences in learning ability. Using dynamic network analysis of fMRI data, researchers identified changes in functional brain networks associated with context-dependent rule learning. Successful rule learners showed specific network characteristics, such as reduced flexible switching between different functional communities and decreased centrality of ventral attention regions while increased assortative mixing of cognitive control regions.
Article
Neurosciences
Maxwell Shinn, Amber Hu, Laurel Turner, Stephanie Noble, Katrin H. Preller, Jie Lisa Ji, Flora Moujaes, Sophie Achard, Dustin Scheinost, R. Todd Constable, John H. Krystal, Franz X. Vollenweider, Daeyeol Lee, Alan Anticevic, Edward T. Bullmore, John D. Murray
Summary: High-throughput experimental methods in neuroscience have led to a surge in techniques for measuring complex interactions and multi-dimensional patterns. However, it is unclear whether these sophisticated measures can be traced back to simpler low-dimensional statistics. In this study, we examined rs-fMRI data using complex topology measures from network neuroscience, and found that spatial and temporal autocorrelation serve as reliable statistics that explain various network topology measures. These findings have important implications for understanding neurobiology and could help establish a connection between complexity measures and brain function.
NATURE NEUROSCIENCE
(2023)
Article
Computer Science, Interdisciplinary Applications
L. Fialho, J. Oliveira, A. Filipe, F. Luz
Summary: This study aimed to investigate spatial processing and navigation strategies in the absence of visual information. A virtual reality task with auditory cues was used to have participants locate and move to target locations. The results showed that task difficulty affected navigation performance and global cognitive functioning was related to both learning and retrieval trials.
Article
Neurosciences
Nadine Diersch, Jose P. Valdes-Herrera, Claus Tempelmann, Thomas Wolbers
Summary: This study investigated the neural mechanisms underlying spatial learning in older adults, highlighting the critical role of the hippocampus in human aging.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Leonie Borne, Ye Tian, Michelle K. Lupton, Johan N. van der Meer, Jayson Jeganathan, Bryan Paton, Nikitas Koussis, Christine C. Guo, Gail A. Robinson, Jurgen Fripp, Andrew Zalesky, Michael Breakspear
Summary: The functional organization of the hippocampus changes smoothly along connectivity gradients and abruptly at inter-areal boundaries, similar to the cortex. This organization allows for flexible integration of hippocampal gradients into cortical networks. By studying fMRI data, researchers found that the functional connectivity gradients of the hippocampus map onto connectivity gradients in the default mode network. The presence of familiar cues accentuates a stepwise transition across the boundary from the anterior to the posterior hippocampus, which is shifted in individuals with mild cognitive impairment or Alzheimer's disease.
Article
Psychology, Mathematical
Maria Florencia Rodriguez, Daniela Ramirez Butavand, Maria Virginia Cifuentes, Pedro Bekinschtein, Fabricio Ballarini, Cristian Garcia Bauza
Summary: This study developed a new software for spatial memory tasks using virtual reality technology, allowing participants to evaluate human spatial memory by walking around in a virtual environment. The results showed that only participants who used spatial cues to guide their behavior demonstrated significant learning during a memory test.
BEHAVIOR RESEARCH METHODS
(2022)
Article
Computer Science, Artificial Intelligence
Mingliang Wang, Jiashuang Huang, Mingxia Liu, Daoqiang Zhang
Summary: This study proposes a temporal dynamics learning (TDL) method for network-based brain disease identification using rs-fMRI time-series data. By integrating network feature extraction and classifier training into a unified framework, it addresses the issues of previous studies paying less attention to the evolution of global network structures over time and treating feature extraction and training as separate tasks.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Neurosciences
Francesca Bottino, Martina Lucignani, Luca Pasquini, Michele Mastrogiovanni, Simone Gazzellini, Matteo Ritrovato, Daniela Longo, Lorenzo Figa-Talamanca, Maria Camilla Rossi Espagnet, Antonio Napolitano
Summary: This study investigated the spatial stability of functional connectivity variations induced by parcellation errors. Using subjects from three public online datasets, the study simulated random parcellation variability and evaluated its effects on twenty-seven graph-theoretical measures. The results showed that certain measures had higher spatial stability while others had lower spatial stability. Multivariate analysis demonstrated significant effects of atlas, datasets, and thresholds. Additionally, spatial stability was influenced by threshold, atlas choice, and scanning parameters. The study highlights the importance of paying attention to parcellation-related spatial errors that may affect the reliability of functional connectivity measures.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Eli J. Cornblath, Arun Mahadevan, Xiaosong He, Kosha Ruparel, David M. Lydon-Staley, Tyler M. Moore, Ruben C. Gur, Elaine H. Zackai, Beverly Emanuel, Donna M. McDonald-McGinn, Daniel H. Wolf, Theodore D. Satterthwaite, David R. Roalf, Raquel E. Gur, Dani S. Bassett
Summary: Individuals with 22q11.2DS show diminished delayed frontal-motor feedback signals and emotional memory signals, while early engagement of motor and visual cortices and insular activation are relatively preserved. Differences in cortical surface area, but not cortical thickness, align with an activation pattern associated with face processing in individuals with 22q11.2DS, indicating intact primary visual processing and insular function, but more affected motor feedback, face processing, and emotional memory processes.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Rebecca P. Lawson, James Bisby, Camilla L. Nord, Neil Burgess, Geraint Rees
Summary: The study provides evidence for the important role of norepinephrine in human behavioral and cognitive responses to uncertainty, showing the impact of neural transmission on behavior and computational responses during uncertain learning process.
Article
Geriatrics & Gerontology
Julien Schmitt, Anne-Lise Paradis, Mathieu Boucher, Laurent Andrieu, Pascal Barneoud, Laure Rondi-Reig
Summary: The study suggests that ApoE4 may lead to flexibility deficits in mice at a younger age, but not memory deficits. The flexibility deficit associated with ApoE4 does not worsen with age or predict memory performance.
NEUROBIOLOGY OF AGING
(2021)
Article
Biology
Ines Gonzalez-Calvo, Keerthana Iyer, Melanie Carquin, Anouar Khayachi, Fernando A. Giuliani, Severine M. Sigoillot, Jean Vincent, Martial Seveno, Maxime Veleanu, Sylvana Tahraoui, Melanie Albert, Oana Vigy, Celia Bosso-Lefevre, Yann Nadjar, Andrea Dumoulin, Antoine Triller, Jean-Louis Bessereau, Laure Rondi-Reig, Philippe Isope, Fekrije Selimi
Summary: The study revealed the importance of Susd4 gene in synaptic function and plasticity, with its constitutive loss affecting motor coordination adaptation and learning in mice. Additionally, SUSD4 was found to interact with proteins regulating AMPA receptor turnover, potentially playing a role in neurodevelopmental diseases.
Article
Multidisciplinary Sciences
Blanca Marin Bosch, Aurelien Bringard, Maria G. Logrieco, Estelle Lauer, Nathalie Imobersteg, Aurelien Thomas, Guido Ferretti, Sophie Schwartz, Kinga Igloi
Summary: The study reveals that moderate intensity exercise enhances hippocampal memory performance and increases levels of endocannabinoids and BDNF, suggesting a synergistic modulation of underlying neural plasticity mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Karen Arnaud, Vanessa Oliveira Moreira, Jean Vincent, Glenn Dallerac, Chantal Dubreuil, Edmond Dupont, Max Richter, Ulrike C. Mueller, Laure Rondi-Reig, Alain Prochiantz, Ariel A. Di Nardo
Summary: Elevated APP levels in the choroid plexus impact proliferation in neurogenic niches and long-term expression of mutated APP in the choroid plexus leads to reduced hippocampus function and behavioral deficits. Targeting APP in the choroid plexus may provide a means to improve brain function and alleviate disease-related burdens.
LIFE SCIENCE ALLIANCE
(2021)
Article
Multidisciplinary Sciences
Schmitt Julien, Paradis Anne-Lise, Boucher Mathieu, Andrieu Laurent, Barneoud Pascal, Rondi-Reig Laure
Summary: This article discusses the navigation data of 14 month-old mice in the Starmaze task, serving as positive controls for memory deficit in a model of familial Alzheimer's disease. The data illustrate the extraction of various navigation scores and provide a reference for healthy controls, normal aging, and a model of pathological memory deficit.
Article
Biochemistry & Molecular Biology
Daniel Bush, H. Freyja Olafsdottir, Caswell Barry, Neil Burgess
Summary: This study reveals the use of phase coding during neuronal replay, similar to the theta phase precession observed during navigation. Each replay event involves the forward propagation of decoded locations along the recapitulated trajectory.
Article
Neurosciences
Arturo Torres-Herraez, Thomas C. Watson, Laure Rondi-Reig
Summary: During sleep, coordinated neuronal oscillations across different brain regions support various physiological functions. This study investigated the coordination between the cerebellum and hippocampus during sleep in mice. The results showed sleep stage-specific coordination of oscillations between these two structures, as well as the modulation of hippocampal activity by cerebellar oscillations. These findings suggest multiple physiological mechanisms that support offline, bidirectional interaction within distributed cerebello-hippocampal networks.
JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Laure Rondi-Reig
Summary: In a recent study, researchers discovered that targeted activation of a specific part of the cerebellum can significantly inhibit hippocampal seizures in mice, providing potential applications for treating temporal lobe epilepsy.
TRENDS IN NEUROSCIENCES
(2022)
Article
Neurosciences
Andrea Castegnaro, David Howett, Adrienne Li, Elizabeth Harding, Dennis Chan, Neil Burgess, John King
Summary: The study aimed to assess the diagnostic potential of memory for object locations in iVR environments in high-risk individuals for AD dementia. The results showed impaired spatial feature binding in patients with mild cognitive impairment (aMCI), which was associated with the early spread of tau pathology in AD. These test results were able to accurately differentiate aMCI patients from controls.
Article
Behavioral Sciences
Charles Laidi, Nathan Neu, Aurelie Watilliaux, Axelle Martinez-Teruel, Mihoby Razafinimanana, Jennifer Boisgontier, Sevan Hotier, Marc-Antoine d'albis, Richard Delorme, Anouck Amestoy, Stefan Holiga, Myriam Ly-Le Moal, Pierrick Coupe, Marion Leboyer, Josselin Houenou, Laure Rondi-Reig, Anne-Lise Paradis
Summary: This study investigated the navigation behavior of individuals with autism spectrum disorder (ASD) and typically developing (TD) adults, as well as the relationship with their brain anatomy. The findings showed that individuals with ASD had similar navigation behavior and cerebellar anatomy compared to the TD controls.
Article
Biochemistry & Molecular Biology
Andrea Castegnaro, Zilong Ji, Katarzyna Rudzka, Dennis Chan, Neil Burgess
Summary: This study developed a new model to analyze the path integration process in healthy elderly and Alzheimer's disease patients. The results showed that early AD patients have errors in estimating turns, and MCI+ patients have larger errors in outbound turns and inbound directions compared to other groups.
Article
Computer Science, Artificial Intelligence
Micha Burkhardt, Julia Bergelt, Lorenz Goenner, Helge Ulo Dinkelbach, Frederik Beuth, Alex Schwarz, Andrej Bicanski, Neil Burgess, Fred H. Hamker
Summary: We introduce a large-scale neurocomputational model called 'Spacecog' that integrates recent findings from mechanistic models of visual and spatial perception. The model successfully interfaces spatial memory and imagery with mechanisms of object localization, saccade execution, and attention through coordinate transformations in the brain's parietal areas. Our evaluation in a realistic virtual environment demonstrates the model's effectiveness and opens up new possibilities in the assessment of neuropsychological data and human spatial cognition.
Review
Neurosciences
Laure Rondi-Reig, Anne-Lise Paradis, Mehdi Fallahnezhad
Summary: This review focuses on the functional and anatomical links between the cerebellum and the hippocampus and their role in goal-directed navigation and spatial cognition. The interactions between these two structures are explored at different scales, including macroscopic, mesoscopic, and cellular levels. The different anatomical pathways that may support this multiscale interaction are summarized.
