Ketogenic Diet Modulates NAD+-Dependent Enzymes and Reduces DNA Damage in Hippocampus

Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders

(2018) Katrin Augustin et al.   LANCET NEUROLOGY

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration

(2017) Pauline Vaur et al.   FASEB JOURNAL

Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease

(2017) Robert J. Pawlosky et al.   JOURNAL OF NEUROCHEMISTRY

Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus

(2017) Mackenzie C. Cervenka et al.   NEUROLOGY

The NAD+/PARP1/SIRT1 Axis in Aging

(2017) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Current status of poly(ADP-ribose) polymerase inhibitors and future directions

(2017) Akihiro Ohmoto et al.   OncoTargets and Therapy

Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism?

(2017) Marwa Elamin et al.   Frontiers in Molecular Neuroscience

Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage

(2017) Juan Liu et al.   Scientific Reports

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

(2016) Berta N Vazquez et al.   EMBO JOURNAL

Targeting of microRNA-199a-5p protects against pilocarpine-induced status epilepticus and seizure damage via SIRT1-p53 cascade

(2016) Dong Wang et al.   EPILEPSIA

Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity

(2016) Tiffany Greco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

(2016) Md. Torequl Islam   NEUROLOGICAL RESEARCH

Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34

(2016) Yan Shen et al.   PLoS One

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes

(2015) Hee Jae Lee et al.   JOURNAL OF MEDICINAL FOOD

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

(2015) Sara Martire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Poly(ADP-ribosylation) and neurodegenerative disorders

(2015) Davide Alessandro Basello et al.   MITOCHONDRION

ARTD1 (PARP1) activation and NAD+ in DNA repair and cell death

(2014) Elise Fouquerel et al.   DNA REPAIR

Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress

(2014) Csaba Hegedűs et al.   Redox Biology

Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro

(2013) Shengjun Wang et al.   BRAIN RESEARCH

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

(2013) Julio Morales et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Use of the modified Atkins diet for treatment of refractory childhood epilepsy: A randomized controlled trial

(2013) Suvasini Sharma et al.   EPILEPSIA

Poly(ADP-ribose): PARadigms and PARadoxes

(2013) Alexander Bürkle et al.   MOLECULAR ASPECTS OF MEDICINE

Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

(2013) Carles Cantó et al.   MOLECULAR ASPECTS OF MEDICINE

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells

(2012) Reas S. Khan et al.   Frontiers in Cellular Neuroscience

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures

(2011) Eun Ae Jeong et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective and Anti-inflammatory Activities of Ketogenic Diet on MPTP-induced Neurotoxicity

(2010) Xinxin Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

Reduced Pain and Inflammation in Juvenile and Adult Rats Fed a Ketogenic Diet

(2009) David N. Ruskin et al.   PLoS One

A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy

(2008) Elizabeth G. Neal et al.   EPILEPSIA

Tissue-specific regulation of SIRT1 by calorie restriction

(2008) D. Chen et al.   GENES & DEVELOPMENT

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY