Article
Engineering, Environmental
Hao Yuan, Shuting Yi, Lufan Jia, Sicheng Chen, Ting Guo, Tao Meng
Summary: In this study, a living cell-inspired nanoscale multienzyme complex was designed to enable efficient cascade reactions and enhance the detection sensitivity of biosensors. The systematic study of this nanocomplex can inspire further investigation into the rules of cellular catalytic behaviors.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Weiqing Xu, Lei Jiao, Yu Wu, Liuyong Hu, Wenling Gu, Chengzhou Zhu
Summary: Biological cascade catalysis involving multiple enzymes guides efficient and selective substrate transformations in vivo, with MOFs and nanozymes being widely used to enhance enzyme stability. Breakthroughs have been made in sensitive detection of various targets through diverse signal output modes, demonstrating the potential of MOFs in cascade reaction systems.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Sergio Gonzalez-Granda, Jesus Albarran-Velo, Ivan Lavandera, Vicente Gotor-Fernandez
Summary: The combination of metal-, photo-, enzyme-, and/or organocatalysis is a versatile approach in synthetic chemistry, particularly for the creation of chiral centers. This review focuses on the recent developments in the simultaneous use of enzymes and transition metal catalysts, as well as the integration of multiple bioprocesses and metal-catalyzed transformations in linear cascades. Challenges such as catalyst compatibility, reaction media, and cross-reactivities are addressed by strategies such as catalyst coimmobilization, compartmentalization, and flow chemistry. The review also highlights the application of bionanohybrid materials, where enzymes and metals are coimmobilized on suitable supports.
Article
Multidisciplinary Sciences
Ming Zhang, Rammile Ettelaie, Lianlian Dong, Xiaolong Li, Ting Li, Xiaoming Zhang, Bernard P. Binks, Hengquan Yang
Summary: A practical one-pot cascade catalysis method was developed by combining Pickering emulsions with continuous flow. The co-localization of catalytically active sub-compartments within droplets of a Pickering emulsion resulted in cell-like microreactors, which showed enhanced catalysis efficiency and controlled kinetics of cascade catalysis.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Huan Xia, Na Li, Wenquan Huang, Yang Song, Yanbin Jiang
Summary: This study synthesized Imitative NH₂-MIL-101 with highly efficient peroxidase-like activity, which served as an excellent catalyst for oxidations of various peroxidase substrates and provided potential matrix for enzyme immobilization. The material also showed synergistic effect in enzymatic cascade reactions, enhancing the catalytic activity.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Wei Kang, Xiao Ma, Deepika Kakarla, Huawei Zhang, Yunming Fang, Baizhu Chen, Kongfu Zhu, Danni Zheng, Zhiyue Wu, Bo Li, Chuang Xue
Summary: Cells use self-assembled biomaterials to coordinate reactions, but mimicking such spatial organization in engineered systems is challenging. This study demonstrates that protein cages can enhance cascade reactions by organizing enzymes, leading to increased productivity. This versatile system offers a powerful tool for enzyme spatial organization in biocatalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Chemical
Peikun Li, Yanchao Wang, Xiuyan Luo, Zixin Geng, Jiahui Jia, Ruirui Wang, Jiandong Cui, Hongjie Bian, Shiru Jia
Summary: A new nanozyme/natural enzyme hybrid biosensor was developed for ultrasensitive detection of L-glutamic acid (L-Glu). Fe3O4 nanoparticles with peroxidase-like activity and stability were used as a nanozyme and carrier to immobilize L-Glutamate oxidase (GLOD), forming a chem-enzyme cascade detector. The Fe3O4-GOLD showed a wide linear range and low detection limit, as well as excellent stability.
Article
Chemistry, Physical
Lei Wan, Rachel S. Heath, Clare F. Megarity, Adam J. Sills, Ryan A. Herold, Nicholas J. Turner, Fraser A. Armstrong
Summary: The ability to drive and observe rapid enzyme catalysis in both directions is achieved by immobilizing cascade components within electrode nanopores and coupling reactions to fast, quasi-reversible NADP(+)/ NADPH electrochemistry. By using two electrodes in sequence, each containing an enantioselective alcohol dehydrogenase for one halfcycle, efficient one-pot de-racemizers can be achieved.
Article
Chemistry, Physical
Siyuan Li, Yidi Zhang, Hao Jin, Hang Gao, Shuwei Liu, Wanrui Shi, Wei Sun, Yi Liu, Hao Zhang
Summary: Diabetes-related chronic wounds with hyperglycemia and weak alkaline environment make it difficult for wound healing due to bacterial growth and biofilm formation. Therefore, reshaping the pathological wound microenvironment to prevent bacterial infection is crucial for rescuing stalled healing progress in diabetes-related chronic wounds.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Hongtong Hu, Peikun Li, Zichen Wang, Yingjie Du, Geling Kuang, Yuxiao Feng, Shiru Jia, Jiandong Cui
Summary: The combination of MOF mimics and natural enzymes allows for the design of efficient and stable chemo-enzyme composite catalysts, promising for applications in biosensing and biomimetic catalysis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yang Zhu, Wenyu Wang, Junjie Cheng, Yunteng Qu, Yi Dai, Manman Liu, Jianing Yu, Chengming Wang, Huijuan Wang, Sicong Wang, Chao Zhao, Yuen Wu, Yangzhong Liu
Summary: The Mn/PSAE constructed here demonstrates significant catalytic activity in weakly acidic tumor environments, which enables the generation of sufficient reactive oxygen species (ROS) through a series of cascade reactions to effectively kill tumor cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Organic
Freideriki Michailidou, Andrea Rentmeister
Summary: Enzyme-mediated methylation is a crucial reaction in nature, leading to a variety of modified natural products and adjusting the activity of biomacromolecules. Recent research has focused on the use of specific enzymes in biocatalysis and biomolecular labeling. Development of (chemo)-enzymatic cascades for selective methylation, alkylation, and photocaging has emerged as valuable tools for studying biological methylation and generating site-specifically alkylated products.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Biophysics
Yong Liu, Xinxin Shao, Deqiang Kong, Guangquan Li, Quanshun Li
Summary: Thermophilic lipase QLM from Alcaligenes sp. was successfully immobilized in Cu-3(PO4)2-based inorganic hybrid nanoflower through biomimetic mineralization. The immobilized enzyme exhibited enhanced stability and reusability compared with the free enzyme, making it a promising candidate for future biocatalytic applications. The optimization of temperature and pH conditions, as well as the protective effect of the nanoflower shell, were critical factors contributing to the favorable properties of the immobilized enzyme.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Chemical
Yulian Wang, Jiayi Liu, Tianjiao Shi, Qihao Wang, Jun Zhang, Yibin Zhu, Chuang Li, Zhigang Yuan, Jin Yao, Wanzhong Yin
Summary: Mineralizing CO2 with magnesium salt is an effective and achievable method to reduce the greenhouse effect. This study successfully prepared hydrated magnesium carbonate as a functional material under the regulation of biosugars, which has significant economic benefits. The formation mechanism of porous spherical nesquehonite was also revealed.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Materials Science, Biomaterials
Hao Shen, Haimei Shi, Bin Feng, Chuanfan Ding, Shaoning Yu
Summary: In this study, a versatile multienzyme cascade nanoplatform for biosensing was developed by combining metal-organic framework (MOF)-based nanozyme with natural enzymes. The nanoplatform exhibited excellent activity and recognition sites, enabling sarcosine/acetylcholine sensing and expanding the application of nanozymes in enzymatic bio-catalysis.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Gousia Begum, Thuniki Naveen Reddy, K. Pranay Kumar, Koude Dhevendar, Shashi Singh, Miriyala Arnarnath, Sunil Misra, Vijaya K. Rangari, Rohit Kumar Rana
ACS APPLIED MATERIALS & INTERFACES
(2016)
Article
Chemistry, Physical
Thuniki Naveen Reddy, Gousia Begum, Rohit Kumar Rana
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2017)
Article
Biochemical Research Methods
Gousia Begum, Shikha Lalwani, Rohit Kumar Rana
BIOCONJUGATE CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Kalpana Javvaji, Gousia Begum, Shruti S. Deshpande, Rohit K. Rana, Sunil Misra
CHEMICAL RESEARCH IN TOXICOLOGY
(2018)
Article
Nanoscience & Nanotechnology
Joydeb Manna, Gousia Begum, K. Pranay Kumar, Sunil Misra, Rohit K. Rana
ACS APPLIED MATERIALS & INTERFACES
(2013)
Article
Chemistry, Multidisciplinary
Stan C. Davis, Vonda C. Sheppard, Gousia Begum, Ye Cai, Yunnan Fang, John D. Berrigan, Nils Kroeger, Kenneth H. Sandhage
ADVANCED FUNCTIONAL MATERIALS
(2013)
Article
Chemistry, Multidisciplinary
Gousia Begum, Rohit Kumar Rana
CHEMICAL COMMUNICATIONS
(2012)
Article
Chemistry, Multidisciplinary
Gousia Begum, Joydeb Manna, Rohit Kumar Rana
CHEMISTRY-A EUROPEAN JOURNAL
(2012)
Article
Chemistry, Physical
Gousia Begum, Shashi Singh, Nandini Rangaraj, G. Srinivas, Rohit K. Rana
JOURNAL OF MATERIALS CHEMISTRY
(2010)
Article
Chemistry, Physical
Gousia Begum, M. Vijaya Laxmi, Rohit Kumar Rana
JOURNAL OF MATERIALS CHEMISTRY
(2012)
Article
Engineering, Biomedical
Gousia Begum, Cathleen Oschatz, Martin Oschatz, Stefan Kaskel, Eike Brunner, Nils Kroeger
BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Thuniki Naveen Reddy, Songhita Meher, Gousia Begum, Binod B. Panda, Rohit K. Rana
Article
Chemistry, Multidisciplinary
Rakesh Chilivery, Gousia Begum, Vahinipathi Chaitanya, Rohit Kumar Rana
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Nanoscience & Nanotechnology
Gousia Begum, Patturu Swathi, Arun Kumar Bandarapu, Jayadev Nayak, Rohit Kumar Rana
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)