Review
Materials Science, Multidisciplinary
Fujun Yang, Zhiqiang Kong, Qingyu Ji, Shumeng Li, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: Platelets, as abundant corpuscles in the blood, play important roles in normal physiological processes and disease occurrence. In recent years, significant progress has been made in platelet-inspired nanotherapeutics, especially in the fields of biotechnology and nanomedicine. This article provides an overview of platelet-inspired nanotherapeutics for biomedical applications. It discusses the recent trends of biomimetic platelet-inspired nanosystems, the functional modulation of platelet aggregation, activation, and inhibition, platelet derivative-based nanotherapeutics, and the clinical application prospects of these emerging nanotherapeutics with their rationale, advantages, and challenges highlighted.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Shujun Cui, Jifu Mao, Mahmoud Rouabhia, Said Elkoun, Ze Zhang
Summary: Polymerization (PPy) is a widely studied conductive biomaterial, but its rigidity limits its practical applications. By reinforcing a soft PPy membrane with electrospun PU and PLLA fibers, this study has successfully enhanced its flexibility and tensile strength while maintaining electrical conductivity and cytocompatibility. The membrane shows promise for various biomedical applications.
Review
Chemistry, Multidisciplinary
H. T. Kim Duong, Ashkan Abdibastami, Lucy Gloag, Liam Barrera, J. Justin Gooding, Richard D. Tilley
Summary: Magnetic Particle Imaging (MPI) is a non-invasive technique that offers high quality images with no radiation, high depth penetration and minimal tissue background. The selection of suitable nanoparticles as tracers is crucial for optimal results, and the synthetic pathways as well as surface modifications play important roles in their biomedical applications.
Article
Biophysics
Oluwafemi S. Obisesan, Timothy O. Ajiboye, Sabelo D. Mhlanga, Hazel T. Mufhandu
Summary: Magnetic nanoparticles (MNPs) have become a focus of attention in the past decade due to their unique properties, making them suitable for drug delivery and various biomedical applications when combined with biodegradable polymers. This review discusses the synthesis of polycaprolactones (PCL), methods of synthesizing magnetic iron oxide nanoparticles, and the synthesis of PCL-based composites. It comprehensively reviews the application of these composites in drug delivery, cancer treatment, wound healing, hyperthermia, bone tissue engineering, and other biomedical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Ehsanul Hoque Apu, Md Nafiujjaman, Srikumar Sandeep, Ashley Makela, Ali Khaleghi, Seppo Vainio, Christopher H. Contag, Jinxing Li, Ilangko Balasingham, Taeho Kim, Nureddin Ashammakhi
Summary: Advances in nanotechnology have led to the development of magnetoelectric nanoparticles (MENPs) with unique properties that can be used in various biomedical applications, including drug delivery, neural stimulation, bio-imaging, and biosensing.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Multidisciplinary Sciences
Amalia Mesaros, Alba Garzon, Mircea Nasui, Rares Bortnic, Bogdan Vasile, Otilia Vasile, Florin Iordache, Cristian Leostean, Lelia Ciontea, Josep Ros, Ovidiu Pana
Summary: A Ga3+-substituted spinel magnetite nanoparticles Ga0.9Fe2.1O4 were successfully synthesized using both solvothermal decomposition method and microwave-assisted heating method. The TD method produced nanoparticles with the expected spinel structure, while the MW method produced additional gallium suboxide. The nanoparticles showed good biocompatibility and cellular metabolism activity in vitro.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Multidisciplinary
Muhammad Nadeem, Rijma Khan, Nausheen Shah, Ishrat Rehman Bangash, Bilal Haider Abbasi, Christophe Hano, Chunzhao Liu, Sana Ullah, Syed Salman Hashmi, Akhtar Nadhman, Jonathan Celli
Summary: Nanotechnology has wide applications in health, agriculture, and industry, and the biological approach of synthesizing nanoparticles, particularly iron oxide nanoparticles using microbes, has gained significant attention in biomedical research. However, the issues of cytotoxicity and biodegradability remain as major hurdles for commercialization.
Review
Materials Science, Biomaterials
Ruixue Wei, Youzhi Xu, Mengzhou Xue
Summary: Hollow iron oxide nanoparticles are a promising class of nanostructures with low toxicity, good biocompatibility, and intrinsic magnetic properties, making them attractive in biomedical applications. Various strategies for synthesis, surface functionalization, and biomedical applications of hollow iron oxide nanoparticles have been reviewed, highlighting their potential in magnetic resonance imaging, drug delivery, and cancer therapy. Prospects for further development of hollow iron oxide nanoparticles have also been discussed.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Multidisciplinary Sciences
Ren Hao Soon, Zhen Yin, Metin Alp Dogan, Nihal Olcay Dogan, Mehmet Efe Tiryaki, Alp Can Karacakol, Asli Aydin, Pouria Esmaeili-Dokht, Metin Sitti
Summary: This article presents a pangolin-inspired bi-layered soft robot design that achieves heating >70 degrees C at distances >5cm without compromising compliance and safety, thus providing a new option for biomedical applications.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Sangiliyandi Gurunathan, Ah Reum Lee, Jin Hoi Kim
Summary: SARS-CoV-2 has caused a pandemic of COVID-19, and some patients have acquired secondary infections such as black fungus disease. Prompt diagnosis and treatment are necessary to prevent high mortality and morbidity rates. Uncontrolled diabetes and immunosuppression are major risk factors, and the use of steroids can increase the risk of black fungus infection. Novel and effective antimicrobial agents are needed to combat this infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Nadja C. Bigall, Marina Rodio, Sahitya Avugadda, Manuel Pernia Leal, Riccardo Di Corato, John S. Conteh, Romuald Intartaglia, Teresa Pellegrino
Summary: This study focused on developing a scale-up protocol for increasing the yield of polymeric magnetic nanobeads for biomedical applications, while also proposing a cross-linking strategy to improve their structural stability in different solutions and during surface functionalization.
JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Article
Multidisciplinary Sciences
Bahig A. Eldeeb, Walaa M. Abd El-Raheem, Shehab Elbeltagi
Summary: In this study, superparamagnetic iron oxide nanoparticles (SPIONs) were successfully synthesized using Citrus sinensis peel extract. The fabricated SPIONs demonstrated eco-friendly, biocompatible, cost-effective, and highly stable properties. The synthesized SPIONs exhibited antimicrobial, antioxidant, anti-inflammatory, and catalytic dye degradation activities, as well as excellent performance in fluid magnetic hyperthermia (MHT), making them suitable for biomedical applications.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Mohammad Imran, Vemana Gowd, Puspita Saha, Summya Rashid, Anis Ahmad Chaudhary, Marwa Yousry A. Mohamed, Abdullah S. Alawam, Rehan Khan
Summary: Nanotechnology is being used as a model for developing better treatments for various diseases, but it still faces challenges such as inadequate circulation, insufficient accumulation at the target region, and undesired toxicity. Scientists are producing cell-membrane camouflaged nanoparticles as a biomimetic technique to overcome these challenges and improve therapeutic efficacy. These biomimetic nanoparticles have potential applications in diagnosing and treating diseases, including drug administration, immunisation, immunological regulation, and detoxification.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Ashok Kumar Mandal, Saurav Katuwal, Felix Tettey, Aakash Gupta, Salyan Bhattarai, Shankar Jaisi, Devi Prasad Bhandari, Ajay Kumar Shah, Narayan Bhattarai, Niranjan Parajuli
Summary: This article provides a comprehensive review of the synthesis approaches of zinc oxide nanoparticles (ZnO-NPs) and their biological activity in the medical field. ZnO-NPs, with their biocompatibility and biodegradability, can serve as effective nanocarriers for conventional drugs. The article also highlights the green synthesis methods using plants, bacteria, and fungi.
Article
Nanoscience & Nanotechnology
Chichong Lu, Xue Xu, Tingting Zhang, Zhijie Wang, Yuyun Chai
Summary: This study presents a simple and efficient method to engineer manganese-doped iron oxide nanoclusters (MnIO NCs) with excellent water-solubility, colloidal stability, biocompatibility, and superparamagnetic properties. MnIO NCs show great potential in T-1-T-2 dual-mode magnetic resonance imaging for deep tissue.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biophysics
M. Birgul Akolpoglu, Yasemin Inceoglu, Seda Kizilel
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Syeda Rubab Batool, Muhammad Anwaar Nazeer, Duygu Ekinci, Afsun Sahin, Seda Kizilel
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Pelin Erkoc, Ileyna Uvak, Muhammad Anwaar Nazeer, Syeda Rubab Batool, Yazan Nitham Odeh, Ozan Akdogan, Seda Kizilel
MACROMOLECULAR BIOSCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Mukrime Birgul Akolpoglu, Nihal Olcay Dogan, Ugur Bozuyuk, Hakan Ceylan, Seda Kizilel, Metin Sitti
Review
Engineering, Biomedical
M. Birgul Akolpoglu, Yasemin Inceoglu, Ugur Bozuyuk, Ana Rita Sousa, Mariana B. Oliveira, Joao F. Mano, Seda Kizilel
Summary: The focus of current research is on overcoming challenges such as islet donor shortage, engraftment, prolonged islet availability, and post-transplant vascularization through the design of 3D cell clusters that can accurately secrete insulin and have superior features. These engineered heterocellular islet organoids aim to address the current obstacles in islet transplantation protocols and have the potential to improve clinical outcomes.
Article
Biochemistry & Molecular Biology
Syeda Rubab Batool, Muhammad Anwaar Nazeer, Erdost Yildiz, Afsun Sahin, Seda Kizilel
Summary: This study synthesized single and dual-crosslinked anthracene-functional chitosan-based hydrogels without toxic initiators, demonstrating that the dual-crosslinked hydrogels had higher Young's modulus and cell volume compared to the single-crosslinked hydrogels, without affecting cytotoxicity. Additionally, altering the hydrogel properties can modulate cell morphology.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Engineering, Biomedical
Muhammad Anwaar Nazeer, Ismail Can Karaoglu, Onur Ozer, Cem Albayrak, Seda Kizilel
Summary: The article discusses the challenges and strategies in engineering vascularized tissue constructs, emphasizing on the importance of clinical translation and remaining challenges in the field. It also provides detailed insights into neovascularization steps, roles of extracellular matrix elements, decellularization, cell, and growth factor-based therapeutic angiogenesis strategies, as well as delivery methods of growth factors in biomaterial scaffolds. Interdisciplinary approaches involving biomaterials science advancement and fabrication techniques are critically evaluated as part of the discussion.
APL BIOENGINEERING
(2021)
Article
Polymer Science
Saeid Darvishi, Muhammad Anwaar Nazeer, Madhusudan Tyagi, Qingteng Zhang, Suresh Narayanan, Seda Kizilel, Erkan Senses
Summary: The study found that nonlinear polymers can significantly alter the mechanical properties of polymer nanocomposites, and attractive NPs in highly branched matrices can markedly slow down the average dynamics of the polymer. Additionally, the nanoscale dynamics of particles in compact nonlinear matrices show strong decoupling from bulk viscoelasticity.
Article
Engineering, Biomedical
Ayesha Gulzar, Erdost Yildiz, Humeyra N. Kaleli, Muhammad A. Nazeer, Noushin Zibandeh, Anjum N. Malik, Ayse Y. Tas, Ismail Lazoglu, Afsun Sahin, Seda Kizilel
Summary: This study proposes a new method for corneal crosslinking using a ruthenium-based water-soluble photoinitiator and visible light. The results demonstrate that the ruthenium-based approach has superior biomechanical properties, biocompatibility, and optical transparency compared to the riboflavin/UV-A method. It offers a promising non-surgical therapy option for all ectatic corneal pathologies.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Tugba Bal, Ismail Can Karaoglu, Fusun Sevval Murat, Esra Yalcin, Yoshihiro Sasaki, Kazunari Akiyoshi, Seda Kizilel
Summary: Cell-based therapies have advantages over traditional drug-based or injection-based treatments. Nanogels, used as physical barriers between the immune system and cellular implants, have potential for modulation of cellular microenvironments. By incorporating nanogels into hydrogels, researchers have developed a system with immunological acceptance and without internalization of nanoparticles.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Nanoscience & Nanotechnology
Alican Kusoglu, Kardelen Yangin, Sena N. Ozkan, Sevgi Sarica, Deniz Ornek, Nuriye Solcan, Ismail C. Karaoglu, Seda Kizilel, Pinar Bulutay, Pinar Firat, Suat Erus, Serhan Tanju, Sukru Dilege, Ece Ozturk
ACS APPLIED BIO MATERIALS
(2023)
Article
Polymer Science
Selcan Karaz, Gizem Akay, Ismail C. Karaoglu, Mertcan Han, Sedat Nizamoglu, Seda Kizilel, Erkan Senses
Summary: Shear forces play a significant role in cellular processes and are particularly important in cardiovascular diseases. Although various stimuli have been explored for on-demand release, developing drug delivery systems that respond to physiological-level shear stresses is challenging. Liposomes embedded in hydrogel matrices offer a promising solution as they can dynamically interact with their surroundings. However, understanding the interaction between liposomes and hydrogels, as well as their response to shear forces, is crucial for optimal drug delivery systems.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Ismail Can Karaoglu, Aybaran Olca Kebabci, Seda Kizilel
Summary: This study investigates the effects of Eosin Y (EY), triethanolamine (TEA), and N-vinyl-2-pyrrolidone (NVP) concentrations on the stiffness and gelation time of GelMA hydrogels. An artificial neural network (ANN) model is developed to accurately predict the properties of GelMA hydrogels. The study also establishes non-toxic concentration ranges for each component, enabling safer use of GelMA hydrogels in biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ugur Bozuyuk, Ipek S. Gokulu, Nihal Olcay Dogan, Seda Kizilel
Article
Engineering, Biomedical
D. C. Oran, T. Lokumcu, Y. Inceoglu, M. B. Akolpoglu, O. Albayrak, T. Bal, M. Kurtoglu, M. Erkan, F. Can, T. Bagci-Onder, S. Kizilel
MATERIALS TODAY BIO
(2019)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
