Article
Chemistry, Multidisciplinary
Yuyan Li, Fanghua Zhang, Wendong Liu, Mingzheng Shao, Zhe Hao, Hongyan Zhang, Ruizhong Zhang, Xiyan Li, Libing Zhang
Summary: A DNA nanoprobe activated by glutathione (GSH) was developed for spatially selective sensing and imaging of miRNA in living cells. The nanoprobe consisted of metal-organic frameworks (MOFs) and DNA hairpin probes tethered to the MOF surface, with a disulfide bond in the hairpin loop. Cleavage of the disulfide bond by GSH triggered a strand-displacement reaction with target miRNAs, enabling fluorescence signal readout in situ. The combination of endogenous GSH activation and MOF improved the spatial resolution of miRNA detection and imaging.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Xia Li, Fang Yang, Chunfang Gan, Ruo Yuan, Yun Xiang
Summary: This study develops a 3D DNA nanprobe for simultaneous monitoring of multiple miRNAs in live cells, showing enhanced reaction rate and stability compared to conventional probes.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Zhe Dong, Debo Gao, Yuancheng Li, Kang An, Jing Ni, Ling Meng, Han Wu
Summary: This study develops DNA nanoparticles with GSH-responsive controllable release of hairpin reactants for the analysis and imaging of low-abundance target mRNA in living cells. The DNA nanoparticles exhibit stability, cell-specific penetration, and precise controllability. By combining multi-amplifiers and programmable DNA nanostructures, the strategy enables accurately triggered release of hairpin reactants, achieving sensitive imaging and quantitative evaluation of survivin mRNA in carcinoma cells.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Yinghui Feng, Qi Liu, Xinyi Zhao, Miao Chen, Xiaotong Sun, Hexiang Li, Xiaoqing Chen
Summary: In this study, a framework nucleic acid (FNA)-based nonenzymatic spatial-confinement amplifier was developed for rapid and reliable intracellular miRNA imaging. By encapsulating the localized catalytic hairpin assembly (L-CHA) reactor in the inner cavity of the FNA and utilizing the spatial-confinement effect, the reaction rate was accelerated and the dynamic performance was improved.
ANALYTICAL CHEMISTRY
(2022)
Review
Multidisciplinary Sciences
Qianying Zhang, Shengshi Xu, Jingyi Zheng, Jian-Rong Zhang, Jun-Jie Zhu
Summary: This review summarizes the latest progress in Au-DNA self-assembled nanomachines for biosensing applications. The functional modules for building Au-DNA nanomachines are introduced, and the biosensing applications using electro-chemical or fluorescent signals as the output are summarized. The challenges and potential opportunities for Au-DNA nanomachines in biomedical applications are also discussed.
Article
Biophysics
Bin-Cheng Yin, Bang-Ce Ye, Jin-Yu Wang, Hua-Dong Li, Pei-Qiang Ma, Ying Zhou
Summary: We developed a DNA nanomachine initiated by a miRNA-induced silencing complex (miRISC) for imaging miRNA activity in living cells. The nanomachine was activated by the miRISC-mediated RNA cleavage reaction, resulting in autonomous movement and release of fluorescently labeled DNA strands. It successfully detected miR-21 activity in different cell lines and showed versatility in detecting other miRNAs. Compared to existing methods, this nanomachine has advantages in terms of simplicity, analysis time, and signal output. It expands the application of DNA nanomachine in miRNA activity detection and has potential for basic research and clinical biomedicine.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Jing Li, Anmin Wang, Xiaohai Yang, Kemin Wang, Jin Huang
Summary: This study aimed to develop an integrated amplification platform for detecting intracellular miRNA, termed self-powered FRET flares (SPF), which achieved target recycling and signal amplification under the trigger of intracellular miRNA-21 without the need for auxiliary additives. By utilizing AS1411 aptamer to target specific cancer cells and facilitating cell internalization of assembly DNA nanostructures, SPF demonstrated rapid response to miRNA-21 and improved detection sensitivity compared to previous FRET flares without amplification, showing promise for diverse tasks in biological and medical applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Zhijun Li, Qiannan Li, Yanan Wu, Kun Yuan, Mingqing Shi, Yiwei Li, Hong-Min Meng, Zhaohui Li
Summary: Efficient monitoring of microRNA is highly important for cancer research. In this study, a multivalent self-assembled DNA nanowire was designed for fast quantification of intracellular target miRNAs. The experimental results showed that the DNA nanowire probe successfully and quickly monitored miRNA-21 in living cells and in vivo. This developed strategy may serve as a general platform for detecting targets in living cells and has great potential for biological and diagnostic research.
Article
Chemistry, Analytical
Jihua Zhang, Hao Zhang, Sujuan Ye, Xingxiang Wang, Lindong Ma
Summary: This study developed two smart binary star ratio probes for precise imaging and quantification of miRNAs. The probes showed good stability in living cells and were successfully used for accurate tracing and quantification of miR-203. The reported BSR probes have the potential to be a reliable tool for monitoring biomolecule dynamics in living cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Shuai Wang, Liyan Zhang, Ailing Kan, Xiaowen Xu, Nan Zhang, Wei Jiang
Summary: In this study, a MnO2 nanosheet-mediated target-binding-induced fluorescence resonance energy transfer (FRET) strategy was developed for detection and imaging of multiplexed miRNAs in living cells. The strategy successfully enabled simultaneous imaging of miRNA-373 and miRNA-96 in MDA-MB-231 and L02 cells, revealing higher expression levels of target miRNAs in MDA-MB-231 cells compared to L02 cells. This approach provides an alternative method for simultaneous accurate detection and imaging of multiplexed miRNAs with potential biomedical applications.
Article
Biochemical Research Methods
Yuling Liang, Huihui Yang, Wen Yin, Yanfei Zhang, Yuzhi Xu, Si-Yang Liu, Zong Dai, Xiaoyong Zou
Summary: In this study, we report the use of polydopamine-modified gold nanoparticles as nanocarriers for long-term monitoring of miRNA in living cells. This method achieves high sensitivity and selectivity and effectively protects the probes from hydrolysis in the intracellular environment.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tapas Ghosh, Shu Wang, Dharmendra Kashyap, Rohit G. Jadhav, Tanmay Rit, Hem Chandra Jha, Brian G. Cousins, Apurba K. Das
Summary: Self-assembled benzoselenadiazole (BSe)-capped tripeptide based nanofibrillar hydrogels have been developed that possess intrinsic anticancer and anti-inflammatory activities.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Li Yu-Yan, Zhang Hong-Yan, Liu Wen-Dong, Shao Ming-Zheng, Zhang Rui-Zhong, Zhang Li-Bing
Summary: The identification and detection of new biomarkers have accelerated the advancement of high-performance detection technologies. MicroRNA has emerged as a specific biomarker for cancer diagnosis and prognosis, and its detection is crucial for enhancing disease diagnostic accuracy. DNA fluorescent nanoprobes have become an effective tool for monitoring and analyzing microRNA and dynamic cellular and organism changes. However, traditional DNA nanoprobes are limited in achieving high precision and resolution imaging signals due to the interference of biological autofluorescence, off-target effects, and lack of temporal and spatial control. Activated DNA nanoprobes, as a newly developed paradigm, have shown promising potential in overcoming these limitations by modulating imaging and sensing properties through exogenous or endogenous factors.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xin Xu, Yifan Jiang, Chunhua Lu
Summary: This study developed an ATP-responsive DNA nanohydrogel for cancer cells specific fluorescence imaging and chemotherapy. The nanohydrogel disassembled and released the loaded drug after endocytosis by cancer cells and response to high intracellular ATP level. The released drug played a role in fluorescence imaging and chemotherapy of cancer cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Jun-Xian Liu, Xiao-Ming Sun, Meng-Kun Xin, Ya-Ling Chen, Da Liu, Cheng-Yu Li
Summary: A light-gated approach and a functionalized nanocarrier are proposed to improve the controllability and biological uptake of cascade amplification DNA circuits. The biosensor showed favorable sensitivity and specificity for microRNA detection, demonstrating its potential for cancer imaging and targeted therapy.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Junji Li, Zi-Xuan Liu, Yi-Xuan Li, Guofang Shu, Xue-Ji Zhang, Robert S. Marks, Dan Shan
Summary: In this study, a tailored metal-organic framework transducer material Cu BDC(NH2)@2-MI was synthesized using 2-methylimidazole as a competitive ligand, which allowed for the modulation of its morphology and catalytic activity. The 2-MI-doped MOF exhibited well-tuned morphology and showed efficient performance in electrochemical H2O2 reduction. This novel design could potentially enable the utilization of proprietary MOFs materials beyond the laboratory.
Article
Biophysics
Xiaofeng Jin, Guanhua Li, Tailin Xu, Lei Su, Dan Yan, Xueji Zhang
Summary: Continuous glucose monitoring platform with optimized linear range and long-term stability was developed using a biocompatible conjugated polymer. The system included a small design with signal conditioning, programmable electrochemical chip, and wireless connection. Biocompatibility tests and animal experiments confirmed successful in vivo blood glucose monitoring.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Xiaoyu Hua, Jingjing Fan, Lingzhi Yang, Jun Wang, Yongqiang Wen, Lei Su, Xueji Zhang
Summary: This study presents a rapid electrochemical detection method for miRNA let-7a using the polyA-H probe, with signal amplification through LAMP and i-motif structure formation. The total detection time is short and the sensitivity is high.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Zhongzeng Zhou, Jing Wang, Guanhua Li, Yanxia Chen, Tailin Xu, Xueji Zhang
Summary: The study presents a portable electrochemical platform for multi-channel sensing and analysis in microdroplet arrays. The platform demonstrates high accuracy and practicality, making it suitable for drug discovery and cell biology research. It also features cloud data management and remote analysis capabilities.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Y. Li, S. Tang, Z. Cong, D. Lu, Q. Yang, Q. Chen, X. Zhang, S. Wu
Summary: By using metal-organic framework exoskeletons to protect bacterial microswimmers from enzyme degradation, a versatile system capable of drug delivery and improved therapeutic efficacy has been developed. This multifunctional biohybrid microswimmer design shows potential for targeted disease treatment and active drug delivery in harsh environments.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Engineering, Environmental
Qin Xiang, Wei Li, Yan Tan, Jianwei Shi, Mingjie Dong, Jiale Cheng, Jingkun Huang, Weiyun Zhang, Youcong Gong, Qiqi Yang, Lingzhi Yang, Haifeng Dong, Xueji Zhang
Summary: In this study, a mitochondria-targeted, 808 nm near-infrared light-triggered upconversion carbon dots coordinated porphyrinic MOFs nano-photosensitizer was designed for enhanced photodynamic therapy. The system showed excellent anticancer ability both in vitro and in vivo.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Yan Huang, Yiyi Zhang, Wenbin Hao, Huiting Lu, Haifeng Dong, Xueji Zhang
Summary: To achieve fast, convenient, and highly sensitive detection of microRNA (miRNA), palladium-gold (Pd-Au) bimetallic nanoplates with high photothermal effect were synthesized and combined with locked nucleic acid (LNA) detection probe to develop a photothermal lateral flow locked nucleic acid biosensor (P-LFLNAB) for miRNA detection. The P-LFLNAB enables sensitive and selective miRNA-21 detection with detection limit down to 0.094 pM using a smartphone with external thermal imager, which is 639.5 times lower than that of the conventional gold nanoparticles based colorimetric lateral flow biosensor and the most sensitive enzyme-free lateral flow biosensor for miRNA detection. Besides, the P-LFLNAB achieved single-base mismatch discrimination and can quantify signals in various cell lysates. This highly sensitive, selective and portable P-LFLNAB with smartphone readout has great potential in point-of-care test of miRNAs-related biomedical application.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Xiangdan Meng, Sirong Sun, Chenchen Gong, Junyan Yang, Zhou Yang, Xueji Zhang, Haifeng Dong
Summary: In this study, we report the design of a Ti-based metal-organic framework (MIL) and silver nanoparticles (Ag NPs) heterostructure, MIL@Ag. It is found that the introduction of Ag NPs significantly improves the electron transfer efficiency and O2 adsorption capacity of MIL, leading to enhanced reactive oxygen species (ROS) generation for sonodynamic therapy (SDT). Under ultrasound irradiation, the activated electrons and holes from MIL and Ag NPs produce superoxide radicals and hydroxyl radicals, respectively, improving the therapeutic efficiency of SDT. MIL@Ag-PEG-mediated SDT demonstrates effective cancer cell killing and bacterial infection eradication. Thus, MIL@Ag-PEG provides a promising strategy for enhancing SDT performance through rational heterostructure design of sonosensitizers.
Article
Chemistry, Analytical
Shuangshuang Yang, Jinya Du, Menglian Wei, Yan Huang, Yufan Zhang, Yeyu Wang, Jinze Li, Wei Wei, Yuchun Qiao, Haifeng Dong, Xueji Zhang
Summary: Rapid, simple, sensitive and reliable approaches for quantifying biogenic amines in food samples are essential for food safety. Here, the authors reported a Fe3O4@Au nanoparticles based multimodal readout LFIA for rapid quantification of putrescine and histamine. The assay showed high sensitivity and could be easily expanded to detect other biogenic amines.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biophysics
Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao
Summary: This study proposes an in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly (MLCHA) and photonic crystals (PCs). The MLCHA probes can penetrate exosomes nondestructively and generate amplified fluorescence signals upon recognition of the target miRNA. The fluorescence signal is further enhanced by PCs to improve sensitivity. The developed biosensor not only detects exosomal miRNA in a concentration-dependent manner but also distinguishes samples from cancer and healthy states, showing potential for non-invasive clinical diagnostics.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Mengyun Zhou, Yong Luo, Lirong Wang, Chuan Fan, Tailin Xu, Xueji Zhang
Summary: The outbreak of COVID-19 has posed a great challenge to global health systems. A rapid and sensitive POCT diagnostic platform for SARS-CoV-2 that can be deployed on-site is crucial in containing the epidemic. A portable microdroplet detection platform with temperature control and micro-stirring has been developed, enabling high-throughput and ultrafast COVID-19 diagnosis. The platform, utilizing a PN junction as the temperature controller and incorporating an ultrasonic micro-stirring unit, shows good linearity and low LOD, providing results in a short time. This integrated platform offers a promising tool for point-of-care diagnosis of COVID-19 in resource-limited settings.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Kun Yu, Mengjie Li, Huining Chai, Qian Liu, Xin Hai, Mingwei Tian, Lijun Qu, Tailin Xu, Guangyao Zhang, Xueji Zhang
Summary: This study presents a portable colorimetric and electrochemical dual-mode sensor based on MOF-818 nanozyme for the detection of cellular secreted H2O2 and H2S. The sensor enables accurate detection of H2O2 and H2S through colorimetric and electrochemical methods. By combining with a smartphone and miniature electrochemical analyzer, it allows for in situ detection of H2O2 and H2S released from live cells, showcasing potential applications in various fields.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Tingyi Yan, Guangyao Zhang, Kun Yu, Huining Chai, Mingwei Tian, Lijun Qu, Haifeng Dong, Xueji Zhang
Summary: Maintaining normal levels of vitamin C is crucial for a healthy immune system. The development of real-time non-invasive wearable sensors for monitoring vitamin C in sweat shows promise in personalized health management. In this study, a smartphone light-driven enzyme-free wearable photoelectrochemical sensor was presented for precise monitoring of sweat vitamin C.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Ying Liu, Xin Wang, Hanjun Chen, Tingting Wu, Yu Cao, Zhihong Liu
Summary: Chemodynamic therapy (CDT) is a promising strategy for cancer treatment, but its efficiency is limited by insufficient intracellular H2O2 level. This study presents a method to enhance CDT by silencing the CAT gene to accumulate H2O2 in tumor cells. Cu-siRNA nanocomposites are fabricated and modified with HA for active tumor targeting. Cu+ is generated by reduction of released Cu2+ by GSH, which then catalyzes H2O2 to produce toxic hydroxyl radicals to kill tumor cells. CAT siRNA efficiently inhibits H2O2 consumption, leading to H2O2 accumulation. Cu-siRNA@ HA exhibits good biocompatibility and therapeutic efficiency, offering a new way to supply H2O2 in CDT with potential for clinical application.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Yaodong Hu, Shuaibing Yu, Nan Ma, Jinming Kong, Xueji Zhang
Summary: In this study, a Rose Bengal-Mediated photoinduced atom transfer radical polymerization (photo-ATRP) method was used to achieve highly sensitive detection of target DNA (tDNA), which is of great significance in the field of early disease screening.
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.
