X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

(2014) Alexandra Grubman et al.   Metallomics

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

(2014) Alexandra Grubman et al.   Acta Neuropathologica Communications

Quantification of ZnO Nanoparticle Uptake, Distribution, and Dissolution within Individual Human Macrophages

(2013) Simon A. James et al.   ACS Nano

NCL disease mechanisms

(2013) David N. Palmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Assessment of trace elements in human brain using inductively coupled plasma mass spectrometry

(2013) Nikolaus Krebs et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Direct in vivo imaging of essential bioinorganics in Caenorhabditis elegans

(2013) Simon A. James et al.   Metallomics

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

(2013) Dominic J. Hare et al.   Metallomics

Contribution of calcium-conducting channels to the transport of zinc ions

(2013) Alexandre Bouron et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

(2013) Katja M. Kanninen et al.   PLoS One

Progressive Retinal Degeneration and Glial Activation in the CLN6nclf Mouse Model of Neuronal Ceroid Lipofuscinosis: A Beneficial Effect of DHA and Curcumin Supplementation

(2013) Myriam Mirza et al.   PLoS One

Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life

(2013) Wolfgang Maret   Advances in Nutrition

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

(2013) K. M. Kanninen et al.   Biology Open

Friedreich ataxia: metal dysmetabolism in dorsal root ganglia

(2013) Arnulf H Koeppen et al.   Acta Neuropathologica Communications

Tools to study distinct metal pools in biology

(2012) Elizabeth J. New   DALTON TRANSACTIONS

Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen

(2012) Jade B. Aitken et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

(2012) Katrijn Coen et al.   JOURNAL OF CELL BIOLOGY

Diagnostic Approach to Childhood-Onset Cerebellar Atrophy

(2012) Almundher Al-Maawali et al.   JOURNAL OF CHILD NEUROLOGY

Caenorhabditis elegans Maintains Highly Compartmentalized Cellular Distribution of Metals and Steep Concentration Gradients of Manganese

(2012) Gawain McColl et al.   PLoS One

Disruption of the Autophagy-Lysosome Pathway Is Involved in Neuropathology of the nclf Mouse Model of Neuronal Ceroid Lipofuscinosis

(2012) Melanie Thelen et al.   PLoS One

Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish

(2012) Guang Yan et al.   PLoS One

The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cells

(2012) Katherine A. Price et al.   Chemical Science

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis

(2011) Mark J. Hackett et al.   ANALYST

Effect of dietary iron deficiency and overload on the expression of ZIP metal-ion transporters in rat liver

(2011) Hyeyoung Nam et al.   BIOMETALS

Deficient mitochondrial Ca2+ buffering in the Cln8mnd mouse model of neuronal ceroid lipofuscinosis

(2011) Julia Kolikova et al.   CELL CALCIUM

TRPML: Transporters of metals in lysosomes essential for cell survival?

(2011) Kirill Kiselyov et al.   CELL CALCIUM

Elevated labile Cu is associated with oxidative pathology in Alzheimer disease

(2011) Simon A. James et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetically encoded ratiometric biosensors to measure intracellular exchangeable zinc in Escherichia coli

(2011) Da Wang et al.   JOURNAL OF BIOMEDICAL OPTICS

High expression of disease-related Cln6 in the cerebral cortex, purkinje cells, dentate gyrus, and hippocampal ca1 neurons

(2011) Melanie Thelen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Combined use of hard X-ray phase contrast imaging and X-ray fluorescence microscopy for sub-cellular metal quantification

(2011) Ewelina Kosior et al.   JOURNAL OF STRUCTURAL BIOLOGY

Distinct Early Molecular Responses to Mutations Causing vLINCL and JNCL Presage ATP Synthase Subunit C Accumulation in Cerebellar Cells

(2011) Yi Cao et al.   PLoS One

Measuring steady-state and dynamic endoplasmic reticulum and Golgi Zn2+ with genetically encoded sensors

(2011) Y. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel

(2010) Jonathan L. Eichelsdoerfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered microglial copper homeostasis in a mouse model of Alzheimer’s disease

(2010) Zhiqiang Zheng et al.   JOURNAL OF NEUROCHEMISTRY

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain

(2010) Dominic J. Hare et al.   Metallomics

Elemental mapping of frozen-hydrated cells with cryo-scanning X-ray fluorescence microscopy

(2010) S. Matsuyama et al.   X-RAY SPECTROMETRY

Manganese Accumulates within Golgi Apparatus in Dopaminergic Cells as Revealed by Synchrotron X-ray Fluorescence Nanoimaging

(2009) Asunción Carmona et al.   ACS Chemical Neuroscience

Mammalian Zinc Transporters: Nutritional and Physiologic Regulation

(2009) Louis A. Lichten et al.   Annual Review of Nutrition

Alterations of Zinc Transporter Proteins ZnT-1, ZnT-4 and ZnT-6 in Preclinical Alzheimer's Disease Brain

(2009) Ganna Lyubartseva et al.   BRAIN PATHOLOGY

Genetically Encoded Sensors to Elucidate Spatial Distribution of Cellular Zinc

(2009) Philip J. Dittmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elemental X-ray imaging using the Maia detector array: The benefits and challenges of large solid-angle

(2009) C.G. Ryan et al.   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation

(2009) C. Hogstrand et al.   TRENDS IN MOLECULAR MEDICINE

Insights into Zn2+ homeostasis in neurons from experimental and modeling studies

(2008) Robert A. Colvin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hepatocellular transport and gastrointestinal absorption of lanthanum in chronic renal failure

(2008) An R.J. Bervoets et al.   KIDNEY INTERNATIONAL

Zn2+binding to human calbindin D28kand the role of histidine residues

(2008) Mikael C. Bauer et al.   PROTEIN SCIENCE