Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Metallothioneins as dynamic markers for brain disease in lysosomal disorders

(2013) Martina Cesani et al.   ANNALS OF NEUROLOGY

Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup

(2013) C. Groth et al.   DEVELOPMENT

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

(2013) Patrick J. Schultheis et al.   HUMAN MOLECULAR GENETICS

High precision isotope measurements reveal poor control of copper metabolism in Parkinsonism

(2013) F. Larner et al.   Metallomics

Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis

(2013) Katja M. Kanninen et al.   PLoS One

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

(2013) K. M. Kanninen et al.   Biology Open

Mutations in SLC30A10 Cause Parkinsonism and Dystonia with Hypermanganesemia, Polycythemia, and Chronic Liver Disease

(2012) Marialuisa Quadri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Human ZIP4 Transporter Has Two Distinct Binding Affinities and Mediates Transport of Multiple Transition Metals

(2012) Sagar Antala et al.   BIOCHEMISTRY

Mutation of the parkinsonism gene ATP13A2 causes neuronal ceroid-lipofuscinosis

(2012) Jose Bras et al.   HUMAN MOLECULAR GENETICS

Picomolar Concentrations of Free Zinc(II) Ions Regulate Receptor Protein-tyrosine Phosphatase β Activity

(2012) Matthew Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading

(2012) Chia-Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hypoxia imaging agent Cu II (atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

(2012) Lin W. Hung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disruption of the Autophagy-Lysosome Pathway Is Involved in Neuropathology of the nclf Mouse Model of Neuronal Ceroid Lipofuscinosis

(2012) Melanie Thelen et al.   PLoS One

Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish

(2012) Guang Yan et al.   PLoS One

Inhibition of TDP-43 Accumulation by Bis(thiosemicarbazonato)-Copper Complexes

(2012) Sarah J. Parker et al.   PLoS One

Effects of a Copper-Deficient Diet on the Biochemistry, Neural Morphology and Behavior of Aged Mice

(2012) Silvia Bolognin et al.   PLoS One

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

(2012) B. Dehay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manganese exposure induces α-synuclein aggregation in the frontal cortex of non-human primates

(2012) Tatyana Verina et al.   TOXICOLOGY LETTERS

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Kufs Disease, the Major Adult Form of Neuronal Ceroid Lipofuscinosis, Caused by Mutations in CLN6

(2011) Todor Arsov et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron

(2011) Jorge J. Pinilla-Tenas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Effect of dietary iron deficiency and overload on the expression of ZIP metal-ion transporters in rat liver

(2011) Hyeyoung Nam et al.   BIOMETALS

TRPML: Transporters of metals in lysosomes essential for cell survival?

(2011) Kirill Kiselyov et al.   CELL CALCIUM

Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses

(2011) Maria Kousi et al.   HUMAN MUTATION

Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

(2011) Mark A. Greenough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

(2011) Cynthia P. W. Soon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel zinc bis(thiosemicarbazone) complex for live cell imaging

(2011) Disha Dayal et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan terriers

(2011) Fabiana H.G. Farias et al.   NEUROBIOLOGY OF DISEASE

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

(2011) Paul A. Adlard et al.   PLoS One

Measuring steady-state and dynamic endoplasmic reticulum and Golgi Zn2+ with genetically encoded sensors

(2011) Y. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

A One Base Pair Deletion in the Canine ATP13A2 Gene Causes Exon Skipping and Late-Onset Neuronal Ceroid Lipofuscinosis in the Tibetan Terrier

(2011) Anne Wöhlke et al.   PLoS Genetics

miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro

(2010) Hailan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

Brain α-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation

(2009) Junchao Tong et al.   BRAIN

Alterations of Zinc Transporter Proteins ZnT-1, ZnT-4 and ZnT-6 in Preclinical Alzheimer's Disease Brain

(2009) Ganna Lyubartseva et al.   BRAIN PATHOLOGY

Metal Ion Physiopathology in Neurodegenerative Disorders

(2009) Silvia Bolognin et al.   NEUROMOLECULAR MEDICINE

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into Zn2+ homeostasis in neurons from experimental and modeling studies

(2008) Robert A. Colvin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Developmental neurotoxicity testing in vitro: Models for assessing chemical effects on neurite outgrowth

(2008) Nicholas M. Radio et al.   NEUROTOXICOLOGY

Assessment of Chemical Effects on Neurite Outgrowth in PC12 cells Using High Content Screening

(2008) Nicholas M. Radio et al.   TOXICOLOGICAL SCIENCES

A new large animal model of CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G>>>A) leading to excision of exon 3

(2007) Tony Frugier et al.   NEUROBIOLOGY OF DISEASE