New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish

Attenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells

(2014) Antonios D. Konitsiotis et al.   PLoS One

A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization

(2013) Kristina Hofmann et al.   JOURNAL OF LIPID RESEARCH

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

Secretion and Signaling Activities of Lipoprotein-Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals

(2013) Wilhelm Palm et al.   PLOS BIOLOGY

Imaging the Sialome during Zebrafish Development with Copper-Free Click Chemistry

(2012) Karen W. Dehnert et al.   CHEMBIOCHEM

Hedgehog Secretion and Signal Transduction in Vertebrates

(2012) Kaitlyn E. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxysterols are allosteric activators of the oncoprotein Smoothened

(2012) Sigrid Nachtergaele et al.   Nature Chemical Biology

Dispatched and Scube Mediate the Efficient Secretion of the Cholesterol-Modified Hedgehog Ligand

(2012) Hanna Tukachinsky et al.   Cell Reports

Metabolic Labeling of Fucosylated Glycans in Developing Zebrafish

(2011) Karen W. Dehnert et al.   ACS Chemical Biology

Bioorthogonal chemical tagging of protein cholesterylation in living cells

(2011) William P. Heal et al.   CHEMICAL COMMUNICATIONS

Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes

(2011) Xinxin Gao et al.   FEBS LETTERS

Two Distinct Sites in Sonic Hedgehog Combine for Heparan Sulfate Interactions and Cell Signaling Functions

(2011) Shu-Chun Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

(2011) Xin Chen et al.   JOURNAL OF CELL BIOLOGY

Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics

(2011) Tamar Geiger et al.   Nature Protocols

Modulators of the hedgehog signaling pathway

(2010) Philipp Heretsch et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Visualizing enveloping layer glycans during zebrafish early embryogenesis

(2010) J. M. Baskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan Sulfate-modulated, Metalloprotease-mediated Sonic Hedgehog Release from Producing Cells

(2009) Tabea Dierker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust Fluorescent Detection of Protein Fatty-Acylation with Chemical Reporters

(2009) Guillaume Charron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Following the Hedgehog to New Cancer Therapies

(2009) Andrzej A. Dlugosz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Getting a chemical handle on proteinpost-translational modification

(2009) William P. Heal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

(2008) J. M. Bailey et al.   CLINICAL CANCER RESEARCH

Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog

(2008) John A. Buglino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

(2008) S. T. Laughlin et al.   SCIENCE

The Hedgehog protein family

(2008) Thomas R Bürglin   GENOME BIOLOGY