Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-β

Plasma Carbonic Anhydrase II protein is Elevated in Alzheimer's Disease

(2017) Bong Geom Jang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer’s Disease

(2014) Masha G. Savelieff et al.   ACCOUNTS OF CHEMICAL RESEARCH

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Natural Compounds against Alzheimer’s Disease: Molecular Recognition of Aβ1-42 Peptide bySalvia sclareoidesExtract and its Major Component, Rosmarinic Acid, as Investigated by NMR

(2013) Cristina Airoldi et al.   Chemistry-An Asian Journal

Metal Binding of Flavonoids and Their Distinct Inhibition Mechanisms Toward the Oxidation Activity of Cu2+–β-Amyloid: Not Just Serving as Suicide Antioxidants!

(2013) William Maung Tay et al.   INORGANIC CHEMISTRY

Tuning Reactivity of Diphenylpropynone Derivatives with Metal-Associated Amyloid-β Species via Structural Modifications

(2013) Yuzhong Liu et al.   INORGANIC CHEMISTRY

Ligand-Field and Ligand-Binding Analysis of the Active Site of Copper-Bound Aβ Associated with Alzheimer’s Disease

(2013) Chandradeep Ghosh et al.   INORGANIC CHEMISTRY

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

(2013) Fernando L. Palhano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid-β–neuropeptide interactions assessed by ion mobility-mass spectrometry

(2013) Molly T. Soper et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-  species

(2013) S.-J. Hyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

(2012) Sharmistha Sinha et al.   ACS Chemical Neuroscience

2012 Alzheimer’s disease facts and figures

(2012)   Alzheimers & Dementia

Copper and Oxidative Stress in the Pathogenesis of Alzheimer’s Disease

(2012) Gözde Eskici et al.   BIOCHEMISTRY

Morin Inhibits the Early Stages of Amyloid β-Peptide Aggregation by Altering Tertiary and Quaternary Interactions to Produce “Off-Pathway” Structures

(2012) Justin A. Lemkul et al.   BIOCHEMISTRY

Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils

(2012) Mie Hirohata et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins

(2012) Gianfranco Balboni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target

(2012) Peter Faller et al.   CHEMISTRY-A EUROPEAN JOURNAL

The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

(2012) Cristina Rodríguez-Rodríguez et al.   COORDINATION CHEMISTRY REVIEWS

Metal-associated amyloid-β species in Alzheimer's disease

(2012) Amit S Pithadia et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species

(2012) Xiaoming He et al.   DALTON TRANSACTIONS

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactivity of Diphenylpropynone Derivatives Toward Metal-Associated Amyloid-β Species

(2012) Amit S. Pithadia et al.   INORGANIC CHEMISTRY

Site Specific Interaction of the Polyphenol EGCG with the SEVI Amyloid Precursor Peptide PAP(248–286)

(2012) Nataliya Popovych et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dual-function triazole–pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation

(2012) Michael R. Jones et al.   Metallomics

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context

(2012) Richard J. Wall et al.   TOXICOLOGY

A partially folded structure of amyloid-beta(1–40) in an aqueous environment

(2011) Subramanian Vivekanandan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myricetin: A Naturally Occurring Regulator of Metal-Induced Amyloid-β Aggregation and Neurotoxicity

(2011) Alaina S. DeToma et al.   CHEMBIOCHEM

Misfolded proteins in Alzheimer's disease and type II diabetes

(2011) Alaina S. DeToma et al.   CHEMICAL SOCIETY REVIEWS

Visible-Near-Infrared and Fluorescent Copper Sensors Based on Julolidine Conjugates: Selective Detection and Fluorescence Imaging in Living Cells

(2011) Debabrata Maity et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper in Alzheimer disease: too much, too little, or misplaced?

(2011) Peter Faller   FREE RADICAL BIOLOGY AND MEDICINE

Development of Bifunctional Stilbene Derivatives for Targeting and Modulating Metal-Amyloid-β Species

(2011) Joseph J. Braymer et al.   INORGANIC CHEMISTRY

Tale of a Twist: Magnetic and Optical Switching in Copper(II) Semiquinone Complexes

(2011) Pratik Verma et al.   INORGANIC CHEMISTRY

Iron(II) Binding to Amyloid-β, the Alzheimer’s Peptide

(2011) Fatima Bousejra-ElGarah et al.   INORGANIC CHEMISTRY

Redox-Rich Spin–Spin-Coupled Semiquinoneruthenium Dimers with Intense Near-IR Absorption

(2011) Tanaya Kundu et al.   INORGANIC CHEMISTRY

Characterization of pyridinylimine and pyridinylmethylamine derivatives and their corresponding metal complexes

(2011) Joseph J. Braymer et al.   INORGANICA CHIMICA ACTA

Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-β aggregation

(2011) Jung-Suk Choi et al.   Metallomics

Diphenylpropynone derivatives as probes for imaging β-amyloid plaques in Alzheimer’s brains

(2010) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Two Functions, One Molecule: A Metal-Binding and a Targeting Moiety to Combat Alzheimer's Disease

(2010) Christelle Hureau  et al.   CHEMBIOCHEM

Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers

(2010) Jason Shearer et al.   CHEMICAL COMMUNICATIONS

Is there a redox reaction between Cu(II) and gallic acid?

(2010) Joyce Ferreira Severino et al.   FREE RADICAL RESEARCH

Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substoichiometric Levels of Cu2+Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

(2010) Claire J. Sarell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thermodynamic Analysis of the Molecular Interactions between Amyloid β-Peptide 42 and (−)-Epigallocatechin-3-gallate

(2010) Shi-Hui Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

18F-labeled flavones for in vivo imaging of β-amyloid plaques in Alzheimer’s brains

(2009) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Copper and Zinc Binding to Amyloid-β: Coordination, Dynamics, Aggregation, Reactivity and Metal-Ion Transfer

(2009) Peter Faller   CHEMBIOCHEM

The chemistry of Alzheimer’s disease

(2009) Arvi Rauk   CHEMICAL SOCIETY REVIEWS

Effects of Clioquinol on Metal-Triggered Amyloid-β Aggregation Revisited

(2009) Allana M. Mancino et al.   INORGANIC CHEMISTRY

Naturally occurring phytochemicals for the prevention of Alzheimer’s disease

(2009) Jiyoung Kim et al.   JOURNAL OF NEUROCHEMISTRY

Design, Selection, and Characterization of Thioflavin-Based Intercalation Compounds with Metal Chelating Properties for Application in Alzheimer’s Disease

(2009) Cristina Rodríguez-Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small Molecule Modulators of Copper-Induced Aβ Aggregation

(2009) Sarmad S. Hindo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of novel β-amyloid probes based on 3,5-diphenyl-1,2,4-oxadiazole

(2008) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

Sequestration of Copper from β-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents

(2008) Wei-hui Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amyloid-β Peptide of Alzheimer’s Disease Binds CuIin a Linear Bis-His Coordination Environment: Insight into a Possible Neuroprotective Mechanism for the Amyloid-β Peptide

(2008) Jason Shearer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zinc-Amyloid β Interactions on a Millisecond Time-Scale Stabilize Non-fibrillar Alzheimer-Related Species

(2008) Dror Noy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thioflavin Derivatives as Markers for Amyloid-β Fibrils: Insights into Structural Features Important for High-Affinity Binding

(2007) Rodrigue Leuma Yona et al.   ChemMedChem