期刊
CHEMICAL COMMUNICATIONS
卷 46, 期 48, 页码 9137-9139出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02446e
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资金
- National Institutes of Health [P20 RR-016464]
- Alzheimers Association [IIRG-07-5821]
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016464] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P30EB009998] Funding Source: NIH RePORTER
The fatal neurological disorder Alzheimer's disease has been linked to soluble neurotoxic oligomers of amyloid-beta (A beta) peptides. Herein we demonstrate that Cu(1+) ligated within A beta(42) oligomers (Ab sequence: DAEFRHDSGYEVHHQKLVFFAE DVGSNKGAIIGLMVGGVVIA) possesses a highly dioxygen sensitive tetrahedral coordination geometry. The biological implications of these findings are discussed.
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