Article
Polymer Science
Felix Reisbeck, Alexander Ozimkovski, Mariam Cherri, Mathias Dimde, Elisa Quaas, Ehsan Mohammadifar, Katharina Achazi, Rainer Haag
Summary: A dual-responsive drug delivery system was synthesized in this study, which exhibited enhanced drug release under different stimuli and efficient inhibition of cancer cell growth. The system showed good biocompatibility and tolerability while achieving targeted drug release and cytotoxic effects on cancer cells.
Article
Biochemistry & Molecular Biology
Ender Sarigul, Merve Zaim, Mehmet Senel, Tugba Sagir, Sevim Isik
Summary: A novel drug carrier was designed with an interior for drug encapsulation and a biocompatible surface, showing inhibitory effects on the proliferation of gastric adenocarcinoma cells.
Article
Pharmacology & Pharmacy
Jocelyn Fernanda Romero, Svenja Herziger, Mariam Cherri, Mathias Dimde, Katharina Achazi, Ehsan Mohammadifar, Rainer Haag
Summary: This study compares the differences between polymeric and monomeric amphiphilic systems with similar hydrophilic-lipophilic balance in terms of biocompatibility, aggregation behavior, and solubilization potential of hydrophobic compounds. The results show that the polymeric system has higher cell viability and drug loading capacity compared to the monomeric system.
Article
Polymer Science
Eman H. Ahmed, Ahmed E. Abdelhamid, M. E. Vylegzhanina, A. Ya. Volkov, T. E. Sukhanova, Magdy M. H. Ayoub
Summary: Hyperbranched polyamidoamines (PAMAM) have been widely investigated for therapeutic applications, but their cytotoxicity caused by their cationic charges has limited their use. Zwitterionic chitosan (ZWCs) can cover the surface of PAMAM and reduce cytotoxicity. The encapsulation of 5-Fluorouracil by the complex formed from PAMAM and ZWCs has been successfully established for high efficiency drug delivery.
Review
Biochemistry & Molecular Biology
Zhiguo Li, Xuexun Fang, Dahai Yu
Summary: Transdermal drug delivery (TDD) has emerged as an effective alternative to traditional oral and injection administration, with potential for enhanced anti-obesity drug delivery. Obesity is a global epidemic with significant health threats, requiring more effective drug delivery strategies. Despite most studies being in the animal stage, the application of TDD in anti-obesity drugs could bring safe and effective therapies to obese patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Mahsa Shahriari, Prashant Kesharwani, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Cancer is a widespread disease with various treatment modalities and challenges. Chemotherapy has limitations due to toxicity and drug resistance. Curcumin, a natural compound with multiple therapeutic properties, has poor solubility and limited bioavailability. Cyclodextrin complexes of curcumin improve its properties, and beta-cyclodextrin is commonly used. This review focuses on comparing different curcumin-cyclodextrin formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Eleftherios Halevas, Barbara Mavroidi, Chrysoula Kokotidou, Anna Mitraki, Maria Pelecanou, Marina Sagnou
Summary: A dendritic-linear-dendritic hybrid copolymer was employed to encapsulate artemisinin, enhancing its solubility and maintaining its anticancer activity in two cancer cell lines. The novel nano-formulations demonstrate potential as carriers and bioavailability enhancers for hydrophobic natural products.
JOURNAL OF NANOPARTICLE RESEARCH
(2021)
Review
Oncology
Zile Fu, Xiaoming Zhang, Yanfeng Gao, Jia Fan, Qiang Gao
Summary: This article discusses the crucial role of the immune system in cancer initiation, evolution, invasion, and metastasis. Therapeutics targeting the modulation or boosting of anticancer immune responses have advanced significantly, with the identification of both conventional and emerging drugs that can enhance anticancer immunity. Additionally, advancements in drug delivery systems allow for novel therapeutic strategies and new modes of action in tumor immunology.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Polymer Science
Sylwia Ronka, Aleksandra Kowalczyk, Dagmara Baczynska, Anna K. K. Zolnierczyk
Summary: This research focuses on the preparation of polymeric nanocarriers containing flavonoid-naringenin, xanthohumol, or isoxanthohumol based on Pluronics using the thin-film formation method. The study evaluates the size and stability of the formed micelles using Dynamic light scattering (DLS) analysis and demonstrates that the proposed systems effectively distribute the drug into tumor tissues, making them ideal candidates for passive targeting of cancer cells. The in vitro cytotoxicity of the flavonoids in the Pluronic formulations is investigated, and mixed polymeric micelles are designed as successful drug delivery systems.
Review
Pharmacology & Pharmacy
Mounir M. Salem-Bekhit, Abdullah M. E. Youssof, Fars K. Alanazi, Fadilah Sfouq Aleanizy, Alsuwyeh Abdulaziz, Ehab I. Taha, Amro Abd Al Fattah Amara
Summary: Bacterial ghosts, as empty cell envelopes of nonliving bacterial cells, have been tested as an advanced drug delivery system for various materials. They have diverse applications, including in vaccine and tumor therapy. The safety and stability aspects of using ghost bacteria as delivery systems are important considerations for further development.
Review
Pharmacology & Pharmacy
Kyeong Jin Cho, Young-Eun Cho, Jihoon Kim
Summary: The lymphatic system is a crucial target in controlling cancer progression and adaptive immune response. Nano-sized materials have shown advantages in delivering drugs to lymph nodes and overcoming barriers associated with lymphatic physiology. Sustained drug delivery systems have the potential to improve the therapeutic index of immune modulating agents.
Review
Chemistry, Inorganic & Nuclear
Yi Gou, GuoJin Huang, Jinlong Li, Feng Yang, Hong Liang
Summary: This review discusses the research progress in designing and synthesizing non-platinum metal coordination compounds, as well as the delivery methods using nanocarriers. Various types of nanocarriers, such as carbon-based, amphiphilic copolymer-based, polysaccharide-based, protein- or peptide-based nanocarriers, have been widely used for delivering compounds based on ruthenium, copper, gold, iridium, palladium, and zinc.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Nanoscience & Nanotechnology
Jiaxin Zhao, Yan Zhou, Yanyan Wang, Qin Liang, Xuenan Ma, Xiaoteng Jia, Danming Chao
Summary: This study successfully prepared a conductive crosslinked viologen hydrogel using an electroactive hyperbranched polyamidoamine as the crosslinking center. The hydrogel exhibited improved mechanical properties, desirable stretchability, high ionic conductivity, biocompatibility, antibacterial properties, and wearable strain-sensing performance. It also demonstrated high efficiency in drug release at a lower voltage and pH-stimulus drug release behavior in acidic and alkalescent environments. This work provides a new design strategy for conductive hydrogels in multiple stimulus-responsive drug delivery systems.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Pharmacology & Pharmacy
Lu Tang, Jing Li, Qingqing Zhao, Ting Pan, Hui Zhong, Wei Wang
Summary: Nanotechnology plays a crucial role in cancer treatment, improving drug delivery efficiency and pharmacokinetics. Small molecule drugs and biological macromolecule drugs are the main types of anticancer agents, with nano-encapsulation technology playing a key role in their delivery.
Article
Pharmacology & Pharmacy
Zahra Sobhani, Reza Khalifeh, Mina Banizamani, Maryam Rajabzadeh
Summary: This paper reports a pH-responsive nanocarrier ZnO QD-PG-FA for the delivery of the anticancer drug doxorubicin. The carrier exhibits excellent drug release performance and antitumor activity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Sarvenaz Karimi Haghighi, Ali Nemati Kharat
Summary: TS-1 with a micro/mesoporous hierarchical framework and regular pores diameter of 3-5 nm was efficiently produced by using TES as a silica source under hydrothermal conditions. The cost of production was reduced by decreasing the TPAOH/SiO2 molar ratio and using cheaper TES instead of TEOS, resulting in enhanced catalytic activity in propylene epoxidation reactions with hydrogen peroxide in methanol.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Polymer Science
Mehrnaz Aliahmadi, Ali Nemati Kharat
Summary: In this study, complexes of Zinc(II), Cadmium(II), and Mercury(II) with Xantphos were synthesized and characterized by X-ray crystallography. The thermal decomposition of the complexes led to the formation of corresponding metal oxide nanoparticles, which were characterized by various techniques including XRD, SEM, and IR spectroscopy.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Zeinab Souri, Mohsen Adeli, Ebrahim Mehdipour, Abdolah Yari, Azim Shams, Siamak Beyranvand, Shabnam Sattari
Summary: Metal nanoparticles are decorated on MoS2 sheets through a RAFT reaction, forming MoS2-AgNPs hybrids for electrochemical determination. This straightforward method allows for adjustment of MoS2-AgNPs distance, enabling the construction of hybrid systems with unique properties.
Article
Chemistry, Multidisciplinary
Ievgen S. Donskyi, Chuanxiong Nie, Kai Ludwig, Jakob Trimpert, Rameez Ahmed, Elisa Quaas, Katharina Achazi, Joerg Radnik, Mohsen Adeli, Rainer Haag, Klaus Osterrieder
Summary: The study shows that graphene derivatives with long alkyl chains can effectively inhibit coronavirus replication by disrupting the viral envelope, and within a specific concentration range, these graphene platforms exhibit strong antiviral activity against the virus while showing low toxicity to human cells.
Review
Chemistry, Multidisciplinary
Ehsan Nazarzadeh Zare, Xuanqi Zheng, Pooyan Makvandi, Homa Gheybi, Rossella Sartorius, Cynthia K. Y. Yiu, Mohsen Adeli, Aimin Wu, Ali Zarrabi, Rajender S. Varma, Franklin R. Tay
Summary: Metal-based nanoentities are widely used in industrial and biomedical fields, with their biological impacts influenced by factors such as size, shape, and composition. The size and shape of metallic nanostructures affect cell viability, while nonspherical metal-based nanoarchitectures have anisotropic properties that make them exciting candidates for biomedical applications.
Article
Chemistry, Multidisciplinary
Ehsan Mohammadifar, Vahid Ahmadi, Mohammad Fardin Gholami, Alexander Oehrl, Oleksandr Kolyvushko, Chuanxiong Nie, Ievgen S. Donskyi, Svenja Herziger, Joerg Radnik, Kai Ludwig, Christoph Boettcher, Jurgen P. Rabe, Klaus Osterrieder, Walid Azab, Rainer Haag, Mohsen Adeli
Summary: In this study, biocompatible polyglycerol units are crosslinked in two dimensions using a graphene-assisted strategy to produce highly functional and water-soluble polyglycerol nanosheets. Compared to their 3D counterparts, these 2D polyglycerols exhibit stronger virus inhibition, suggesting their superiority in biomedicine and bioengineering applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Ali Nemati Kharat, Alireza Mohammadrezaee, Mehrnaz Aliahmadi
Summary: Oxygenated compounds affect the acidic functional groups of the catalyst, while mercaptans have a significant impact on the metallic sites of the catalyst. Deactivation with methanol leads to irreversible loss of catalyst activity, while deactivation with dimethyl disulfide allows for full recovery of the catalyst.
REACTION KINETICS MECHANISMS AND CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Sumati Bhatia, Ievgen S. Donskyi, Stephan Block, Chuanxiong Nie, Angelique Burdinski, Daniel Lauster, Joerg Radnik, Andreas Herrmann, Rainer Haag, Kai Ludwig, Mohsen Adeli
Summary: The study demonstrated that optimal deployment of sialic acid targeting ligands on a flexible 2D platform allows for binding and wrapping of influenza A virus (IAV) particles. Different degrees of sialic acid functionalized 2D platforms were compared for their binding potential, with higher levels of functionalization showing increased binding potential for IAV.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Zeinab Zohreband, Mohsen Adeli, Abedin Zebardasti
Summary: The specific interactions between MoS2 and gelatin matrix resulted in a biomimetic hydrogel with self-healing and molecular recognition properties, showing promise for future biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Inorganic & Nuclear
Sara Dindar, Ali Nemati Kharat, Alireza Abbasi
Summary: A green and convenient catalytic N-methylation of aniline and n-hexylamine using methanol as a dual methylation agent and solvent was investigated, with a new ruthenium carbonyl complex as the homogeneous catalyst. The complex's solid-state structure was determined by X-ray crystallographic analysis, showing excellent conversion and selectivity towards N-methylaniline and N,N-hexyldimethylamine at 140 degrees C.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Obida Bawadkji, Mariam Cherri, Andreas Schaefer, Svenja Herziger, Philip Nickl, Katharina Achazi, Ievgen S. Donskyi, Mohsen Adeli, Rainer Haag
Summary: This work describes a one-pot approach for covalent functionalization of few-layer black phosphorus via anionic ring opening polymerization of glycidol to obtain multifunctional BP-polyglycerol with high amphiphilicity, suitable for near-infrared-responsive drug delivery and biocompatibility. The functionalized BP-PG shows promise for a broad range of biomedical applications.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yuting Deng, Yang Gao, Tiantian Li, Sutong Xiao, Mohsen Adeli, Raul D. Rodriguez, Wei Geng, Qiu Chen, Chong Cheng, Changsheng Zhao
Summary: This study develops a cobalt selenide-based biocatalyst with an amorphous Ru@CoSe nanolayer for ultrafast and broadspectrum catalytic ROS-elimination. The biocatalyst shows excellent catalase-like kinetics and can efficiently rescue the proliferation of mesenchymal stem cells in an oxidative stress environment. The study offers an effective nanomedicine for catalytic ROS-scavenging and ultrafast healing of inflammatory wounds, and provides a strategy to design biocatalytic metal compounds.
Article
Construction & Building Technology
Ahmad Soleimani, Mohsen Mahdavi Adeli, Farshad Zamani, Hamid Haghshenas Gorgani
Summary: This research investigates a rotary disk with variable cross-section and incompressible hyperelastic material with functionally graded properties in large hyperelastic deformations. The changes in cross-section and material properties are expressed using a power relation, with (m) representing the changes in cross-section and (n) representing the manner of changes in material properties. The constants used for hyperelastic material have been obtained from experimental data. The obtained equations have been solved for different m, n, and angular velocity values, and the values of radial stresses, tangential stresses, and elongation have been compared. The results show that m and n have a significant impact on disk behavior, and the expected behavior of the disk can be obtained by an optimal selection of these two parameters.
STEEL AND COMPOSITE STRUCTURES
(2022)
Article
Chemistry, Multidisciplinary
Nasim Khosravani, Vahid Ahmadi, Ali Kakanejadifard, Mohsen Adeli
Summary: This study synthesized a thermosensitive two-dimensional polymeric network that can efficiently load antibiotics and has good antibacterial activity and drug delivery performance.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)