Article
Biochemistry & Molecular Biology
Qun Liu, Bo Li, Yan Li, Xiaodeng Yang, Congde Qiao, Wei Hu, Mingxia Liu
Summary: pH-sensitive and amphiphilic chitosan derivatives were synthesized and studied for their rheological properties, showing that high degree of substitution and pH near the isoelectric points corresponded to low viscosity and viscoelasticity. Strong networks formed at high concentrations, and the role of Ca2+ varied depending on concentration levels. Molecular dynamics simulations were also used to examine intermolecular hydrogen bonds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Zhi Zhao, Jinyu Han, Shangen Xu, Zheng Jin, Tan Hui Yin, Kai Zhao
Summary: This report presents the encapsulation of amoxicillin in N-2-Hydroxypropyl trimethyl ammonium chloride chitosan and N,O-carboxymethyl chitosan nanoparticles for biomedical applications. The synthesized nanoparticles demonstrated sustained drug release, good cytocompatibility and broad-spectrum antimicrobial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Paper & Wood
Lujie Wang, Xiaodong Wen, Xujun Zhang, Shuntao Yuan, Qingbo Xu, Feiya Fu, Hongyan Diao, Xiangdong Liu
Summary: In this study, antibacterial cotton fabric was prepared using CMC and CPTC as raw materials, showing excellent laundering durability and bacteriostatic reduction rate. The modified cotton fabrics demonstrated safety and comfort in terms of cytotoxicity, vapor transmissibility, tensile strength, water absorption, and flexibility, maintaining good antibacterial efficacy even after repeated washing cycles.
Article
Chemistry, Applied
Ao Zheng, Xiao Wang, Jie Wang, Xianzhen Xin, Yuanman Yu, Yang Liu, Jing Wang, Kaige Lv, Lingyan Cao
Summary: This study explored the synergistic effect of sulfonated chitosan and BMP-2, with results showing that 26SCS can affect the structure of BMP-2 protein and enhance its biological activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Adriana Trapani, Stefania Cometa, Elvira De Giglio, Filomena Corbo, Roberta Cassano, Maria Luisa Di Gioia, Sonia Trombino, Md Niamat Hossain, Sante Di Gioia, Giuseppe Trapani, Massimo Conese
Summary: A widely investigated approach to bypass the blood brain barrier is represented by the intranasal delivery of therapeutic agents exploiting the olfactory or trigeminal connections nose-brain. As for Parkinson's disease (PD), characterized by dopaminergic midbrain neurons degeneration, currently there is no disease modifying therapy. Although several bio-nanomaterials have been evaluated for encapsulation of neurotransmitter dopamine (DA) or dopaminergic drugs in order to restore the DA content in parkinsonian patients, the premature leakage of the therapeutic agent limits this approach. To tackle this drawback, we undertook a study where the active was linked to the polymeric backbone by a covalent bond. Thus, novel nanoparticles (NPs) based on N,O-Carboxymethylchitosan-DA amide conjugate (N,O-CMCS-DA) were prepared by the nanoprecipitation method and characterized from a technological view point, cytotoxicity and uptake by Olfactory Ensheating Cells (OECs). Thermogravimetric analysis showed high chemical stability of N,O-CMCS-DA NPs and X-ray photoelectron spectroscopy evidenced the presence of amide linkages on the NPs surface. MTT test indicated their cytocompatibility with OECs, while cytofluorimetry and fluorescent microscopy revealed the internalization of labelled N,O-CMCS-DA NPs by OECs, that was increased by the presence of mucin. Altogether, these findings seem promising for further development of N,O-CMCS-DA NPs for nose-to-brain delivery application in PD.
Article
Biochemistry & Molecular Biology
Emad Naseri, Christopher Cartmell, Matthew Saab, Russell G. Kerr, Ali Ahmadi
Summary: This study investigated a novel hybrid biomaterial ink consisting of starch and N,O-carboxymethyl chitosan (NOCC), used for fabricating controlled release biodegradable wound dressing scaffolds via a low-temperature solvent-free 3D printing technique. By altering the ratio of NOCC to starch in the biomaterial ink, drug release and inhibition zone size can be controlled. Increasing NOCC accelerated drug release and led to larger zones of inhibition, attributed to enhanced hydrophilicity of NOCC-dominated scaffolds.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Food Science & Technology
Ngoc Nguyen, Trieu Nguyen, Phu Le Hong, Thi Kieu Hanh Ta, Bach Thang Phan, Hanh Nguyen Thi Ngoc, Hang Phung Thi Bich, Nhi Dinh Yen, Toi Vo Van, Hiep Thi Nguyen, Diep Tran Thi Ngoc
Summary: This study investigated the efficacy of preserving Ngoc Linh ginseng using coatings of chitosan derivatives and polyvinyl alcohol (PVA) solutions. The findings showed that the coated ginseng samples performed better in terms of preservation compared to the non-coated samples, with the NOCC-PVA solution exhibiting a better effect than the COS-PVA solution.
Article
Biochemistry & Molecular Biology
Ashiq Hussain Pandit, Safiya Nisar, Khalid Imtiyaz, Masood Nadeem, Nasreen Mazumdar, M. Moshahid Alam Rizvi, Sharif Ahmad
Summary: The synthesized N,O-CMCS/MAGG hydrogel showed promising applications in localized delivery of anticancer drugs. The hydrogel exhibited pH-responsive swelling behavior, good mechanical properties, excellent self-healing and thixotropic properties due to the reversible Schiff base linkages. The Dox-loaded hydrogel demonstrated significant killing effect against breast cancer cells, indicating its potential in anticancer drug delivery.
Article
Biochemistry & Molecular Biology
Katarzyna Lewandowska, Marta Szulc
Summary: The study characterized mixtures based on carboxymethyl chitosan (CMCh) and poly(N-vinylpyrrolidone) (PVP) using various analytical techniques. The results showed that CMCh/PVP mixtures had higher apparent viscosity and good miscibility in aqueous solution.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Li Xu, Zhanying Ren, Guolin Li, Danni Xu, Jiaqian Miao, Jingxuan Ju, Xuan Mo, Xianghui Wang, Hongping Deng, Min Xu
Summary: A liver-targeting gadolinium-based MRI contrast agent was developed using galactose functionalized o-carboxymethyl chitosan, which exhibited higher hepatocyte uptake, excellent biocompatibility, and better T1-weighted signal enhancement in the liver. The agent showed good safety in vivo at a specific dose.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan Gao, Xiaochen Gong, Shuang Yu, Zheng Jin, Qicheng Ruan, Chunjing Zhang, Kai Zhao
Summary: The study found that N-2-Hydroxypropyl trimethyl ammonium chloride chitosan/N, O-carboxymethyl chitosan nanoparticles (N-2-HACC/CMCS NPs) showed good immunogenicity and no toxicity as a universal vaccine adjuvant/delivery system. The prepared N-2-HACC/OVA/CMCS NPs induced higher levels of antibodies and immune responses in mice, suggesting their potential in enhancing humoral, cellular, and mucosal immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mahalakshmi Pandian, Vignesh Selvaprithviraj, Aathira Pradeep, Jayakumar Rangasamy
Summary: The developed N,O-CMC/AgNps hydrogel is adhesive, injectable, conductive, bio-compatible, and exhibits antibacterial and self-healing properties, making it suitable for the treatment of infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Min Yuan, Zeping Wang, Yifan Rao, Ying Wang, Bo Gao, Jiabing Yu, Hui Li, Xianping Chen
Summary: This paper reports an efficient, green, and low-cost method to produce O/N/S co-doped hierarchically porous graphene using laser direct writing on wood. The resulting materials have a three-dimensional framework, large specific surface area, and rich heteroatoms doping, leading to excellent electrochemical performance for microsupercapacitors.
Article
Biochemistry & Molecular Biology
Ali A. Altam, Liping Zhu, Weijie Wang, Hajo Yagoub, Shuguang Yang
Summary: Carboxymethyl cellulose and chitosan complex beads have various potential applications, but their poor mechanical properties hinder their use. This study found that thermal treatment during bead preparation can enhance the stability, pressure resistance, and swelling capability of the beads.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Yuzhen Ma, Kun Gao, Huahua Yu, Weixiang Liu, Yukun Qin, Ronge Xing, Song Liu, Pengcheng Li
Summary: Damage to the cell membrane induced by O-CSLn-Cu treatment resulted in significant morphological and physiological changes in plant fungal pathogens. This included downregulation of membrane fatty acids, enzymes, and proteins, as well as increased membrane permeability.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Yutao Hao, Jing Wen, Xiaobo Gao, Ding Nan, Juan Pan, Yuhan Yang, Baodong Chen, Zhong Lin Wang
Summary: This study presents a flexible self-rebound cambered triboelectric nanogenerator for self-powered sensing in equestrian sports. The nanogenerator has superior resiliency and stability, and can provide fast response time and real-time statistics data.
Article
Polymer Science
Lamis Ahmed Aboelmagd, Emad Tolba, Zeinab Ahmed AbdelAziz
Summary: Functional cotton fabrics with silver-based nanoparticles (AgNPs) have been developed using chitosan and chitosan-organosilica solutions as adhesives. The cotton fabrics treated with chitosan-organosilica/AgNPs solution showed good stability against washing and maintained high antimicrobial activity even after multiple laundering cycles.
Article
Biochemistry & Molecular Biology
Heinz C. Schroeder, Xiaohong Wang, Meik Neufurth, Shunfeng Wang, Rongwei Tan, Werner E. G. Mueller
Summary: Two biocatalytically produced inorganic biomaterials, bio-silica and bio-polyphosphate (bio-polyP), have shown great potential in regenerative medicine and other medical applications. Bio-silica is synthesized by a group of enzymes called silicateins, which form amorphous hydrated silica from monomeric precursors. Bio-polyP has morphogenetic activity and can induce cell differentiation, as well as provide metabolic energy through enzymatic cleavage of its high-energy phosphoanhydride bonds. Silicatein and alkaline phosphatase are key enzymes involved in the metabolism and biological activity of these materials.
Article
Materials Science, Multidisciplinary
Werner E. G. Mueller, Hadrian Schepler, Meik Neufurth, Shunfeng Wang, Veronica Ferrucci, Massimo Zollo, Rongwei Tan, Heinz C. Schroeder, Xiaohong Wang
Summary: The polyP hydrogel formulation can accelerate the healing of chronic wounds and provide more metabolic energy by encapsulating and killing bacteria.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Polymer Science
Wenjie Wu, Zhong Lin Wang, Liqun Zhang
Summary: Dielectric elastomers (DEs) are special materials that deform in response to an electric field. The current main mechanism suggests that the deformations in DEs are induced by Maxwell stress. However, a new molecular mechanism based on entropy-dominated elasticity has been proposed recently, highlighting its importance in the process.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mousa AlTarabeen, Qosay Al-Balas, Amgad Albohy, Werner Ernst Georg Mueller, Peter Proksch
Summary: Manzamines are a group of compounds extracted from Acanthostrongylophora ingens species. We have identified and characterized seven compounds. Based on previous screening work by Mayer et al., who suggested that manzamine A could be an inhibitor of RSK1 kinase, our work focused on targeting the RSK1 N-terminal kinase domain. Docking using Autodock Vina software showed that Manzamine A N-oxide (5) exhibited the highest activity with an IC50 value of 3.1 μM.
Article
Pharmacology & Pharmacy
Shunfeng Wang, Meik Neufurth, Hadrian Schepler, Rongwei Tan, Zhending She, Bilal Al-Nawas, Xiaohong Wang, Heinz C. Schroeder, Werner E. G. Mueller
Summary: Amorphous calcium carbonate (ACC) precipitated in the presence of inorganic polyphosphate (polyP) has shown potential as a material for bone regeneration. ACC center dot PP particles, stabilized by polyP, have enzymatic activity that promotes the transformation of ACC into crystalline polymorphs. In experiments conducted in vitro and in vivo, ACC center dot PP was found to stimulate cell migration and accelerate wound healing, particularly in chronic wounds.
Article
Polymer Science
Ahmed Salama, Safaa Saleh, Ragab E. Abou-Zeid, Engy M. Akl, Emad Tolba
Summary: Biocompatible polymers are used to manufacture surgical implants that can degrade in the body without requiring additional removal surgery. In this study, flaxseed mucilage was used to prepare composite scaffolds made of calcium phosphate embedded in the mucilage matrix. The scaffolds were characterized and found to consist of mucilage/dicalcium phosphate dihydrate and mucilage/hydroxyapatite phases. Cell viability tests showed that the hybrids formed at different pH conditions were non-cytotoxic, indicating the potential of the developed composite as a bone graft substitute material.
Article
Chemistry, Analytical
Xue Wang, Zhiping Feng, Gaoqiang Zhang, Luna Wang, Liang Chen, Jin Yang, Zhonglin Wang
Summary: Recent advances in flexible pressure sensors have made them promising technologies for human epidermal pulse wave monitoring. A 3 x 1 flexible pressure sensor array was developed using three single-electrode sensors with small area to measure pulse waves at different local positions of the radial artery. The designed single sensor has a small area of 6 x 6 mm² and demonstrates high pressure sensitivity, fast response time, wide frequency range, and stability.
Article
Computer Science, Information Systems
Jiabin Zhang, Erming Su, Chengyu Li, Shuxing Xu, Wei Tang, Leo N. Y. Cao, Ding Li, Zhong Lin Wang
Summary: This study introduces an intelligent artifact-monitoring system (SAMS) based on a porous carbon black (CB)/Ecoflex triboelectric nanogenerator (PCE-TENG) that can monitor collisions in real-time and absorb vibrations during artifact transportation. The system consists of six PCE-TENGs attached to the inner wall of the artifact transport package, allowing collision monitoring and protection in different directions. This research presents a practical strategy for artifact transportation monitoring and package engineering, which could have significant implications for the field.
Article
Multidisciplinary Sciences
Yang Zou, Yansong Gai, Puchuan Tan, Dongjie Jiang, Xuecheng Qu, Jiangtao Xue, Han Ouyang, Bojing Shi, Linlin Li, Dan Luo, Yulin Deng, Zhou Li, Zhong Lin Wang
Summary: Inspired by the structure of shark gill cleft, a stretchable, multichannel respiratory sensor capable of accurately monitoring the breathing rate and depth of the human body is reported. With good stretchability, accuracy, and long-term stability, this sensor shows promising potential for future applications in self-powered smart wearables for mobile medical diagnostic analysis.
FUNDAMENTAL RESEARCH
(2022)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)