Article
Materials Science, Ceramics
Xiaoting Wang, Liting Qu, Changren Zhou, Tao Yu
Summary: Adding a moderate amount of Si can improve the biodegradability and mechanical properties of CPC, without affecting injectability.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Yu Fu, Shengjie Cui, Yanheng Zhou, Lixin Qiu
Summary: Osteoarthritis (OA) is a degenerative disease that causes chronic pain and joint swelling in millions of patients. Current non-surgical treatment for OA can only relieve pain, and the efficacy of mesenchymal stem cell (MSC)-secreted exosomes therapy is uncertain. In this study, dental pulp stem cell (DPSC)-derived exosomes were shown to effectively improve subchondral bone remodeling, inhibit bone sclerosis and osteophyte formation, and alleviate cartilage degradation and synovial inflammation in a mouse knee OA model. Furthermore, DPSC-derived exosomes repressed osteoclast activation by inhibiting TRPV4 activation. These findings suggest that a single injection of DPSC-derived exosomes may be a potential strategy for knee OA treatment and TRPV4 inhibition could be a promising target for clinical OA treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Thanuja D. K. Herath, Leonardo Saigo, Benoit Schaller, Anis Larbi, Swee Hin Teoh, Charles James Kirkpatrick, Bee Tin Goh
Summary: This study showed that autologous neutrophils may have a positive effect on promoting new bone formation, providing potential clinical benefits for bone regeneration in oral and maxillofacial surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sheng Zhan, Li Lu, Shu-shan Pan, Xiao-qian Wei, Rong-rong Miao, Xiao-hui Liu, Ming Xue, Xiu-kun Lin, Huan-li Xu
Summary: This study found that plumbagin inhibits glioma growth through targeting NQO1/GPX4-mediated ferroptosis, suggesting its potential as a novel inducer or candidate for anti-glioma therapy.
BRITISH JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Kirstine Sandal Norregaard, Henrik Jessen Jurgensen, Henrik Gardsvoll, Lars Henning Engelholm, Niels Behrendt, Kent Soe
Summary: Cancer-induced bone degradation involves osteoclasts and cancer cells contributing to the degradation process and interacting with each other in the pathological process of primary bone cancers and bone metastases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hailiang Xu, Lei Zhu, Fang Tian, Chengwen Wang, Weidong Wu, Botao Lu, Liang Yan, Shuaijun Jia, Dingjun Hao
Summary: In this study, a novel strontium-modified calcium phosphate cement (SMPC) was developed by introducing tristrontium silicate, which showed better injectability and a shorter setting time compared to traditional calcium phosphate cement (CPC). SMPC also promoted cell proliferation and differentiation, and facilitated bone regeneration in vivo. Therefore, 5% SMPC is a promising substitute material for bone repair with excellent physicochemical properties and biological activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Feng Wu, Zhenxu Wu, Zhijun Ye, Guoqing Niu, Zhiliang Ma, Peibiao Zhang
Summary: In this study, a composite material consisting of bioactive glass particles (BGPs) and neferine (Nef) was developed for bone regeneration. The material was found to inhibit osteoclasts and enhance osteogenesis. Animal experiments showed that the material effectively promoted new bone formation at the skull defect site.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Article
Chemistry, Medicinal
Farah Alwani Azaman, Margaret E. Brennan E. Fournet, Suzina Sheikh Ab Hamid, Muhamad Syahrul Fitri Zawawi, Valdemiro Amaro da Silva Junior, Declan M. M. Devine
Summary: The field of bone tissue engineering is developing various bone graft substitute materials to reconstruct new bone tissue while maintaining native bone characteristics. Insufficient scaffold degradation is currently the critical limitation for tailoring bone formation turnover rate. This study examines novel scaffold formulations, and results show that the CS/HAp/FAp 1:1 formulation can improve scaffold degradation and bone regeneration, providing a cost-effective alternative to traditional methods (BMP-2).
Article
Biology
Stephen B. Waters, Joseph R. Dominguez, Hyun-Dong Cho, Nicolene A. Sarich, Asrar B. Malik, Kaori H. Yamada
Summary: Research demonstrates that KAI has protective effects in VEGF-A-induced vascular leakage and cancer metastasis, while an EC-specific KIF13B knockout mouse model reveals the role of KIF13B in regulating pathological angiogenesis, vascular leakage, tumor growth, and cancer metastasis induced by VEGF-A.
LIFE SCIENCE ALLIANCE
(2021)
Article
Engineering, Multidisciplinary
Xiyu Li, Qin Zou, Jiawei Wei, Wei Li
Summary: The study found that the stepwise-degraded scaffold is more advantageous for in vivo osteogenesis, with higher mechanical strength and longer integrity. Additionally, the multifunctional HZ particles help with anti-infection and tracking during scaffold degradation.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Kai Dai, Qinghao Zhang, Shunshu Deng, Yuanman Yu, Fuwei Zhu, Shuang Zhang, YuanZhong Pan, Dandan Long, Jing Wang, Changsheng Liu
Summary: Constructing in vivo osteo-organoids by implanting bone morphogenetic protein-2-loaded scaffolds into the internal muscle pocket near the femur of mice supports the growth and subsequent harvest of therapeutically useful cells, and these cells demonstrate therapeutic potentials in cell therapies such as mitigating chronic liver fibrosis and reconstituting impaired immune organs.
Article
Engineering, Biomedical
Jiabing Fan, Chung-Sung Lee, Soyon Kim, Xiao Zhang, Joan Pi-Anfruns, Mian Guo, Chen Chen, Matthew Rahnama, Jiong Li, Benjamin M. Wu, Tara L. Aghaloo, Min Lee
Summary: The study found that Trb3 promotes osteoblastic commitment of MSCs while inhibiting adipocyte differentiation, regulating cell-fate choice through BMP/Smad and Wnt/beta-catenin signals. Local delivery of Trb3 using a GelCA-PLGA scaffold stimulated bone regeneration and inhibited fat-filled cyst formation, demonstrating a potential therapeutic strategy for improved skeletal regeneration and treatment of bone-loss disease.
Article
Materials Science, Biomaterials
Haoming Liu, Gaojie Yang, Hao Yin, Zhenxing Wang, Chunyuan Chen, Zhengzhao Liu, Hui Xie
Summary: A novel calcium phosphate material with a 2D nanostructure was developed, showing enhancement of in vitro osteogenic differentiation through macrophage-mediated signal pathway. The encapsulated CaP nanomaterials in a gelatin hydrogel demonstrated the ability to mediate in vivo ossification via a macrophage polarization related pathway, suggesting a potential alternative for bone autograft in orthopedic applications.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ayumi Kuga, Kouhei Tsuchida, Harit Panda, Makoto Horiuchi, Akihito Otsuki, Keiko Taguchi, Fumiki Katsuoka, Mikiko Suzuki, Masayuki Yamamoto
Summary: Nrf2 activity is regulated by the Keap1-mediated and beta-TrCP-mediated pathways. When Keap1 activity is suppressed, the beta-TrCP-mediated pathway cooperates with the Keap1-mediated pathway to increase Nrf2 activity, resulting in severe growth retardation and esophageal epithelial abnormalities.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiongcheng Xu, Ziqin Chen, Long Xiao, Yanmei Xu, Nianqi Xiao, Weiqiu Jin, Yuling Chen, Yanfen Li, Kai Luo
Summary: This study aimed to investigate the effects of nanosilicate-incorporated PCL (PCL/LAP) nanofibrous membranes on periodontal ligament cells (PDLCs) in vitro and periodontal regeneration in vivo. The results showed that the PCL/LAP nanofibrous membrane exhibited good biocompatibility and bioactivity, enhanced the proliferation and osteogenic differentiation of PDLCs, and promoted periodontal regeneration by orchestrating the immunomodulatory effects of PDLCs. Therefore, the PCL/LAP nanofibrous membrane has the potential to be a promising biomaterial for periodontal regeneration therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)