期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 3, 期 32, 页码 6634-6644出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb00676g
关键词
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资金
- Department of Bio-technology (DBT), New Delhi (DBT project) [BT/01/CEIB/11/V/13]
- CSIR, New Delhi (CSIR grant) [09/080(0776)/2011-EMR-1]
A conventional drug delivery system requires a delivery vehicle which often faces various problems such as inefficient drug loading into the delivery vehicle and its release, cytotoxicity and biodegradability of the delivery vehicle, etc., whereas a supramolecular gel based self-delivery system delivers a gelator drug at the target site without using any vehicle thereby getting rid of such problems. Here, a simple salt formation strategy has been employed to convert a well known anti-allergic drug (cetirizine) to a supramolecular gelator for the purpose of making a topical gel for in vivo self-delivery applications. The salt of cetirizine and tyramine (salt 3) displays excellent gelation properties in methylsalicylate/menthol. The gels are characterised by electron microscopy, and table top- and dynamic rheology. The gelator salt 3 displays excellent physiological stability in phosphate buffer saline (PBS) and it is biocompatible in mouse macrophage RAW 264.7 and mouse myoblast C2C12 cell lines. A methylsalicylate/menthol topical gel of salt 3 is successfully self-delivered in treating the 2,4-dinitrochlorobenzene (DNCB)-induced allergic skin condition in mice.
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