Treatment targets in systemic lupus erythematosus: biology and clinical perspective

Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study

(2012) Brad H. Rovin et al.   ARTHRITIS AND RHEUMATISM

Dual regulation of IRF4 function in T and B cells is required for the coordination of T–B cell interactions and the prevention of autoimmunity

(2012) Partha S. Biswas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

B cell biomarkers of rituximab responses in systemic lupus erythematosus

(2011) Edward M. Vital et al.   ARTHRITIS AND RHEUMATISM

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells

(2011) H. Travis Ichikawa et al.   ARTHRITIS AND RHEUMATISM

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models

(2011) Simanta Pathak et al.   ARTHRITIS RESEARCH & THERAPY

Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes

(2011) Kimberly E. Taylor et al.   PLoS Genetics

The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial

(2010) J. T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus

(2010) Kai W. Bekar et al.   ARTHRITIS AND RHEUMATISM

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Regulatory B Cells (B10 Cells) Have a Suppressive Role in Murine Lupus: CD19 and B10 Cell Deficiency Exacerbates Systemic Autoimmunity

(2010) R. Watanabe et al.   JOURNAL OF IMMUNOLOGY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus

(2010) Silvia N Kariuki et al.   ARTHRITIS RESEARCH & THERAPY

A polymorphism withinIL21Rconfers risk for systemic lupus erythematosus

(2009) Ryan Webb et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Three checkpoints in lupus development: central tolerance in adaptive immunity, peripheral amplification by innate immunity and end-organ inflammation

(2009) H Kanta et al.   GENES AND IMMUNITY

Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets

(2009) Jennifer H. Anolik et al.   IMMUNOLOGIC RESEARCH

Kallikrein genes are associated with lupus and glomerular basement membrane–specific antibody–induced nephritis in mice and humans

(2009) Kui Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Human Transitional B Cell Populations Revealed by B Cell Depletion Therapy

(2009) Arumugam Palanichamy et al.   JOURNAL OF IMMUNOLOGY

C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse

(2009) Scott E. Wenderfer et al.   MOLECULAR IMMUNOLOGY

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

(2009) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the genetic basis and immunopathogenesis of systemic lupus erythematosus from the study of mouse models

(2009) Yui-Ho Cheung et al.   SEMINARS IN IMMUNOLOGY

EULAR points to consider for conducting clinical trials in systemic lupus erythematosus

(2008) C Gordon et al.   ANNALS OF THE RHEUMATIC DISEASES

Cytokine-producing B lymphocytes—key regulators of immunity

(2008) Frances E Lund   CURRENT OPINION IN IMMUNOLOGY

Genetic variation in the CRP promoter: association with systemic lupus erythematosus

(2008) Jeffrey C. Edberg et al.   HUMAN MOLECULAR GENETICS

Clinical trials in systemic lupus erythematosus (SLE): lessons from the past as we proceed to the future – the EULAR recommendations for the management of SLE and the use of end-points in clinical trials

(2008) G Bertsias et al.   LUPUS

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS