Dual regulation of IRF4 function in T and B cells is required for the coordination of T–B cell interactions and the prevention of autoimmunity

Low-Dose Targeted Complement Inhibition Protects against Renal Disease and Other Manifestations of Autoimmune Disease in MRL/lpr Mice

(2014) C. Atkinson et al.   JOURNAL OF IMMUNOLOGY

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Fine tuning of IRF-4 expression by SWAP-70 controls the initiation of plasma cell development

(2011) Michaël Chopin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells

(2011) E. Hams et al.   JOURNAL OF IMMUNOLOGY

Germinal center B and follicular helper T cells: siblings, cousins or just good friends?

(2011) Stephen L Nutt et al.   NATURE IMMUNOLOGY

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

(2011) Wataru Ise et al.   NATURE IMMUNOLOGY

Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells

(2010) Valérie Staudt et al.   IMMUNITY

Single Round of Antigen Receptor Signaling Programs Naive B Cells to Receive T Cell Help

(2010) Bazarragchaa Damdinsuren et al.   IMMUNITY

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

The immortality of humoral immunity

(2010) Raul Elgueta et al.   IMMUNOLOGICAL REVIEWS

Estrogen Receptors Bind to and Activate theHOXC4/HoxC4Promoter to Potentiate HoxC4-mediated Activation-induced Cytosine Deaminase Induction, Immunoglobulin Class Switch DNA Recombination, and Somatic Hypermutation

(2010) Thach Mai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

(2010) Partha S. Biswas et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 Receptor Is Critical for the Development of Memory B Cell Responses

(2010) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

(2010) Kim L Good-Jacobson et al.   NATURE IMMUNOLOGY

Control systems and decision making for antibody production

(2010) Christopher C Goodnow et al.   NATURE IMMUNOLOGY

B cell follicles and antigen encounters of the third kind

(2010) Jason G Cyster   NATURE IMMUNOLOGY

Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4

(2009) E. Carreras et al.   BLOOD

Follicular helper T cells as cognate regulators of B cell immunity

(2009) Louise J McHeyzer-Williams et al.   CURRENT OPINION IN IMMUNOLOGY

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

(2009) Hyokjoon Kwon et al.   IMMUNITY

Estrogen directly activates AID transcription and function

(2009) Siim Pauklin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SLAT/Def6 Plays a Critical Role in the Development of Th17 Cell-Mediated Experimental Autoimmune Encephalomyelitis

(2009) A. J. Canonigo-Balancio et al.   JOURNAL OF IMMUNOLOGY

A Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4+CD25- T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice

(2009) E. Jang et al.   JOURNAL OF IMMUNOLOGY

HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

(2009) Seok-Rae Park et al.   NATURE IMMUNOLOGY

A coming-of-age story: activation-induced cytidine deaminase turns 10

(2009) Rebecca K Delker et al.   NATURE IMMUNOLOGY

B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers

(2009) Thinh Huy Tran et al.   NATURE IMMUNOLOGY

A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

(2009) J. A. Bubier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-21 stimulates B-cell immunoglobulin E synthesis in human beings concomitantly with activation-induced cytidine deaminase expression and differentiation into plasma cells

(2008) Shinji Kobayashi et al.   HUMAN IMMUNOLOGY

Tyrosine-Phosphorylation-Dependent Translocation of the SLAT Protein to the Immunological Synapse Is Required for NFAT Transcription Factor Activation

(2008) Stéphane Bécart et al.   IMMUNITY

Sites and Stages of Autoreactive B Cell Activation and Regulation

(2008) Mark J. Shlomchik   IMMUNITY

IRF-4-Binding Protein Inhibits Interleukin-17 and Interleukin-21 Production by Controlling the Activity of IRF-4 Transcription Factor

(2008) Qinzhong Chen et al.   IMMUNITY

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

The role of IL-21 in regulating B-cell function in health and disease

(2008) Rachel Ettinger et al.   IMMUNOLOGICAL REVIEWS

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

(2008) M. Huber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells

(2008) K. Honma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology