Review
Biochemistry & Molecular Biology
Enzo Manchon, Nell Hirt, Jean-David Bouaziz, Nabila Jabrane-Ferrat, Reem Al-Daccak
Summary: Endosome-derived small extracellular vesicles (EVs), also known as exosomes, play a critical role in intercellular communication and have therapeutic potential in regenerative medicine. Stem cell-derived EVs are effective in repair and regeneration, with the human placenta offering a promising allogeneic stem cell source. Advancements in cell-free therapeutics provide new hope and perspectives for safe and effective treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Quan-Wen Liu, Qi-Ming Huang, Han-You Wu, Guo-Si-Lang Zuo, Hao-Cheng Gu, Ke-Yu Deng, Hong-Bo Xin
Summary: Stem cell therapy has the potential to repair tissues and improve functional recovery, but faces challenges such as ethical barriers and immune rejection. Human amnion-derived stem cells (hADSCs) show advantages over other stem cells, including high pluripotency and immunomodulatory effects, making them a promising source for cell therapy and regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Dane Kim, Alisa E. Lee, Qilin Xu, Qunzhou Zhang, Anh D. Le
Summary: GMSCs, a unique subpopulation of mesenchymal stem cells isolated from human gingival tissues, possess potent regenerative potential and the ability to differentiate into neural cell lineages. They also exhibit strong immunomodulatory and anti-inflammatory effects, making them a promising source for tissue engineering and regenerative therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Glyn Nigel Stacey, Jie Hao
Summary: In recent years, significant progress has been made in China in establishing hPSCs for the manufacture of cell therapies. The National Stem Cell Resource Center and its partner organizations have over 600 hPSC lines formally recorded, with 47 of them also registered for European Commission funded research projects. This national and international coordination aims to promote the translation of Chinese hPSC-based products into clinical use according to established standards.
CELL PROLIFERATION
(2022)
Article
Cell Biology
Giulia Gaggi, Andrea Di Credico, Simone Guarnieri, Maria Addolorata Mariggio, Angela Di Baldassarre, Barbara Ghinassi
Summary: Human amniotic fluids stem cells (hAFSCs) can differentiate into spinal motor neurons and form functional neuromuscular junctions, providing a promising approach for the study and treatment of neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell & Tissue Engineering
Zijun Cai, Di Liu, Yuntao Yang, Wenqing Xie, Miao He, Dengjie Yu, Yuxiang Wu, Xiuhua Wang, Wenfeng Xiao, Yusheng Li
Summary: This article reviews the relationship between sarcopenia and stem cells, discussing the roles of satellite cells (SCs) and muscle-derived stem cells (MDSCs) in sarcopenia. Studies have shown that changes in the number and function of stem cells can trigger sarcopenia and have adverse effects on stem cells. A better understanding of the role of stem cells, especially SCs and MDSCs, in muscle, is important for developing novel therapeutic approaches to combat sarcopenia.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biotechnology & Applied Microbiology
Qian Wei, Xi Liu, Jian-Long Su, Ya-Xi Wang, Zi-Qiang Chu, Kui Ma, Qi-Lin Huang, Hai-Hong Li, Xiao-Bing Fu, Cui-Ping Zhang
Summary: Chronic non-healing wounds pose a significant threat to both the physical and mental health of patients, with abnormal behavior of remaining cells identified as the main obstacle to healing. Mesenchymal stem cells (MSCs) therapy has emerged as a promising option for chronic wound healing, primarily due to their exocrine functions. Small extracellular vesicles derived from MSCs (MSC-sEVs) have been reported to regulate cellular behavior and have a positive impact on various stages of wound healing. This review discusses the characteristics and therapeutic potential of MSC-sEVs in chronic wound treatment, as well as their application avenues and strategies for large-scale production and engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ping Lyu, Yiming Song, Ruiye Bi, Zucen Li, Yali Wei, Qin Huang, Chen Cui, Dongzhe Song, Xuedong Zhou, Yi Fan
Summary: Apical periodontitis (AP) is a common inflammatory disease caused by bacterial infection in the periapical region of the tooth. The regeneration of damaged periapical alveolar bone and surrounding periodontium tissues has been a challenging task in clinical practice, but mesenchymal stem cells (MSCs) play a crucial role in mediating the immune system and promoting regeneration.
Review
Cell Biology
Yuxuan Zhong, Xiang Li, Fanglin Wang, Shoushuai Wang, Xiaohong Wang, Xiaohong Tian, Shuling Bai, Di Miao, Jun Fan
Summary: Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. Exosomes play an important role in promoting tissue regeneration and provide new ideas for adipose tissue engineering research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Tzu-Cheng Sung, Yi-Peng Jiang, Jhe-Yu Hsu, Qing-Dong Ling, Hao Chen, Suresh S. Kumar, Yung Chang, Shih-Tien Hsu, Qingsong Ye, Akon Higuchi
Summary: This study successfully generated universal hiPSCs without gene editing and evaluated their resistance to immune reactions, demonstrating that the cells maintained stable characteristics even after continuous passages.
CELL PROLIFERATION
(2021)
Article
Cell & Tissue Engineering
Lydia J. Beeken, Darren S. J. Ting, Laura E. Sidney
Summary: Ocular surface inflammatory disorders are highly prevalent, heterogeneous diseases with a common factor of corneal inflammation. Current medications have limitations, and regenerative medicine cell therapies, particularly mesenchymal stem cells, show promise but require further investigation for successful clinical translation.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Jayavardini Vasanthan, Narasimman Gurusamy, Sheeja Rajasingh, Vinoth Sigamani, Shivaani Kirankumar, Edwin L. Thomas, Johnson Rajasingh
Summary: Mesenchymal stem cells (MSCs) are multipotent cells with the potential for tissue regeneration, can be easily isolated and cultured in vitro, and have been proven to be valuable for therapy. Quality control parameters, mechanisms of action, and applications in regenerative medicine and tissue engineering are important aspects to consider when utilizing MSCs.
Article
Biochemistry & Molecular Biology
Nela Pilbauerova, Jan Schmidt, Tomas Soukup, Romana Koberova Ivancakova, Jakub Suchanek
Summary: This study aimed to observe the effect of uncontrolled-rate freezing on DPSCs stored for 6 and 12 months. It was found that DPSCs retained their stemness markers and low-level expression of hematopoietic markers even after one year of cryopreservation at -80 degrees C, suggesting that DPSCs can still be successfully used in potential clinical applications after a year of uncontrolled cryopreservation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Forough Mahdavi-Jouibari, Benyamin Parseh, Ezatolah Kazeminejad, Ayyoob Khosravi
Summary: Cartilage lesions are common and challenging to regenerate. Stem cell-based therapies, especially using Mesenchymal stem cells (MSCs) and Stem cells from human exfoliated deciduous teeth (SHED), offer promising solutions for cartilage regeneration. MSCs can differentiate into mature chondrocytes and engraft into the host, while SHED-derived secretome contains biomolecules that promote tissue regeneration, including cartilage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Florian A. Schmid, J. Koudy Williams, Thomas M. Kessler, Arnulf Stenzl, Wilhelm K. Aicher, Karl-Erik Andersson, Daniel Eberli
Summary: Urinary incontinence is a major global health issue affecting over 400 million people worldwide. Stress urinary incontinence is the most prevalent subtype, primarily caused by pregnancy, childbirth, and pelvic trauma. Current treatments include physiotherapy, behavioral changes, and surgery, but alternative, minimally invasive options are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Emergency Medicine
Lente H. M. Dankelman, Sanne Schilstra, Frank F. A. IJpma, Job N. Doornberg, Joost W. Colaris, Michael H. J. Verhofstad, Mathieu M. E. Wijffels, Jasper Prijs
Summary: This review summarizes literature on the use of convolutional neural networks (CNNs) for the detection and classification of fractures on CT scans. The results show that CNNs have high accuracy and can help improve automated and clinician-aided diagnostics.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Review
Orthopedics
Timon H. Geurkink, Hamez Gacaferi, Perla J. Marang-van de Mheen, Jan W. Schoones, Jurriaan H. de Groot, Jochem Nagels, Rob G. H. H. Nelissen
Summary: This review systematically reviewed the evidence regarding nonsurgical management and tendon transfer surgery for neurologic scapular winging. The results showed that nonsurgical management had variable rates of spontaneous recovery, while surgical management significantly improved patients' active forward flexion, pain scores, and shoulder function and scores.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Medicine, Research & Experimental
Marcus P. J. van Diemen, Dimitrios Ziagkos, Matthijs D. Kruizinga, Menno R. Benard, Philip Lambrechtse, Joris A. J. Jansen, Barbara A. M. Snoeker, Maaike G. J. Gademan, Adam F. Cohen, Rob G. H. H. Nelissen, Geert Jan Groeneveld
Summary: Low muscle quality and a sedentary lifestyle are indicators for a slow recovery after total knee arthroplasty (TKA), and mitochondrial function may also affect recovery. In this pilot study, the researchers monitored activity using a wrist-mounted activity tracker and examined the relationship between mitochondrial function and recovery after TKA. They found that mitochondrial function, grip strength, and activity were significantly related to recovery. Using activity trackers before and after TKA could provide valuable information for surgeons to predict and intervene in cases of low recovery.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Editorial Material
Geriatrics & Gerontology
Ajla Hodzic Kuerec, Andrea B. B. Maier
Summary: Rapamycin is an FDA-approved immunosuppressive drug and a leading candidate for targeting aging. It inhibits mTOR kinase by binding to FK506-binding proteins (FKBP) and has similar chemical structure with its analogs, which are referred to as 'rapalogs.' The development of rapalogs aimed to improve pharmacological properties of rapamycin.
Article
Biochemistry & Molecular Biology
Ye Ella Tian, Vanessa Cropley, Andrea B. Maier, Nicola T. Lautenschlager, Michael Breakspear, Andrew Zalesky
Summary: Using brain imaging and physiological data from the UK Biobank, researchers establish normative models of biological age for various organ systems and find that biological aging of one organ selectively influences the aging of others, revealing a multiorgan aging network. They also report organ age profiles for chronic diseases, showing that advanced biological aging extends from the primary organ to multiple systems. Advanced body age is associated with lifestyle factors, telomere lengths, mortality risk, and predicts survival time and premature death. This research sheds light on the multisystem nature of human aging and the potential for early identification of individuals at risk.
Article
Endocrinology & Metabolism
N. R. Gadgaard, C. Varnum, R. G. H. H. Nelissen, C. Vandenbroucke-Grauls, H. T. Sorensen, A. B. Pedersen
Summary: The impact of comorbidity on infection risk among hip fracture patients is not clear, but a high incidence of infection was found. Comorbidity was identified as an important risk factor for infection up to 1 year after surgery. The results indicate a need for increased investment and support for patients with high comorbidity in pre- and postoperative programs.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Heather van Brug, Frits Rosendaal, Liza van Steenbergen, Rob G. H. H. Nelissen, Maaike G. J. Gademan, Shao-Hsien Liu
Summary: This study used deterministic data linkage to link the Dutch Foundation for Pharmaceutical Statistics and Dutch Arthroplasty Register in order to investigate opioid prescriptions before/after arthroplasty. The results showed that linkage on hospital postcode was insufficient, but linkage on patient postcode and low-molecular-weight heparin (LMWH) had good quality. A subset of the study population linked on patient postcode and LMWH accounted for 42% of the total arthroplasties performed after 2013.
Article
Infectious Diseases
Henk Scheper, Rachid Mahdad, Brenda Elzer, Claudia Lowik, Wierd Zijlstra, Taco Gosens, Joris C. T. van der Lugt, Robert J. P. van der Wal, Rudolf W. Poolman, Matthijs P. Somford, Paul C. Jutte, Pieter K. Bos, Richard E. Zwaan, Rob G. H. H. Nelissen, Leo G. Visser, Mark G. J. de Boer
Summary: Moderate to heavy wound drainage and persistent wound drainage were strongly associated with prosthetic joint infection (PJI), and additional parameters are needed to guide the decision to reoperate on patients for suspected acute PJI.
JOURNAL OF BONE AND JOINT INFECTION
(2023)
Article
Rehabilitation
Rose Goonan, Edward Mohandoss, Celia Marston, Jaqueline Kay, Anurika Priyanjali De Silva, Andrea B. Maier, Esmee Reijnierse, Marlena Klaic
Summary: This study evaluated the physical and functional outcomes of the 'Ending Pyjama Paralysis' intervention in geriatric rehabilitation patients. The results showed that this intervention did not lead to additional functional and physical benefits in this setting.
CLINICAL REHABILITATION
(2024)
Article
Nutrition & Dietetics
Kaisy Xinhong Ye, Lina Sun, Su Lin Lim, Jialiang Li, Brian K. Kennedy, Andrea Britta Maier, Lei Feng
Summary: This study reported on the nutrient intake and prevalence of malnutrition risk in a community sample of older adults in Singapore. The findings showed that a majority of older adults exceeded the recommended intake for sugar and saturated fat, while their intake of dietary fiber and calcium were insufficient. Additionally, a significant proportion of older adults were found to be at moderate to high malnutrition risk.
Article
Geriatrics & Gerontology
Elena Sandalova, Jorming Goh, Zi Xiang Lim, Zhi Meng Lim, Diogo Barardo, Rajkumar Dorajoo, Brian K. Kennedy, Andrea B. Maier
Summary: Targeting molecular processes of aging can help prevent age-related diseases and extend people's healthy lifespan. Geroprotectors have the potential to increase healthspan and lifespan, but their translation to humans is limited. Alpha-Ketoglutarate (AKG) has been extensively studied in animal models, but there are few studies on its geroprotective properties in humans.
Review
Geriatrics & Gerontology
Jessica K. Lu, Marcella Sijm, Georges E. Janssens, Jorming Goh, Andrea B. Maier
Summary: Remote monitoring technologies (RMTs) allow continuous, unobtrusive, and real-time monitoring of the cardiovascular system. This systematic review provides an overview of existing RMTs measuring cardiovascular functions in community-dwelling adults.
Article
Geriatrics & Gerontology
Marjolein Klop, Rianne A. A. de Heus, Andrea B. Maier, Anne van Alphen, Marianne J. Floor-Westerdijk, Mathijs Bronkhorst, Rene J. F. Melis, Carel G. M. Meskers, Jurgen A. H. R. Claassen, Richard J. A. van Wezel
Summary: Orthostatic hypotension (OH) is common in older adults and has various negative effects. Current diagnosis relies on single-time point cuff measurements, while continuous blood pressure (BP) devices are not suitable for daily monitoring. Near-infrared spectroscopy (NIRS) has potential diagnostic value in continuously measuring cerebral oxygenation, but further validation is needed. This study aimed to compare NIRS-measured cerebral oxygenation with continuous BP and transcranial Doppler-measured cerebral blood velocity (CBv) during postural changes. The results showed that BP and O(2)Hb had good curve-based correlations in the initial 30 seconds after standing up, with significant associations between early and 1-minute BP recovery and O(2)Hb. Associations between CBv and O(2)Hb were poor, but stronger for long-channel than short-channel measurements. The findings suggest that NIRS-measured O(2)Hb in the first 30 seconds after postural change is well associated with BP, and long-channel NIRS specifically reflects cerebral blood flow during postural transitions, providing insights into OH consequences.
Article
Geriatrics & Gerontology
Laure M. G. Verstraeten, Janneke P. van Wijngaarden, Dong Y. Kim, Carel G. M. Meskers, Andrea B. Maier
Summary: This study evaluates the feasibility of using bioelectric impedance analysis (BIA) to measure muscle mass in geriatric rehabilitation inpatients. The results show that BIA is feasible in this population but needs to address technical and refusal issues.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Annetje M. de Rooij, Andrea B. Maier, Stella Trompet, Carel G. M. Meskers
Summary: The study aimed to investigate the predictive value of pre-stroke impairment of activities of daily living (ADL) for ADL decline after stroke. The results showed that pre-stroke ADL measured by the Barthel Index (BI) and Instrumental Activities of Daily Living (IADL) scale did not predict post-stroke ADL decline in community dwelling older subjects with known vascular risk factors.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)