Article
Cell Biology
Bin Yuan, Jing Yang, Louis Dubeau, Yanfen Hu, Rong Li
Summary: The study identified the crucial role of an ER beta-specific phosphotyrosine residue in mouse ovarian development and function, with mutant mice showing reduced fertility and decreased ovarian cell proliferation. These findings provide strong genetic and molecular evidence for the impact of isotype-specific ER beta phosphorylation in ovarian tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This review focuses on the role of ER alpha and ER beta in polycystic ovary syndrome (PCOS), ovarian cancer, and premature ovarian failure (POF), as well as the major challenges of existing therapies. It provides a reference for the treatment of estrogen target tissue ovarian diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yingjun Chen, Qinghua Liu, Ruiyan Liu, Chan Yang, Xiaodong Wang, Zaohong Ran, Shanshan Zhou, Xiang Li, Changjiu He
Summary: This study in a mouse model revealed that early folliculogenesis requires a minimum of two weeks, with different stages showing specific characteristics such as oocyte size at Type 4-5 stage and theca folliculi formation at PD10-12. The study also highlighted the importance of the PD22-23 period for studying puberty initiation, providing valuable insights into the biological events of this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Environmental Sciences
Haojia Ma, Keishi Ishida, Chenke Xu, Kyosuke Takahashi, Yu Li, Chenhao Zhang, Qiyue Kang, Yingting Jia, Wenxin Hu, Daisuke Matsumaru, Tsuyoshi Nakanishi, Jianying Hu
Summary: The study found that TPhP delayed puberty timing in mice and affected ovarian function, possibly by inhibiting estrogen receptor signaling. After 40 days of exposure to TPhP, a significant decrease in the number of follicles was observed in mice, indicating a decline in ovarian reserve.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Liyuan Li, Rui Hua, Kaiqiang Hu, Huiling Chen, Yuemiao Yin, Xiaojin Shi, Kezheng Peng, Qing Huang, Ying Qiu, Xue Li, Qingfei Liu, Shangfeng Liu, Zhao Wang
Summary: SIRT6 is a key enzyme involved in metabolism, DNA damage repair, and aging. This study reveals that SIRT6 plays an important role in follicular development, and its absence leads to disruptions in ovarian development, puberty, and estrus cycle, as well as decreases in the number of secondary and antral follicles and collagen in the ovarian stroma.
Article
Environmental Sciences
Jingyi Song, Xiaochen Ma, Feixue Li, Jing Liu
Summary: This study found that gestational exposure of female mice to multiple pyrethroids at recommended safe doses had irreversible adverse effects on the ovaries in female offspring. The exposure regulated the expression of miRNAs during early developmental stages, disrupting key biological processes and signaling pathways governing follicular development and ovarian functions. However, lactational and peripubertal exposure to pyrethroid mixture did not significantly affect follicular development and ovarian functions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylene Brunelle, Nicolas Gevry, Bruce D. Murphy
Summary: This study identifies SF-1 as a key regulator of the formation of the ovarian reserve, with its depletion leading to smaller ovaries and reduced primordial follicles. The study also identifies the dysregulated pathways and genes involved in follicle formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Chenchen Sun, Xiaoxu Yang, Tianxiao Wang, Min Cheng, Yangyang Han
Summary: Biomechanics, as a physical phenomenon, plays a crucial role in the growth, development, and normal physiological functions of the ovary. It is also involved in ovarian diseases and cancer, providing new insights for research and treatment of ovarian-related diseases.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Yi Ming Guo, Tie Cheng Sun, Hui Ping Wang, Xi Chen
Summary: Melatonin has strong endogenous effects of eliminating free radicals and resisting oxidative damages, it can regulate ovarian biological rhythm, promote follicles formation, and improve oocyte quality and fertilization rate. Additionally, it plays a role as antioxidative and participates in biological rhythm regulation, and has effects on various ovarian related diseases such as ovarian aging and polycystic ovary syndrome (PCOS).
Article
Cell Biology
S. Ataei-Nazari, M. Amoushahi, JF. Madsen, J. Jensen, A. Heuck, A. Mohammadi-Sangcheshmeh, K. Lykke-Hartmann
Summary: CDK6 plays a regulatory role in the primordial-to-primary transition of ovarian follicles, indicating that cell cycle regulation is an essential part of follicle development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Carolina Lliberos, Seng H. Liew, Ashley Mansell, Karla J. Hutt
Summary: This study investigated the impact of chronic low-grade systemic inflammation mediated by the inflammasome on ovarian aging, finding that by suppressing the inflammatory processes, the depletion of follicles could be delayed and the fertile window extended.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Ewa Oc, Anna Hrabia
Summary: This study investigated the differential miR expression profiles in the chicken ovary using high-throughput transcriptome analyses, revealing the potential role of miRs in regulating matrix metalloproteinase expression during follicular growth and atresia. Identified miR target pairs were associated with pathways involved in MMP inhibition, axonal guidance signaling, HIF1 alpha signaling, and GP6 signaling, providing novel insights into the molecular mechanisms underlying follicle development in chickens.
Article
Cell Biology
Luyi Chen, Wei Zhang, Ruiqi Huang, Xiaoping Miao, Jianying Li, Dongliang Yu, Yan Li, Wei Hsu, Mengsheng Qiu, Zunyi Zhang, Feixue Li
Summary: This study demonstrates the crucial role of Wls in female fertility and luteinization, with the deletion of Wls leading to impaired ovarian function and corpus luteum formation.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Heidi Vanden Brink, Adrienne J. Pisch, Marla E. Lujan
Summary: This study found variability in follicle number per ovary assessments across different ultrasonographic methods, with 2D-RT potentially misclassifying PCOM, while 2D-RT with Grid and MPV-RT could be clinically feasible alternatives for obtaining FNPO and classifying PCOM. Efforts to reduce variation in FNPO will clarify the relevance of PCOM in women's health.
FERTILITY AND STERILITY
(2021)
Article
Biochemistry & Molecular Biology
Yasuhiko Kato, Christelle Alexa G. Perez, Nur Syafiqah Mohamad Ishak, Quang D. Nong, Yuumi Sudo, Tomoaki Matsuura, Tadashi Wada, Hajime Watanabe
Article
Environmental Sciences
Nikko Adhitama, Tomoaki Matsuura, Yasuhiko Kato, Hajime Watanabe
MARINE ENVIRONMENTAL RESEARCH
(2018)
Article
Microbiology
Martijn Callens, Hajime Watanabe, Yasuhiko Kato, Jun Miura, Ellen Decaestecker
Article
Multidisciplinary Sciences
Nur Izzatur Binti Ismail, Yasuhiko Kato, Tomoaki Matsuura, Hajime Watanabe
Article
Biochemistry & Molecular Biology
Marin Ogawa, Atsuko Uyeda, Kazuo Harada, Yu Sato, Yasuhiko Kato, Hajime Watanabe, Kohsuke Honda, Tomoaki Matsuura
Article
Biochemistry & Molecular Biology
Andrea P. Cabalzar, Peter D. Fields, Yasuhiko Kato, Hajime Watanabe, Dieter Ebert
Article
Multidisciplinary Sciences
Quang Dang Nong, Tomoaki Matsuura, Yasuhiko Kato, Hajime Watanabe
Article
Multidisciplinary Sciences
Nikko Adhitama, Yasuhiko Kato, Tomoaki Matsuura, Hajime Watanabe
Article
Ecology
Xuan Zhang, Hajime Ohtsuki, Wataru Makino, Yasuhiko Kato, Hajime Watanabe, Jotaro Urabe
Summary: Studies have shown that ectosymbiotic bacteria affect the growth rate of D. pulex, with differences seen between genotypes and individuals fed different algal diets, which may impact the genetic structures of populations.
ECOLOGICAL RESEARCH
(2021)
Article
Environmental Sciences
Pijar Religia, Nhan Duc Nguyen, Quang Dang Nong, Tomoaki Matsuura, Yasuhiko Kato, Hajime Watanabe
Summary: A study on the mutation of the CYP360A8 gene in D. magna was conducted, revealing that the mutant is more sensitive to the herbicide paraquat, confirming the role of CYP360A8 in paraquat detoxification.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Developmental Biology
Nur Izzatur Binti Ismail, Yasuhiko Kato, Tomoaki Matsuura, Cristian Gomez-Canela, Carlos Barata, Hajime Watanabe
Summary: The ABC transporter Scarlet and its binding partner White are crucial for pigment synthesis in insect eyes and serve as genetic markers. Recent studies have revealed additional functions of these transporters in the neuronal system, specifically in histaminergic signaling. Mutations in Scarlet cause spinning behavior in juvenile crustaceans, which can be rescued by histamine supplementation. However, the irreversible role of Scarlet in the development of histaminergic neurons suggests a complex mechanism underlying the spinning behavior.
Article
Developmental Biology
Nhan Duc Nguyen, Tomoaki Matsuura, Yasuhiko Kato, Hajime Watanabe
Article
Genetics & Heredity
Christelle Alexa Garcia Perez, Shungo Adachi, Quang Dang Nong, Nikko Adhitama, Tomoaki Matsuura, Toru Natsume, Tadashi Wada, Yasuhiko Kato, Hajime Watanabe, John M. Greally
Summary: Long noncoding RNAs (lncRNAs) are extensively transcribed and studied, but those overlapping with mRNA in the sense orientation have been less explored. We investigated the lncRNA DAPALR overlapping with the 5' UTR of the male determining gene Doublesex1 (Dsx1) in Daphnia magna. Through affinity purification, we identified an RNA binding protein, Shep, as a DAPALR binding protein. Shep binds to Dsx1 5' UTR by recognizing the overlapping sequence and suppresses mRNA translation. In vitro and in vivo analyses indicated that DAPALR enhances Dsx1 translation efficiency by sequestering Shep. This mechanism may play a significant role in displaying dimorphic gene expressions, such as sex determination, and could explain binary expression in various developmental processes.
Article
Multidisciplinary Sciences
Yusrifar Kharisma Tirta, Shungo Adachi, Christelle Alexa Garcia Perez, Nikko Adhitama, Quang Dang Nong, Toru Natsume, Yasuhiko Kato, Hajime Watanabe
Summary: CELF1 suppresses the expression of Dsx1 in both females and males, possibly by setting a threshold of Dsx1 expression, to avoid unintended Dsx1 expression and sexual ambiguity.
Article
Multidisciplinary Sciences
Ayaka Kitamura, Chen Jiayue, Tomoya Suwa, Yasuhiko Kato, Tadashi Wada, Hajime Watanabe
Summary: Neonatal administration of diethylstilbestrol (DES) to mice causes long-lasting up-regulation of inflammatory Cxcl chemokines in the vaginal epithelium. This study also reveals DES-induced non-coding RNAs that may be responsible for the activation of Cxcl chemokines. The findings suggest that DES-mediated inflammation is associated with the carcinogenic process.