Clinical lung xenotransplantation - what donor genetic modifications may be necessary?

Human TNF-related apoptosis-inducing ligand-expressing dendritic cells from transgenic pigs attenuate human xenogeneic T cell responses

(2012) Elisabeth Kemter et al.   XENOTRANSPLANTATION

Identification of human preformed antibody targets in GTKO pigs

(2012) Christopher Burlak et al.   XENOTRANSPLANTATION

B-Cell Depletion Extends the Survival of GTKO.hCD46Tg Pig Heart Xenografts in Baboons for up to 8 Months

(2011) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Expression of Pro- and Antiapoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation

(2011) Peter D. Campbell et al.   CELL TRANSPLANTATION

CD47: a new player in phagocytosis and xenograft rejection

(2011) Nalu Navarro-Alvarez et al.   Cellular & Molecular Immunology

Controlling coagulation dysregulation in xenotransplantation

(2011) Peter J Cowan et al.   Current Opinion in Organ Transplantation

Intracerebral xenotransplantation: recent findings and perspectives for local immunosuppression

(2011) Xavier Lévêque et al.   Current Opinion in Organ Transplantation

Ecto-5′-Nucleotidase (CD73) Decreases Mortality and Organ Injury in Sepsis

(2011) György Haskó et al.   JOURNAL OF IMMUNOLOGY

Innate immunity and coagulation

(2011) C. T. ESMON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Knockout rats generated by embryo microinjection of TALENs

(2011) Laurent Tesson et al.   NATURE BIOTECHNOLOGY

Efficient gene targeting mediated by a lentiviral vector-associated meganuclease

(2011) Araksya Izmiryan et al.   NUCLEIC ACIDS RESEARCH

Use of the 2A Peptide for Generation of Multi-Transgenic Pigs through a Single Round of Nuclear Transfer

(2011) Wei Deng et al.   PLoS One

Germline Transgenic Pigs by Sleeping Beauty Transposition in Porcine Zygotes and Targeted Integration in the Pig Genome

(2011) Wiebke Garrels et al.   PLoS One

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein C anticoagulant system—anti-inflammatory effects

(2011) Charles T. Esmon   Seminars in Immunopathology

Generation of Soluble Human Tumor Necrosis Factor-α Receptor 1-Fc Transgenic Pig

(2011) Bumrae Cho et al.   TRANSPLANTATION

Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection

(2011) Bao-Ngoc H. Nguyen et al.   XENOTRANSPLANTATION

Genes, BACs and artificial chromosomes

(2011) S. Kraner et al.   XENOTRANSPLANTATION

Coagulopathy in α-galactosyl transferase knockout pulmonary xenotransplants

(2011) Errol L. Bush et al.   XENOTRANSPLANTATION

Gal/non-Gal antigens in pig tissues and human non-Gal antibodies in the GalT-KO era1

(2011) Michael E. Breimer   XENOTRANSPLANTATION

Versatile co-expression of graft-protective proteins using 2A-linked cassettes

(2011) Nella Fisicaro et al.   XENOTRANSPLANTATION

Genetically-modified pig mesenchymal stromal cells: xenoantigenicity and effect on human T-cell xenoresponses

(2011) Mohamed Ezzelarab et al.   XENOTRANSPLANTATION

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

(2011) Björn Petersen et al.   XENOTRANSPLANTATION

Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk

(2011) Vered Padler-Karavani et al.   XENOTRANSPLANTATION

Transgenic Overexpression of CD39 Protects Against Renal Ischemia-Reperfusion and Transplant Vascular Injury

(2010) S. Crikis et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Recipient Tissue Factor Expression Is Associated With Consumptive Coagulopathy in Pig-to-Primate Kidney Xenotransplantation

(2010) C. C. Lin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Antiinflammatory and Anticoagulant Effects of Transgenic Expression of Human Thrombomodulin in Mice

(2010) S. Crikis et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

(2010) Aaron Klug   Annual Review of Biochemistry

Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases

(2010) Masahito Watanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells

(2010) Toshihiro Kobayashi et al.   CELL

Coagulation, platelet activation and thrombosis in xenotransplantation

(2010) Moritz Schmelzle et al.   Current Opinion in Organ Transplantation

Role of regulatory T cells in xenotransplantation

(2010) Philip J OʼConnell et al.   Current Opinion in Organ Transplantation

Immunological Property of Antibodies against N-Glycolylneuraminic Acid Epitopes in Cytidine Monophospho-N-Acetylneuraminic Acid Hydroxylase-Deficient Mice

(2010) H. Tahara et al.   JOURNAL OF IMMUNOLOGY

PILOT EVALUATION OF ANTI-GPIB EFFECTS ON PLATELET SEQUESTRATION IN AN EX VIVO XENOGENEIC PIG LIVER PERFUSION MODEL

(2010) L. Burdorf et al.   TRANSPLANTATION

ANTI-GPIB FAB REDUCES ACTIVATION AND SEQUESTRATION OF HUMAN PLATELETS IN A XENOGENEIC PIG LUNG PERFUSION MODEL

(2010) L. Burdorf et al.   TRANSPLANTATION

Non-Human Primate Regulatory T Cells: Current Biology and Implications for Transplantation

(2010) Eefje M. Dons et al.   TRANSPLANTATION

LONGTERM CLINICAL RECOVERY IN PARKINSONIAN MONKEY RECIPIENTS OF CTLA4-IG TRANSGENIC PORCINE NEURAL PRECURSORS

(2010) Aron R. badin et al.   TRANSPLANTATION

Identification of New Carbohydrate and Membrane Protein Antigens in Cardiac Xenotransplantation

(2010) Guerard W. Byrne et al.   TRANSPLANTATION

Characterization of baboon NK cells and their xenogeneic activity

(2010) Sarah B. Kennett et al.   XENOTRANSPLANTATION

The potential of genetically-modified pig mesenchymal stromal cells in xenotransplantation

(2010) Mohamed Ezzelarab et al.   XENOTRANSPLANTATION

Genetic engineering including superseding microinjection: new ways to make GM pigs

(2010) Cesare Galli et al.   XENOTRANSPLANTATION

On the need for porcine embryonic stem cells to produce Gal KO pigs expressing multiple transgenes to advance xenotransplantation research

(2010) Mark B. Nottle et al.   XENOTRANSPLANTATION

Foxp3 regulates human natural CD4+CD25+ regulatory T-cell-mediated suppression of xenogeneic response

(2010) Lei Sun et al.   XENOTRANSPLANTATION

Review Article: CD47 in xenograft rejection and tolerance induction

(2010) Yong-Guang Yang   XENOTRANSPLANTATION

Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation

(2010) Yuko Miwa et al.   XENOTRANSPLANTATION

Generation and characterization of pigs transgenic for human hemeoxygenase-1 (hHO-1)

(2010) B. Petersen et al.   XENOTRANSPLANTATION

Complement regulation in the GalT KO era

(2010) Shuji Miyagawa et al.   XENOTRANSPLANTATION

Investigation of potential carbohydrate antigen targets for human and baboon antibodies

(2010) Peter Yeh et al.   XENOTRANSPLANTATION

Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig-to-Baboon Xenotransplantation

(2009) C. Knosalla et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance

(2009) B. Ekser et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Production of a reporter transgenic pig for monitoring Cre recombinase activity

(2009) Li Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular nucleotides as negative modulators of immunity

(2009) Francesco Di Virgilio et al.   CURRENT OPINION IN PHARMACOLOGY

The discovery of the endothelial cell protein C receptor

(2009) C. T. ESMON   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses

(2009) Jingjing Wu et al.   TRANSPLANTATION

The Innate Immune Response and Activation of Coagulation in α1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients

(2009) Mohamed Ezzelarab et al.   TRANSPLANTATION

HLA-E/Human β2-Microglobulin Transgenic Pigs: Protection Against Xenogeneic Human Anti-Pig Natural Killer Cell Cytotoxicity

(2009) Elisabeth H. Weiss et al.   TRANSPLANTATION

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

(2009) Marianne Oropeza et al.   XENOTRANSPLANTATION

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

(2009) Carol J. Phelps et al.   XENOTRANSPLANTATION

Current status of xenotransplantation and prospects for clinical application

(2009) Richard N. Pierson et al.   XENOTRANSPLANTATION

Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI

(2008) J. C. Roussel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Progress and prospects: Zinc-finger nucleases as gene therapy agents

(2008) D Carroll   GENE THERAPY

Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses

(2008) Jeff S. Isenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P17. Administration of Clodronate Confers Added Protection Against HALR

(2008) Tiffany A. Stoddard et al.   JOURNAL OF SURGICAL RESEARCH

Xenotransplantation: The next generation of engineered animals

(2008) Anthony J.F. d'Apice et al.   TRANSPLANT IMMUNOLOGY

Xenotransplantation of solid organs in the pig-to-primate model

(2008) Burcin Ekser et al.   TRANSPLANT IMMUNOLOGY

In Vitro Suppression of Xenoimmune-Mediated Macrophage Activation by Human CD4+CD25+ Regulatory T Cells

(2008) Yiling Fu et al.   TRANSPLANTATION

Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation

(2008) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Pre-treatment of porcine pulmonary xenograft with desmopressin: a novel strategy to attenuate platelet activation and systemic intravascular coagulation in an ex-vivo model of swine-to-human pulmonary xenotransplantation

(2008) Young Tae Kim et al.   XENOTRANSPLANTATION

Recombinant pig TFPI efficiently regulates human tissue factor pathways

(2008) K. F. Eddy Lee et al.   XENOTRANSPLANTATION

Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling

(2007) J. S. Isenberg et al.   BLOOD