Protein C anticoagulant system—anti-inflammatory effects

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice

(2010) Edward Kerschen et al.   JOURNAL OF CLINICAL INVESTIGATION

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

(2010) Chunzhang Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Far from the Heart: Counteracting coagulation

(2010) Charles T Esmon   NATURE MEDICINE

Role of Coagulation Factors in Cerebral Venous Sinus and Cerebral Microvascular Thrombosis

(2010) Mutsumi Nagai et al.   NEUROSURGERY

Activated Protein C Protects Against Myocardial Ischemia/ Reperfusion Injury via Inhibition of Apoptosis and Inflammation

(2009) Sarah T.B.G. Loubele et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

(2009) F. Niessen et al.   BLOOD

Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement

(2009) G. L. Van Sluis et al.   BLOOD

Role of activated protein C and its receptor in inhibition of tumor metastasis

(2009) M. Bezuhly et al.   BLOOD

Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock

(2009) J. XU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

INCREASE IN ACTIVATED PROTEIN C MEDIATES ACUTE TRAUMATIC COAGULOPATHY IN MICE

(2009) Brian B. Chesebro et al.   SHOCK

Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells

(2008) J.-S. BAE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS