Article
Pharmacology & Pharmacy
Lei He, Donglin Feng, Hui Guo, Yueyuan Zhou, Zhaozhao Li, Kuo Zhang, Wangqian Zhang, Shuning Wang, Zhaowei Wang, Qiang Hao, Cun Zhang, Yuan Gao, Jintao Gu, Yingqi Zhang, Weina Li, Meng Li
Summary: This study provides the first analysis of the pharmacokinetics of BPC157, showing linear pharmacokinetic characteristics in rats and beagle dogs. The main excretory pathways of BPC157 were found to be urine and bile. These findings are important for the clinical translation of BPC157.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Olga I. Butranova, Elena A. Ushkalova, Sergey K. Zyryanov, Mikhail S. Chenkurov, Elena A. Baybulatova
Summary: Infections pose significant risks for elderly patients, with high consumption of antimicrobial agents leading to increased toxicity, organ deterioration, longer hospital stays, ICU admissions, disability, and even death. The efficacy and safety of antibiotics in the elderly are influenced by age-related changes in physiological and pathological factors, affecting drug absorption, distribution, metabolism, and excretion. Pharmacokinetic changes in elderly patients are also influenced by factors like body composition, nutritional status, and concomitant drug use. Understanding these age-related pharmacokinetic alterations is crucial for optimizing antibiotic therapy in the elderly.
Article
Food Science & Technology
Shanoo Suroowan, Hassan Hadi Abdallah, Mohamad Fawzi Mahomoodally
Summary: Herbal and conventional medicine combination can be potentially dangerous, leading to perilous herb-drug interactions and toxicity. Different plant species have different pharmacological properties, and should not be mixed with drugs having the same properties. Herbal medicines should be used at low doses for a short period of time and under the supervision of healthcare professionals to avoid potential adverse and toxic effects.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Olga I. Butranova, Elena A. Ushkalova, Sergey K. Zyryanov, Mikhail S. Chenkurov
Summary: Neonatal infections, particularly neonatal sepsis, contribute significantly to mortality rates and require empiric antibiotic therapy. However, the rise of antibacterial resistance has led to the use of antibiotics from higher-risk groups associated with less clinical experience. Choosing the proper dosing regimen is complicated in neonates due to the high variability in the maturation of organ systems. The developmental changes of pharmacokinetic parameters in preterm and full-term infants should be considered in neonatal intensive care units.
Article
Pharmacology & Pharmacy
Wei Yin, T. Eric Ballard, Sean Xiaochun Zhu, Samuel Hsiao, Hao Chen, Yuexian Li, Swapan K. Chowdhury, Annette Stevenson, Tom Hui, Allen Hunt, Mahnaz Asgharnejad, Steve Han
Summary: This study suggests that soticlestat and its metabolites are rapidly cleared and eliminated, reducing the risk of dose accumulation from repeated dosing and supporting further investigation of soticlestat.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yvonne Fuell, Christian Wallasch, Ashley Hilton, Oliver Planz
Summary: This study reveals the absorption, distribution, metabolism, and excretion of Zapnometinib in rats. It has low absorption from the gastrointestinal tract, with most of it being excreted via feces. It is rapidly and widely distributed in circulatory and visceral tissues, but has low penetration into the brain.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Adam Truskewycz, Hong Yin, Nils Halberg, Daniel T. H. Lai, Andrew S. Ball, Vi Khanh Truong, Agata Marta Rybicka, Ivan Cole
Summary: This article discusses the therapeutic potential of carbon quantum dots (CQDs) in biomedical applications. CQDs have shown biocompatibility and have been used for drug solubility, targeting, and facilitating drug delivery. They can also be triggered by environmental conditions or external stimuli, and their fluorescence is valuable for diagnostic purposes. The article also examines the toxicity of CQDs and their compatibility with larger nanoparticle carriers. The future of CQDs in theragnostic applications looks promising due to their multifunctional attributes and biocompatibility.
Article
Environmental Sciences
Jeong Weon Choi, Munhee Kim, Geurim Song, Younglim Kho, Kyungho Choi, Mi-Yeon Shin, Sungkyoon Kim
Summary: In this study, the absorption, distribution, metabolism, and excretion of polycyclic aromatic hydrocarbons (PAHs) in humans were investigated. It was found that all the PAHs were rapidly absorbed and excreted in urine within a short period of time. The fractional urinary excretion of PAH metabolites ranged from 0.07% to 11.3%, with a half-life of 3.4 to 11.0 hours. Two-compartment models successfully described the toxicokinetic characteristics of each PAH.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Pharmacology & Pharmacy
Hirotaka Kushida, Takashi Matsumoto, Yasushi Ikarashi
Summary: Uncaria Hook contains active alkaloids with therapeutic effects on cardiovascular and central nervous system ailments. The pharmacokinetic studies show rapid absorption and metabolism of Uncaria Hook alkaloids, highlighting their importance for understanding treatment efficacy and safety. The neuroprotective effects of these alkaloids against diseases such as Alzheimer's and Parkinson's, as well as the challenges in pharmacokinetic differences between pure and crude drug products, offer potential for further research and development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Pengfei Li, Jun Peng, Yuexin Li, Lili Gong, Yali Lv, He Liu, Tianhong Zhang, Song Yang, Hongchuan Liu, Jinglai Li, Lihong Liu
Summary: This study systematically evaluated the pharmacokinetics, bioavailability, metabolism, and excretion of ASD in rats for the first time. The ultra-low oral bioavailability of ASD was confirmed to be due to poor gastrointestinal permeability, extensive pre-absorption degradation, and biotransformation. In addition to being excreted in urine and bile, ASD possibly undergoes complex metabolic elimination after intravenous administration.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Elka S. Waller, Ben J. Yardeny, Wan Yun Fong, Xue Yi Gan, Stephen V. Jimenez, Yijun Pan, Joshua H. Abasszade, Joseph A. Nicolazzo
Summary: Alzheimer's disease not only affects the neurological system but may also have an impact on other non-neurological systems, affecting the metabolism and excretion of drugs. Therefore, dosage adjustments may be necessary to ensure optimal pharmacotherapy for individuals with Alzheimer's disease.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Agriculture, Multidisciplinary
Lisha Wang, Zhi Wang, Tianji Xia, Fangrui Cao, Linhu Ye, Ruile Pan, Suwei Jin, Mingzhu Yan, Qi Chang
Summary: This study found that Cajaninstilbene acid (CSA) is primarily absorbed through passive transport and that metabolism is the major barrier limiting its oral bioavailability. Four new CSA metabolites were discovered in rats, mainly excreted through bile.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Editorial Material
Chemistry, Medicinal
Jacek R. Wisniewski
Summary: Accurate determination of protein abundances is crucial for understanding elimination mechanisms in tissues. Mass spectrometry and global proteomics are two common methods used for protein quantification, with the former allowing simple and accurate measurement of individual proteins, and the latter enabling quantification of hundreds to thousands of proteins in a single analysis.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Physical
Meng Ding, Lei Xu, Yumeng Zhang, Wei Li, Yuqing Zhao
Summary: A sensitive method was developed to detect AD-1 and its major metabolites in rat feces, showing the excretion profiles after oral administration which may help understand the poor bioavailability of AD-1. In silico ADME predictions suggest that the metabolites are non-toxic and have passive gastrointestinal absorption, while previous studies have shown a potent cytotoxicity of M5, a metabolite of AD-1, against ovarian cancer cells. Further molecular docking studies indicate that M5 effectively binds to PARP-1, providing potential novel solutions for treating ovarian cancer.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Chemistry, Medicinal
Vaclav Tvrdy, Jana Pourova, Eduard Jirkovsky, Vladimir Kren, Katerina Valentova, Premysl Mladenka
Summary: Silymarin, extracted from the seeds of Silybum marianum, contains flavonolignans and flavonoids and is used as a hepatoprotective agent. However, its low oral bioavailability and potential drug interactions have sparked debates. The main reasons for poor systemic oral bioavailability are rapid conjugation and efflux of flavonolignans, with most human studies showing no interactions with other drugs.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Jung Gi Lee, Jae Ha Ryu, Seon-Myung Kim, Moon-Young Park, San-Ho Kim, Young G. Shin, Jong-Woo Sohn, Ha Hyung Kim, Zee-Yong Park, Jae Young Seong, Jae Il Kim
BIOCHEMICAL PHARMACOLOGY
(2018)
Article
Biochemical Research Methods
Jin-Ju Byeon, Min-Ho Park, Seok-Ho Shin, Byeong ill Lee, Yuri Park, Jangmi Choi, Nahye Kim, Yeonjae Kang, Young G. Shin
BIOMEDICAL CHROMATOGRAPHY
(2018)
Article
Biochemical Research Methods
Min-Ho Park, Jin-Ju Byeon, Seok-Ho Shin, Nahye Kim, Yuri Park, Byeong Ill Lee, Jangmi Choi, Young G. Shin
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2018)
Article
Pharmacology & Pharmacy
Yuri Park, Nahye Kim, Jangmi Choi, Min-Ho Park, Byeong ill Lee, Seok-Ho Shin, Jin-Ju Byeon, Young G. Shin
Article
Biochemistry & Molecular Biology
Byeong ill Lee, Min-Ho Park, Seok-Ho Shin, Jin-Ju Byeon, Yuri Park, Nahye Kim, Jangmi Choi, Young G. Shin
Article
Biochemistry & Molecular Biology
Jin-Ju Byeon, Min-Ho Park, Seok-Ho Shin, Yuri Park, Byeong Ill Lee, Jang-mi Choi, Nahye Kim, Seo-jin Park, Min-jae Park, Jeong-hyeon Lim, Young-Guk Na, Young G. Shin
Article
Biochemistry & Molecular Biology
Byeong Ill Lee, Min-Ho Park, Jin-Ju Byeon, Seok-Ho Shin, Jangmi Choi, Yuri Park, Yun-Hee Park, Jeiwook Chae, Young G. Shin
Article
Biochemistry & Molecular Biology
Yuri Park, Min-Ho Park, Jin-Ju Byeon, Seok-Ho Shin, Byeong Ill Lee, Jang-mi Choi, Nahye Kim, Seo-jin Park, Min-jae Park, Jeong-hyeon Lim, Young G. Shin
Article
Biology
Seok-Ho Shin, Yuri Park, Min-Ho Park, Jin-Ju Byeon, Byeong Ill Lee, Jangmi Choi, Young G. Shin
Article
Pharmacology & Pharmacy
Byeong ill Lee, Seo-jin Park, Yuri Park, Seok-Ho Shin, Jang-mi Choi, Min-jae Park, Jeong-hyeon Lim, Sun Young Kim, Hyangsook Lee, Young G. Shin
Summary: The OHPAS linker exhibited stability in both in vitro and in vivo experiments, while the VC-PABC linker showed relative instability. This is attributed to the sensitivity of the VC-PABC linker to a hydrolytic enzyme present in mouse plasma. Further experiments are needed to fully evaluate the efficacy and toxicity of the OHPAS linker.
Article
Biochemistry & Molecular Biology
Jangmi Choi, Min-Ho Park, Seok-Ho Shin, Jin-Ju Byeon, Byeong Ill Lee, Yuri Park, Young G. Shin
Summary: The study found that the concentration of SAS in mouse brain was much lower than in plasma, with only a small percentage of SAS metabolized into significant metabolites SP and Ac-SP. The results suggest that metabolites such as SP and Ac-SP may be responsible for the pharmacological effects in the brain, rather than SAS itself.
Article
Chemistry, Multidisciplinary
Seo-jin Park, Byeong ill Lee, Min-Ho Park, Jangmi Choi, Yuri Park, Min-jae Park, Jeong-hyeon Lim, Jiyu Lee, Sangsoo Hwang, Jeongmin Lee, Young G. Shin
Summary: Trastuzumab emtansine (T-DM1) is the first FDA-approved ADC for metastatic HER2+ breast cancer. An immuno-affinity capture LC-MS/MS assay was developed to quantify the antibody-conjugated drug of T-DM1, which was successfully applied to evaluate linker stability in vitro and preclinical PK study in rats. This assay could be beneficial for other ADCs with similar linker-cytotoxic drug platform.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Minjae Park, Byeong Ill Lee, Jangmi Choi, Yuri Park, Seo-Jin Park, Jeong-Hyeon Lim, Jiyu Lee, Young G. Shin
Summary: A LC-qTOF-MS assay was developed for the evaluation of drug metabolism and pharmacokinetics properties of Daporinad in mice. The method showed good linearity, accuracy, precision, and stability. In vitro and in vivo metabolite identification studies were conducted, revealing a total of 25 metabolites and ten different types of metabolism.
Article
Biochemistry & Molecular Biology
Jeong-Hyeon Lim, Minjae Park, Yuri Park, Seo-Jin Park, Jiyu Lee, Sangsoo Hwang, Jeongmin Lee, Yujin Lee, Eunjeong Jo, Young G. Shin
Summary: There have been attempts to improve the pharmacokinetic characteristics of anti-tumor small-molecule drugs by conjugating them with large molecules such as monoclonal antibodies (ADCs). Albumin, a abundant protein in the blood, has also been proposed as a large molecule to be conjugated with anti-cancer small-molecule drugs. However, few studies have been conducted for the in vivo prepared albumin-drug conjugates due to the lack of robust bioanalytical methods. In this study, a bioanalytical method using immunoprecipitation and LC-qTOF/MS was developed for the quantification of albumin-conjugated MAC glucuronide phenol linked SN-38 in mouse plasma.
Article
Biochemical Research Methods
Byeong Ill Lee, Min-Ho Park, Soon Chul Heo, Yuri Park, Seok-Ho Shin, Jin-Ju Byeon, Jae Ho Kim, Young G. Shin
BIOMEDICAL CHROMATOGRAPHY
(2018)