Article
Multidisciplinary Sciences
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Summary: This study develops an experimental platform for tracking cancer stem cells in colorectal cancer and identifies dormant LGR5(+) cancer stem cells. Transcriptome analysis reveals an upregulation of cell-adhesion molecule COL17A1 in dormant cancer stem cells, and chemotherapy disrupts this dormancy through FAK-YAP activation. Inhibition of YAP signaling prevents chemoresistant cells from exiting dormancy and delays tumor regrowth.
Article
Oncology
Shengbo Han, Decai Wang, Yan Huang, Zhu Zeng, Peng Xu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Yuhang Hu, Fan Wang, Jie Wang, Yong Zhao, Wenfeng Zhuo, Gang Zhao
Summary: Research has shown that the emergence of Schwann cells around premalignant lesions of colon cancer may be an early indicator promoting tumorigenesis. This study explored the communication between colon cancer cells and Schwann cells, and identified NGF and exosomal miR-21-5p as potential therapeutic targets for colon cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Taohua Yue, Jichang Li, Jing Zhu, Shuai Zuo, Xin Wang, Yucun Liu, Jia Liu, Xiaoyun Liu, Pengyuan Wang, Shanwen Chen
Summary: Immunotherapy can be effective in treating cancer, but many colorectal cancer patients do not respond to it. This study shows that reducing H2S levels can help reverse the tumor-supportive functions and improve the efficacy of immunotherapy.
Review
Biochemistry & Molecular Biology
Md Rezaul Islam, Shopnil Akash, Md Mominur Rahman, Feana Tasmim Nowrin, Tamanna Akter, Sheikh Shohag, Abdur Rauf, Abdullah S. M. Aljohani, Jesus Simal-Gandara
Summary: Colon cancer is the world's second leading cause of cancer-related deaths, and its death rates have increased due to modern lifestyle. Natural compounds in medicinal plants show potential in combating colon cancer through activation of signaling pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Multidisciplinary Sciences
Jiexi Li, Zhengdao Lan, Wenting Liao, James W. W. Horner, Xueping Xu, Jielin Liu, Yohei Yoshihama, Shan Jiang, Hong Seok Shim, Max Slotnik, Kyle A. A. LaBella, Chang-Jiun Wu, Kenneth Dunner Jr, Wen-Hao Hsu, Rumi Lee, Isha Khanduri, Christopher Terranova, Kadir Akdemir, Deepavali Chakravarti, Xiaoying Shang, Denise J. J. Spring, Y. Alan Wang, Ronald A. A. DePinho
Summary: Sex plays an important role in cancer incidence, spectrum, and outcomes, particularly in colorectal cancer (CRC) where men have higher metastases and mortality rates. A study using a murine CRC model revealed that oncogenic mutant KRAS (KRAS*) CRC in males showed higher metastases and worse outcomes. Further analysis found that the Y-chromosome gene histone demethylase KDM5D, driven by KRAS*-mediated activation of the STAT4 transcription factor, contributed to the sex differences in KRAS* CRC. Deletion of Kdm5d in cancer cells improved tight junction integrity, reduced invasiveness, and enhanced cancer cell killing by CD8(+) T cells. On the contrary, mice with a Kdm5d transgene had a higher propensity for invasive tumors. Therefore, the upregulation of Y chromosome KDM5D via KRAS*-STAT4 pathway disrupts cancer cell adhesion properties and tumor immunity, providing a potential therapeutic strategy for reducing metastasis risk in men with KRAS* CRC.
Article
Oncology
Yansong Xu, Yi Chen, Chenyan Long, Huage Zhong, Fangfang Liang, Ling-xu Huang, Chuanyi Wei, Shaolong Lu, Weizhong Tang
Summary: Preoperative CEA level, grading, and PNI were identified as independent risk factors for LNM in colon cancer. The nomogram constructed in this study demonstrated good consistency and calibration capabilities for predicting LNM risk in both the training and validation sets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wojciech M. Ciszewski, Malgorzata Chmielewska-Kassassir, Lucyna A. Wozniak, Katarzyna Sobierajska
Summary: This study found a close correlation between TYMS and invasion ability in colon cancer cells, as well as its crucial role in EMT regulation. It suggests that chemotherapeutics targeting TYMS expression may enhance the effectiveness of colon cancer treatment, especially in the metastatic stage.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Xia Ji, Aisheng Dong
Summary: This case report describes the FDG PET/CT findings of a rare renal and postcaval lymph node metastasis from colon cancer, which showed increased FDG uptake and mimicked a primary renal cancer with postcaval lymph node metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jakub Rech, Daniel Sypniewski, Dorota Zelaszczyk, Natalia Szkaradek, Wojciech Rogoz, Anna Waszkielewicz, Henryk Marona, Ilona Bednarek
Summary: The study revealed that four novel xanthone derivatives have the potential to inhibit proliferation, motility, and induce apoptosis in colon cancer cells, with comparable activity to cisplatin and 5-fluorouracil. Further research and development of these compounds as novel drugs for colorectal cancer treatment is recommended.
Article
Immunology
Xuejie Li, Zuyi Yang, Bi Chen, Lei Gu, Guoyan Tian, Xinbing Sui
Summary: In this study, the expression of SOCS3 in colon primary tumor and lung metastasis, as well as its relationship with macrophages, was investigated. The results showed that high expression of SOCS3 was associated with poor prognosis and immune cell infiltration in various cancer types, particularly in colon cancer. Additionally, lung metastasis exhibited higher expression of CD163 and SOCS3, and high expression of SOCS3 was more likely to be associated with high expression of CD163 in lung metastasis. These findings suggest that SOCS3 could serve as a prognostic marker and therapeutic target for immunotherapy in different tumors, particularly in colon cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Arka Saha, Nancy Gavert, Thomas Brabletz, Avri Ben-Ze'ev
Summary: Induction of Mucin2 expression by L1 is required during mucinous colon cancer progression and can serve as a marker for diagnosis and a target for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Qinwen Tai, Wei Xue, Mengying Li, Shuli Zhuo, Heng Zhang, Fa Fang, Jinhui Zhang
Summary: A prediction model for the survival rates of metastatic colon cancer patients at 1-, 3-, and 5-years was developed using data from the SEER database. The model showed excellent predictive accuracy and can assist in clinical decision-making and individualized treatment.
FRONTIERS IN GENETICS
(2022)
Article
Biology
Tong Xu, Mathijs Verhagen, Rosalie Joosten, Wenjie Sun, Andrea Sacchetti, Leonel Munoz Sagredo, Veronique Orian-Rousseau, Riccardo Fodde
Summary: Phenotypic plasticity plays a crucial role in allowing carcinoma cells to acquire transient mesenchymal features for invasion and metastasis. Epithelial-to-mesenchymal (EMT) and mesenchymal-to-epithelial (MET) transitions are regulated by a broad range of epigenetic mechanisms, including alternative splicing (AS). In this study, we focus on the role of AS in eliciting phenotypic plasticity in colon cancer and identify specific RNA-binding proteins (RBPs) that alter AS patterns, leading to the generation of splicing isoforms associated with increased invasion and metastasis. Further validation studies show that these RBPs and splicing isoforms promote local invasion and distant metastasis in colon cancer and are associated with poor survival.
Article
Multidisciplinary Sciences
Navid Mohammad Mirzaei, Wenrui Hao, Leili Shahriyari
Summary: The complex network of cell and molecule interactions in the tumor microenvironment creates a diverse ecosystem. The proximity of cells and molecules to their activators and inhibitors is crucial for tumor progression. Using a combination of partial differential equations and linear elasticity, we investigate the impact of spatial interactions on the tumor microenvironment. Our findings reveal interesting patterns of cell and cytokine distribution influenced by macrophages. We also observe the recruitment and suppression of cytotoxic T cells at macrophage sites. Additionally, anti-tumor macrophages reorganize patterns in favor of a more spatially restricted cancer and necrotic core. Sensitivity analysis suggests that macrophages play a key role in controlling cancer cell population and spatial arrangement in the tumor microenvironment.
Article
Multidisciplinary Sciences
Mark Schmitt, Fatih Ceteci, Jalaj Gupta, Marina Pesic, Tim W. Bottger, Adele M. Nicolas, Kilian B. Kennel, Esther Engel, Matthias Schewe, Asude Callak Kirisozu, Valentina Petrocelli, Yasamin Dabiri, Julia Varga, Mallika Ramakrishnan, Madina Karimova, Andrea Ablasser, Toshiro Sato, Melek C. Arkan, Frederic J. de Sauvage, Florian R. Greten
Summary: In solid tumors, dying cancer cells release ATP and activate paracrine effects on neighboring tumor epithelial cells, triggering an mTOR-dependent pro-survival program and rendering the surviving epithelial cells sensitive to mTOR inhibition. This dependency is due to increased production of reactive oxygen species and DNA damage associated with neighboring cell death.