Review
Pharmacology & Pharmacy
Chenhui Ma, Li Han, Zheying Zhu, Cheng Heng Pang, Guoyu Pan
Summary: This review provides an overview of mineral metabolism and its relationship with the pathogenesis of NAFLD. Perturbation of minerals has been found to be associated with the pathological features of NAFLD and potential therapeutic strategies are highlighted. Future directions for targeting mineral metabolism in the treatment of NAFLD are also discussed.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Article
Biochemistry & Molecular Biology
Susara Madduma Hewage, Suvira Prashar, O. Karmin, Yaw L. Siow
Summary: Lingonberry supplementation can protect against high-fat diet-induced liver injury by alleviating hepatic lipid accumulation, oxidative stress, and inflammatory response.
Review
Biochemistry & Molecular Biology
Carlos Jimenez-Cortegana, Alba Garcia-Galey, Malika Tami, Pilar del Pino, Isabel Carmona, Soledad Lopez, Gonzalo Alba, Victor Sanchez-Margalet
Summary: NAFLD affects a quarter of the global population and poses a significant health and economic burden across all countries. The lack of approved pharmacotherapy and well-established diagnostic strategies for this disease highlights the urgency for further research and management efforts. Studies have shown a strong relationship between the hormone leptin and the development of NAFLD, suggesting potential advancements in disease management through further investigation of its role.
Article
Gastroenterology & Hepatology
Ramy Younes, Olivier Govaere, Salvatore Petta, Luca Miele, Dina Tiniakos, Alastair Burt, Ezio David, Fabio Maria Vecchio, Marco Maggioni, Daniela Cabibi, Duncan McLeod, Maria Jesus Pareja, Anna Ludovica Fracanzani, Rocio Aller, Chiara Rosso, Javier Ampuero, Rocio Gallego-Duran, Angelo Armandi, Gian Paolo Caviglia, Marco Y. W. Zaki, Antonio Liguori, Paolo Francione, Grazia Pennisi, Antonio Grieco, Giovanni Birolo, Piero Fariselli, Mohammed Eslam, Luca Valenti, Jacob George, Manuel Romero-Gomez, Quentin Mark Anstee, Elisabetta Bugianesi
Summary: Lean Caucasian subjects with NAFLD may progress to advanced liver disease, develop metabolic comorbidities, and experience cardiovascular disease and liver-related mortality, independent of longitudinal progression to obesity and PNPLA3 genotype. These patients represent one end of a wide spectrum of phenotypic expression of NAFLD.
Review
Biochemistry & Molecular Biology
Yoon Mee Yang, Ye Eun Cho, Seonghwan Hwang
Summary: Alcoholic liver disease (ALD), caused by excessive alcohol consumption, results in liver damage. Studies have shown that there is a relationship between hepatic oxidative stress and inflammatory responses, which may be useful for developing therapeutic approaches for ALD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Stephen D. H. Malnick, Pavel Alin, Marina Somin, Manuela G. Neuman
Summary: Both alcohol-induced liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) involve abnormal fat accumulation in the liver, potentially caused by excessive alcohol consumption and the combination of alcohol consumption and medications. The liver pathology is similar in both conditions, progressing from simple steatosis to inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Evaluating the medical history of alcohol consumption, laboratory markers, AST/ALT ratio, and features of the metabolic syndrome can help estimate the contribution of alcohol intake and metabolic syndrome to liver steatosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Shendong Wang, Zhaojun Liu, Jiafeng Geng, Liangge Li, Xiujing Feng
Summary: Non-alcoholic fatty liver disease (NAFLD) is a global public health problem with no specific drug to reverse it. Ferroptosis has been implicated in the progression of NAFLD, although its mechanism of action remains poorly understood.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Daryl Ramai, Antonio Facciorusso, Erika Vigandt, Bryan Schaf, Waleed Saadedeen, Aditya Chauhan, Sara di Nunzio, Aashni Shah, Luca Giacomelli, Rodolfo Sacco
Summary: NASH is a chronic and progressive form of non-alcoholic fatty liver disease with increasing global incidence, posing an epidemic and public health threat. The disease is associated with major morbidity and mortality, with patients at risk of developing hepatocellular carcinoma. Current evidence suggests a multi-hit model involving various pathways leading to progressive fibrosis and oncogenesis, highlighting the complexity of the disease.
Review
Environmental Sciences
Alexey A. Tinkov, Michael Aschner, Abel Santamaria, Alfred R. Bogdanov, Yousef Tizabi, Miriam B. Virgolini, Ji-Chang Zhou, Anatoly V. Skalny
Summary: The objective of this study was to review existing epidemiological and laboratory findings supporting the role of toxic metal exposure in non-alcoholic fatty liver disease (NAFLD). The existing studies demonstrate a link between exposure to cadmium, lead, arsenic, and mercury and an increased risk of NAFLD, as well as altered liver injury markers. Laboratory studies also show that metal exposure leads to hepatic lipid accumulation and affects metabolic pathways and inflammatory response.
ENVIRONMENTAL RESEARCH
(2023)
Review
Medicine, General & Internal
Elizabeth E. Powell, Vincent Wai-Sun Wong, Mary Rinella
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common global health issue with significant associations with metabolic syndrome and type 2 diabetes, leading to serious complications like cirrhosis and hepatocellular carcinoma. While cardiovascular disease and extrahepatic malignancy are the main causes of death in NAFLD patients, advanced liver fibrosis is a key prognostic marker for liver-related outcomes and overall mortality.
Review
Biochemistry & Molecular Biology
Aleksandra Hliwa, Bruno Ramos-Molina, Dariusz Laski, Adriana Mika, Tomasz Sledzinski
Summary: Non-alcoholic fatty liver disease (NAFLD) is a major global public health problem characterized by alterations in hepatic lipid metabolism that can lead to serious liver complications. Mass spectrometry-based lipidomics platforms allow for in-depth analysis of lipid changes in NAFLD patients, focusing on alterations in long-chain and short-chain fatty acids levels as well as the expression of genes encoding lipid interconversion enzymes in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Rafael Paternostro, Michael Trauner
Summary: Non-alcoholic fatty liver disease (NAFLD) is a liver disease with various pathologies. In addition to lifestyle changes and a few specific medications, there are new treatment options being studied. Treating complications of end-stage liver disease caused by non-alcoholic steatohepatitis (NASH) is important for the treatment of the complete clinical spectrum of NAFLD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Immunology
Yamei Duan, Xiongfeng Pan, Jiayou Luo, Xiang Xiao, Jingya Li, Prince L. Bestman, Miyang Luo
Summary: This study found a significant association between inflammatory cytokines and non-alcoholic fatty liver disease (NAFLD). Increased concentrations of C-reactive protein (CRP), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and intercellular adhesion molecule-1 (ICAM-1) were significantly associated with increased risks of NAFLD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marta Alonso-Pena, Maria Del Barrio, Ana Peleteiro-Vigil, Carolina Jimenez-Gonzalez, Alvaro Santos-Laso, Maria Teresa Arias-Loste, Paula Iruzubieta, Javier Crespo
Summary: Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disorders ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). NAFLD could result from dysfunction in multiple pathways and various molecular triggers. NASH involves inflammatory and fibrotic processes. Additionally, NAFLD is closely associated with several extra-hepatic comorbidities. Due to the heterogeneity and multifactorial etiology of NAFLD, clinical trials for treatment have had limited success. A narrative review of the phenotypic characteristics of NAFLD patients and personalized treatment could lead to better outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Andrea A. Howard, Donald R. Hoover, Kathryn Anastos, Xi Wu, Qiuhu Shi, Howard D. Strickler, Stephen R. Cole, Mardge H. Cohen, Andrea Kovacs, Michael Augenbraun, Patricia S. Latham, Phyllis C. Tien
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2010)
Article
Surgery
Claire R. Edwards, A. Katharine Hindle, Patricia S. Latham, Sidney W. Fu, Fred J. Brody
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2013)
Article
Multidisciplinary Sciences
Ali Ramezani, Thomas D. Nolin, Ian R. Barrows, Myrna G. Serrano, Gregory A. Buck, Renu Regunathan-Shenk, Raymond E. West, Patricia S. Latham, Richard Amdur, Dominic S. Raj
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Jacqueline Olender, Bi-Dar Wang, Travers Ching, Lana X. Garmire, Kaitlin Garofano, Youngmi Ji, Tessa Knox, Patricia Latham, Kenneth Nguyen, Johng Rhim, Norman H. Lee
MOLECULAR CANCER RESEARCH
(2019)
Article
Microbiology
Aileen Y. Chang, Sarah R. Tritsch, Abigail J. Porzucek, Arnold M. Schwartz, Margaux Seyler-Schmidt, Arielle Glass, Patricia S. Latham, St. Patrick Reid, Gary L. Simon, Christopher N. Mores
Summary: The article discusses the development of a mouse model for post-acute arthritis of chikungunya and how it could be used to study potential novel therapies for CHIKV arthritis.
Article
Cell Biology
Shuyun Rao, Xiaochun Yang, Kazufumi Ohshiro, Sobia Zaidi, Zhanhuai Wang, Kirti Shetty, Xiyan Xiang, Md Imtaiyaz Hassan, Taj Mohammad, Patricia S. Latham, Bao-Ngoc Nguyen, Linda Wong, Herbert Yu, Yousef Al-Abed, Bibhuti Mishra, Michele Vacca, Gareth Guenigault, Michael E. D. Allison, Antonio Vidal-Puig, Jihane N. Benhammou, Marcus Alvarez, Paivi Pajukanta, Joseph R. Pisegna, Lopa Mishra
Summary: The study found that SPTBN1 promotes the development of NASH and liver cancer, and intervention in SPTBN1 can protect mice from damage caused by a high-fat diet, making it a potential therapeutic target.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ashutosh S. Yende, Emily C. Williams, Andrew Pletcher, Alexandra Helfand, Helen Ibeawuchi, Tanya M. North, Patricia S. Latham, Anelia Horvath, Maho Shibata
Summary: TRIM28 is found to be significantly upregulated in high-grade and metastatic prostate cancers. Through a genetically-engineered mouse model, scientists discovered that TRIM28 plays an important role in the progression of prostate cancer. Despite a reduction in luminal cells resembling proximal luminal lineage cells, the mouse prostates still evolved into invasive prostate carcinoma with a shorter overall survival.
Article
Multidisciplinary Sciences
Sarah R. Tritsch, Abigail J. Porzucek, Arnold M. Schwartz, Abigale M. Proctor, Richard L. Amdur, Patricia S. Latham, Gary L. Simon, Christopher N. Mores, Aileen Y. Chang
Summary: Chikungunya virus (CHIKV) can cause persistent arthritis in patients, but there is no standard treatment available. Preliminary data suggests that decreased IL2 levels and Treg dysfunction may play a role in the development of CHIKV arthritis.
SCIENTIFIC REPORTS
(2023)
Letter
Nutrition & Dietetics
WMN Ratnayake, GS Gilani
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2003)
Article
Nutrition & Dietetics
SJ Bhathena, AA Ali, C Haudenschild, P Latham, T Ranich, AI Mohamed, CT Hansen, MT Velasquez
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2003)
Article
Oncology
T Ikegami, L Ha, K Arimori, P Latham, K Kobayashi, S Ceryak, Y Matsuzaki, B Bouscarel