Review
Biochemistry & Molecular Biology
Lesley Jia Wei Pua, Chun-Wai Mai, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Chee-Onn Leong, Wei-Meng Lim, Ling-Wei Hii
Summary: JNK and p38 MAPK signaling pathways play important roles in nasopharyngeal carcinoma (NPC), promoting tumor processes such as cell proliferation, apoptosis, inflammation, metastasis, and angiogenesis. Although the underlying mechanisms are not fully understood, further research on JNK and p38 MAPK could provide important insights for diagnosis, prognosis, and treatment decision-making in NPC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Serhii A. Liakhov, Igor A. Schepetkin, Olexander S. Karpenko, Hanna Duma, Nadiia M. Haidarzhy, Liliya N. Kirpotina, Anastasia R. Kovrizhina, Andrei Khlebnikov, Irina Y. Bagryanskaya, Mark T. Quinn
Summary: In this study, 13 derivatives of a JNK inhibitor were synthesized, with 8 compounds showing submicromolar binding affinity for at least one JNK isoform, and most of them exhibiting anti-inflammatory effects. Selected compounds also directly confirmed JNK inhibition, indicating their potential as lead compounds for anti-inflammatory drug development.
Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Article
Gastroenterology & Hepatology
Lili Fu, Zhongming Wu, Yanjun Chu, Wenbin Chen, Ling Gao, Shumin Mu, Jiajun Zhao
Summary: The study revealed the therapeutic effects of Astragalus mongholicus Bunge (AMB) on nonalcoholic fatty liver disease (NAFLD). Quercetin was identified as the main active component of AMB, which alleviated NAFLD by regulating the AMPK/MAPK/TNF-alpha and AMPK/ACC/CPT1 alpha signaling pathways to inhibit inflammation and lipid accumulation.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2022)
Article
Cardiac & Cardiovascular Systems
Jing Tan, Wei Gao, Wanchao Yang, Xianzhang Zeng, Linlin Wang, Xiaoguang Cui
Summary: JNK1 exacerbates ischemia-reperfusion injury in lung transplantation, while JNK2 alleviates it. JNK1 silencing attenuates lung graft dysfunction by inhibiting inflammation and apoptosis.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Hyunwook Cho, Jung-Mi Hah
Summary: JNK3 plays a crucial role in neurodegenerative diseases, and this study summarizes the research on JNK3 inhibitors, focusing on structural and docking insights.
Article
Biochemistry & Molecular Biology
Tzu-Yu Hou, Shi-Bei Wu, Hui-Chuan Kau, Chieh-Chih Tsai
Summary: This study found that TGF-beta 1 induced myofibroblast transdifferentiation in human Graves' orbital fibroblasts through the p38 and JNK pathways, resulting in upregulation of CTGF, α-SMA, fibronectin, TIMP-1, and TIMP-3, while inhibiting the activities of MMP-2/-9.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Igor A. Schepetkin, Anastasia R. Kovrizhina, Ksenia S. Stankevich, Andrei I. Khlebnikov, Liliya N. Kirpotina, Mark T. Quinn, Matthew J. Cook
Summary: This study synthesized a panel of novel tryptanthrin oxime analogs and evaluated their binding affinity to JNK1-3 and inhibition of cellular inflammatory responses. Compound 1j exhibited high binding affinity to JNK1-3 and demonstrated anti-inflammatory activity by inhibiting the production of multiple proinflammatory cytokines. Molecular modeling confirmed the binding mode of 1j to JNK3.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zhigang Fang, Hyeong-Geug Kim, Menghao Huang, Kushan Chowdhury, Ming O. Li, Suthat Liangpunsakul, X. Charlie Dong
Summary: This study demonstrates the protective role of Sesn1/2/3 in hepatic lipotoxicity-induced oxidative stress by reducing JNK phosphorylation and activity, leading to decreased lipotoxicity and oxidative stress in liver cells.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olivia Molinar-Inglis, Jacob M. Wozniak, Neil J. Grimsey, Lennis B. Orduna-Castillo, Norton Cheng, Ying Lin, Monica L. Gonzalez Ramirez, Cierra A. Birch, John D. Lapek, David J. Gonzalez, JoAnn Trejo
Summary: This study identified candidate proteins regulated by PAR1-p38 signaling that may play important roles in endothelial dysfunction, by analyzing the global phosphoproteome in human cultured endothelial cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Oncology
Keiko Tanimura, Tadaaki Yamada, Mano Horinaka, Yuki Katayama, Sarina Fukui, Kenji Morimoto, Takayuki Nakano, Shinsaku Tokuda, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Junji Uchino, Kazue Yoneda, Seiji Yano, Toshiyuki Sakai, Koichi Takayama
Summary: Through activation of the JNK/c-Jun signaling, novel adaptive resistance has been identified as a key factor leading to failure of ALK-TKIs treatment, suggesting that combination therapy targeting JNK and ALK-TKIs may significantly delay regrowth of lung cancer cells and potentially improve patient outcomes.
Article
Biochemistry & Molecular Biology
Anna A. Zhdankina, Dmitry I. Tikhonov, Sergey V. Logvinov, Mark B. Plotnikov, Andrei I. Khlebnikov, Nataliya G. Kolosova
Summary: Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment worldwide. JNK inhibitor IQ-1S shows potential in preventing and treating AMD, as it improves histological abnormalities associated with retinopathy in the OXYS rat model, including improved blood circulation, increased functional activity of the retinal pigment epithelium, reduced VEGF expression, and increased PEDF expression.
Article
Biochemistry & Molecular Biology
Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska, Mark T. Quinn
Summary: The JNK family, including JNK1-3 proteins, regulates various physiological processes. The study aimed to find JNK inhibitors with high selectivity for JNK3. 26 new tryptanthrin-6-oxime analogs were synthesized and evaluated, and compounds 4d and 4e showed high selectivity for JNK3 and inhibited inflammatory responses. The results suggest the potential for developing anti-inflammatory drugs with selectivity for JNK3.
Article
Oncology
Yaofeng Xu, Yuguo Gu, Wanbo Ji, Qirong Dong
Summary: The study explored the activation of ERK and JNK signaling pathway and osteogenesis-related factors in knee osteoarthritis patients. The levels of P-JNK, P-ERK, and OMD were significantly altered in the subchondral bone of knee arthritis participants, as well as in the model group of mice. Treatment with anisomycin showed varying effects on osteoblasts, influencing OMD and OCN levels.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Agriculture, Multidisciplinary
Wan Wang, Cong Xu, Xuan Zhou, Le Zhang, Liya Gu, Zhijing Liu, Jiage Ma, Juncai Hou, Zhanmei Jiang
Summary: This study explored the effects of probiotics and prebiotics in alleviating neurodegenerative diseases. The combination of Lactobacillus plantarum and galactooligosaccharides was found to reduce oxidative stress and increase levels of nuclear factor erythroid 2-related factor 2 in the brain. Additionally, the combination regulated the gut microbiota metabolite butyrate, which inhibited expression of p-JNK, downregulated pro-apoptotic proteins and inflammatory mediators, and upregulated synaptic protein expression. This suggests that Lactobacillus plantarum combined with galactooligosaccharides may have potential in alleviating neurodegeneration and memory impairment induced by D-galactose.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)