Article
Endocrinology & Metabolism
Brittany A. Stork, Adam Dean, Andrea R. Ortiz, Pradip Saha, Nagireddy Putluri, Maricarmen D. Planas-Silva, Iqbal Mahmud, Kimal Rajapakshe, Cristian Coarfa, Stefan Knapp, Philip L. Lorenzi, Bruce E. Kemp, Benjamin E. Turk, John W. Scott, Anthony R. Means, Brian York
Summary: CaMKK2 plays a central role as a metabolic fuel sensor in the liver, contributing significantly to whole body systems metabolism. The study reveals that CaMKK2 ablation improves peripheral insulin sensitivity by promoting glucose metabolism through phosphorylation and regulation of GAPDH, and by reducing peroxisomal fatty acid catabolism through modulation of PEX3.
MOLECULAR METABOLISM
(2022)
Article
Chemistry, Multidisciplinary
Lele Ji, Ya Zhao, Linjie He, Jing Zhao, Tian Gao, Fengzhou Liu, Bingchao Qi, Fei Kang, Gang Wang, Yilin Zhao, Haitao Guo, Yuanfang He, Fei Li, Qichao Huang, Jinliang Xing
Summary: The study reveals that AKAP1 in brown adipocytes plays a role in regulating energy expenditure and fatty acid oxidation, making it a potential therapeutic target for obesity. Inhibiting AKAP1 effectively alleviates obesity and insulin resistance.
Article
Endocrinology & Metabolism
Qihang Li, Meng Zhao, Yupeng Wang, Fang Zhong, Jing Liu, Ling Gao, Jiajun Zhao
Summary: This study found that high circulating free fatty acid (FFA) levels were associated with the development of diabetes. The longitudinal changes and sustained high levels of serum FFA were more closely linked to a higher risk of incident diabetes compared to high baseline FFA levels.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jinyan Nan, Ji Seon Lee, Seung-Ah Lee, Dong-Sup Lee, Kyong Soo Park, Sung Soo Chung
Summary: The study showed that ACSL1 localizes to the outer membrane of mitochondria in C2C12 myotubes through interaction with CPT1b, and overexpression of ACSL1 increased FAO rates and improved insulin resistance. Targeting ACSL1 to mitochondria is crucial for enhancing FAO in myotubes and reducing insulin resistance in obesity-related metabolic disorders.
MOLECULES AND CELLS
(2021)
Article
Cell Biology
Danja J. Den Hartogh, Filip Vlavcheski, Adria Giacca, Rebecca E. K. MacPherson, Evangelia Tsiani
Summary: This study found that carnosic acid (CA) in rosemary extract can alleviate palmitate-induced insulin resistance and restore insulin-stimulated glucose uptake and GLUT4 levels. Additionally, CA inhibited the phosphorylation/activation of JNK, mTOR, and p70S6K and activated AMPK.
Article
Chemistry, Medicinal
Qingxuan Zeng, Hongbin Deng, Yinghong Li, Tianyun Fan, Yang Liu, Sheng Tang, Wei Wei, Xiaojia Liu, Xixi Guo, Jiandong Jiang, Yanxiang Wang, Danqing Song
Summary: Berberine directly targets the NEK7 protein via hydrogen bonding, inhibiting the NEK7-NLRP3 interaction and subsequent IL-1 beta release. NEK7 is considered a key target of BBR in the treatment of NLRP3-related inflammatory diseases, and the development of novel inhibitors targeting the NEK7-NLRP3 interaction may be achievable.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mona Synnove Bjune, Carine Lindquist, Marit Hallvardsdotter Stafsnes, Bodil Bjorndal, Per Bruheim, Thomas A. Aloysius, Ottar Nygard, Jon Skorve, Lise Madsen, Simon N. Dankel, Rolf Kristian Berge
Summary: This study explored the link between fatty acid oxidation, amino acid metabolism, and TCA cycle-related intermediate metabolites using synthetic fatty acid analogues in male Wistar rats. The results indicated that hepatic expression of Hibch was significantly increased in rats treated with 3-thia fatty acids, leading to enhanced fatty acid oxidation and ketogenesis. Plasma 3-HIB and MMA were identified as novel markers reflective of altered hepatic fatty acid flux in this model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Pharmacology & Pharmacy
Minmin Gong, Huiyan Duan, Fan Wu, Yanlin Ren, Jing Gong, Lijun Xu, Fuer Lu, Dingkun Wang
Summary: This study revealed that berberine can modulate the LTB4-BLT1 axis to alleviate insulin resistance and inflammation, suggesting a potential anti-inflammatory and anti-diabetic function of this compound.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Andre C. Carpentier
Summary: Insulin plays a significant role in regulating adipose tissue fatty acid metabolism by inhibiting NEFA flux. Insulin resistance in adipose tissue may lead to various metabolic abnormalities and complications of diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Mattia Quattrocelli, Michelle Wintzinger, Karen Miz, Manoj Panta, Ashok D. Prabakaran, Grant D. Barish, Navdeep S. Chandel, Elizabeth M. McNally
Summary: This study found that intermittent use of glucocorticoids can improve metabolic status, exercise tolerance, and energy expenditure in mice with diet-induced obesity. These effects are associated with the regulation of adiponectin, and are achieved through the modulation of glucocorticoid receptor and the CAMKK2-AMPK cascade in muscle metabolism.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Sport Sciences
Xiquan Weng, Chaoge Wang, Yu Yuan, Zhenhuan Wang, Jujiao Kuang, Xu Yan, Hao Chen
Summary: The study investigated the effects of exercise and cold exposure on insulin sensitivity and serum free fatty acid levels in diet-induced obese rats. The results showed that both exercise and cold exposure independently reduced insulin resistance. Exercise reduced serum free fatty acids, while cold exposure had no effect. There was a positive correlation between insulin resistance and serum free fatty acid levels. The combination of exercise and cold exposure reduced subcutaneous and visceral fat ratios. Additionally, exercise and cold exposure increased protein expression related to fatty acid uptake and oxidation in muscle.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Biochemistry & Molecular Biology
Ashraf Nahle, Yemisi Deborah Joseph, Sandra Pereira, Yusaku Mori, Frankie Poon, Hilda E. Ghadieh, Aleksandar Ivovic, Tejas Desai, Simona S. Ghanem, Suman Asalla, Harrison T. Muturi, Emelien M. Jentz, Jamie W. Joseph, Sonia M. Najjar, Adria Giacca
Summary: The study showed that NMN can improve glucose tolerance caused by a high-fat diet, but it may impair glucose tolerance under normal levels of free fatty acids. Therefore, caution should be exercised when considering the therapeutic use of NMN due to its dual effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Katarzyna Lipke, Adriana Kubis-Kubiak, Agnieszka Piwowar
Summary: Free fatty acids (FFAs) play vital roles in the organism but disturbances in fatty acid homeostasis can lead to lipotoxicity, contributing to the development of diseases such as insulin resistance and diabetes. Lipotoxic effects primarily affect organs such as the pancreas, liver, skeletal muscles, cardiac muscle, and kidneys.
Article
Pharmacology & Pharmacy
Enxue Tan, Zhihong Gao, Qian Wang, Baosheng Han, Honghong Shi, Lihua Wang, Guozhen Zhu, Yanjuan Hou
Summary: Berberine alleviates renal fibrosis by inhibiting NLRP3 inflammasome activation and protects tubular epithelial cells by promoting fatty acid beta-oxidation.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)