Article
Chemistry, Physical
Tessa Gilmore, Pelagia-Irene Gouma
Summary: This perspective discusses two types of functional nanomaterials, amyloid fibrils and metal oxide nanowires and nanogrids, which rely on their polymorphism to exhibit important properties in sensing and catalysis.
Review
Pharmacology & Pharmacy
Yalin Cong, Didar Baimanov, Yunlong Zhou, Chunying Chen, Liming Wang
Summary: Inorganic nanomaterials (INMs) have attractive applications in biomedical fields, but their delivery is hindered by biological barriers. The structure and components of biological barriers, as well as the physicochemical properties of INMs, contribute to their penetration capacity.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biophysics
Dhesmon Lima, Ariane Ribicki, Luana Goncalves, Ana Carolina Mendes Hacke, Luma Clarindo Lopes, Romaiana Picada Pereira, Karen Wohnrath, Sergio Toshio Fujiwara, Christiana Andrade Pessoa
Summary: A new hybrid organic-inorganic silsesquioxane material, SiAMPy(+)Cl(-), was synthesized and used to successfully generate stable nanoconjugates with gold nanoparticles. The nanoconjugates were applied in the construction of electrochemical immunosensing devices and showed great potential for fast and accurate diagnosis of Chagas disease.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Mengyuan Wang, Shizhuo Su, Xin Zhong, Derui Kong, Bo Li, Yujie Song, Chunman Jia, Yifan Chen
Summary: A novel redox-active organic-inorganic hybrid material based on tetrathiafulvalene derivatives and titanium dioxide has been synthesized, demonstrating remarkably enhanced photocatalytic performance. Characterizations of the hybrid reveal advantages such as stability and separation of photogenerated charges.
Article
Chemistry, Multidisciplinary
Masoud Mohammadi, Minoo Khodamorady, Bahman Tahmasbi, Kiumars Bahrami, Arash Ghorbani-Choghamarani
Summary: This review discusses the use of alpha and gamma-alumina as coatings and in various fields, as well as the synthesis of boehmite nanoparticles and their potential application as catalysts. Various methods for synthesizing boehmite nanoparticles and the factors influencing their properties are reviewed, along with the discussion on different types of catalysts immobilized on boehmite nanoparticles.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Polymer Science
Houssem Chabane, Sebastien Livi, Xavier P. Morelle, Rodolphe Sonnier, LoicDumazert, Jannick Duchet-Rumeau, Jean-Francois Gerard
Summary: Designing innovative multi-functional thermoset polymers is a major challenge in materials science. In this study, two novel polyhedral imidazolium ionic liquids supported on oligomeric silsesquioxane nanocages were synthesized and utilized to nanostructure a model epoxy network. The resulting ionic hybrid O/I epoxy-amine networks exhibit excellent thermal stability, hydrophobicity, mechanical performances, and improved fire resistance compared to their neat counterparts.
Review
Chemistry, Multidisciplinary
Chumei Ye, Lauren N. McHugh, Celia Chen, Sian E. Dutton, Thomas D. Bennett
Summary: Crystalline materials have been crucial for the development of hybrid organic-inorganic perovskites (HOIPs), leading to interesting applications like solar cells and optoelectronic devices. Recently, the glassy state of HOIPs, which retains the basic building blocks of crystalline HOIPs but lacks long-range periodic order, has been discovered. The emerging family of glasses formed from HOIPs exhibit diverse properties complementary to their crystalline state. This mini review highlights the chemical diversity of 3D and 2D crystalline HOIPs and showcases the production of glasses from these materials, with a focus on achievements in melt-quenched glasses. Our perspective on the future of this new family of materials is also provided.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Jongbeom Na, Dehua Zheng, Jeonghun Kim, Mengyou Gao, Alowasheeir Azhar, Jianjian Lin, Yusuke Yamauchi
Summary: Smart supercapacitors are a promising energy storage solution due to their high power density, long cycle life, and low-maintenance requirements. Functional polymers and inorganic nanomaterials are used for their mechanical and energy storage properties, enabling commercial applications in flexible wearables, displays, and self-generation. Combining organic and inorganic hybrid materials is deemed the best option for realizing smart supercapacitors, facilitating new strategies for material synthesis in smart energy storage applications.
Article
Chemistry, Physical
Ana Cristina Martinez, Walid Dachraoui, Rajesh Murugesan, Emmanuel Baudrin, Arnaud Demortiere, Matthieu Becuwe
Summary: The study investigates the impact of chemical surface modification on the electrochemical response of nanometric lithium iron phosphate using a hybrid organic/inorganic approach. It was found that the redox mediator grafting approach has an unpredictable impact on the electrochemical activity of the material.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
Lili Tan, Shang-Jie Yu, Yiran Jin, Jiaming Li, Peng-peng Wang
Summary: We report the first class of chiral plasmonic metal-semiconductor core-shell nanostructures that utilize structurally chiral nanoparticles as chirality inducing templates to grow functional shell materials. The core-shell structures exhibit enhanced and tunable chiroptical activity, and can drive chirality-dependent photocatalytic hydrogen generation under circularly polarized light.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Fan Yuan, Youyuan Xia, Qin Lu, Qin Xu, Yun Shu, Xiaoya Hu
Summary: The flexible electrochemical sensor has great potential in personalized medical testing as it can continuously track physiological signals without discomfort or invasiveness. However, its development currently faces difficulties such as limited conductive material properties and the inability of commonly used flexible substrates to withstand high temperatures. This work classified commonly used inorganic nanomaterials for flexible electrochemical sensors according to their morphology and introduced the fabrication methods for nanomaterial-based sensors. Additionally, the application and detection performance of flexible electrochemical sensors for chemical and biological sensing were summarized.
Review
Chemistry, Physical
Ming-Hsien Chan, Zhi-Xuan Chang, Chi-Ying F. Huang, L. James Lee, Ru-Shi Liu, Michael Hsiao
Summary: This review article focuses on the potential of using biomimetic nanoparticles derived from exosomes as drug carriers in cancer therapy, highlighting their targeting capabilities and biocompatibility. Challenges in exosome research include inefficient separation methods, difficulties in characterization/tracking, and a lack of specific biomarkers.
NANOSCALE HORIZONS
(2022)
Article
Chemistry, Multidisciplinary
Junjun Liu, Lin Yang, Ping Qin, Shiqing Zhang, Ken Kin Lam Yung, Zhifeng Huang
Summary: Inorganic nanoparticles are a versatile platform for biomedical applications, particularly in the study and application of chiral effects. Recent research focuses on characterizing 3D stereochirality, bionic fabrication of hierarchical chirality, studying optical activities, and experimental demonstration in biomedical applications. These studies pave the way for fully understanding and utilizing chiral effects in the design and fabrication of inorganic chiral nanoparticles for practical problem-solving in environment and public health.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Qianwen Guan, Tingting Zhu, Zeng-Kui Zhu, Huang Ye, Shihai You, Peng Xu, Jianbo Wu, Xinyi Niu, Chengshu Zhang, Xitao Liu, Junhua Luo
Summary: In this study, a pair of unprecedented three-dimensional chiral halide perovskitoids was successfully synthesized, demonstrating unique chiroptoelectronic performance. The new material exhibited natural chiroptical activity and the ability to distinguish circularly polarized light, as well as sensitive X-ray detection performance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Inorganic & Nuclear
Maciej Ptak, Adam Sieradzki, Mantas Simenas, Miroslaw Maczka
Summary: The article provides an overview of the unique properties of hybrid organic-inorganic perovskites (HOIPs) and their importance in modern materials chemistry, highlighting the use of molecular spectroscopy methods in studying HOIPs.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Analytical
Harsha P. Gunawardena, Yongling Ai, Jinshan Gao, Richard N. Zare, Hao Chen
Summary: Microdroplet reactions have attracted attention for their ability to accelerate reactions, such as ultrafast protein digestion occurring in less than 1 ms. This study integrated a microdroplet protein digestion technique with automated sample flow injection and online mass spectrometry (MS) analysis, resulting in a rapid and reliable method for characterizing monoclonal antibodies (mAbs). The method allows for the assessment of the safety and quality of antibody drugs through structural characterization.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xiaowei Song, Qingce Zang, Chao Li, Tianhao Zhou, Richard N. N. Zare
Summary: We developed an immunoassay-based desorption electrospray ionization mass spectrometry imaging (immuno-DESI-MSI) technique for visualizing functional macromolecules. Boronic acid mass tags (BMTs) were synthesized to label antibodies as MSI probes, which can be released from the antibody by cleaving the boronic ester bond under acidic conditions. The BMTs can work in both optical and MS imaging modes and can be readily identified due to the introduction of the boron element.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Mohammad Mofidfar, Xiaowei Song, John T. T. Kelly, Mitchell H. H. Rubenstein, Richard N. N. Zare
Summary: Using silicone wristband electrospray ionization mass spectrometry (SWESI-MS), the internal surface of a wristband can be exposed to sweat metabolites and the external surface can be exposed to environmental factors. A small amount of a water:methanol solution can effectively extract metabolites and chemicals from various sources. This method allows for onsite sampling, simple testing, and automatic data searching, making it suitable for monitoring hazardous chemical contamination and sweat-secreted metabolites.
ISRAEL JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yifan Meng, Elumalai Gnanamani, Richard N. Zare
Summary: In this study, hydroxyl radicals generated in situ were used for an organic transformation to synthesize anilines from aryl acids and ammonia/primary or secondary amines via decarboxylation. This one-step reaction occurred at room temperature without the need for metal catalysts or organic solvents. The scope of this transformation includes various types of amines and aromatic acids, enabling the synthesis of aniline and N-substituted anilines in a single step.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Agriculture, Multidisciplinary
Tianying Lu, Caicai Fu, Yonghua Xiong, Zheling Zeng, Yunkai Fan, Xiao Dai, Xiaolin Huang, Jun Ge, Xiaoyang Li
Summary: AFB1 contamination in edible oils is a significant concern for safety. Enzymatic degradation provides a promising method, but its efficiency is hindered by low enzyme activity and stability. In this study, an amphipathic laccase-inorganic hybrid nanoflower (Lac NF-P) was developed as a biocatalyst to degrade AFB1 in peanut oil. Lac NF-P exhibited 134- and 3.2-fold higher degradation efficiency compared to laccase and Lac NF, respectively. Within 3 hours, Lac NF-P reduced AFB1 concentration from 50-150 μg/kg to less than 0.96 μg/kg in peanut oil without affecting its quality. This study opens up new possibilities for developing biocatalysts to detoxify mycotoxins in edible oils.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yifan Meng, Elumalai Gnanamani, Richard N. Zare
Summary: Using room-temperature water microdroplets and applying negative high voltage at the sprayer source, toluene can react with CO2 to form phenylacetic acid in one step without any catalyst. The chemical components of these microdroplets are identified by mass spectrometry, and product structures are confirmed by tandem mass spectrometry. Mechanistic studies reveal that benzyl radicals formed from hydroxyl radicals at the water microdroplet interface drive these carboxylation reactions. This water microdroplet chemistry is general, enabling the activation and subsequent carboxylation of aryl alpha-C-H groups.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Letter
Multidisciplinary Sciences
Adriaan Davidse, Richard N. Zare
Article
Multidisciplinary Sciences
Xiaowei Song, Chanbasha Basheer, Richard N. Zare
Summary: Water microdroplets containing ammonia are synthesized in a gas-liquid-solid heterogeneous catalytic system without the need for electric potential or irradiation. The conversion rate reaches 32.9 ± 1.38 nmol s(-1) cm(-2) at room temperature. This eco-friendly and low-cost one-step nitrogen-fixation strategy converts widely available starting materials into a value-added product.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Tao Zhang, Sarah E. Noll, Jesus T. Peng, Amman Klair, Abigail Tripka, Nathan Stutzman, Casey Cheng, Richard N. Zare, Alexandra J. Dickinson
Summary: Understanding the principles of plant growth is essential for agriculture and multicellular development research. Using DESI-MSI, we mapped the chemical distribution in developing maize roots and discovered various small molecule patterns across the stem cell differentiation gradient. Through the analysis of TCA cycle metabolites in Arabidopsis and maize, we found that these metabolites are enriched in developmentally opposing regions and control root development in distinct ways. These findings shed light on plant development and offer practical methods for regulating plant growth.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Sason Shaik, David Danovich, Richard N. Zare
Summary: This paper describes the nature of hydrogen bond using valence bond theory. The analysis shows that polarization and charge transfer are the most important interactions in hydrogen bonds, and their sum is identical for different energy decomposition analysis methods. The total covalent-ionic resonance energy of the hydrogen bond is linearly correlated with the dissociation energy of the bond. The contributions of ionic structures to the hydrogen bond increase the positive charge on the hydrogen and contribute to catalytic reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biochemical Research Methods
Yifan Meng, Wei Hang, Richard N. Zare
Summary: Mass spectrometry imaging (MSI) allows for the chemical mapping of molecules and elements in a high-throughput manner without the need for labeling. A microlensed fiber, made from grinding an optical fiber, is used to achieve subcellular spatial resolution. This universal and economical technique can be adapted to various laser-based mass spectrometry methods.
Article
Multidisciplinary Sciences
Yu Xia, Juan Li, Yuanzheng Zhang, Yongguang Yin, Bolei Chen, Yong Liang, Guibin Jiang, Richard N. Zare
Summary: Spontaneous generation of reactive oxygen species (ROS) occurs when water vapor contacts hydrogen-bonded hydroxyl groups on a silicate surface, which is confirmed by time-resolved FT-IR spectroscopy. The involvement of water vapor in ROS generation is further supported by studying the reaction of D2O vapor and hydroxyl groups on a silicate surface. It is proposed that the change of the hydrogen-bonding network and electron transfer onto the silicate surface during water vapor-solid contact process contribute to ROS production.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Yifan Meng, Richard N. Zare, Elumalai Gnanamani
Summary: In this study, a catalyst-free and reagent-free method for converting benzoic acid to phenol in water solution using electrospray technique was reported. The conversion mechanism was characterized using mass spectrometry, tandem mass spectrometry, and oxygen isotope labeling, revealing the direct decarboxylation of benzoic acid to phenol in microdroplets. This environmentally friendly approach provides a new route for the synthesis of phenol and related aromatic alcohols.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Bin Li, Mingli Hu, Jun Ge, Wei Xu, Jinghan Wu, Yao Tong, Zhengyi Zhao, Xiuxiu Liu, Ling He
Summary: This paper reported the reactions of direct Csp(2)-H chalcogenylation and halogenation of N-arylpyrrolidone under the action of PIFA without a directing group and under metal-free conditions. Diphenyl selenide/sulfur and selenium phenyl halides were used as reaction reagents to obtain chalcogenylated and halogenated N-arylpyrrolidone products, respectively. The mechanistic studies indicated that a radical pathway was likely involved in these reactions. Preliminary antitumor tests showed that these compounds have moderate to potent activities against human acute leukemia cells K562 in vitro, which may be used as lead compounds for subsequent research.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Applied
Xiaoyang Li, Yufei Cao, Jiarong Xiong, Jun Li, Hai Xiao, Xinyang Li, Qingqiang Gou, Jun Ge
Summary: Combining enzymatic and single-metal-atom catalysis shows promise for green chemical synthesis. This study presents a one-pot chemoenzymatic cascade reaction for the asymmetric synthesis of (R)-1-(4-biphenyl) ethanol, using a highly active and selective enzyme-metal-single-atom hybrid as the catalyst. The Pd single atoms anchored lipase (Pd1/CALB-P) efficiently drives cascade reactions in aqueous solution, achieving facile synthesis of chiral biaryl alcohols.
CHINESE JOURNAL OF CATALYSIS
(2023)
