Article
Engineering, Biomedical
Lingna Sun, Mingrui Fan, Dong Huang, Bingqin Li, Ruoting Xu, Feng Gao, Yanzuo Chen
Summary: A clodronate-loaded liposome and fibroblast-derived exosome hybrid drug delivery system, named EL-CLD, was designed for the treatment of pulmonary fibrosis. This system effectively targeted fibrotic lung tissue by homing to fibroblasts and showed enhanced therapeutic efficacy compared to traditional drug delivery methods. The EL-CLD system acted as an efficient carrier for anti-fibrotic drugs, improving tissue accumulation and delivery while reducing inflammatory responses.
Review
Biochemistry & Molecular Biology
Dimitrios Goutas, Alexandros Pergaris, Nikolaos Goutas, Stamatios Theocharis
Summary: Exosomes, cell-secreted nanoparticles, play a crucial role in intercellular communication. They have advantages over synthetic drugs in terms of biocompatibility, tissue infiltration ability, and stability. However, artificial exosomes have limited targeting ability and efficacy. Therefore, researchers have been engineering stem cell-derived exosomes to improve their selectiveness and effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Yunpeng Fan, Wenwen Wu, Ning Xie, Yi Huang, Haiping Wu, Juan Zhang, Xiaolan Guo, Shijia Ding, Bin Guo
Summary: The development of a holistic solution is crucial for the advancement of exosome-based liquid biopsy, which enables early and non-invasive diagnosis of diseases. This study successfully developed a novel system for targeted enrichment and analysis of exosomes, focusing on patients with non-small cell lung cancer.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Oncology
Xiaoyun He, Gaoyan Kuang, Yongrong Wu, Chunlin Ou
Summary: Exosomes are small vesicles secreted by cells and can carry various cargo including RNA, DNA, proteins, and metabolites. Studies have shown that exosomal microRNAs play a crucial role in the progression of diseases such as diabetes mellitus, affecting processes like pancreatic beta-cell injury and insulin resistance. Understanding the mechanisms of exosomal miRNAs in diabetes mellitus can provide valuable insights for identifying diagnostic biomarkers and drug targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Liangyun Li, Yihui Bi, Shaoxi Diao, Xiaofeng Li, Tong Yuan, Tao Xu, Cheng Huang, Jun Li
Summary: This review article highlights the role of exosomal lncRNAs in the development of HCC, showing their crucial involvement in the growth and progression of HCC and their potential as therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Alexander Scholz, Daniel Gerig, Lukas Zimmermann, Mervin Seiberlich, Noah Strobel, Gerardo Hernandez-Sosa, Jasmin Aghassi-Hagmann
Summary: Hybrid systems, combining printed electronics with silicon-based technology, are driving future sensor development. Integrating organic photodiodes into silicon-based systems allows for flexible device measurement and application-driven development. Application scenarios where organic photodiodes are fully integrated into silicon systems are promising.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Review
Cell Biology
Hao Zhou, Xiaoyun He, Yuxiang He, Chunlin Ou, Pengfei Cao
Summary: Exosomes play crucial roles in a range of human diseases, especially malignant tumors, by transmitting cargo for intercellular communication. Exosomal circRNAs have the potential to regulate tumor cell metastasis and serve as valuable diagnostic biomarkers and therapeutic targets in cancer patients. The mechanism by which exosomal circRNAs modulate metastatic phenomena and the prospects of their clinical applications in tumor therapy are discussed in this review.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Inorganic & Nuclear
Xiaoliang Qi, Yajing Xiang, Erya Cai, Xinxin Ge, Xiaojing Chen, Wei Zhang, Zhangping Li, Jianliang Shen
Summary: The clinical management of bacterial infections has become a global public health challenge. Photothermal therapy (PTT), which uses laser irradiation to kill bacteria, has gained attention due to its low invasiveness and avoidance of drug-resistant bacteria. Inorganic-organic hybrid nanomaterials have shown potential in PTT antibacterial. This review discusses the fabrication strategies, properties, and current status of nanohybrid PTAs, as well as key issues and future developments in this field.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Oncology
Zhengjun Lin, Yuqiao Ji, Jian Zhou, Guoqing Li, Weifeng Liu, Zhihong Li, Tang Liu
Summary: Despite advances in cancer treatment, resistance to therapy remains a major obstacle. Circular RNAs (circRNAs) are biomolecules with a closed loop structure that can be transferred to tumor cells through exosomes, influencing cancer behavior and therapy resistance. Aberrantly expressed exosomal circRNAs have been found to mediate therapy resistance, making them potential therapeutic targets. This review explores the mechanisms of exosomal circRNAs in modulating cancer therapy resistance and discusses their potential as clinical biomarkers and therapeutic targets in cancer management.
Review
Cell Biology
Shenglong Li, Xiaohong Wang
Summary: Exosomes play a crucial role in cell-to-cell communication signals and genetic material transportation in the tumor microenvironment, facilitating cancer development by interacting with immune cells, endothelial cells, and fibroblasts. Currently, exosomes are emerging as novel noninvasive tumor diagnostic markers with high sensitivity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Min Zhou, Bingshu Li, Cheng Liu, Ming Hu, Jianming Tang, Jie Min, Jianhong Cheng, Li Hong
Summary: The study reveals that M2 macrophages promote myoblast differentiation and muscle regeneration through exosomal miR-501, suggesting a potential therapeutic approach for muscle injuries, including SUI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Physical
Chenghao Xin, Zhelu Hu, Zhuoqun Fang, Mahima Chaudhary, Hengyang Xiang, Xiangzhen Xu, Lionel Aigouy, Zhuoying Chen
Summary: Solution-processed organic and organic-inorganic hybrid thermoelectric devices show strong potential in energy harvesting and smart textile integration, especially when utilizing the photothermal effect of colloidal plasmonic gold nanoparticles. The optimized hybrid photothermoelectric generators demonstrate significantly increased voltage and power output, offering bright prospects for the development of energy harvesting smart textiles.
MATERIALS TODAY ENERGY
(2021)
Article
Materials Science, Biomaterials
Yun-Jie Wei, Jun Li, Zu-E Hu, Xiu Xing, Zi-Wen Zhou, Yuan Yu, Xiao-Qi Yu, Ji Zhang, Yan-Hong Liu, Na Wang
Summary: POD-like nanozymes can act as nanoreactors to generate reactive oxygen species in the tumor microenvironment and overcome drug resistance. However, the limited content of intracellular hydrogen peroxide restricts the effectiveness of the nanozymes. A composite nanozyme named HGPF was designed and constructed to target tumor cells and amplify oxidative stress through catalytic oxidation cascades.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Myrto Ischyropoulou, Kristina Sabljo, Leonie Schneider, Christof M. Niemeyer, Joanna Napp, Claus Feldmann, Frauke Alves
Summary: This study presents a novel drug-delivery system called inorganic-organic hybrid nanoparticles (GMP-IOH-NPs) for selective delivery of GMP to tumor and metastatic sites. It overcomes challenges like chemoresistance and shows excellent antitumor efficacy.
ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Honge Wu, Guang Tao Fei, Jiangang Gao, Jianyong Huang, Li De Zhang
Summary: In this study, a single-phase phosphor with excellent luminescent properties and thermal stability was successfully prepared, which has the potential for application in warm-white lighting.
ACS APPLIED NANO MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Anirudha Jena, Behrouz Bazri, Zizheng Tong, Kevin Iputera, Jheng-Yi Huang, Da-Hua Wei, Shu-Fen Hu, Ru-Shi Liu
Summary: This review focuses on the use of high-voltage cathode materials in all-solid-state batteries, where the redox peak of the cathode components extends beyond 4.7 V. Li-Ni-Mn-O systems are currently being investigated as cathodes for high-voltage cells. Additionally, the compatibility between electrodes and electrolytes at such high potentials is discussed, as well as the importance of controlling anode thickness to reduce solid-electrolyte interphase formation and dendrite growth. The review also discusses strategies for optimizing cell components to minimize electrode-electrolyte impedance and facilitate ion transportation during battery cycling.
Article
Oncology
Yu-Chan Chang, Chien-Hsiu Li, Ming-Hsien Chan, Chih-Yeu Fang, Zhi-Xuan Zhang, Chi-Long Chen, Michael Hsiao
Summary: RAB3C plays a key role in the progression of colorectal cancer (CRC) and its overexpression is associated with drug resistance. RAB3C-induced dystrophin expression promotes vesicle formation and packaging. The RAB3C-dystrophin axis is positively correlated with PIK3CA genetic alterations in CRC patients, providing potential therapeutic options for CRC treatment.
MOLECULAR ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chien-Hsiu Li, Ming-Hsien Chan, Yu-Chan Chang, Michael Hsiao
Summary: Gold nanotechnology has revolutionized molecular biology applications, particularly in diagnosing and treating at the molecular and cellular levels. The combination of plasmonic resonance, biochemistry, and optoelectronic engineering has enhanced molecule detection and increased the possibility of analyzing atoms. Gold nanoparticles offer superior analytical properties that can be utilized for drug screening, gene sequencing, and detecting physiological functions.
Review
Materials Science, Multidisciplinary
Wen-Tse Huang, Veeramani Rajendran, Ming-Hsien Chan, Michael Hsiao, Ho Chang, Ru-Shi Liu
Summary: With the development of technology, the importance and practicality of near-infrared (NIR) light in the biomedical field have gained attention from academia and industry. Luminescent materials with different doping strategies show promise in covering the near-infrared biological windows. The relationship between NIR light, nanophosphors, and biological tissue has been explored, allowing for diagnostic and therapeutic applications in different NIR windows.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yu-Kai Liao, Zizheng Tong, Shin-An Liu, Jui-Hsiung Huang, Ru-Shi Liu, Shu-Fen Hu
Summary: This study used a high-conductivity garnet-type solid electrolyte (LLZTO) and Li-Ga-N composite anode to reduce interfacial resistance and enhance the performance of all-solid-state batteries. The research demonstrated a stable cycling performance and high discharge capacity retention.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Natalia Majewska, Alfonso Munoz, Ru-Shi Liu, Sebastian Mahlik
Summary: This study compares the changes in the luminescence properties of Ga2O3:Cr3+ modified by Al or Sc ion substitution (chemical pressure) and hydrostatic pressure. Ga2-x Al x O3:Cr3+ exhibits the same behavior under chemical and mechanical pressure, while Ga2-x Sc x O3:Cr3+ shows different behavior. Al substitution affects the crystal volume but not the chemical bond angles in the Cr3+ local environment, whereas Sc ions cause lattice distortion and influence the chemical bond lengths and angles. The energy structure diagrams of the d(3) configuration of Cr3+ ion as a function of pressure are calculated by considering the pressure dependence of the Racah parameters. It is suggested that the method and diagrams presented in this paper should be used for interpreting high-pressure experiments involving Cr3+ and other transition metals.
CHEMISTRY OF MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Aishwarya Satpathy, Ting-Yi Su, Wen-Tse Huang, Ru-Shi Liu
Summary: The design of nanoprobes in the NIR-II region has attracted significant attention due to their flexible emission and reduced photon scattering for in vivo fluorescence imaging. Quantum dots, AIEgens, carbon nanotubes, and polymers are constantly being improved for better NIR-II emission. Lanthanides and nanophosphors are extensively explored for NIR-II imaging applications, with nanophosphors showing promising luminescence properties and energy transfer processes. Our review aims to provide insights into nanophosphors for biological imaging applications and compare them with lanthanides in order to understand their mechanism and importance in the future bio-imaging field.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2023)
Article
Cell Biology
Yu-Ching Wen, Van Thi Ngoc Tram, Wei-Hao Chen, Chien-Hsiu Li, Hsiu-Lien Yeh, Phan Vu Thuy Dung, Kuo-Ching Jiang, Han-Ru Li, Jiaoti Huang, Michael Hsiao, Wei-Yu Chen, Yen-Nien Liu
Summary: Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling, but inhibiting AR may promote the development of neuroendocrine prostate cancer (NEPC). Understanding the regulatory mechanisms of AR is crucial for the clinical management of NEPC. This study revealed the tumor-suppressive role of AR and identified its downregulation of CHRM4 expression. CHRM4 overexpression drives neuroendocrine differentiation in prostate cancer cells and is associated with immunosuppressive cytokine responses in the tumor microenvironment (TME). Targeting CHRM4 and evaluating IFNA17 secretion as a prognostic biomarker could be potential therapeutic strategies for NEPC.
CELL DEATH & DISEASE
(2023)
Article
Materials Science, Multidisciplinary
Aishwarya Satpathy, Wen-Tse Huang, Ming-Hsien Chan, Ting-Yi Su, Mikolaj Kaminski, Natalia Majewska, Sebastian Mahlik, Grzegorz Leniec, Slawomir M. Kaczmarek, Michael Hsiao, Ru-Shi Liu
Summary: In the biomedical field, fluorescence imaging in the NIR-II region is growing rapidly due to its advantages of reduced autofluorescence and low photon scattering. This work integrates the ZnGa2O4 spinel oxide system into mesoporous silica and utilizes energy transfer from Cr3+ to Ni2+ to achieve high emission intensity in the NIR-II region. By establishing emission in the NIR-II and NIR-I regions, it enables improved clarity and increased penetration depth for bioimaging purposes.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Crystallography
Kayalvizhi Samuvel Muthiah, Senthilkumar Thirumurugan, Yu-Chien Lin, Rajalakshmi Sakthivel, Udesh Dhawan, An-Ni Wang, Michael Hsiao, Ren-Jei Chung
Summary: Ce3NbO7/g-C3N4 nanocomposites exhibit synergistic enhancement of cancer treatment by generating cytotoxic reactive oxygen species (ROS) and inducing photothermal therapy (PTT) in the tumor microenvironment.
Article
Materials Science, Multidisciplinary
Ming-Hsien Chan, Bo-Gu Chen, Wen-Tse Huang, Ting-Yi Su, Michael Hsiao, Ru-Shi Liu
Summary: Nanomaterials act as multipliers, attaching multiple single atoms to a surface. When applied to biological applications, these catalytic targets become proteins in vivo, illustrating the potential of single-atom nanozyme nanotechnology.
MATERIALS TODAY ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Pavitra Srivastava, Yu-Kai Liao, Kevin Iputera, Shu-Fen Hu, Ru-Shi Liu
Summary: The use of β-SiC as an additive can improve the physical contact between Garnet-type solid-state electrolytes and Li metal, resulting in improved intimacy and robustness by forming lithiophilic Li4SiO4 and hard SiC phases. The optimized Li-SiC|LLZTO|Li-SiC symmetric cell exhibits low interfacial impedance and superior cycling stability.
Article
Chemistry, Multidisciplinary
Loan Thi Ngo, Wen-Tse Huang, Ming-Hsien Chan, Ting-Yi Su, Chien-Hsiu Li, Michael Hsiao, Ru-Shi Liu
Summary: This study investigates the neurotoxicity of all-inorganic lead halide perovskite quantum dots (PeQDs) using Caenorhabditis elegans as a model organism. The results show that PeQDs accumulate mainly in the alimentary system and head region, causing a decrease in locomotor behaviors, pharyngeal pumping, brood decline, short lifespan, and abnormal issues in reproduction. Excessive reactive oxygen species formation is also observed. The neurotoxicity of PeQDs is explained by gene expression. This study provides an insight into the neurotoxicity of PeQDs and inspires the development of nontoxic PeQDs.
Article
Multidisciplinary Sciences
Chi-Ling Chiang, Yifan Ma, Ya-Chin Hou, Junjie Pan, Sin-Yu Chen, Ming-Hsien Chien, Zhi-Xuan Zhang, Wei-Hsiang Hsu, Xinyu Wang, Jingjing Zhang, Hong Li, Lili Sun, Shannon Fallen, Inyoul Lee, Xing-Yu Chen, Yeh-Shiu Chu, Chi Zhang, Tai-Shan Cheng, Wen Jiang, Betty Y. S. Kim, Eduardo Reategui, Robert Lee, Yuan Yuan, Hsiao-Chun Liu, Kai Wang, Michael Hsiao, Chi-Ying F. Huang, Yan-Shen Shan, Andrew S. Lee, L. James Lee
Summary: This study reports a dual targeted extracellular vesicle (dtEV) that can effectively suppress large PDAC tumors. The dtEV carries high loads of therapeutic RNA and is delivered to target cells through electroporation. When used in combination with the chemotherapy drug Gemcitabine, the dtEVs can inhibit tumor growth and prolong animal survival.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Yi-Chieh Yang, Yung-Wei Lin, Wei-Jiunn Lee, Feng-Ru Lai, Kuo-Hao Ho, Chih-Ying Chu, Kuo-Tai Hua, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Yu-Ching Wen, Ming-Hsien Chien
Summary: The versatile RNA-binding protein KSRP plays a critical role in clear cell renal cell carcinoma (ccRCC) by promoting malignant progression through the transcriptional inhibition and post-transcriptional destabilization of NEDD4L transcripts. Targeting KSRP and its pathways could provide a new therapeutic intervention for ccRCC.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)