Article
Fisheries
Yizhi Shao, Jingzhuang Zhao, Guangming Ren, Tongyan Lu, Liming Xu
Summary: In coinfection of rainbow trout, IHNV can enhance the multiplication of IPNV. IPNV multiplication can also be enhanced when IHNV injection occurs prior to IPNV injection.
Article
Virology
Jessica Benkaroun, Katherine Fiona Muir, Rosa Allshire, Cuneyt Tamer, Manfred Weidmann
Summary: The aquatic virus, IPNV, infects farmed fish such as salmonids and causes economic losses. To investigate a serotyping discrepancy, the complete genome of new IPNV isolates was determined using next-generation sequencing. Phylogenetic analyses revealed the emergence of a new variant possibly due to selective pressure from vaccinated IPNV-resistant farmed fish.
Article
Immunology
Felix Docando, Noelia Nunez-Ortiz, Gabriela Goncalves, Claudia R. Serra, Eduardo Gomez-Casado, Diana Martin, Beatriz Abos, Aires Oliva-Teles, Carolina Tafalla, Patricia Diaz-Rosales
Summary: Bacillus subtilis has been proven to be an effective probiotic for aquacultured species, benefiting water quality, fish growth, and immune status. In this study, B. subtilis spores were used as delivery vehicles for the VP2 protein from infectious pancreatic necrosis virus (IPNV). The results showed that the VP2-expressing strain (CRS208) retained its immunomodulatory potential and induced a significant antibody response, making it a promising vaccination strategy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Yizhi Shao, Jingzhuang Zhao, Guangming Ren, Tongyan Lu, Xiaoyu Chen, Liming Xu
Summary: This study found that infectious pancreatic necrosis virus (IPNV) can inhibit the replication of infectious hematopoietic necrosis virus (IHNV) before or simultaneously with IHNV infection, and induce a stronger antiviral response. This inhibition is most sensitive in the liver, and early injection of IPNV can significantly reduce the mortality of fish.
Article
Genetics & Heredity
Borghild Hillestad, Stein Johannessen, Geir Olav Melingen, Hooman K. Moghadam
Summary: This study identified a new variant of IPN virus from a field outbreak in Western Norway, with unique amino acid residues detected that may enhance the virus's ability to escape host defence mechanisms.
FRONTIERS IN GENETICS
(2021)
Article
Veterinary Sciences
B. David Persson, Jacob Gunther Schmidt, Mikhayil Hakhverdyan, Mikael Leijon, Niels Jorgen Olesen, Charlotte Axen
Summary: The IPNV virus found in Lake Vanern in Sweden has low pathogenicity and poses little threat to the salmonid populations. Through infection trials and field monitoring, researchers determined that the virus has a low prevalence in the lake.
VETERINARY SCIENCES
(2023)
Article
Fisheries
Yizhi Shao, Linfang Li, Jingzhuang Zhao, Guangming Ren, Qi Liu, Tongyan Lu, Liming Xu
Summary: Infectious pancreatic necrosis virus (IPNV) is a pathogen that causes infectious pancreatic necrosis (IPN), leading to high mortality and economic losses in salmonid aquaculture. In China, there is currently no available vaccine or antiviral drugs to prevent or treat IPNV infection. This study explores the inhibitory effect of the nucleoside analog 2'-C-methylcytidine (2CMC) on IPNV replication. The results show that 2CMC inhibits viral RNA replication and reduces viral load in rainbow trout, suggesting its potential as a valuable anti-IPNV drug candidate.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Liming Xu, Jingzhuang Zhao, Miao Liu, Guangming Ren, Shi Cheng Han, Yizhi Shao, Yongsheng Cao, Hongbai Liu, Tongyan Lu
Summary: IHNV enhances the multiplication of IPNV during co-infection, with the enhancement becoming stronger with increasing infection time interval, regardless of the infection order.
Article
Virology
Yizhi Shao, Guangming Ren, Jingzhuang Zhao, Tongyan Lu, Qi Liu, Liming Xu
Summary: In this study, a novel IPNV, IPNV-P202019, belonging to genogroup 7, was isolated and identified. The study showed that IPNV genogroups 1 and 5 were still the prevalent genogroups of IPNV in China, while the viral load of IPNV genogroup 7 was too low to cause pathogenicity.
Article
Fisheries
Andreia Filipa-Silva, Ricardo Parreira, Monica Nunes, Maria Teresa Barreto Crespo
Summary: Global demand for seafood is increasing, making aquaculture production of capital importance in terms of fish resources sustainability. Fish disease outbreaks are a significant constraint to fisheries trade and aquaculture production, affecting economic development worldwide. Virological screening in wild and farmed fish populations can identify potential hosts and help prevent major economic losses in the fish industry due to viral infections.
Review
Fisheries
Irtifa Fayaz, Raja Aadil Hussain Bhat, Ritesh Shantilal Tandel, Pragyan Dash, Suresh Chandra, Maneesh Kumar Dubey, Parvaiz Ahmad Ganie
Summary: IPNV is a prevalent virus in salmonid fish, particularly rainbow trout, and its ability to survive in aquatic environments for extended periods poses a challenge for infection prevention and control. This review provides an in-depth analysis of IPNV, including its genome organization, virulence factors, diagnostic tools, and classification methods. It also discusses significant developments in antiviral treatments and the role of bioinformatics in mining knowledge about IPNV. Molecular docking experiments revealed that quercetin and EICAR show strong binding to the VP2 protein of IPNV and have better potential for preventing IPNV compared to other known anti-IPN drugs.
Article
Microbiology
Marcos Godoy, Molly J. T. Kibenge, Marco Montes de Oca, Juan Pablo Pontigo, Yoandy Coca, Diego Caro, Karina Kusch, Rudy Suarez, Ian Burbulis, Frederick S. B. Kibenge
Summary: This study investigated the pathological lesions and viral sequences of IPNV infection in genetically resistant farmed Atlantic salmon in Chile. The findings revealed an increasing number of IPN outbreaks, despite the introduction of resistant strains and vaccination strategies.
Article
Virology
Mi Wu, Zhifei Zhang, Xin Su, Haipeng Lu, Xuesong Li, Chunxiu Yuan, Qinfang Liu, Qiaoyang Teng, Letu Geri, Zejun Li
Summary: This study found significant differences in the replication and pathogenicity of three highly genetically homologous infectious laryngotracheitis virus (ILTV) strains in different culture systems and in chickens. This provides important insights into the key determinants of ILTV pathogenicity.
Article
Fisheries
Kaiyue Duan, Xin Tang, Jingzhuang Zhao, Guangming Ren, Yizhi Shao, Tongyan Lu, Baoquan He, Liming Xu
Summary: The study demonstrates that the vaccine prepared using genogroup HPNV isolate could stimulate nonspecific and specific immune responses, providing significant immune protection to vaccinated rainbow trout.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Ling Shao, Jiuru Zhao, Qian Tang
Summary: The study identified that non-muscle myosin heavy chain 9 (Myh9) plays a crucial role in the entry of IPNV by interacting with viral outer capsid protein VP2. Treatments with different Myh9 inhibitors suppressed IPNV infection, while overexpression of Myh9 promoted viral entry. Additionally, IPNV infection induced the formation of intracellular nanotubes which the virus could utilize for cell-to-cell movement.
Article
Virology
Sergio Hernandez, Gustavo Jimenez, Valentina Alarcon, Cristian Prieto, Francisca Munoz, Constanza Riquelme, Mauricio Venegas, Javier Brahm, Alejandra Loyola, Rodrigo A. Villanueva
ARCHIVES OF VIROLOGY
(2016)
Article
Fisheries
Felipe E. Reyes-Lopez, Jose S. Romeo, Eva Vallejos-Vidal, Sebastian Reyes-Cerpa, Ana M. Sandino, Lluis Tort, Simon Mackenzie, Monica Imarai
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2015)
Article
Fisheries
Felipe E. Rodriguez, Beatriz Valenzuela, Ana Farias, Ana Maria Sandino, Monica Imarai
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Immunology
Kevin Maisey, Ruth Montero, Yolanda Corripio-Miyar, Daniela Toro-Ascuy, Beatriz Valenzuela, Sebastian Reyes-Cerpa, Ana Maria Sandino, Jun Zou, Tiehui Wang, Christopher J. Secombes, Monica Imarai
JOURNAL OF IMMUNOLOGY
(2016)
Article
Virology
Andrea Rivas-Aravena, Patricio Munoz, Patricia Jorquera, Alvaro Diaz, Claudia Reinoso, Sebastian Gonzalez-Catrilelbun, Ana Maria Sandino
Article
Fisheries
Julio Cartagena, Carolina Tambley, Ana Maria Sandino, Eugenio Spencer, Mario Tello
Article
Fisheries
Sebastian Reyes-Cerpa, Eva Vallejos-Vidal, Maria Jose Gonzalez-Brown, Jonathan Morales-Reyes, Diego Perez-Stuardo, Deborah Vargas, Monica Imarai, Victor Cifuentes, Eugenio Spencer, Ana Maria Sandino, Felipe E. Reyes-Lopez
FISH & SHELLFISH IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Valentina Alarcon, Sergio Hernandez, Lorena Rubio, Francisca Alvarez, Yvo Flores, Manuel Varas-Godoy, Giancarlo V. De Ferrari, Michael Kann, Rodrigo A. Villanueva, Alejandra Loyola
SCIENTIFIC REPORTS
(2016)
Article
Genetics & Heredity
Sergio Hernandez, Ariel Diaz, Alejandra Loyola, Rodrigo A. Villanueva
Article
Microbiology
Lorenz Loyola, Vasudevan Achuthan, Kathryn Gilroy, Gillian Borland, Anna Kilbey, Nancy Mackay, Margaret Bell, Jodie Hay, Sriram Aiyer, Dylan Fingerman, Rodrigo A. Villanueva, Ewan Cameron, Christine A. Kozak, Alan N. Engelman, James Neil, Monica J. Roth
Article
Gastroenterology & Hepatology
Francisca Alvarez-Astudillo, Daniel Garrido, Manuel Varas-Godoy, Jose Leonardo Gutierrez, Rodrigo A. Villanueva, Alejandra Loyola
Summary: The research explored the role of the histone variant H3.3 in regulating HBV transcription, finding that H3.3 can positively regulate HBV transcription and is dependent on the histone chaperone HIRA.
ANNALS OF HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cristian Prieto, Juan Montecinos, Gustavo Jimenez, Constanza Riquelme, Daniel Garrido, Sergio Hernandez, Alejandra Loyola, Rodrigo A. Villanueva
Summary: Hepatitis B virus (HBV) HBx protein plays multiple roles in infected cells, functioning in the nucleus to initiate and maintain viral transcription, and in the cytoplasm to alter cellular functions such as metabolism and apoptosis. The nucleocytoplasmic distribution of HBx protein may be regulated by phosphorylation, as shown by the different subcellular localizations of modified HBx proteins, with some predominantly localized in the nuclear compartment.
Article
Biochemistry & Molecular Biology
Sergio Hernandez, Francisca Alvarez-Astudillo, Daniel Garrido, Cristian Prieto, Alejandra Loyola, Rodrigo A. Villanueva
Summary: Research has shown that HBV X protein can generate three distinct isoforms that exhibit different subcellular localizations when expressed in cells. Among these, the XS isoform, which is small in size, displays a predominantly cytoplasmic localization. Additionally, XS plays a crucial role in HBV replication, and infection with HBV genotype H can impact the expression of the XS isoform.
Article
Biotechnology & Applied Microbiology
Sebastian Gonzalez-Catrilelbun, Julio Cartagena, Deborah Vargas, Pamela Breguel-Serrano, Ana Maria Sandino, Andrea Rivas-Aravena
Summary: This research demonstrates that IPNV mRNAs are linked to Vpg and that this protein inhibits cap-dependent translation on infected cells. Also, it is demonstrated that Vpg interacts with eIF4E and that rapamycin treatment partially diminishes the viral protein synthesis.
JOURNAL OF GENERAL VIROLOGY
(2022)
Article
Immunology
Diego Perez-Stuardo, Jonathan Morales-Reyes, Sebastian Tapia, Diego E. Ahumada, Allison Espinoza, Valentina Soto-Herrera, Bernardo Brianson, Valentina Ibaceta, Ana M. Sandino, Eugenio Spencer, Eva Vallejos-Vidal, Felipe E. Reyes-Lopez, Jorge Valdes, Sebastian Reyes-Cerpa
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Virology
Mohamed S. H. Hassan, Ahmed Ali, Motamed Elsayed Mahmoud, Danah Altakrouni, Shahnas M. Najimudeen, Mohamed Faizal Abdul-Careem
Summary: This study compared the efficacy of different vaccination programs against Canadian DMV/1639 IBV and found that the autogenous inactivated DMV/1639 vaccine was more effective in reducing viral loads and boosting virus neutralization titers. Both vaccination programs provided significant protection against pathological effects.
Article
Virology
Wanda Christ, Jonas Klingstrom, Janne Tynell
Summary: The integrated stress response (ISR) is activated in response to SARS-CoV-2 infection, triggering translational arrest and inhibiting stress granule formation. However, the stress-responsive transcription factors ATF4 and CHOP are not induced. Different SARS-CoV-2 variants show variant-specific differences in ISR activation, suggesting potential impacts on pathogenesis and treatment strategies.
Article
Virology
Xiao Han, Hankun Xu, Yifan Weng, Rong Chen, Jidong Xu, Tong Cao, Renjie Sun, Ying Shan, Fang He, Weihuan Fang, Xiaoliang Li
Summary: Classical swine fever virus (CSFV) can inhibit the host innate immunity by decreasing the level of high mobility group box 1 (HMGB1), and CSFV Npro can evade host antiviral immune response through upregulating HMGB1 acetylation.
Article
Virology
Sunjian Lyu, Fulei Xiong, Tianpeng Qi, Weifeng Shen, Qi Guo, Mingming Han, Li Liu, Weishao Bu, Julin Yuan, Bao Lou
Summary: This study identified and characterized a novel temperate A. hydrophila phage, P05B, which has strong lytic ability and stability across different temperatures and pH values.
Article
Virology
Siyuan Liu, Wei Chen, Raphael Nyaruaba, Shunlong Wang, Cihan Yang, Qun Wu, Ying Liu, Puyu Liu, Fei Wang, Jingling Wang, Zhiming Yuan, Dingwei Sun, Han Xia
Summary: Specific, sensitive, and reliable RT-qPCR assays for the detection of OYAV and EBIV have been successfully developed in this study. These assays hold great promise for their potential application in clinical and field samples in the future.
Article
Virology
Rui Wang, Qiang Sun, Jinbo Xiao, Congcong Wang, Xiaoliang Li, Jichen Li, Yang Song, Huanhuan Lu, Ying Liu, Shuangli Zhu, Zhijun Liu, Yong Zhang
Summary: Coxsackievirus A6 (CVA6) has emerged as an important agent causing hand, foot, and mouth disease (HFMD). Mutations in residue 64 of the virus have been found to increase resistance to ribavirin and decrease sensitivity to guanidine hydrochloride. This mutation also leads to increased replication fidelity and reduced pathogenicity. These findings provide a foundation for the development of a safe and effective live attenuated CVA6 vaccine.
Article
Virology
Yao Xiong, Keran Ma, Xiao Zou, Yantao Liang, Kaiyang Zheng, Tiancong Wang, Hong Zhang, Yue Dong, Ziyue Wang, Yundan Liu, Hongbing Shao, Andrew Mcminn, Min Wang
Summary: This study isolated a novel virus, vB_VviC_ZQ26, infecting Vibrio cyclitrophicus from coastal waters near Qingdao, China. It was found that vB_VviC_ZQ26 belongs to a new vibriophage-specific family, Coheviridae, and is mainly found in temperate and tropical epipelagic zones.
Article
Virology
Xing Li, Zhiping Ye, Ewan P. Plant
Summary: By analyzing clinical and cultured samples using the same bioinformatic pipeline, it was found that 5' copyback DVGs are prevalent in human clinical samples but not in cultured samples. Furthermore, there are differences in DVG production and composition between in vivo and in vitro infections.
Article
Virology
Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Suvrotoa Mitra, Animesh Gope, Mamta Chawla-Sarkar
Summary: Rotavirus is a major cause of viral gastroenteritis in infants and continues to be a severe issue in underdeveloped nations. Recent research has shown that a long non-coding RNA called SLC7A11-AS1 is upregulated during rotavirus infection and plays a role in facilitating the virus's propagation by regulating intracellular glutathione and lipid peroxidation.
Article
Virology
Eiichi Hondo, Tetsufumi Katta, Ayato Sato, Naoya Kadofusa, Tomoki Ishibashi, Hiroshi Shimoda, Hirokazu Katoh, Atsuo Iida
Summary: Bat-borne emerging viruses, such as the Ebola virus and Nipah virus, pose a significant threat to public health. In this study, we identified micafungin as a potential antiviral drug against Pteropine orthoreovirus (PRV) and found that it inhibits viral release in human cells through activating the endoplasmic reticulum stress response pathway. This research provides valuable insights into the development of effective treatments for future virus pandemics.
Article
Virology
M. Joubert, N. van den Berg, J. Theron, V. Swart
Summary: This study investigated the host gene expression in asymptomatic avocado nursery trees infected with Avocado sunblotch viroid (ASBVd) using RNA sequencing. The results showed that 631 genes were differentially expressed during infection, with 63% upregulated. ASBVd infection significantly affected plant defence responses, phytohormone networks, gene expression pathways, secondary metabolism, cellular transport, as well as protein modification and degradation. This study provides insights into the molecular interactions underlying avsunviroid-host interactions.
Article
Virology
Wanling Zhang, Haiyan Yang, Zhengyun Liu, Shengyu Wang, Tianyang Chen, Hong Song, Yunbin Xu, Fajin Li, Guo Luo, Huan Wang
Summary: EV71 infection leads to changes in mitochondrial morphology and dynamics in human neuroblastoma cells, resulting in mitochondrial dysfunction that may contribute to nervous system dysfunction.
Article
Virology
Mikhail Oliveira Leastro, Elliot Watanabe Kitajima, Vicente Pallas, Jesus Angel Sanchez- Navarro
Summary: This study reports the construction and validation of an infectious cDNA clone of Citrus leprosis virus C (CiLV-C) based on an agroinfection system. Agro-injected Nicotiana benthamiana plants showed localized lesions similar to the natural infection process. The virus recovered from the infected plant tissue could be mechanically transmitted between plants. The CiLV-C reverse genetic system provides a powerful molecular tool for unraveling the peculiarities of the citrus leprosis pathosystem.
Article
Virology
Manel Essaidi-Laziosi, Francisco J. Perez-Rodriguez, Catia Alvarez, Pascale Sattonnet-Roche, Giulia Torriani, Meriem Bekliz, Kenneth Adea, Matthias Lenk, Tasnim Suliman, Wolfgang Preiser, Marcel A. Mueller, Christian Drosten, Laurent Kaiser, Isabella Eckerle
Summary: This study found that the Omicron variant has different replication characteristics compared to other variants of concern, being able to efficiently produce infectious virus in nasal cells but not lung cells. In addition, the Delta and Omicron variants showed increased infection efficiency in A549 cells. These findings suggest that the variants of concern have better adaptation to humans but do not have an extended host range.
Article
Virology
Martin Faye, Modeste Name Faye, Babacar Ndiaye, Moussa Moise Diagne, Safietou Sankhe, Ndeye Marieme Top, Amadou Diallo, Cheikh Loucoubar, Ndongo Dia, Amadou Alpha Sall, Ousmane Faye
Summary: Genomic surveillance in Senegal since March 2020 has detected the emergence of Omicron BA.4 and BA.5 sublineages in June 2022. Next-generation sequencing and phylogeny analysis of isolates from a cluster of cases in Northern Senegal in July 2022 revealed that the BA.4 cases originated from a XAS recombinant, marking the first reported sequence of this variant from Senegal. Continuous genomic surveillance of positive SARS-CoV-2 samples is crucial.