Article
Microbiology
Jun Li, Rumeng Li, Qi Zhang, Peipei Peng, Xiaoquan Wang, Min Gu, Zenglei Hu, Xinan Jiao, Daxin Peng, Jiao Hu, Xiufan Liu
Summary: This study demonstrates that the H7N9 VLP vaccine provides complete clinical protection against HP H7N9 virus, significantly inhibits virus shedding, and abolishes viral replication in chickens. The VLP vaccine represents a promising alternative strategy for the development of novel H7N9 avian influenza vaccines for chickens.
VETERINARY MICROBIOLOGY
(2021)
Article
Microbiology
Carolin Lieber, Megha Aggarwal, Jeong-Joong K. Yoon, Robert A. Cox, Hae-Ji M. Kang, Julien A. Sourimant, Mart T. Toots, Scott M. Johnson, Cheryl Jones, Zachary R. Sticher, Alexander G. Kolykhalov, Manohar Saindane, Stephen K. Tompkins, Oliver Planz, George Painter, Michael Natchus, Kaori Sakamoto, Richard Plemper
Summary: The nucleoside analog 4'-fluorouridine has been shown to effectively inhibit a broad spectrum of influenza viruses in various cell culture and animal models. It acts as a chain terminator of the influenza virus polymerase and has the potential to be a therapeutic option for vulnerable patient groups and pandemic influenza.
Article
Veterinary Sciences
Jiao Hu, Peipei Peng, Jun Li, Qi Zhang, Rumeng Li, Xiaoquan Wang, Min Gu, Zenglei Hu, Shunlin Hu, Xiaowen Liu, Xinan Jiao, Daxin Peng, Xiufan Liu
Summary: The bivalent H5+H7 VLP vaccine candidate shows promising results in protecting poultry against highly pathogenic H5N1 and H7N9 avian influenza viruses, and may serve as a critical alternative to traditional egg-based inactivated vaccines.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Virology
Yunyueng Jang, Sang Heui Seo
Summary: The study developed an H5 peptide vaccine containing RRRK amino acids which completely protected chickens from H5N6, H5N8, and H5N1 avian influenza viruses. The level of protection depended on the number of antigens in the vaccine with RRRK, with chickens receiving two doses of 5 μg being completely protected. The presence of polybasic amino acids like RRRK was crucial in conferring immunity, suggesting a potential universal vaccine for protecting chickens from various emerging clades of H5Nx avian influenza viruses.
ARCHIVES OF VIROLOGY
(2022)
Article
Microbiology
Yi-qun Chen, Guan-ming Su, Jia-hao Zhang, Bo Li, Kai-xiong Ma, Xu Zhang, Li-hong Huang, Ming Liao, Wen-bao Qi
Summary: Since mid-2016, the highly pathogenic H7N9 avian influenza virus has posed a threat to public health and the poultry industry. Researchers have developed a recombinant vaccine using the herpesvirus of turkeys as a vector, which has shown promising protective effects against H7N9 in chickens. This vaccine has significant implications for the prevention and control of avian influenza.
VETERINARY MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yong-Myung Kang, Hyun-Kyu Cho, Ju Hun Kim, Su Jin Lee, Seo-Jeong Park, Do-Young Kim, Seong Yup Kim, Jung-won Park, Myoung-Heon Lee, Min-Chul Kim, Hyun-Mi Kang
Summary: Multi-clade VLPs have shown to provide improved immunity with single dose vaccination, offering comprehensive protection against various HPAI viruses and being produced in high yield at low cost.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Immunology
Brad Gilbertson, Kanta Subbarao
Summary: There is a widespread and unprecedented spread of highly pathogenic avian influenza A H5N1 viruses in bird species on five continents, with infections also reported in mammals, most likely caused by consuming infected birds. The increase in H5N1 virus infections in different species could lead to the emergence of new viral variants that may adapt to mammals and potentially humans. It is crucial to monitor and assess the presence of mutations in mammalian-origin H5N1 clade 2.3.4.4b viruses that could increase their risk for human pandemics. Although there have been a limited number of human cases so far, the infection of mammals provides opportunities for the virus to acquire mutations that enhance infection, replication, and spread in mammals, which were not observed in the past viruses.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Yu Ye, Huiying Fan, Qi Li, Zhen Zhang, Peisi Miao, Jun Zhu, Jie Liu, Jie Zhang, Ming Liao
Summary: This study provides a comprehensive analysis of the proteome response in Muscovy duck lung tissue during H5N1 avian influenza virus infection. The findings suggest that the infection mechanism and disease progression of H5N1 viruses may be related to specific pathways and protein expressions. The study reveals differences in host immune response between different strains of the H5N1 virus and indicates the involvement of the Akt/mTOR/p70S6K pathway in the host response to H5N1 viruses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Hongbo Zhang, Yanfeng Yao, Yan Li, Jianjun Chen, Ze Chen
Summary: This study isolated multiple H5N1 strains from water samples in Dongting Lake and lakeside backyard poultry, and genetic analysis revealed a diversified genome constellation. The genetic characteristics of some viruses from water samples were similar to those from lakeside poultry. Pathogenic experiments showed that selected isolates were highly pathogenic in SPF chickens but had varied virulence in mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Christine H. T. Bui, Denise I. T. Kuok, Hin Wo Yeung, Ka-Chun Ng, Daniel K. W. Chu, Richard J. Webby, John M. Nicholls, J. S. Malik Peiris, Kenrie P. Y. Hui, Michael C. W. Chan
Summary: The recent HPAI A(H5N6/H5N8) avian isolates have the potential for zoonotic transmission but low transmissibility among humans. They showed differential cellular tropism in human airway organoids and induced low levels of pro-inflammatory cytokines/chemokines.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Veterinary Sciences
Jiho Lee, Deok-hwan Kim, Jinyong Noh, Sungsu Youk, Jei-hyun Jeong, Joong-bok Lee, Seung-Yong Park, In-soo Choi, Sang-Won Lee, Chang-seon Song
Summary: This study developed a live recombinant vaccine that effectively prevents the transmission of H5 HPAIV in poultry and rapidly initiates an immune response.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Nancy Beerens, Evelien A. Germeraad, Sandra Venema, Eline Verheij, Sylvia B. E. Pritz-Verschuren, Jose L. Gonzales
Summary: The study found that recent H5 clade 2.3.4.4 viruses were highly pathogenic for chickens, but had varying pathogenicity for different duck species, especially the most recent H5N6-2017 virus. On the other hand, the H5N8-2016 virus was efficiently transmitted to chickens through contaminated water sources.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Microbiology
Celia Abolnik, Erich Ostmann, Matthew Woods, Daniel B. R. Wandrag, John Grewar, Laura Roberts, Adriaan J. Olivier
Summary: Infection dynamics of influenza A virus in ostriches showed that those infected with H7N1 LPAIV remained generally healthy, while those infected with H5N8 HPAIV showed various degrees of morbidity. Virus shedding in contact birds peaked within a few days post infection and lasted for at least 13 days.
VETERINARY MICROBIOLOGY
(2021)
Article
Virology
Keita Fukao, Takeshi Noshi, Shinya Shano, Kaoru Baba, Kenji Sato, Masashi Sakuramoto, Naohisa Kitade, Hideki Tanioka, Shinji Kusakabe, Takao Shishido
Summary: Baloxavir acid is a promising antiviral drug for the prevention of influenza, showing significant prophylactic efficacy in mice models.
Article
Immunology
Guimei He, Le Ming, Xiang Li, Yuhe Song, Ling Tang, Min Ma, Jie Cui, Tianhou Wang
Summary: In late 2020, 32 highly pathogenic avian influenza A(H5N8) viruses were detected in migratory ducks in Shanghai, China. Phylogenetic analysis revealed 2 sublineages of clade 2.3.4.4b, each forming separate clusters with isolates from East Asia and Europe.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Biochemical Research Methods
Zhen Niu, Deborah Chasman, Amie J. Eisfeld, Yoshihiro Kawaoka, Sushmita Roy
Article
Mathematical & Computational Biology
Jason E. McDermott, Hugh D. Mitchell, Lisa E. Gralinski, Amie J. Eisfeld, Laurence Josset, Armand Bankhead, Gabriele Neumann, Susan C. Tilton, Alexandra Schafer, Chengjun Li, Shufang Fan, Shannon McWeeney, Ralph S. Baric, Michael G. Katze, Katrina M. Waters
BMC SYSTEMS BIOLOGY
(2016)
Article
Microbiology
Jennifer Tisoncik-Go, David J. Gasper, Jennifer E. Kyle, Amie J. Eisfeld, Christian Selinger, Masato Hatta, Juliet Morrison, Marcus J. Korth, Erika M. Zink, Young-Mo Kim, Athena A. Schepmoes, Carrie D. Nicora, Samuel O. Purvine, Karl K. Weitz, Xinxia Peng, Richard R. Green, Susan C. Tilton, Bobbie-Jo Webb-Robertson, Katrina M. Waters, Thomas O. Metz, Richard D. Smith, Yoshihiro Kawaoka, M. Suresh, Laurence Josset, Michael G. Katze
CELL HOST & MICROBE
(2016)
Article
Immunology
Danielle Westhoff Smith, Lindsay Hill-Batorski, Alhaji N'jai, Amie J. Eisfeld, Gabriele Neumann, Peter Halfmann, Yoshihiro Kawaoka
JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Biochemical Research Methods
Deborah Chasman, Kevin B. Walters, Tiago J. S. Lopes, Amie J. Eisfeld, Yoshihiro Kawaoka, Sushmita Roy
PLOS COMPUTATIONAL BIOLOGY
(2016)
Editorial Material
Biochemistry & Molecular Biology
Amie J. Eisfeld, Yoshihiro Kawaoka
Article
Multidisciplinary Sciences
Vineet D. Menachery, Alexandra Schafer, Kristin E. Burnum-Johnson, Hugh D. Mitchell, Amie J. Eisfeld, Kevin B. Walters, Carrie D. Nicora, Samuel O. Purvine, Cameron P. Casey, Matthew E. Monroe, Karl K. Weitz, Kelly G. Stratton, Bobbie-Jo M. Webb-Robertson, Lisa E. Gralinski, Thomas O. Metz, Richard D. Smith, Katrina M. Waters, Amy C. Sims, Yoshihiro Kawaoka, Ralph S. Baric
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Microbiology
Amie J. Eisfeld, David J. Gasper, M. Suresh, Yoshihiro Kawaoka
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
J. E. Kyle, K. E. Burnum-Johnson, J. P. Wendler, A. J. Eisfeld, Peter J. Halfmann, Tokiko Watanabe, Foday Sahr, R. D. Smith, Y. Kawaoka, K. M. Waters, T. O. Metz
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Infectious Diseases
Peter J. Halfmann, Amie J. Eisfeld, Tokiko Watanabe, Tadashi Maemura, Makoto Yamashita, Satoshi Fukuyama, Tammy Armbrust, Isaiah Rozich, Alhaji N'jai, Gabriele Neumann, Yoshihiro Kawaoka, Foday Sahr
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Cell Biology
Hugh D. Mitchell, Amie J. Eisfeld, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bremer, Ji Wen, Jason E. McDermott, Lisa E. Gralinski, Amy C. Sims, Mai Q. Le, Ralph S. Baric, Yoshihiro Kawaoka, Katrina M. Waters
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Lisa M. Bramer, Robert D. Hontz, Amie J. Eisfeld, Amy C. Sims, Young-Mo Kim, Kelly G. Stratton, Carrie D. Nicora, Marina A. Gritsenko, Athena A. Schepmoes, Osamu Akasaka, Michiko Koga, Takeya Tsutsumi, Morio Nakamura, Ichiro Nakachi, Rie Baba, Hiroki Tateno, Shoji Suzuki, Hideaki Nakajima, Hideaki Kato, Kazunari Ishida, Makoto Ishii, Yoshifumi Uwamino, Keiko Mitamura, Vanessa L. Paurus, Ernesto S. Nakayasu, Isaac K. Attah, Andrew G. Letizia, Katrina M. Waters, Thomas O. Metz, Karen Corson, Yoshihiro Kawaoka, Vincent R. Gerbasi, Hiroshi Yotsuyanagi, Kiyoko Iwatsuki-Horimoto
Summary: To better understand the pathology of COVID-19, a multi-omics and correla-tive analysis was conducted on a clinical cohort. Severe patients exhibited elevated levels of pulmonary surfactant, while mild patients showed an increase in the carnosine dipeptidase modifying enzyme (CNDP1). Both mild and severe patients had elevated L-cystine and enzymes related to glutathione metabolism. Neutrophil extracellular traps (NETs) were observed in both patient groups, with higher formation in severe cases. CNDP1 may play a protective role in suppressing PSPB release, while NET formation is correlated with increased PSPB levels and disease severity, potentially leading to pulmonary occlusions.
Article
Microbiology
Amie J. Eisfeld, Peter J. Halfmann, Jason P. Wendler, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Zuleyma Peralta, Tadashi Maemura, Kevin B. Walters, Tokiko Watanabe, Satoshi Fukuyama, Makoto Yamashita, Jon M. Jacobs, Young-Mo Kim, Cameron P. Casey, Kelly G. Stratton, Bobbie-Jo M. Webb-Robertson, Marina A. Gritsenko, Matthew E. Monroe, Karl K. Weitz, Anil K. Shukla, Mingyuan Tian, Gabriele Neumann, Jennifer L. Reed, Harm van Bakel, Thomas O. Metz, Richard D. Smith, Katrina M. Waters, Alhaji N'jai, Foday Sahr, Yoshihiro Kawaoka
CELL HOST & MICROBE
(2017)
Article
Oncology
Teridah Ernala Ginting, Jeremiah Suryatenggara, Salomo Christian, George Mathew
ONCOLYTIC VIROTHERAPY
(2017)
Article
Chemistry, Analytical
Kristin E. Burnum-Johnson, Jennifer E. Kyle, Amie J. Eisfeld, Cameron P. Casey, Kelly G. Stratton, Juan F. Gonzalez, Fabien Habyarimana, Nicholas M. Negretti, Amy C. Sims, Sadhana Chauhan, Larissa B. Thackray, Peter J. Halfmann, Kevin B. Walters, Young-Mo Kim, Erika M. Zink, Carrie D. Nicora, Karl K. Weitz, Bobbie-Jo M. Webb-Robertson, Ernesto S. Nakayasu, Brian Ahmer, Michael E. Konkel, Vladimir Motin, Ralph S. Baric, Michael S. Diamond, Yoshihiro Kawaoka, Katrina M. Waters, Richard D. Smith, Thomas O. Metz