Article
Immunology
Dominique Baeten, Iannis E. Adamopoulos
Summary: This article discusses the pathobiology of axial spondyloarthritis, particularly the role of IL-23/IL-17 axis, and shares relevant lessons learned for translating emerging biological insights into clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katelyn A. Bruno, Logan P. Macomb, A. Carolina Morales-Lara, Jessica E. Mathews, J. Augusto Frisancho, Alex L. Yang, Damian N. Di Florio, Brandy H. Edenfield, Emily R. Whelan, Gary R. Salomon, Anneliese R. Hill, Chathuranga C. Hewa-Rahinduwage, Ashley J. Scott, Henry D. Greyner, Frank A. Molina, Merci S. Greenaway, George M. Cooper, DeLisa Fairweather
Summary: The study found that housing mice in plastic cages increases the progression of viral myocarditis, with male mice being mainly affected by complement activation and increased macrophages, while female mice are mainly affected by mast cell activation and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mingxin Zhu, Han Yang, Yang Lu, Hongmin Yang, Yaohan Tang, Lixia Li, Yaoxi Zhu, Jing Yuan
Summary: This study identified the formation of ELFs in myocardial tissues of VMC, with the number of ELFs correlating with the severity of VMC. Functional ELFs with GCs were found to facilitate the production of local AHA, potentially offering new opportunities for stratification and early identification of VMC patients.
Article
Cardiac & Cardiovascular Systems
Paolo Carai, Laura Florit Gonzalez, Stijn Van Bruggen, Valerie Spalart, Daria De Giorgio, Nadeche Geuens, Kimberly Martinod, Elizabeth Anne Vincent Jones, Stephane Heymans
Summary: The study investigates the contribution of neutrophils to the progression of viral myocarditis (VM) and found that inhibiting neutrophils and neutrophil extracellular traps (NETs) in the acute phase of VM can reduce cardiac inflammation and improve the pathological phenotype.
CARDIOVASCULAR RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Chao Shi, Shanshan Ma, Jinxia Bai, Yan Liu, Yuelong Ma, Xinyuan Lu, Jianyu Zhu, Degang Yang
Summary: This study found that IL-23 expression was significantly increased in the skin of leprosy patients, and Th17 cells produce IL-17A in an IL-23 dependent manner, providing more focused treatment strategies for Mycobacterium leprae.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Immunology
Chun-Wen Chan, Hung-Wen Chen, Yu-Wen Wang, Chia- Lin, Ya-Hui Chuang
Summary: This study found that the Th17 cell-derived cytokine IL-21 plays a role in the pathogenesis of PBC, exacerbating liver inflammation and fibrosis and increasing the numbers and effector activities of CD8+ T cells.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jiang-Min Liu, Quan-Xin Jin, Manabu Fujimoto, Fang-Fang Li, Lin-Bo Jin, Ran Yu, Guang-Hai Yan, Lian-Hua Zhu, Fan-Ping Meng, Qing-Gao Zhang, Gui-Hua Jin
Summary: DHA inhibits the progression of psoriasis by regulating the expression of Th17 cells and related cytokines, improving skin symptoms and immune cell infiltration, restoring cellular composition in the spleen, and ultimately suppressing the development of psoriasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Ahlam M. Ismail, Aliaa M. Higazi, Hanan M. Nomeir, Naglaa M. Farag
Summary: Elevated levels of IL-23, IL-17A, and Th17 cells are associated with ITP pathogenesis in Egyptian children, while the IL-17A polymorphism rs2275913 is not prevalent among them.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Microbiology
Zhao Liu, Qing Liu, Yanyan Xu, Zhao Han, Ling Zhang, Xiaojing Li
Summary: This study aimed to investigate the effect and mechanism of 3% boric acid solution (BAS) on Candida albicans (CA) infection, and found that IL-17, IL-22, and IL-23 are involved in the anti-CA activity in mouse skin, and 3% BAS increased IL-17, IL-22, and IL-23 levels to mediate these effects.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Yimin Xue, Jun Ke, Xiaofen Zhou, Qian Chen, Mingguang Chen, Tingfeng Huang, Fenghui Lin, Feng Chen
Summary: This study demonstrated that MALAT1 knockdown can alleviate the severity of coxsackievirus B3-induced AVMC in mice by inhibiting Th17 cells differentiation. MALAT1 may serve as a novel therapeutic option for AVMC.
Article
Immunology
Quentin Philippot, Masato Ogishi, Jonathan Bohlen, Julia Puchan, Andres Augusto Arias, Tina Nguyen, Marta Martin-Fernandez, Clement Conil, Darawan Rinchai, Mana Momenilandi, Seyed Alireza Mandaviani, Mohammad Keramatipour, Jeremie Rosain, Rui Yang, Taushif Khan, Anna-Lena Neehus, Marie Materna, Ji Eun Han, Jessica Peel, Federico Mele, Marc Weisshaar, Sandra Jovic, Paul Bastard, Romain Levy, Tom Le Voyer, Peng Zhang, Majistor Raj Luxman Maglorius Renkilaraj, Carlos A. Arango-Franco, Simon Pelham, Yoann Seeleuthner, Mathieu Pochon, Manar Mahmoud Ahmad Ata, Fatima Al Ali, Melanie Migaud, Camille Soudee, Tatiana Kochetkov, Anne Molitor, Raphael Carapito, Seiamak Bahram, Bertrand Boisson, Claire Fieschi, Davood Mansouri, Nico Marr, Satoshi Okada, Mohammad Shahrooei, Nima Parvaneh, Zahra Chavoshzadeh, Aurelie Cobat, Dusan Bogunovic, Laurent Abel, Stuart G. Tangye, Cindy S. Ma, Vivien Beziat, Federica Sallusto, Stephanie Boisson-Dupuis, Jacinta Bustamante, Jean-Laurent Casanova, Anne Puel
Summary: Patients with IL-23R deficiency may suffer from Mendelian susceptibility to mycobacterial disease and chronic mucocutaneous candidiasis. IL-23 is essential for the production of IL-17A in MATT cells and for the production of IFN-y in both V62+ y6 T cells and MATT cells.
SCIENCE IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Meijing Wang, Tinghan Li, Zijun Ouyang, Kai Tang, Yuyu Zhu, Chenglin Song, Haiyan Sun, Bin Yu, Xiaoyun Ji, Yang Sun
Summary: This study identified TK-453 as a lead compound with strong affinity for SHP2, demonstrating its potential as a therapeutic target for psoriasis. TK-453 significantly improved skin inflammation in mice by inhibiting the IL-23/Th17 axis.
Article
Medicine, General & Internal
Tomoyo Matsuda-Taniguchi, Masaki Takemura, Takeshi Nakahara, Akiko Hashimoto-Hachiya, Ayako Takai-Yumine, Masutaka Furue, Gaku Tsuji
Summary: Psoriasis is a chronic inflammatory skin disease, and the key role of IL-23 and IL-36γ in its pathogenesis has been identified. Research suggests that metformin may inhibit IL-36γ-induced IL-23 production by modulating NF-κB signaling pathway, potentially contributing to the prevention of psoriasis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jacqueline Georgy, Yvonne Arlt, Jens M. Moll, Meryem Ouzin, Hendrik T. Weitz, Lothar Gremer, Dieter Willbold, Joachim Groetzinger, Felix Thives-Kurenbach, Juergen Scheller, Doreen M. Floss
Summary: This study identified key amino acid residues in the p40 subunit of IL-12/IL-23 that are crucial for binding to IL-12Rβ1, providing insights into the structural basis of cytokine-cytokine receptor interactions and offering potential for the development of novel therapeutic strategies.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biology
Mahima T. Rasquinha, Ninaad Lasrado, Erika Petro-Turnquist, Eric Weaver, Thiagarajan Venkataraman, Daniel Anderson, Uri Laserson, H. Benjamin Larman, Jay Reddy
Summary: In this study, the researchers analyzed the production of heart antigen antibodies in a mouse model of CVB3 myocarditis using the PhIP-Seq technique. They identified several previously unreported protein antibodies that may be relevant to human disease.