Article
Environmental Sciences
Liping Li, Faxuan Wang, Jianjun Zhang, Kai Wang, Xiaoming De, Ling Li, Yuhong Zhang
Summary: The combined effect of DEHP and DBP promotes pancreatic beta cell apoptosis through a ROS-mediated PI3K/Akt/Bcl-2 pathway, significantly higher than the effects of each PAE alone. This effect is not currently considered in safety standards and studies, highlighting the need for further research to establish more impactful and safer standards.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Clemens Holz, Sandra Lange, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Hugo Murua Escobar, Christian Junghanss, Anna Richter
Summary: Numerous hematologic neoplasms, including acute B-lymphoblastic leukemia (B-ALL), are characterized by overexpression of anti-apoptotic BCL-2 family proteins. Recent data indicated that combined BCL-2 and PI3K/AKT inhibition has synergistic anti-proliferative effects on B-ALL cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Xiaoxiang Xu, Ningyuan Xi, Jiashe Chen, Zhiyu Zhou, Mengjie Liu, Guorong Yan, Yeqiang Liu
Summary: In this study, human keratinocytes were used as an in vitro model to investigate the cytotoxic effect of deoxynivalenol (DON). The results showed that DON exposure caused cell damage, oxidative stress, and apoptosis in HaCaT cells through the activation of PI3K/Akt and MAPK pathways. Additionally, DON exposure altered the gene expression involved in apoptosis, MAPK signaling pathway, and PI3K/Akt signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ahmed A. Noser, Ihsan A. Shehadi, Aboubakr H. Abdelmonsef, Maha M. Salem
Summary: A series of novel pyrazolinone chalcones were synthesized and screened for their ability to inhibit cancer proliferation and metastasis. Compound 6b exhibited the highest binding energy and most effective cytotoxic impact, inhibiting the PI3K/Akt and Raf-1/ERK1/2 signaling pathways.
Article
Oncology
Xiaobei Zhang, Xiaokun Wang, Xiaofeng Liu, Weihao Luo, Hongwei Zhao, Yiqing Yin, Kuibin Xu
Summary: Propofol has a protective effect on cardiomyocyte apoptosis induced by doxorubicin by suppressing the PI3K/AKT/Bcl-2 pathway.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Luqian Liu, Meijuan Yan, Rui Yang, Xuqing Qin, Ling Chen, Li Li, Junqiang Si, Xinzhi Li, Ketao Ma
Summary: This study confirmed the protective effect of adiponectin (APN) against lipopolysaccharide (LPS)-induced cardiomyocyte apoptosis, potentially through regulating the connexin43 (Cx43) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Ziyan Chen, Bangjie He, Jungang Zhao, Jiacheng Li, Yifeng Zhu, Leilei Li, Wenming Bao, Jiuyi Zheng, Haitao Yu, Gang Chen
Summary: This study found that brusatol has inhibitory effects on the proliferation and epithelial-mesenchymal transition process of intrahepatic cholangiocarcinoma cells, and promotes apoptosis in these cells through activating the PI3K/Akt pathway. The findings were further validated in animal models, demonstrating the potential therapeutic effect of brusatol on intrahepatic cholangiocarcinoma.
Article
Biochemistry & Molecular Biology
Li-Li Zhu, Gui-Yun Cao, Li-Ying Jia, Guo Zheng, Liang Zhang, Ping Sheng, Zhao-Qing Meng, Xin He, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan
Summary: This study investigated the cardioprotective effect of Muscone on AMI rats and found that Muscone significantly reduced myocardial injury, improved cardiac function, and exerted protective effects by inhibiting oxidative stress and apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Immunology
Qihong Zhang, Tingting Xie, Guodong Mo, Zihao Zhang, Ling Lin, Xiquan Zhang
Summary: ACSL1, as an interferon-stimulated gene, plays a crucial role in restricting the replication of ALV-J and inducing apoptosis in primary monocyte-derived macrophages through the PI3K/Akt signaling pathway, leading to pro-inflammatory phenotypic changes. These results provide evidence that ACSL1 contributes to the antiviral response against ALV-J.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yang
Summary: METTL3 promotes the maturation of miR-126-5p through m6A modification, which in turn targets PTEN to activate the PI3K/Akt/mTOR pathway in ovarian cancer progression. This study provides potential targets for future ovarian cancer treatment and reveals tumorigenic mechanisms regulated by m6A modification.
CANCER GENE THERAPY
(2021)
Article
Oncology
Yi Cheng, Guiying Wang, Lianmei Zhao, Suli Dai, Jing Han, Xuhua Hu, Chaoxi Zhou, Feifei Wang, Hongqing Ma, Baokun Li, Zesong Meng
Summary: The study found that PPM can inhibit CRC cell proliferation, induce cell apoptosis, and promote G0/G1 cell cycle arrest. Additionally, PPM's effect may be related to the PI3K/AKT signaling pathway, with minimal impact on mouse functions and enhanced anticancer effects when combined with 5-FU.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jun Ying, Ruowang Pan, Zhouhao Tang, Jiayin Zhu, Ping Ren, Yang Lou, Enyong Zhang, Dadao Huang, Penghong Hu, Dong Li, Qiyu Bao, Peizhen Li
Summary: This study found that the knockdown of NCL inhibited the proliferation of cervical cancer cells and promoted apoptosis. Mechanistic studies revealed that NCL knockdown achieved this by regulating the PI3K/AKT pathway, upregulating the expression of genes such as FGF, ITGA, TNXB, VEGF, Caspase 3, and Bax, and downregulating the expression of genes such as AKT, GNB4, CDK6, IL6R, LAMA, PDGFD, PPP2RSA, and BCL-2.
Article
Immunology
Chao Niu, Min Li, Yongchong Chen, Xiaoying Zhang, Shan Zhu, Xin Zhou, Lei Zhou, Zhaozhi Li, Jianting Xu, Ji-Fan Hu, Yufeng Wang, Jiuwei Cui
Summary: A novel lncRNA, called NCAL1, was discovered to enhance the cytotoxicity of NK cells by activating Gab2 protein. NCAL1 upregulated Gab2 expression epigenetically, thus promoting NK cell cytotoxicity and potentially serving as a therapeutic target for improving NK cell therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yan Sun, Huan Zhang, Junpeng Meng, Feng Guo, Dianyun Ren, Heshui Wu, Xin Jin
Summary: This study demonstrates that aberrant PCSK9 upregulation promotes cell proliferation and sorafenib resistance in HCC by inducing AKT activation. Additionally, competitive inhibition of PCSK9 palmitoylation enhances the antitumor effects of sorafenib in HCC.
Article
Cell Biology
Wenwen Dong, Bei Luo, Chang Qiu, Xu Jiang, Bo Shen, Li Zhang, Weiguo Liu, Wenbin Zhang
Summary: The study demonstrates that TRIM3 may attenuate cell apoptosis in Parkinson's disease by activating the PI3K/AKT signaling pathway, thereby improving cell viability in PD.
Article
Virology
Naiqing Xu, Xinen Tang, Xin Wang, Miao Cai, Xiaowen Liu, Xiaolong Lu, Shunlin Hu, Min Gu, Jiao Hu, Ruyi Gao, Kaituo Liu, Yu Chen, Xiufan Liu, Xiaoquan Wang
Summary: This study found that the H9N2 subtype avian influenza virus has a high airborne transmissibility, while the H7N9 virus does not. The Hemagglutinin protein of the H9N2 virus was found to play a key role in replication, stability, and airborne transmission.
Article
Virology
Samar S. Ewies, Sabry M. Tamam, Ahmed S. Abdel-Moneim, Sherin R. Rouby
Summary: Contagious ecthyma (CE) is a highly contagious viral disease of sheep and goats worldwide. The study provided a clinical description of CE and screened for genetic variation in the B2L gene. Infected sheep exhibited anorexia and oral lesions, while inoculated chicken embryos showed pock lesions. The B2L gene was successfully amplified and found to be highly conserved.
Article
Virology
Yigal Farnoushi, Dan Heller, Avishai Lublin
Summary: In recent years, new variants of avian reovirus (ARV) have caused a variety of symptoms in chickens worldwide, including viral arthritis/tenosynovitis. This study analyzed emerging ARV variants in Israel and found significant genetic diversity. Most ARV isolates in Israel belonged to genotypic cluster 5 (GC5). The study suggests that Israel has not experienced the emergence of new ARV variants since the introduction of the live vaccine (ISR-7585), but ongoing monitoring is needed due to the continuous emergence of ARV variants.
Article
Virology
Shigeru Tajima, Michiyo Kataoka, Yuki Takamatsu, Hideki Ebihara, Chang-Kweng Lim
Summary: Yokose virus (YOKV), a bat-associated flavivirus, was found to replicate at a slower rate in mosquito cells compared to other mosquito-borne flaviviruses. Specific nucleotide mutations in the virus were identified to enhance its proliferation ability in mosquito cells.
Article
Virology
Alejandra Borjabad, Baojun Dong, Wei Chao, David J. Volsky, Mary Jane Potash
Summary: This study investigated HIV brain disease using a mouse model, and found that poly I:C can reverse associated cognitive impairment and reduce virus burden. The results also revealed transcriptional changes related to neuronal function and innate immune responses.
Article
Virology
Ching-Hung Lin, Feng-Cheng Hsieh, Meilin Wang, Chieh Hsu, Hsuan-Wei Hsu, Chun-Chun Yang, Cheng-Yao Yang, Hung-Yi Wu
Summary: This study demonstrates that the synthesis of coronavirus subgenomic mRNA is not solely determined by the sequence homology between the leader TRS and TRS-B, but also by the disassociation of the coronavirus polymerase from the viral genome. This finding provides a new insight into the transcription mechanism of coronaviruses.
Article
Virology
Nicholas S. Kron, Benjamin W. Neuman, Sathish Kumar, Patricia L. Blackwelder, Dayana Vidal, Delphina Z. Walker-Phelan, Patrick D. I. Gibbs, Lynne A. Fieber, Michael C. Schmale
Summary: Two recent studies documented the genome of a novel virus in marine animals, finding that the virus is widespread in apparently healthy animals but not highly expressed in neurons. The studies also identified viral replication factories and high levels of defective genomes in chronically infected animals.
Article
Virology
Andrew M. Ramey, Laura C. Scott, Christina A. Ahlstrom, Evan J. Buck, Alison R. Williams, Mia Kim Torchetti, David E. Stallknecht, Rebecca L. Poulson
Summary: We successfully detected and characterized highly pathogenic avian influenza viruses in hunter-harvested wild waterfowl samples from western Alaska. Genomic analysis revealed three independent viral introductions into Alaska. Our findings demonstrate the utility and potential limitations of using molecular processing approaches directly on original swab samples for viral research and monitoring.
Article
Virology
Ting Gong, Dongdong Wu, Yongzhi Feng, Xing Liu, Qi Gao, Xiaoyu Zheng, Zebu Song, Heng Wang, Guihong Zhang, Lang Gong
Summary: This study discovered that quercetin can inhibit PEDV replication both in vivo and in vitro, and alleviate the clinical symptoms and intestinal injury caused by the virus. This provides a new direction for the development of PED antiviral drugs.
Article
Virology
Min Zhu, Hao Zeng, Jianqiao He, Yaohui Zhu, Pingping Wang, Jianing Guo, Jinfan Guo, Huabo Zhou, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Ying Chen
Summary: The reassortment between avian H9N2 and Eurasian avian-like (EA) H1N1 viruses may have potentially changed from avian-to-mammals adaptation. This study found that the introduction of EA H1N1 internal genes into H9N2 virus restored the replication capability and resulted in extreme virulence in some cases. This raises new concerns for public health due to the possible coexistence of H9N2 and EA H1N1 viruses in dogs.