Article
Biochemistry & Molecular Biology
Chung-Chun Wu, Ting-Ying Lee, Yu-Jhen Cheng, Der-Yang Cho, Jen-Yang Chen
Summary: Kaempferol efficiently inhibits the reactivation of EBV, making it a potential choice for anti-EBV therapy and cancer prevention.
Article
Medicine, General & Internal
Ruo-Wen Xiao, Fang Wang, Tong -Min Wang, Jiang -Bo Zhang, Zi-Yi Wu, Chang-Mi Deng, Ying Liao, Ting Zhou, Da -Wei Yang, Si-Qi Dong, Wen-Qiong Xue, Yong-Qiao He, Xiao-Hui Zheng, Xi-Zhao Li, Pei -Fen Zhang, Shao-Dan Zhang, Ye -Zhu Hu, Yu-Ying Liu, Yun-Fei Xia, Song Gao, Jian-Bing Mu, Lin Feng, Wei-Hua Jia
Summary: This study identified rare missense mutations in the POLN gene that are associated with familial NPC risk. Experimental studies demonstrated that these mutations impair the protein stability and expression levels of POLN, leading to a compromised ability to promote EBV lytic replication and host cell proliferation.
Article
Biochemistry & Molecular Biology
Praphatson Malat, Tipaya Ekalaksananan, Chukkris Heawchaiyaphum, Supawadee Suebsasana, Sittiruk Roytrakul, Yodying Yingchutrakul, Chamsai Pientong
Summary: Andrographolide inhibits the reactivation of Epstein-Barr virus in EBV-positive cancer cells by inhibiting EBV lytic genes, possibly through histone modifications.
Article
Virology
Kena Lin, Zhiwen Zeng, Xueqi Li, Wenjie Chen, Dongfeng Lin, Shanghang Xie, Zhicong Wu, Mengmeng Li, Sumei Cao, Jinlin Du
Summary: This study investigated the association between hypertension and Epstein-Barr virus (EBV) reactivation. It found that hypertension increased the risk of EBV reactivation, while beta-blockers and angiotensin converting enzyme inhibitors (ACEIs) were associated with a reduced risk of EBV reactivation.
Article
Biochemistry & Molecular Biology
Lee-Wen Chen, Shie-Shan Wang, Chien-Hui Hung, Ya-Hui Hung, Chun-Liang Lin, Pey-Jium Chang
Summary: The unfolded protein response (UPR) is crucial for alleviating endoplasmic reticulum (ER) stress and many viruses manipulate the UPR signaling network. In the lytic cycle of Epstein-Barr virus (EBV), the expression of central UPR regulator GRP78 is up-regulated, and knockdown of GRP78 reduces virus particle production. BMLF1 is identified as a key regulator contributing to the activation of the grp78 gene promoter and can trigger the activation of the UPR senor ATF6.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alexander Buschle, Paulina Mrozek-Gorska, Filippo M. Cernilogar, Andreas Ettinger, Dagmar Pich, Stefan Krebs, Bianca Mocanu, Helmut Blum, Gunnar Schotta, Tobias Straub, Wolfgang Hammerschmidt
Summary: EBV induces massive and global alterations in the chromatin of its host cell before the onset of viral DNA replication, with the viral initiator protein BZLF1 implementing a binary molar switch. This results in locally opening silent chromatin and global-scale inaccessibility of cellular chromatin, leading to a drastic increase in viral transcripts, reduction of cellular transcripts, and loss of chromatin-chromatin interactions.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Li-Jen Liao, Wan-Lun Hsu, Chi-Ju Chen, Yen-Ling Chiu
Summary: Nasopharyngeal carcinoma is endemic in southern Asia and this article describes the molecular abnormalities in NPC and potential molecular mechanisms for future therapy. It provides an up-to-date review on the molecular pathways of NPC, improving our understanding of the disease and highlighting areas for further research.
Article
Microbiology
Katherine A. Willard, Ashley P. Barry, Cliff I. Oduor, John Michael Ong'echa, Jeffrey A. Bailey, Ann M. Moormann, Micah A. Luftig
Summary: In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. These findings provide insight into viral and host factors involved in this process and the potential contribution of promiscuous lytic activity to the formation of EBV-associated diseases.
Review
Oncology
Ramon Yarza, Mateo Bover, Maria Teresa Agullo-Ortuno, Lara Carmen Iglesias-Docampo
Summary: Nasopharyngeal carcinoma (NPC) is a molecularly paradigmatic tumor with complex environmental and host dependent factors, where Epstein Barr Virus (EBV) plays a key role in malignant transformation. The dysregulation of proteasome signaling is central in NPC pathogenesis and could be a potential therapeutic target. Studies have shown the efficacy of immunotherapy in NPC, with novel strategies aiming to reverse immune resistance and favor tumor recognition.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Virology
Jaeyeun Lee, Jennifer Stone, Prashant Desai, John G. Kosowicz, Jun O. Liu, Richard F. Ambinder
Summary: Research found that As2O3 can increase EBV Zta gene expression while blocking late lytic gene expression and virion production. Additionally, the effects of As2O3 on EBV gene expression may be mediated by pathways other than the ISR signaling pathway.
Article
Oncology
Kelly J. Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M. Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
Summary: This study reassessed familial aggregation of cancer in high-risk Taiwanese multiplex families with NPC cases and found evidence of NPC coaggregation within families, but not a broader familial syndrome involving NPC and other tumors. The study also observed elevated rates of secondary cancers among NPC cases, mostly head and neck and hematopoietic cancers, suggesting radiation treatment effects on subsequent cancer risk.
Article
Virology
Ting Shi, Linlin Huang, Zhengrong Chen, Jianmei Tian
Summary: This study investigated the characteristics of primary EBV infection and reactivation in children in Suzhou, China, finding that primary EBV infection was more common in children aged 36 to <72 months and often led to infectious mononucleosis. Reactivation of EBV mainly occurred in children aged 8 to <36 months and was identified as a risk factor for hemophagocytic lymphohistiocytosis (HLH). Among reactivated patients, HLH had a higher viral load compared to EBV infection and respiratory infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Satoru Kondo, Atsushi Okabe, Takuya Nakagawa, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Hirotomo Dochi, Harue Mizokami, Yuki Kitagawa, Tomoya Kurokawa, Masato Mima, Kazuhira Endo, Hisashi Sugimoto, Naohiro Wakisaka, Kiyoshi Misawa, Tomokazu Yoshizaki, Atsushi Kaneda
Summary: Nasopharyngeal carcinoma is a malignancy associated with Epstein-Barr virus and epigenetic abnormalities play important roles in its development. The latent membrane protein 1 (LMP1) is a key factor in inducing aberrant DNA methylation of tumour suppressor genes. This study identified LMP1-inducible methylation genes and demonstrated that DERL3 repression by DNA methylation contributes to the progression of nasopharyngeal carcinoma. The findings suggest potential targets for therapeutic intervention.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Chemistry, Physical
Mengran Guo, Xing Duan, Xingchen Peng, Zhaohui Jin, Hai Huang, Wen Xiao, Qian Zheng, Yongqi Deng, Na Fan, Kepan Chen, Xiangrong Song
Summary: In this study, a lipid-based LMP2-mRNA vaccine was developed and shown to effectively express LMP2 and stimulate antigen-specific T-cell responses in cell assays. It significantly inhibited tumor growth in an LMP2-expressing tumor model after three doses of vaccination.
Article
Biochemistry & Molecular Biology
Dan He, Jun Wang, Chunfang Zhang, Bin Shan, Xiyun Deng, Bin Li, Yanwu Zhou, Wei Chen, Jidong Hong, Yang Gao, Zhuchu Chen, Chaojun Duan
Article
Multidisciplinary Sciences
Ranran Wang, Ying Shi, Ling Chen, Yiqun Jiang, Chao Mao, Bin Yan, Shuang Liu, Bin Shan, Yongguang Tao, Xiang Wang
SCIENTIFIC REPORTS
(2015)
Article
Physiology
Beibei Xu, James F. Guenther, Derek A. Pociask, Yu Wang, Jay K. Kolls, Zongbing You, Bysani Chandrasekar, Bin Shan, Deborah E. Sullivan, Gilbert F. Morris
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2014)
Article
Immunology
Xiaoli Qin, Xiaorui Liu, Bin Shan, Lijuan Shi, Surendra Sharma, Ji Wu, Yi Lin
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2014)
Article
Oncology
Hong T. Nguyen, Yan Zhuang, Lichun Sun, Steven P. Kantrow, Jay K. Kolls, Zongbing You, Ying Zhuo, Bin Shan
CANCER CELL INTERNATIONAL
(2013)
Article
Obstetrics & Gynecology
Yun Sun, Xiaoli Qin, Bin Shan, Wenjing Wang, Qinling Zhu, Surendra Sharma, Ji Wu, Yi Lin
FERTILITY AND STERILITY
(2013)
Article
Medicine, Research & Experimental
Hilaire C. Lam, Suzanne M. Cloonan, Abhiram R. Bhashyam, Jeffery A. Haspel, Anju Singh, J. Fah Sathirapongsasuti, Morgan Cervo, Hongwei Yao, Anna L. Chung, Kenji Mizumura, Chang Hyeok An, Bin Shan, Jonathan M. Franks, Kathleen J. Haley, Caroline A. Owen, Yohannes Tesfaigzi, George R. Washko, John Quackenbush, Edwin K. Silverman, Irfan Rahman, Hong Pyo Kim, Ashfaq Mahmood, Shyam S. Biswal, Stefan W. Ryter, Augustine M. K. Choi
JOURNAL OF CLINICAL INVESTIGATION
(2013)
Article
Oncology
Yan Zhuang, Xiang Wang, Hong T. Nguyen, Ying Zhuo, Xinpeng Cui, Claire Fewell, Erik K. Flemington, Bin Shan
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Yan Zhuang, Hong T. Nguyen, Matthew E. Burow, Ying Zhuo, Samir S. El-Dahr, Xiao Yao, Subing Cao, Erik K. Flemington, Kenneth P. Nephew, Fang Fang, Bridgette Collins-Burow, Lyndsay V. Rhodes, Qiang Yu, Janarthanan Jayawickramarajah, Bin Shan
MOLECULAR CARCINOGENESIS
(2015)
Article
Biochemistry & Molecular Biology
Mu Zhang, Shengyan Xiang, Heui-Yun Joo, Lei Wang, Kendra A. Williams, Wei Liu, Chen Hu, Dan Tong, Joshua Haakenson, Chuangui Wang, Shengping Zhang, Ryan E. Pavlovicz, Amanda Jones, Kristina H. Schmidt, Jinfu Tang, Huiqin Dong, Bin Shan, Bin Fang, Rangasudhagar Radhakrishnan, Peter M. Glazer, Patrick Matthias, John Koomen, Edward Seto, Gerold Bepler, Santo V. Nicosia, Jiandong Chen, Chenglong Li, Liya Gu, Guo-Min Li, Wenlong Bai, Hengbin Wang, Xiaohong Zhang
Article
Multidisciplinary Sciences
James W. Antoon, Elizabeth C. Martin, Rongye Lai, Virgilo A. Salvo, Yan Tang, Ashley M. Nitzchke, Steven Elliott, Seung Yoon Nam, Wei Xiong, Lyndsay V. Rhodes, Bridgette Collins-Burow, Odile David, Guandi Wang, Bin Shan, Barbara S. Beckman, Kenneth P. Nephew, Matthew E. Burow
Article
Multidisciplinary Sciences
Yi Lin, Xiaorui Liu, Bin Shan, Ji Wu, Surendra Sharma, Yun Sun
Article
Respiratory System
Fayong Luo, Yan Zhuang, Mark D. Sides, Cecilia G. Sanchez, Bin Shan, Eric S. White, Joseph A. Lasky
RESPIRATORY RESEARCH
(2014)
Article
Multidisciplinary Sciences
Zhenzi Peng, Jun Wang, Bin Shan, Fulai Yuan, Bin Li, Yeping Dong, Wei Peng, Wenwen Shi, Yuanda Cheng, Yang Gao, Chunfang Zhang, Chaojun Duan
SCIENTIFIC REPORTS
(2017)
Review
Oncology
Xiaohan Qu, Simon Alsager, Ying Zhuo, Bin Shan
Article
Virology
Naiqing Xu, Xinen Tang, Xin Wang, Miao Cai, Xiaowen Liu, Xiaolong Lu, Shunlin Hu, Min Gu, Jiao Hu, Ruyi Gao, Kaituo Liu, Yu Chen, Xiufan Liu, Xiaoquan Wang
Summary: This study found that the H9N2 subtype avian influenza virus has a high airborne transmissibility, while the H7N9 virus does not. The Hemagglutinin protein of the H9N2 virus was found to play a key role in replication, stability, and airborne transmission.
Article
Virology
Samar S. Ewies, Sabry M. Tamam, Ahmed S. Abdel-Moneim, Sherin R. Rouby
Summary: Contagious ecthyma (CE) is a highly contagious viral disease of sheep and goats worldwide. The study provided a clinical description of CE and screened for genetic variation in the B2L gene. Infected sheep exhibited anorexia and oral lesions, while inoculated chicken embryos showed pock lesions. The B2L gene was successfully amplified and found to be highly conserved.
Article
Virology
Yigal Farnoushi, Dan Heller, Avishai Lublin
Summary: In recent years, new variants of avian reovirus (ARV) have caused a variety of symptoms in chickens worldwide, including viral arthritis/tenosynovitis. This study analyzed emerging ARV variants in Israel and found significant genetic diversity. Most ARV isolates in Israel belonged to genotypic cluster 5 (GC5). The study suggests that Israel has not experienced the emergence of new ARV variants since the introduction of the live vaccine (ISR-7585), but ongoing monitoring is needed due to the continuous emergence of ARV variants.
Article
Virology
Shigeru Tajima, Michiyo Kataoka, Yuki Takamatsu, Hideki Ebihara, Chang-Kweng Lim
Summary: Yokose virus (YOKV), a bat-associated flavivirus, was found to replicate at a slower rate in mosquito cells compared to other mosquito-borne flaviviruses. Specific nucleotide mutations in the virus were identified to enhance its proliferation ability in mosquito cells.
Article
Virology
Alejandra Borjabad, Baojun Dong, Wei Chao, David J. Volsky, Mary Jane Potash
Summary: This study investigated HIV brain disease using a mouse model, and found that poly I:C can reverse associated cognitive impairment and reduce virus burden. The results also revealed transcriptional changes related to neuronal function and innate immune responses.
Article
Virology
Ching-Hung Lin, Feng-Cheng Hsieh, Meilin Wang, Chieh Hsu, Hsuan-Wei Hsu, Chun-Chun Yang, Cheng-Yao Yang, Hung-Yi Wu
Summary: This study demonstrates that the synthesis of coronavirus subgenomic mRNA is not solely determined by the sequence homology between the leader TRS and TRS-B, but also by the disassociation of the coronavirus polymerase from the viral genome. This finding provides a new insight into the transcription mechanism of coronaviruses.
Article
Virology
Nicholas S. Kron, Benjamin W. Neuman, Sathish Kumar, Patricia L. Blackwelder, Dayana Vidal, Delphina Z. Walker-Phelan, Patrick D. I. Gibbs, Lynne A. Fieber, Michael C. Schmale
Summary: Two recent studies documented the genome of a novel virus in marine animals, finding that the virus is widespread in apparently healthy animals but not highly expressed in neurons. The studies also identified viral replication factories and high levels of defective genomes in chronically infected animals.
Article
Virology
Andrew M. Ramey, Laura C. Scott, Christina A. Ahlstrom, Evan J. Buck, Alison R. Williams, Mia Kim Torchetti, David E. Stallknecht, Rebecca L. Poulson
Summary: We successfully detected and characterized highly pathogenic avian influenza viruses in hunter-harvested wild waterfowl samples from western Alaska. Genomic analysis revealed three independent viral introductions into Alaska. Our findings demonstrate the utility and potential limitations of using molecular processing approaches directly on original swab samples for viral research and monitoring.
Article
Virology
Ting Gong, Dongdong Wu, Yongzhi Feng, Xing Liu, Qi Gao, Xiaoyu Zheng, Zebu Song, Heng Wang, Guihong Zhang, Lang Gong
Summary: This study discovered that quercetin can inhibit PEDV replication both in vivo and in vitro, and alleviate the clinical symptoms and intestinal injury caused by the virus. This provides a new direction for the development of PED antiviral drugs.
Article
Virology
Min Zhu, Hao Zeng, Jianqiao He, Yaohui Zhu, Pingping Wang, Jianing Guo, Jinfan Guo, Huabo Zhou, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Ying Chen
Summary: The reassortment between avian H9N2 and Eurasian avian-like (EA) H1N1 viruses may have potentially changed from avian-to-mammals adaptation. This study found that the introduction of EA H1N1 internal genes into H9N2 virus restored the replication capability and resulted in extreme virulence in some cases. This raises new concerns for public health due to the possible coexistence of H9N2 and EA H1N1 viruses in dogs.
