The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold

Synergistic Binding of the Leader and Core Peptides by the Lantibiotic Synthetase HalM2

(2015) Gabrielle N. Thibodeaux et al.   ACS Chemical Biology

In vitro catalytic activity of N-terminal and C-terminal domains in NukM, the post-translational modification enzyme of nukacin ISK-1

(2015) Chinatsu Shimafuji et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Product Formation by the Promiscuous Lanthipeptide Synthetase ProcM is under Kinetic Control

(2015) Yi Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural analysis of leader peptide binding enables leader-free cyanobactin processing

(2015) Jesko Koehnke et al.   Nature Chemical Biology

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

(2015) Brandon J Burkhart et al.   Nature Chemical Biology

Dissecting the catalytic and substrate binding activity of a class II lanthipeptide synthetase BovM

(2014) Hongchu Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Developmental and Activity-Dependent Expression of LanCL1 Confers Antioxidant Activity Required for Neuronal Survival

(2014) Chao Huang et al.   DEVELOPMENTAL CELL

Dissecting Reactions of Nonlinear Precursor Peptide Processing of the Class III Lanthipeptide Curvopeptin

(2014) Natalia A. Jungmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Price To Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases ProcM and HalM2

(2014) Christopher J. Thibodeaux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lanthionine synthetase C–like protein 2 (LanCL2) is a novel regulator of Akt

(2014) Min Zeng et al.   MOLECULAR BIOLOGY OF THE CELL

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

(2014) Manuel A. Ortega et al.   NATURE

Processing of X-ray snapshots from crystals in random orientations

(2014) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Cyanobactin Heterocyclase Enzyme: A Processive Adenylase That Operates with a Defined Order of Reaction

(2013) Jesko Koehnke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NisC Binds the FxLx Motif of the Nisin Leader Peptide

(2013) André Abts et al.   BIOCHEMISTRY

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry

(2013) Weixin Tang et al.   Nature Chemical Biology

In vitro activity of the nisin dehydratase NisB

(2013) N. Garg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, Function, and Biology of the Enterococcus faecalis Cytolysin

(2013) Daria Van Tyne et al.   Toxins

Discovery, Biosynthesis, and Engineering of Lantipeptides

(2012) Patrick J. Knerr et al.   Annual Review of Biochemistry

Evaluation of NVB302 versus vancomycin activity in an in vitro human gut model of Clostridium difficile infection

(2012) G. S. Crowther et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lanthionine Synthetase C-like Protein 1 Interacts with and Inhibits Cystathionine β-Synthase

(2012) Wei-xia Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Evolution of lanthipeptide synthetases

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis

(2011) Zhao Qin Bao et al.   STRUCTURE

Experimental phasing withSHELXC/D/E: combining chain tracing with density modification

(2010) George M. Sheldrick   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Effect of duramycin on chloride transport and intracellular calcium concentration in cystic fibrosis and non-cystic fibrosis epithelia

(2010) IGOR OLIYNYK et al.   APMIS

Steady-State Kinetic and Inhibition Studies of the Mammalian Target of Rapamycin (mTOR) Kinase Domain and mTOR Complexes

(2010) Zhihua Tao et al.   BIOCHEMISTRY

New antibiotics for selective treatment of gastrointestinal infection caused byClostridium difficile

(2010) Alan P Johnson   EXPERT OPINION ON THERAPEUTIC PATENTS

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

(2010) Yuki Goto et al.   PLOS BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Form and flexibility in phosphoinositide 3-kinases

(2009) Roger Williams et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Lantibiotics: Mode of Action, Biosynthesis and Bioengineering

(2009) G. Bierbaum et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Emerging Treatments in Cystic Fibrosis

(2009) Andrew M. Jones et al.   DRUGS

Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione

(2009) W. Zhang et al.   GENES & DEVELOPMENT

LANCL2 Is Necessary for Abscisic Acid Binding and Signaling in Human Granulocytes and in Rat Insulinoma Cells

(2009) Laura Sturla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

Pulmonary pharmacokinetics and safety of nebulized duramycin in healthy male volunteers

(2008) Ilka Steiner et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY